Approved Initiative Concepts

Approved Initiative Concepts

A concept describes the basic purpose, scope, and objectives of a potential solicitation of grants or contracts. Approved concepts are posted here to alert researchers to areas of NINDS research interest and to give researchers maximal lead time to plan projects. Please note that not every concept will lead to a Funding Opportunity Announcement (FOA). NINDS bases this determination on scientific and programmatic priorities and the availability of funds. Furthermore, even if they do convert, the actual FOA may differ in certain details from its originating concept.

The National Advisory Neurological Disorders and Stroke (NANDSC) Council conducts all NINDS concept clearances.

Council Round Concept Title Point of Contact Description Link to Council Discussion Category
2021/10 HEAL Pathway to Independence Award in Pain and SUD Research DP Mohapatra This concept seeks to increase the independent investigator workforce in research areas supported by the NIH HEAL Initiative, by facilitating a timely transition of outstanding postdoctoral researchers from mentored research positions to independent, tenure-track or equivalent faculty positions. The program will provide independent NIH research support during this transition in order to help awardees to launch competitive, independent research careers in research areas supported by the NIH HEAL Initiative. Furthermore, this concept also seeks to enhance biomedical research workforce diversity of independent investigators in research areas supported by the NIH HEAL Initiative. Presentation and Discussion begins at 3:19:50 and ends at 3:41:37 HEAL, new concept
2021/10 HEAL Advancing Health Equity in Pain and Comorbidities Cheryse Sankar The goal of this proposal is to expand on the HEAL Initiative's efforts to advance health equity. Specifically, this Funding Opportunity Announcement proposal aims to develop, test, and implement novel, multi-level, culturally appropriate interventions and/or adapt, test and evaluate efficacy and effectiveness of existing interventions in NIH designated populations that disproportionately experience negative health outcomes (HDPs). Interventions that target HDPs with chronic pain in addition to at least one comorbid condition (OUD, mental health disorders and/or chronic health conditions) are of the highest priority. Presentation and Discussion begins at 3:19:50 and ends at 3:41:37 HEAL, new concept
2021/10 HEAL Enhancing the Clinical Pain Management Workforce Initiative Linda Porter One goal of this proposed concept is to promote the expansion and enhancement of a diverse workforce of highly trained scientists in the area of clinical pain research through a nation-wide mentoring and networking program. It will provide mentoring and skills necessary to support practitioners who seek a career in clinical pain management research. Another goal is to create an environment where early-stage clinical pain researchers can connect and collaborate with early and experienced basic and translational researchers through a centralized network and sponsored events. The concept will promote collaborative research across the continuum of basic to clinical research to ensure that research outcomes are meaningful to people who suffer with acute or chronic pain. Presentation and Discussion begins at 3:19:50 and ends at 3:41:37 HEAL, new concept
2021/10 HEAL: Coordinated Pain Care in Health Care Systems Linda Porter There is a pressing need for access to coordinated pain management for people with chronic pain, especially those with other chronic health conditions. Pain care often is delivered as a single intervention such as medication or injections, through one setting, and by a single health care provider. This approach often results in inadequate pain relief and poor health outcomes. This proposed concept would support research projects to embed effective coordinated pain care into health care systems. The coordinated care strategy could be centered in primary care settings with an integrated referral system to specialty care or could be centered in specialty care programs and coordinated with primary care. A coordinating center will support the development and implementation of the research projects, ensure collaboration across the project teams, provide regulatory support, and promote adoption of effective coordinated models of pain care in health care systems. Presentation and Discussion begins at 3:19:50 and ends at 3:41:37 HEAL, new concept
2021/10 Next Generation HEAL Biomarker Program: Translational Tools to Facilitate Clinical Trials for Pain Therapeutics Ram Arudchandran Pain therapeutics development has been hampered by a dearth of specific and sensitive biological signatures or clinical measures that predict and/or monitor response to therapy. By supporting mechanistic research that is directed toward the development, validation, and implementation of a biological signature or clinical measure of pain, this concept aims to develop a toolkit of measures that will facilitate Phase II clinical trials for pain therapeutics or improve treatment decisions in pain management. Presentation and Discussion begins at 3:19:50 and ends at 3:41:37 HEAL, new concept
2021/10 Clinical Trial Readiness for Functional Neurological Disorders Codrin Lungu This proposed concept aims to address the lack of available standardized outcome measures to enhance clinical trial readiness across Functional Neurological Disorders (FNDs). Successful applications will result in fit-for-purpose validation of biomarkers, endpoints, and clinical outcome assessments that can be directly applicable for planned FND clinical trials and the collection of high-level evidence. Presentation and Discussion begins at 4:18:10 new concept
2021/10 Identification of Clinical Outcome Assessments to Measure Efficacy through Natural History Studies of Ultra-Rare Neurological and Neuromuscular Diseases Jill Morris The goal of this proposed concept is to support both retrospective and prospective natural history studies of individuals with ultra-rare neurological diseases to identify and evaluate the utility of clinical outcome assessments (COAs). In turn, COAs could be used to determine efficacy in clinical trials and remove major barriers to therapy development. This funding opportunity will be aimed specifically towards ultra-rare disorders with therapies being actively developed with an expectation of clinical trials in the near future. Presentation and Discussion begins at 4:24:20 new concept
2021/10 NINDS Doctoral Readiness (DR.) Program Michelle Jones-London This concept seeks to diversify the pool of well-trained post-baccalaureates who plan to pursue scientifically rigorous neuroscience research-focused Ph.D. programs. This will be achieved by creating a pilot program to bridge the critical career stage gap between college and graduate school for individuals with little to no access to rigorous research opportunities. Importantly, this proposed concept aims to examine the impact of a well-structured, two-year research experience at an institution with an outstanding graduate training environment on preparedness and candidacy for neuroscience doctoral programs. Presentation and Discussion begins at 4:30:18 new concept
2021/10 NeuroBioBank (NBB) Communications and Outreach Initiative Daniel Miller The goal of this proposed concept is to strengthen communication and outreach of the NIH Neurobiobank (NBB), to better provide the scientific research community with high quality human brain tissues. Through an open competition, an organization will be selected to meet the need for a coordinated communications strategy within the multi-site structure of the NBB. This will enable harmonized messaging and increased efficiency in outreach and public education about the importance of human brain donation. Presentation and Discussion begins at 4:43:40 new concept
2021/10 Reissue: CDE/Monitoring/Data Archive Contract Recompetition Carolina Mendoza-Puccini This concept supports an open competition for a five-year contract covering four areas: the monitoring of NINDS intramural clinical trials, data archiving, statistical support, and development and maintenance of the NINDS Common Data Elements (CDEs) project. Use of the CDEs helps to improve data accuracy, consistency, and interoperability among datasets, and have been integrated in data science strategic plans for NIH and NINDS. The proposed solicitation is for a recompetition of the NINDS Center for Clinical Trials Resources (CCTR). n/a reissued concept
2021/10 Reissue: Stroke Preclinical Assessment Network (SPAN) Francesca Bosetti The Stroke Pre-Clinical Assessment Network (SPAN) utilizes a novel, adaptive, secured system and a multi-site approach for parallel testing of promising cerebrovascular protective interventions designed to extend the treatment time window and/or improve outcome when combined with thrombolysis, thrombectomy or both in acute ischemic stroke. We propose the continuation of the network's activities (SPAN-Next) to screen and select highly promising treatment candidates for possible further study in human clinical trials. This FOA is a reissue of RFAs NS-18-033 and NS-18-034 and will include an open competition for the network testing sites and interventions and a limited competition for the Coordinating Center. n/a reissued concept
2021/10 Reissue: BRAIN Initiative: Research Resources Grants for Technology Integration and Dissemination U24 Natalie Trzcinski The overall goal of this funding opportunity is to accelerate the scientific impact of the NIH BRAIN Initiative through rapid dissemination of developed and validated technologies and resources broadly to the neuroscience research community. This FOA provides up to five years of support to projects that are highly relevant to the NIH BRAIN Initiative, disseminating resources for integration into neuroscience research practice. This FOA is a reissue of RFA-NS-19-006 and does not differ significantly from the previously issued FOA. n/a BRAIN, reissued concept
2021/10 Reissue: Prospective Observational Comparative Effectiveness Research in clinical Neurosciences Adam Hartman Given the high cost of traditional randomized controlled trials (RCTs) and their potential limitations, other approaches to developing rigorous evidence to support clinical decision-making are needed. One example of this approach is the prospective observational comparative effectiveness study (CER): the conduct of research comparing the benefits and harms of different existing interventions and strategies to prevent, diagnose, treat and monitor health conditions in "real world" settings. The purpose of this Funding Opportunity Announcement (FOA) is to encourage grant applications for investigator-initiated prospective observational CERs to NINDS. This FOA is a reissue of PAR-19-171, and now allows for limited studies of outcomes that are not included in typical care, and emphasizes the need for additional justification of why the proposed study cannot be done as an RCT. n/a reissued concept
2021/10 Reissue: Data Harmonization, Curation, and Secondary Analysis of Exsting Clinical Datasets Christine Swanson-Fischer This proposed concept will support interdisciplinary teams to curate, harmonize, and propose innovative, hypothesis-driven methods for performing secondary data analyses of existing multi-site clinical research datasets within the NINDS mission. Consistent with the FAIR (findable, accessible, interoperable and reusable) data principles, all awardees must make the datasets and associated processes and tools widely available to the scientific research community. This FOA is a reissue of RFA-NS-20-007 and does not differ from the previously issued FOA. n/a reissued concept
2021/10 Reissue: Small Vessel VCID Biomarker Validation Consortium Coodinating Center (U24) Rod Corriveau The overall goal of this concept is to deliver high-quality biomarkers ready for use in clinical trials, and for generating scientific breakthroughs in our understanding and treatment of vascular contributions to cognitive impairment and dementia (VCID). This proposed funding opportunity will continue support for a coordinating center for the NINDS small vessel VCID biomarkers consortium established in 2016, under NS-16-019 and NS-16-020. n/a reissued concept
2021/10 Reissue: Development of Biomarkers or Biomarkers Signatures for Neurological & Neuromuscular Disorders Carol Taylor-Burds The goal of this funding opportunity is to enable the development of biomarkers or biomarker signatures ready for definitive analytical and clinical validation, as research tools for therapeutic development or for informing clinical practice. The FOA uses a phased mechanism, wherein the initial R61 phase supports rigorous characterization of the biomarker in clinical samples or data as well as optimization, and preliminary validation of the detection method needed to measure the biomarker/signature. The subsequent R33 phase supports the preliminary clinical validation of the biomarker or biomarker signature to test the potential utility of the biomarker for a specified use in clinical trials or clinical practice. This FOA is a reissue of PAR-19-315 with minor revised scope: work in animal models will no longer be allowed and the biomarker must be tested for a specified context of use in the R33 phase. n/a reissued concept