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-The National Institute of Child Health and Human Development (NICHD). National Institute of Neurological Disorders and Stroke (NINDS), and National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invite applications from investigators willing to participate in a cooperative research network designed to reduce the incidence of hypoglycemia in children and young adults. -The Diabetes Research in Children Network (DirecNet) currently consists of five academic centers were selected from among respondents to a previous announcement (RFA-HD-01-009) to support a network focusing on glucose monitoring in children. This RFA serves to expand the mission of DirecNet. The network will use new tools to evaluate factors and mechanisms contributing to hypoglycemia and will set up clinical trials to test novel therapies, prevention strategies and devices designed to focus on hypoglycemia prevention for individuals with type1 diabetes. -It is anticipated that a maximum of five awards for Clinical Centers (CCs) and one award for a Data Coordinating Center (DCC) will be made. Approximately $2 million (total costs) [Direct plus Facilities and Administrative (F & A) costs] will be appropriated from the Balanced Budget Act Funds for Type 1 Diabetes. This commitment is contingent upon the availability of funds.

The objective of this funding opportunity announcement is to help ensure that highly trained scientists will be available in adequate numbers and in appropriate research areas to carry out the Nations biomedical, behavioral, and clinical research agenda.The participating Institutes of the National Institutes of Health (NIH) provide individual predoctoral research training fellowship awards to promising doctoral candidates who have the potential to become productive, independent investigators in research fields relevant to the missions of these participating NIH Institutes and Centers.

Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint takes advantage of economies of scale, confronts challenges too large for any single Institute or Center, and develops research tools and infrastructure that serve the entire neuroscience community. In FY 2007, the Blueprint is focusing on neurodegeneration. Mechanism of Support. This funding opportunity will utilize the Exploratory/Developmental (R21) to solicit grant applications from applicant organizations that propose to develop biomarkers of neurodegenerative disease. Funds Available and Anticipated Number of Awards. The participating organizations intend to commit a total of $2,750,000 to this FOA for payment of applications responsive to this announcement. The anticipated number of awards is 12-14. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. 

The NIH Blueprint for Neuroscience is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint takes advantage of economies of scale, confronts challenges too large for any single Institute or Center, and develops research tools and infrastructure that will serve the entire neuroscience community. In 2007, the Blueprint is focusing on neurodegeneration. This funding opportunity announcement (FOA) solicits short-term mentored career development (K18) grant applications from established investigators seeking short-term mentored career development and enhancement training experiences of six-twelve months, for example, during a sabbatical year, to acquire new interdisciplinary perspectives and capabilities in research on neurodegeneration. The participating organizations intend to commit a total of $1,250,000 to this FOA for payment of applications responsive to this announcement.

The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint takes advantage of economies of scale, confronts challenges too large for any single Institute or Center, and develops research tools and infrastructure that serve the entire neuroscience community. In FY 2007, the Blueprint is focusing on neurodegeneration. This funding opportunity solicits Individual Research Fellowship (F32) grant applications from promising applicants with the potential to become productive, independent investigators in research on neurodegenerative disease. Each applicant must have at least one primary sponsor/mentor and one co-sponsor/mentor representing different disciplines, with one in an allied discipline not traditionally associated with training in neurodegenerative processes. The participating organizations intend to commit a total of $1,250,000 to this Request for Applications (RFA) for payment of applications responsive to this announcement.

Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint takes advantage of economies of scale, confronts challenges too large for any single Institute or Center, and develops research tools and infrastructure that serve the entire neuroscience community. In FY 2007, the Blueprint is focusing on neurodegeneration. Mechanism of Support. This funding opportunity will utilize the Exploratory/Developmental (R21) to solicit grant applications from applicant organizations that propose to develop biomarkers of neurodegenerative disease. Funds Available and Anticipated Number of Awards. The participating organizations intend to commit a total of $2,750,000 to this RFA for payment of applications responsive to this announcement. The anticipated number of awards is 12-14. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. 

Purpose: The goal of the NIH-funded Knockout Mouse Project (KOMP) is to generate a comprehensive resource of null mutant alleles, with a reporter, using gene targeting mutagenesis in mouse strain C57BL/6. The construction of the KOMP mutant collection is being funded in projects submitted in response to RFA-HG-05-007 and RFA-DA-06-009. The purpose of this Funding Opportunity Announcement (FOA) is to establish a resource repository to collect and archive the null mutant alleles, primarily in the form of cryo-preserved embryonic stem (ES) cells, as well as associated DNA constructs, and cryo-preserved embryos or live mice created by the KOMP. The successful KOMP repository should aim to become self supporting over time. The KOMP Repository will distribute ES cells, embryos and/or live mice to eligible scientists, and provide reanimation services to establish and distribute live mice from archived ES cell lines or other cryo-preserved materials. The Repository will provide data on new KOMP-generated resources to the Data Coordination Center that was funded on the basis of an application submitted to RFA-HG-05-008. The Repository will also provide a public website, maintain an internal tracking database, operate a customer service and technical assistance center, interact with the other KOMP grantees, and coordinate with other national and international mouse resources. Applicants for this FOA must have a proven track record of establishing and managing a cryopreserved archive of murine ES cells, embryos, and DNA constructs, a colony of live mice, and successful distribution of these materials to qualified investigators. Documentation of this track record must be provided Mechanism of Support: This Funding Opportunity Announcement (FOA) will utilize the U42 cooperative agreement (Animal Models, and Animal and Biological Material Resource Cooperative Agreement) grant mechanism

-The purpose of this Funding Opportunity Announcement (FOA), Mechanisms, Models, Measurement, & Management in Pain Research, issued by the National Institute of Nursing Research (NINR) is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs. -New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences.Although great strides have been made in some areas, such as the identification of neural pathways of pain, the experience of pain and the challenge of treatment have remained uniquely individual and unsolved.Research to address these issues conducted by interdisciplinary and multidisciplinary research teams is strongly encouraged, as is research from underrepresented, minority, disabled, or women investigators. -This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-544, that utilizes the R01 mechanism and PA-06-543, that utilizes the R03 mechanism.

-The purpose of this Funding Opportunity Announcement (FOA), Mechanisms, Models, Measurement, & Management in Pain Research, issued by the National Institute of Nursing Research (NINR) is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs. -New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences.Although great strides have been made in some areas, such as the identification of neural pathways of pain, the experience of pain and the challenge of treatment have remained uniquely individual and unsolved.Research to address these issues conducted by interdisciplinary and multidisciplinary research teams is strongly encouraged, as is research from underrepresented, minority, disabled, or women investigators. -This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-544, that solicits applications under the R01 mechanism and PA-06-542, that solicits applications under the R21 mechanism.

-The purpose of this Funding Opportunity Announcement (FOA), “Mechanisms, Models, Measurement, & Management in Pain Research,” issued by the National Institute of Nursing Research (NINR) is to inform the scientific community of the pain research interests of the various Institutes and Centers (ICs) at the National Institutes of Health (NIH) and to stimulate and foster a wide range of basic, clinical, and translational studies on pain as they relate to the missions of these ICs.  -New advances are needed in every area of pain research, from the micro perspective of molecular sciences to the macro perspective of behavioral and social sciences. Although great strides have been made in some areas, such as the identification of neural pathways of pain, the experience of pain and the challenge of treatment have remained uniquely individual and unsolved. Research to address these issues conducted by interdisciplinary and multidisciplinary research teams is strongly encouraged, as is research from underrepresented, minority, disabled, or women investigators. -This FOA will utilize the R01 grant mechanism and runs in parallel with FOAs of identical scientific scope, PA-06-542, that solicits applications under the R21 mechanism, and PA-06-543, that solicits applications under the R03 mechanism.