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Purpose. The National Institute of Neurological Disorders and Stroke (NINDS), National Cancer Institute (NCI), National Heart, Lung, and Blood Institute (NHBLI), National Human Genome Research Institute (NHGRI), National Institute on Aging (NIA), National Institute of Child Health and Human Development (NICHD), National Institute on Deafness and Other Communication Disorders (NIDCD), and the National Institute of Environmental Health Sciences (NIEHS), in conjunction with the Ataxia-Telangiectasia Children’s Project (A-TCP) and the A-T Ease Foundation, invite research grant applications aimed at understanding or treating Ataxia-Telangiectasia (A-T). The aim of this FOA is to encourage basic, translational and clinical studies to determine how the symptoms of A-T develop, to stimulate the development of resources to further A-T research, to accelerate research into promising therapeutic approaches for A-T and to stimulate progress in A-T research through encouraging and facilitating interdisciplinary interactions. Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental (R21) award mechanism and runs in parallel with two other FOAs of identical scientific scope (R01, PA-07-272 and R03, PA-07-274) that solicit applications under the NIH Traditional Research Project Grant (R01) mechanism, and the NIH Small Research Grant (R03) mechanism, respectively. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Budget and Project Period. The total project period for an application submitted in response to this funding opportunity may not exceed two years. Direct costs are limited to $275,000 over an R21 two-year period, with no more than $200,000 in direct costs allowed in any single year. The R21 is not renewable. Eligible Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

Purpose. The National Institute of Neurological Disorders and Stroke (NINDS), National Cancer Institute (NCI), National Human Genome Research Institute (NHGRI), National Institute on Aging (NIA), National Institute of Child Health and Human Development (NICHD), and the National Institute of Environmental Health Sciences (NIEHS), in conjunction with the Ataxia-Telangiectasia Children’s Project (A-TCP) and the A-T Ease Foundation, invite research grant applications aimed at understanding or treating Ataxia-Telangiectasia (A-T). The aim of this FOA is to encourage basic, translational and clinical studies to determine how the symptoms of A-T develop, to stimulate the development of resources to further A-T research, to accelerate research into promising therapeutic approaches for A-T and to stimulate progress in A-T research through encouraging and facilitating interdisciplinary interactions. Mechanism of Support. This FOA will utilize the NIH Small Research Grant (R03) award mechanism and runs in parallel with two other FOAs of identical scientific scope (R01, PA-07-272 and R21, PA-07-273) that solicit applications under the NIH Traditional Research Project Grant (R01) mechanism, and the NIH Exploratory/Developmental Grant (R21) mechanism, respectively. The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. The R03 is intended to support small research projects that can be carried out in a short period of time with limited resources. The R03 is not renewable. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Budget and Project Period: Budgets for direct costs of up to $50,000 per year and a project duration of up to two years may be requested for a maximum of $100,000 direct costs over a two-year project period. Eligible Organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Indian/Native American Tribal Government (Federally Recognized); Indian/Native American Tribal Government (Other than Federally Recognized); Indian/Native American Tribally Designated Organization; Non-domestic (non-U.S.) Entity (Foreign Organization); Hispanic-serving Institution; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian Serving Institutions; Regional Organization; Other(s): Eligible agencies of the Federal government; Faith-based or community based organizations.

-Purpose. This Funding Opportunity Announcement (FOA) solicits grant applications proposing the development and conduct of innovative, collaborative research and research training projects, between developed and developing country scientists, on brain disorders throughout life, relevant to low- and middle-income nations. The collaborative research programs are expected to contribute to the long-term goal of building sustainable research capacity in developing countries to address neurological/neurodevelopmental (including sensory, motor, cognitive and behavioral) function and impairment throughout life.  -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PAR-06-420, that solicits applications under the Exploratory/Developmental Grant (R21) award mechanism.  -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. The anticipated number of awards is six to ten. 

-Purpose. This Funding Opportunity Announcement (FOA) issued by the Office of Research on Women's Health (ORWH) and co-sponsoring Institutes and Centers (ICs) of the National Institutes of Health (NIH) solicits grant applications from organizations/institutions that propose to examine the etiology, diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS) in diverse groups and across the lifespan. Applications that address gaps in the understanding of the environmental and biological risk factors, the determinants of heterogeneity among patient populations, and the common mechanisms influencing the multiple body systems that are affected in CFS are encouraged. The NIH is interested in funding interdisciplinary research that will enhance our knowledge of the disease process and improve the diagnosis, treatment, and quality of life of all persons with CFS. -Mechanism of Support. This FOA will use the NIH Small Research Grant (R03) award mechanism and runs in parallel with FOAs of identical scientific scope, PA-07-265 and PA-07-264, which solicit applications under the Research Project Grant (R01) and the Exploratory/Developmental Grant (R21) award mechanisms respectively. -The R03 grant mechanism supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology. 

-Purpose. This Funding Opportunity Announcement (FOA) issued by the Office of Research on Women's Health (ORWH) and co-sponsoring Institutes and Centers (ICs) of the National Institutes of Health (NIH) solicits investigator-initiated grant applications that propose to examine the etiology, diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS) in diverse groups and across the lifespan. Applications that address gaps in the understanding of the environmental and biological risk factors, the determinants of heterogeneity among patient populations, and the common mechanisms influencing the multiple body systems that are affected in CFS are encouraged. The NIH is interested in particularly interested in funding interdisciplinary research that will enhance our knowledge of the disease process and improve the diagnosis, treatment, and quality of life of all persons with CFS. -Mechanism of Support. This FOA will use the NIH Exploratory/Developmental Grant (R21) award mechanism and runs in parallel with FOAs of identical scientific scope, PA-07-265 and PA- 07-263, which solicit applications under the Research Project Grant (R01) and the Small Research Grant (R03) award mechanisms, respectively. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

-Purpose. This Funding Opportunity Announcement (FOA) issued by the Office of Research on Women's Health (ORWH) and co-sponsoring Institutes and Centers (ICs) of the National Institutes of Health (NIH) solicits investigator(s)-initiated applications that propose to examine the etiology, diagnosis, pathophysiology, and treatment of chronic fatigue syndrome (CFS), also known as myalgic encephalomyelitis (ME/CFS) in diverse groups and across the lifespan. Applications that address gaps in the understanding of the environmental and biological risk factors, the determinants of heterogeneity among patient populations, and the common mechanisms influencing the multiple body systems that are affected in CFS are encouraged. The NIH is particularly interested in funding interdisciplinary research that will enhance our knowledge of the disease process and improve the diagnosis, treatment, and quality of life of all persons with CFS. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PA-07-263, which solicits applications under the R03 mechanism and PA-07-264, which solicits applications under the R21 mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

Purpose. This announcement solicits applications for research project grants that will leverage and complement the ongoing technology development being pursued in the National Technology Centers for Networks and Pathways (TCNPs), a program of the NIH Roadmap for Medical Research. These collaborative projects should focus either on addressing a challenging biological problem using the technology developed in one or more of the TCNPs, or on the development of technology that will complement that which is being developed in the centers. Applicants may request support for their own work as well as supplemental support for components pursued in the participating TCNP. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Eligible Institutions/Organizations. Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organization (Other than Small Business); State Government; U.S. Territory or Possession; Non-domestic (non-U.S.) Entity (Foreign Organization); Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Other(s): Eligible agencies of the Federal government.

-Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system. By pooling resources and expertise, the Blueprint takes advantage of economies of scale, confronts challenges too large for any single Institute or Center, and develops research tools and infrastructure that serve the entire neuroscience community. -This FOA is issued in complement with the NIH Notice NOT-EB-07-002. These FOAs intend to support modification, and enhancement of existing neuroimaging informatics tools and resources that are hosted or being considered for inclusion into the NIH Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC). Examples of such tools include image segmentation, image registration, image processing pipelines, statistical analysis packages, spatial alignment and normalization algorithms, and data format translators. Resources include well-characterized test datasets, data formats, and databases, among others. The proposed work shall significantly improve the interoperability and adoptability of neuroimaging informatics tools and resources and result in enhanced dissemination, adoption, and evolution of such tools and resources by the broader neuroimaging research community. This R03 announcement aims in particular to support NIH grantees with significant research in the subject domain area of developing neuroimaging informatics tools and resources but who are not currently eligible to apply for Administrative Revision (formerly “supplements”) under the NOT-EB-07-002. Applicants who are not currently funded by the NIH and who are associated with significant research in the subject domain area should also apply through this FOA.

-Purpose. This funding opportunity announcement (FOA) is for projects from individual-investigators or small groups to collaborate with the NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). For a description of the NCBCs see http://www.bisti.nih.gov/ncbc/. The intention of the collaborating projects is to engage researchers across the nation in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. -Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PAR-07-250 that solicits applications under the R21 mechanism, and which solicits innovative, high risk/high impact new areas that are lacking preliminary data or development. -Successful applications will be funded by the participating ICs.

-Purpose. This funding opportunity announcement (FOA) is for projects from individual-investigators or small groups to collaborate with the NIH Roadmap for Medical Research National Centers for Biomedical Computing (NCBCs). For a description of the NCBCs see http://www.bisti.nih.gov/ncbc/. The intention of the collaborating projects is to engage researchers across the nation in building an excellent biomedical computing environment, using the computational tools and biological and behavioral application drivers of the funded NCBCs as foundation stones. -Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the R21 grant mechanism and runs in parallel with an FOA of identical scientific scope, PAR-07-249 that solicits applications under the R01 mechanism. -This FOA is intended to support exploratory biomedical informatics and computational biology research-applications should be innovative, with high risk-high impact in new areas that are lacking preliminary data or development. Applications for R21 awards should describe projects distinct from those supported through the traditional R01 mechanism. For example, long-term projects, or projects designed to increase knowledge in a well-established area will not be considered for R21 awards. -Successful applications will be funded by the participating ICs.