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The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung, and Blood Institute (NHLBI) encourage investigator-initiated research grant applications for projects studying pathogenesis and therapies for the muscular dystrophies. Responses to this announcement may include basic, translational or patient-oriented studies of Duchenne/Becker muscular dystrophy, facioscapulohumeral dystrophy, myotonic dystrophy or other forms of muscular dystrophy. This Funding Opportunity Announcement (FOA) will use the NIH Exploratory/Developmental Research Grant Award (R21) mechanism and runs in parallel with a program announcement of identical scientific scope (PA 05-038) that will utilize the traditional research project grant (R01) mechanism.  R21 applications may request up to $275,000 direct costs for the two-year term of the grant. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the number, quality, and costs of the applications received. Eligible organizations include for-profit and non-profit organizations, public or private institutions such as universities, colleges, hospitals and laboratories, units of State and local governments, eligible agencies of the Federal government, domestic or foreign institutions/organizations; Faith-based or community-based organizations, Indian/Native American Tribal Government (Federally Recognized), Indian/Native American Tribal Government (Other than Federally Recognized), Indian/Native American Tribally Designated Organizations. Eligible principal investigators include any individuals with the skills, knowledge, and resources necessary to carry out the proposed research. Applicants may submit more than one application, provided each application is scientifically distinct. 

The primary objective of this funding opportunity announcement is to help ensure that diverse pools of highly trained scientists will be available in appropriate research areas to carry out the Nations biomedical, behavioral, health services, or clinical research agenda.This initiative seeks to improve the diversity of the health-related research workforce by supporting the training of predoctoral students from groups that have been shown to be underrepresented.Such candidates include individuals from underrepresented racial and ethnic groups, individuals with disabilities, and individuals from disadvantaged backgrounds.Detailed eligibility criteria are described in the full announcement.

-This PA provides updated guidelines for the National Institute of General Medical Sciences (NIGMS) Minority Biomedical Research Support (MBRS) Support of Competitive Research (SCORE) Program SC1 mechanism for Research Advancement Awards. -The SCORE Program is a developmental program designed to increase the research competitiveness of faculty at minority-serving institutions (MSIs), and the research capabilities of MSIs To better achieve these objectives, the existing SCORE (S06) program, which had the structure of a non-thematic program project, has been revised so that separate funding opportunities exist for individual investigator-initiated research awards and for a stand-alone institutional award. The mechanisms used for these funding opportunities are the SC1, SC2 (PAR-06-492) and SC3 (PAR-06-493) awards for individual investigators and the S06 (PAR-06-490) award for institutions. The funding opportunities of the SC2, SC3 and S06 award mechanisms may be found at the NIGMS website, http://www.nigms.nih.gov/Minority/MBRS/. Research proposed under any of the investigator-initiated SCORE award mechanisms must fall within the scope of the NIH mission, which is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. -This announcement for the SC1 award outlines the investigator-initiated research project for faculty who are at the most advanced stages of development, i.e., who are engaged in state-of-the-art biomedical or behavioral research and productive as evidenced by a steady track record of peer-reviewed publications, yet they have not had significant non-SCORE support and are planning to transition to other major external sources of support. It is the expectation of this award that by providing support to conduct competitive research and mentoring to SC1 PIs through participation in grantsmanship workshops and biennial PI meetings, they will be successful in securing non-SCORE external support.

-This PA provides updated guidelines for the National Institute of General Medical Sciences (NIGMS) Minority Biomedical Research Support (MBRS) Support of Competitive Research (SCORE) Program SC2 mechanism for Pilot Project Awards. -The SCORE Program is a developmental program designed to increase the research competitiveness of faculty at minority-serving institutions (MSIs), and the research capabilities of MSIs. To better achieve these objectives, the existing SCORE (S06) program, which had the structure of a non-thematic program project, has been revised so that separate funding opportunities exist for individual investigator-initiated research awards and for a stand-alone institutional award. The mechanisms used for these funding opportunities are the SC1, SC2 and SC3 awards for individual investigators and the S06 award for institutions. The funding opportunities of the SC1 (PAR-06-491), SC3 (PAR-06-493) and S06 (PAR-06-490) award mechanisms may be found at the NIGMS website, http://www.nigms.nih.gov/Minority/MBRS/. Research proposed under any of the investigator-initiated SCORE award mechanisms must fall within the scope of the NIH mission, which is science in pursuit of fundamental knowledge about the nature and behavior of living systems and the application of that knowledge to extend healthy life and reduce the burdens of illness and disability. -This announcement for the SC2 award outlines the individual investigator-initiated pilot research project for faculty members who are in their early stages of development and are seeking to gather preliminary data or more advanced investigators interested in switching to a different research field from the one in which an individual has been engaged in and published.

-The purpose of this PAR is to invite qualified scientific investigators to submit applications designed to identify small molecule reagents that specifically prevent or ameliorate a protein folding or processing defect in simple and complex genetic diseases that are of interest to the participating institutes. -This funding opportunity will use the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, PAR-06-480, that solicits applications with the R21 mechanism. The total project period for an application in response to this PAR may not exceed 5 years. -Organizations that have any of the following characteristics may submit applications: For profit or non-profit, public or private institutions, such as universities, colleges, hospitals, and laboratories, units of State and local governments, or domestic institutions/organizations.

This funding opportunity announcement (FOA), issued as an initiative of the trans-NIH Bioengineering Consortium (BECON), is aimed at enhancing nanoscience and nanotechnology research approaches that have the potential to make valuable contributions to biology and medicine. Nanoscience and nanotechnology refer to research at the atomic, molecular or macromolecular levels, at the length scale of approximately 1 - 100 nanometers. The purpose of this initiative is to stimulate cross-cutting, integrative research in these fields of science and technology. In particular, this initiative invites research on: i) the creation and use of structures, devices and systems that have novel properties and functions because of their small size, that may be used to achieve a fundamental understanding of biological processes and /or contribute to disease detection, therapy, or prevention; ii) conception and fabrication of devices, that will effectively detect and analyze nanoscale entities of relevance to biomedicine; and iii) the study of biological systems at the nanoscale for the explicit purpose of using that information to develop nanotechnologies and nanostructured materials that will in turn benefit biology and medicine. It is anticipated that the research projects that will be most responsive to this FOA will require interdisciplinary collaborations among investigators with expertise in a range of disciplines, including but not limited to engineering, physics, chemistry, cellular and molecular biology, materials and computer science. Applications submitted in response to this PA may propose hypothesis-driven, discovery-driven, developmental, or design-directed research.

The Office of Research Integrity (ORI, DHHS), the National Institute of Nursing Research (NINR, NIH), the National Institute of General Medical Sciences (NIGMS, NIH), the National Institute of Neurological Disorders and Stroke (NINDS, NIH), the National Library of Medicine (NLM, NIH), and the Agency for Healthcare Research and Quality (AHRQ, DHHS) invite applications to support empirical research on research integrity. Proposals must have clear relevance to biomedical, behavioral health sciences, and health services research. Applicants are strongly encouraged to take into consideration problems or issues that have relevance to specific missions of DHHS, AHRQ, or NIH institutes and centers.

-The National Institutes of Health (NIH) will award Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) to eligible institutions as the primary means of supporting graduate and postdoctoral research training to help ensure that a diverse and highly trained workforce is available to assume leadership roles related to the Nations biomedical, behavioral and clinical research agenda. -The primary objective is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation. -This program supports predoctoral, postdoctoral and short term research training programs at domestic institutions of higher education with the T32 funding mechanism. Note that programs solely for short-term research training should not apply to this announcement, but rather the separate (T35) NRSA Short-Term Institutional program exclusively reserved for short-term programs(see http://grants1.nih.gov/grants/guide/pa-files/PA-05-117.html)

The NINDS seeks to fund high quality clinical trials to evaluate treatments for neurological disorders. This Funding Opportunity Announcement (FOA) invites applications under the NINDS Clinical Trial Planning Grant Program, the purpose of which is to provide support for the organization of activities critical for the successful implementation of high-risk, complex, or large-scale clinical trials. The planning grant is intended to (a) allow for early peer review for the rationale and design of the proposed clinical trial; (b) provide support for the development of a detailed manual of operations and procedures; and (c) provide support to develop essential elements of a clinical trial, such as the development of tools for data management and oversight of the research, the definition of recruitment strategies, the finalization of the protocol, analytical techniques, facilities, administrative procedures, obtaining IND/IDE, and the establishment of collaborative arrangements. The purpose of the NINDS planning grant is not to obtain preliminary data or to conduct pilot studies to support the rationale or the clinical trial. The expected product of the planning grant is a detailed clinical trial research plan including a complete manual of operations and procedures. Included in the planning grant application must be a completed study protocol and projected direct costs for the future phase III trial.

-This programannouncement (PA) is being issued in conjunction with PA-06-419, BIOENGINEERING RESEARCH GRANTS, and PA-06-418, EXPLORATORY/DEVELOPMENTAL (R21) BIOENGINEERING RESEARCH GRANTS. -This funding opportunity will use the NIH R01 research grant award mechanism. -Participating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic, applied, and translational multi-disciplinary research that addresses important biological or medical research problems. -In the context of this program, a partnership is a multi-disciplinary research team that applies an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. -The partnership must include appropriate bioengineering or allied quantitative sciences in combination with biomedical and/or clinical components.