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This funding opportunity announcement (FOA) solicits Small Business Technology Transfer (STTR) grant applications from small business concerns (SBCs) that propose innovative research in biomedical computational science and technology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here biomedical computing or biomedical information science and technology includes, database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational research including the development of structural, functional, integrative, and analytical models and simulations.

This funding opportunity announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose innovative research in biomedical computational science and technology to promote the progress of biomedical research. There exists an expanding need to speed the progress of biomedical research through the power of computing to manage and analyze data and to model biological processes. The NIH is interested in promoting research and developments in biomedical computational science and technology that will support rapid progress in areas of scientific opportunity in biomedical research. As defined here biomedical computing or biomedical information science and technology includes, database design, graphical interfaces, querying approaches, data retrieval, data visualization and manipulation, data integration through the development of integrated analytical tools, and tools for electronic collaboration, as well as computational research including the development of structural, functional, integrative, and analytical models and simulations.

-The National Institute of Mental Health (NIMH), National Institute on Aging (NIA), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute on Drug Abuse (NIDA), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institute on Neurological Disorders and Stroke (NINDS), and National Cancer Institute (NCI) request research grant applications to study neuroimmune molecules and mechanisms involved in regulating normal and pathological central nervous system (CNS) function. -This FOA will use the Exploratory/Development (R21) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-05-054, that solicits applications under the NIH Research Project (R01). -Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

The National Institute of Mental Health (NIMH) and its Center for Mental Health Research on AIDS as well as the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (NINDS) invite applications proposing novel models of HIV-related central or peripheral nervous system damage that can be used to screen for compounds showing promise as treatments in the patient population.

The National Institute of Mental Health (NIMH) and its Center for Mental Health Research on AIDS as well as the National Institute on Drug Abuse (NIDA) and the National Institute of Neurological Disorders and Stroke (MINDS) invite applications proposing novel models of HIV-related central or peripheral nervous system damage that can be used to screen for compounds showing promise as treatments in the patient population.

-Special Note:The participating NIH Institutes and Centers (ICs) have distinctive guidelines, requirements, salary and research support levels provided under the auspices of this funding opportunity announcement in order to accommodate the career needs of researchers working in fields related to their specific research missions. Candidates are therefore strongly encouraged to contact the staff person in the relevant Institute or Center listed under Section VII (http://grants.nih.gov/grants/guide/contacts/pa-06-527_contacts.htm) prior to preparing an application to discuss issues of eligibility and review the specific provisions of this award.Below are the general provisions of the Independent Scientist Award (K02). -In general, the Independent Scientist Award (K02) provides support for newly independent scientists (see IC provisions) who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers. -The K02 is intended to foster the development of outstanding scientists and to enable them to expand their potential to make significant contributions to their field of research.

-This announcement solicits applications for research project grants that will leverage and complement the ongoing technology development being pursued in the National Technology Centers for Networks and Pathways (TCNPs), a program of the NIH Roadmap for Medical Research. These collaborative projects should focus either on addressing a challenging biological problem using the technology developed in one or more of the TCNPs, or on the development of technology that will complement that which is being developed in the centers. Applicants may request support for their own work as well as supplemental support for components pursued in the participating TCNP. -Because the nature and scope of the proposed research will vary, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. -This PA will use the R01 mechanism.

This Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH), the National Institute on Aging (NIA), the National Institute of Alcohol Abuse and Alcoholism (NIAAA), the National Institute of Biomedical Imaging and Bioengineering (NIBIB), and the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH), invites NIH Exploratory/Developmental Grant (R21) applications from organizations/institutions that propose the development of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging in human brain, and that incorporate pilot or clinical feasibility evaluation in pre-clinical studies, model development, or clinical studies.

This Funding Opportunity Announcement (FOA) issued by the National Institute of Mental Health (NIMH), the National Institute on Aging (NIA), National Institute of Alcohol Abuse and Alcoholism (NIAAA), and the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH), invites Phase II Developmental (R33) grant applications from organizations/institutions that propose the development of novel radioligands for positron emission tomography (PET) or single photon emission computed tomography (SPECT) imaging in human brain, and that incorporate pilot or clinical feasibility evaluation in pre-clinical studies, model development, or clinical studies.

-The Mentored Clinical Scientist Research Career Development Award (K08) represents the continuation of a long-standing NIH program that provides support and protected time to individuals with a clinical doctoral degree for an intensive, supervised research career development experience in the fields of biomedical and behavioral research, including translational research.Individuals with a clinical doctoral degree interested in pursuing a career in patient-oriented research should refer to the NIH Mentored Patient-Oriented Research Career Development Award (K23). -An award is for a period of 3 to 5 years and provides support for salary and research-related costs. The amount funded as salary for a career development award varies among the NIH participating Institutes and Centers (ICs). Therefore, the applicant is strongly advised to contact the relevant IC for any distinct guidelines, requirements, and allowable funds (http://grants.nih.gov/grants/guide/contacts/pa-06-512_contacts.htm). -Applications may be submitted on behalf of the candidate (principal investigator) by any domestic for-profit or non-profit institution/organization, or public or private institution, such as a university, colleges, hospital or laboratory.Foreign institutions are not eligible to apply.