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The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision by advancing safe, non-addictive, and prevention-oriented approaches to chronic pain.

This is a non-competitive funding opportunity intended to fund a single award. The National Institute of Neurological Disorders and Stroke is announcing its intent to issue a single source cooperative agreement award to Massachusetts General Hospital to support the renewal of the Post-Stroke Vascular Cognitive Impairment & Dementia (VCID) program, an ongoing, multi-site clinical research initiative designed to elucidate mechanisms linking stroke to subsequent cognitive impairment and dementia. The award will enable completion of the scientific aims initiated under the original U19 cooperative agreement (RFA-NS-19-012) and advance national priorities described in the National Plan to Address Alzheimer"s Disease.This is a Notice of Funding Opportunity (NOFO) for a Single Source that will invite an application from Massachusetts General Hospital. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and only meritorious application(s) will be considered for funding.

This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility, for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. This NOFO will renew the HEALthy Brain and Child Development (HBCD) Research Project Sites.The HBCD Study is a nationwide, multi-site, longitudinal study that follows children from birth through childhood. The study examines brain and behavioral development, with a focus on how prenatal substance exposure affects health outcomes.The HBCD Consortium consists of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single overall Consortium Administrative Core (HCAC); and (3) a single central Data Coordinating Center (HDCC). As such, this NOFO runs in parallel with a companion NOFO that solicits applications for the HCAC and the HDCC (RFA-DA-27-014). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, and participate in project activities.

This is a Notice of Funding Opportunity (NOFO) is for a Limited Competition that will invite applications from eligible organizations to apply. Please see Section III. Eligibility, for additional information. In accordance with NIH standard peer-review processes, the applications will be peer-reviewed, and only meritorious applications will be considered for funding. This NOFO will renew the HEALthy Brain and Child Development (HBCD) Consortium Administrative Core (HCAC) and Data Coordinating Center (HDCC).The HBCD Study is a nationwide, multi-site, longitudinal study that follows children from birth through childhood. The study examines brain and behavioral development, with a focus on how prenatal substance exposure affects health outcomes.The HBCD Consortium consists of three highly integrated components: (1) a set of linked Research Project Sites, (2) a single overall HCAC; and (3) a single central HDCC. As such, this NOFO runs in parallel with a companion NOFO that solicits applications for linked research sites (RFA-DA-27-013). It is expected that investigators, upon funding, will work jointly with NIH scientific staff to assist, guide, coordinate, or participate in project activities.

The purpose of the NINDS Child Neurology Career Development Program (CNCDP) is to facilitate and support the research career development of physicians specialized in Child Neurology who have made a commitment to independent research careers. The CNCDP is a single national program, implemented by one or more PD/PIs, together with an advisory committee composed of basic and clinical investigators who have a strong record of funded research and successful training of physicianscientists. The CNCDP will generally provide three consecutive years of support to individuals to provide them with the knowledge, tools and research experience that will enable them to develop a significant research project funded by an individual career development award or research grant.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for the conduct of scientific research utilizing data from expanded access (EA) for investigational drugs or biological products as described in section 561 of the Federal Food, Drug, and Cosmetic Act (21 U.S.C. 360bbb). These applications will target intermediate size populations of patients living with amyotrophic lateral sclerosis (ALS) who are not eligible for ongoing clinical trials for the prevention, diagnosis, mitigation, treatment, or cure of ALS.

pNINDS will extend this funding opportunity for one more receipt date and Council./p

This Notice of Funding Opportunity (NOFO) invites applications to serve as the National Institute of Neurological Disorders and Stroke (NINDS) Human Biospecimen and Data Repository in Neurological Disorders. This repository will maintain the current collection of biospecimens as well as support expansion of the collection in accordance with the NINDS mission. The NINDS Human Biospecimen and Data Repository will distribute biospecimens broadly to qualified academic and industry researchers to advance basic, translational and clinical research in neurological disorders.

pUpdating the receipt date./p

The purpose of this NOFO is to establish the NIH Blueprint for Neuroscience Research Coordination Center for Interoception Research (BPCCIR). Interoception, for the purpose of this NOFO, encompasses the processes by which an organism or a person senses, interprets, integrates, and regulates signals that represent the internal states. The goals of the NBCCIR are to: 1) promote a multidisciplinary approach for interoception research, and 2) bridge the gap between brain and body studies through a cooperative agreement funding mechanism, U24. This NOFO aims to foster interactions within the broad community of interoception researchers, rather than focusing on disease-specific subdisciplines. Specifically, the NOFO will support efforts to: 1) establish and maintain a multidisciplinary team of interoception researchers to oversee and guide NBCCIR activities; 2) create and support digital communication platforms to facilitate networking, collaborations, and information dissemination; 3) plan, organize, and host at least one scientific meeting per year that will include NIH-funded interoception researchers, trainees, and other stakeholders; 4) identify challenges and future technological and scientific opportunities for the field of interoception and develop common terminology, data standards, and common data elements; and 5) generate metrics of success and plans to ensure the sustainability of the interoception research community.