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NINDS Interest in Pain Research | View information, FAQs, resources, and available funding notices and opportunities.

All NINDS-related funding opportunity announcements (FOAs), request for applications (RFAs), program announcements (PAs), and other NIH Guide announcements are listed.Search the Closed Announcements tab to find expired opportunities. Search the Notices tab to find all Notices.

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Expiration Date: Tuesday, November 22, 2022FOA Number: RFA-NS-22-030Release Date: Tuesday, September 20, 2022Announcement Type: RFA
Reissue RFA-NS-11-010: The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite applications to participate as a Data Coordinating Center in the Network for Excellence in Neuroscience Clinical Trials. This clinical research network will develop and conduct multiple, scientifically sound, possibly biomarker-informed exploratory clinical trials evaluating the most promising therapies, whether from academic, foundation or industry discoveries. Examples include Phase 2 clinical trials and clinical research studies aimed at validating biomarkers and clinical outcomes in preparation for clinical trials. The network will provide a robust, standardized, and accessible infrastructure to facilitate rapid development and implementation of protocols in neurological disorders affecting adult and/or pediatric populations. While the network will not be specific to one disease, it will have the capacity to coordinate a cadre of specialist investigators to implement studies efficiently in response to disease-specific opportunities. This FOA solicits applications for the Data Coordinating Center (DCC). Separate FOAs solicit applications for the Clinical Sites and the Clinical Coordinating Center.
Expiration Date: Tuesday, November 22, 2022FOA Number: RFA-NS-22-031Release Date: Tuesday, September 20, 2022Announcement Type: RFA
The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite currently awarded NeuroNEXT sites and potential new sites to participate as a Clinical Site in the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT). This clinical research network develops and conducts multiple, scientifically sound, possibly biomarker-informed exploratory clinical trials evaluating the most promising therapies for neurological disorders, whether from academic, foundation or industry discoveries. Examples include Phase 2 clinical trials and clinical research studies aimed at validating biomarkers and clinical outcomes in preparation for clinical trials. The network provides a robust, standardized, and accessible infrastructure to facilitate rapid development and implementation of protocols in neurological disorders affecting adult and/or pediatric populations. While the network is not specific to one disease, it has the capacity to coordinate a cadre of specialist investigators to implement studies efficiently in response to disease-specific opportunities. This FOA solicits applications for Clinical Sites. Separate FOAs solicit applications for the Clinical Coordinating Center and the Data Coordinating Center.
Expiration Date: Tuesday, November 22, 2022FOA Number: RFA-NS-22-029Release Date: Tuesday, September 20, 2022Announcement Type: RFA
Reissue RFA-NS-11-009: The purpose of this funding opportunity announcement (FOA), issued by NINDS, is to invite applications to participate as a Clinical Coordinating Center in the Network for Excellence in Neuroscience Clinical Trials. This clinical research network will develop and conduct multiple, scientifically sound, possibly biomarker-informed exploratory clinical trials evaluating the most promising therapies, whether from academic, foundation or industry discoveries. Examples include Phase 2 clinical trials and clinical research studies aimed at validating biomarkers and clinical outcomes in preparation for clinical trials. The network will provide a robust, standardized, and accessible infrastructure to facilitate rapid development and implementation of protocols in neurological disorders affecting adult and/or pediatric populations. While the network will not be specific to one disease, it will have the capacity to coordinate a cadre of specialist investigators to implement studies efficiently in response to disease-specific opportunities. This FOA solicits applications for the Clinical Coordinating Center (CCC). Separate FOAs solicit applications for the Clinical Sites and the Data Coordinating Center.
Expiration Date: Tuesday, November 22, 2022FOA Number: RFA-NR-23-001Release Date: Friday, September 16, 2022Announcement Type: RFA
This Funding Opportunity Announcement (FOA) encourages UG3/UH3 phased cooperative research applications to accelerate implementation of effective non-opioid interventions for chronic pain management in rural and remote populations. Projects include pragmatic, implementation, or hybrid effectiveness-implementation trials to improve pain management and reduce the use of inappropriate opioid medications. Awards made under this FOA will initially support a milestone-driven, planning phase (UG3) of 1 to 2 years, with possible transition to an implementation phase (UH3) of up to 4 years duration (5 years total for the two phases). UG3 projects that have met the scientific milestone and feasibility requirements may transition to the UH3 phase. The UG3/UH3 application must be submitted as a single application, following the instructions described in this FOA. The overall goal of this initiative is to support the "real world" implementation of effective interventions to manage pain in rural and remote areas. Results from the trials supported by this funding opportunity announcement (FOA) should inform policy makers, payers, community stakeholders, as well as health care providers and patients in the primary care, emergency department, hospital, home health, or dental setting. This FOA requires that the investigators partner with one or more rural healthcare system(s) to plan and implement the intervention. During the planning phase, investigators must develop an additional one or more community-based partnership(s). Studies may propose to integrate multi-component, bundled, or multi-level interventions that have demonstrated efficacy.
Expiration Date: Wednesday, November 30, 2022FOA Number: RFA-DA-23-037Release Date: Thursday, September 8, 2022Announcement Type: RFA
The FOA is expected to be published in early 2022 with an expected application due date in Fall 2022. (from NOT-DA-21-085, TJZ 3/11/2022).
Research Category: Neural Exposome, ONETOXExpiration Date: Tuesday, November 22, 2022FOA Number: RFA-OD-22-016Release Date: Tuesday, August 30, 2022Announcement Type: RFAContact: David Jett

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications for a Laboratory Core for the Environmental influences on Child Health Outcomes (ECHO) program. The ECHO Laboratory Core will provide leadership, project management, and infrastructure for all activities related to ECHO Cohort biospecimens and data generated from biospecimen assays. The main roles of the ECHO Laboratory Core are to: (1) facilitate ECHO Cohort biospecimen collection and processing; (2) manage the ECHO Cohort Biorepository; (3) perform or facilitate a wide range of biospecimen assays to support ECHO Cohort analyses; and (4) coordinate biospecimen information and assay results.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites for follow-up of existing ECHO Cohort participants and for recruitment of new pregnant participants (RFA-OD-22-018), for Cohort Study Sites only for follow-up of existing ECHO Cohort participants (RFA-OD-22-019), for Cohort Study Sites only for recruitment of new pregnant participants (RFA-OD-22-017), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Data Analysis Center (RFA-OD-22-022), and for an ECHO Measurement Core (RFA-OD-22-020).

Research Category: Neural Exposome, ONETOXExpiration Date: Tuesday, November 22, 2022FOA Number: RFA-OD-22-019Release Date: Tuesday, August 30, 2022Announcement Type: RFAContact: David Jett

This funding opportunity announcement (FOA) invites applications to renew current ECHO Cohort Study Sites to extend the capacity of the ECHO Cohort to further investigate the roles of a broad range of early exposures from society to biology on ECHOs five key child health outcome areaspre-, peri- and postnatal, upper and lower airways, obesity, neurodevelopment, and positive healthamong diverse populations. The objectives of this FOA are to solicit applications to 1) lead collaborative ECHO Cohort science, 2) follow up existing ECHO Cohort participants, and 3) implement the ECHO Cohort Data and Biospecimen Collection Protocol using the ECHO Cohort consortiums central data capture system, e.g., REDCap Central. This FOA does not support site-specific analyses and science. Only current ECHO Cohort awardees are eligible to apply. This new funding period will be 7 years in duration provided successful performance in the UG3 phase and the UH3 phase.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites for a limited competition of follow-up of existing ECHO Cohort participants AND of recruitment of new pregnant participants, their resulting offspring, and, if available, the conceiving partner (RFA-OD-22-018), for ECHO Cohort Study Sites only for an open competition of recruitment of new pregnant participants, their resulting offspring, and, if available, the conceiving partner (RFA-OD-22-017), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Data Analysis Center (RFA-OD-22-022), for an ECHO Measurement Core (RFA-OD-22-020), and for an ECHO Laboratory Core (RFA-OD-22-016).

Research Category: Neural Exposome, ONETOXExpiration Date: Tuesday, November 22, 2022FOA Number: RFA-OD-22-022Release Date: Tuesday, August 30, 2022Announcement Type: RFAContact: David Jett

This funding opportunity announcement (FOA) invites applications for a Data Analysis Center for the NIH Environmental influences on Child Health Outcomes (ECHO) program. The Data Analysis Center's main roles are to 1) lead, standardize, and integrate ECHO Cohort Protocol data capture, management, and storage through a central data system; 2) provide analytic support and expertise to analysis proposals approved by the ECHO Cohort consortium; and 3) enrich research infrastructure and data science to facilitate broader sharing of ECHO Cohort data and resources with the scientific community.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites for follow-up of existing ECHO Cohort participants and for recruitment of new pregnant participants (RFA -OD-22-018), for Cohort Study Sites only for follow-up of existing ECHO Cohort participants (RFA-OD-22-019), for Cohort Study Sites only for recruitment of new pregnant participants (RFA-OD-22-017), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Measurement Core (RFA-OD-22-020), and for an ECHO Laboratory Core (RFA-OD-22-016).

Research Category: Neural Exposome, ONETOXExpiration Date: Tuesday, November 22, 2022FOA Number: RFA-OD-22-017Release Date: Tuesday, August 30, 2022Announcement Type: RFAContact: David Jett

This funding opportunity announcement (FOA) invites applications for new ECHO Cohort Study Sites to extend and expand the capacity of the ECHO Cohort to further investigate the roles of a broad range of early exposures from society to biology, including the preconception period, on ECHOs five key child health outcome areaspre-, peri- and postnatal, upper and lower airways, obesity, neurodevelopment, and positive healthamong diverse populations. The objectives of this FOA are to solicit applications to 1) lead collaborative ECHO Cohort science, 2) recruit new pregnant participants from diverse populations, their resulting offspring, and, if available, the conceiving partner, 3) develop and implement the ECHO Cohort Preconception Pilot Study, and 4) implement the ECHO Cohort Data and Biospecimen Collection Protocol using the ECHO Cohort consortiums central data capture system, e.g., REDCap Central.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites only for a limited competition of follow-up of existing ECHO Cohort participants (RFA-OD-22-019), for ECHO Cohort Study Sites only for a limited competition of follow-up of existing ECHO Cohort participants AND of recruitment of new pregnant participants, their resulting offspring, and, if available, the conceiving partner (RFA-OD-22-018), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Data Analysis Center (RFA-OD-22-022), for an ECHO Measurement Core (RFA-OD-22-020), and for an ECHO Laboratory Core (RFA-OD-22-016).

Research Category: Neural Exposome, ONETOXExpiration Date: Tuesday, November 22, 2022FOA Number: RFA-OD-22-020Release Date: Tuesday, August 30, 2022Announcement Type: RFAContact: David Jett

This funding opportunity announcement (FOA) invites applications for a Measurement Core for the Environmental influences on Child Health Outcomes (ECHO) program. Working collaboratively with the other members of the ECHO Cohort consortium, the ECHO Cohort Measurement Core will: 1) develop and refine measures for the ECHO Cohort Protocol, including methods to implement the measures; 2) assist all ECHO Cohort Study Sites, Cores, and Centers in implementing and evaluating the ECHO Cohort Protocol which comprises standardized measures at specified study visits; and 3) lead strategic decision-making to incorporate new and revised measures to advance ECHO Cohort science while moderating participant and staff burden.

This FOA runs in parallel with companion FOAs that solicit applications for Cohort Study Sites for follow-up of existing ECHO Cohort participants and for recruitment of new pregnant participants (RFA-OD-22-018), for Cohort Study Sites only for follow-up of existing ECHO Cohort participants (RFA-OD-22-019), for Cohort Study Sites only for recruitment of new pregnant participants (RFA-OD-22-017), for an ECHO Coordinating Center (RFA-OD-22-021), for an ECHO Data Analysis Center (RFA-OD-22-022), and for an ECHO Laboratory Core (RFA-OD-22-016).