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Postural Orthostatic Tachycardia Syndrome (POTS) is a debilitating condition that affects between 0.2 and 1% of the US population and may be even more prevalent since the COVID-19 pandemic. The conditionimpairs individuals' ability to participate in routine activities such as working, attending school, exercising and activities of daily life. POTS primarily affects women of child-bearing age, with most studies reporting 80-90% female predominance. While many individuals with POTS report symptoms beginning in adolescence, up to half of all individuals with POTS develop it in adulthood. The impact of POTS across the lifespan has until now not been well studied, and given the female preponderance of the condition there is an unmet need to study how the condition is impacted by events such as menarche, pregnancy and menopause. There is a compelling need to stimulate research focused on improving diagnosis and treatment of POTS. This may include development of biomarkers and diagnostic tools as well as translational studies and mechanistic clinical trials to guide the development of interventions aimed at preventing and curing POTS. This NOSI signals interest in this important area with the goal of stimulating research applications to address these critical needs.

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) intend to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) that solicits applications focused on the neurological and psychiatric manifestations of infection-associated chronic illnesses, including the post-acute sequelae of COVID-19 (Neuro-PASC) as well as other chronic illnesses with a potential infectious trigger (post-treatment Lyme Disease, myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS], postural orthostatic tachycardia syndrome [POTS], post-viral fatigue syndromes, etc.). Projects that investigate common neuropsychiatric mechanisms across multiple infection-associated chronic illnesses would be of particular interest, although this is not a requirement (i.e., applications can focus on a single condition).

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) intend to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) that solicits applications focused on the neurological and psychiatric manifestations of infection-associated chronic illnesses, including the post-acute sequelae of COVID-19 (Neuro-PASC) as well as other chronic illnesses with a potential infectious trigger (post-treatment Lyme Disease, myalgic encephalomyelitis/chronic fatigue syndrome [ME/CFS], postural orthostatic tachycardia syndrome [POTS], post-viral fatigue syndromes, etc.). Projects that investigate common neuropsychiatric mechanisms across multiple infection-associated chronic illnesses would be of particular interest, although this is not a requirement (i.e., applications can focus on a single condition).

National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite exploratory and innovative researchapplications focused on theneurological and neuropsychiatric manifestationsof COVID-19 (neuro-COVID) andPost-Acute Sequelae of SARS-CoV-2 Infection (neuro-PASC) and on the effect of COVID-19 on pre-infection neurologic conditions. Applications investigating the pathophysiology and mechanisms of neuro-COVID and neuro-PASC and neurologically-focused human subjects research, as well as those proposing studies of scientifically compelling pathways to prevent the development of neuro-PASC or to accelerate the development of effective treatments forPASC-related neurological complications are of particular interest for this FOA. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in the first quarter of 2023 with an expected application due date in late Spring 2023. This FOA will utilize the R01 activity code. Details of the planned FOA are provided below.

National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite exploratory and innovative researchapplications focused on theneurological and neuropsychiatric manifestationsof COVID-19 (neuro-COVID) andPost-Acute Sequelae of SARS-CoV-2 Infection (neuro-PASC) and on the effect of COVID-19 on pre-infection neurologic conditions. Applications investigating the pathophysiology and mechanisms of neuro-COVID and neuro-PASC and neurologically-focused human subjects research, as well as those proposing studies of scientifically compelling pathways to prevent the development of neuro-PASC or to accelerate the development of effective treatments forPASC-related neurological complications are of particular interest for this FOA. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in the first quarter of 2023 with an expected application due date in late Spring 2023. This FOA will utilize the R21 activity code. Details of the planned FOA are provided below.

This NINDS Notice provides additional guidance for requesting funded extensions for NINDS K award recipients impacted by COVID-19.

The NINDS F32 is designed specifically to support postdoctoral fellows who are beginning their training period in a new laboratory or research environment. Applicants are only eligible to apply for the NINDS F32 either before beginning or within the first 12 months of joining the postdoctoral lab in which the fellowship will be active. Given this eligibility window, many applicants apply either before or within the first 3 months in the laboratory (~30% of applicants have been in the postdoctoral laboratory for less than 3 months). At the start of the COVID-19 pandemic many laboratories across the country shut down. This would have been particularly detrimental to those transitioning to their new positions, which in most cases required not only a change in research institution but a move to a different city and/or state. Clearly, for those starting a new postdoctoral position right as the pandemic hit, labs began to close down amid uncertainty and remote interactions were just beginning to be developed. Although pandemic-related delays were not unique to a specific cohort of trainees, the individuals who were just starting in new postdoctoral positions during the initial months of the pandemic were some of the hardest hit in terms of their ability to integrate into and begin research-related activities in new laboratories. Consequently, NINDS will provide a 1-receipt cycle extension of eligibility to individuals who started in their new laboratory between February 1 and May 30 of 2020. Ordinarily, the last NINDS F32 due date for these individuals would have been February, 2021. With this extension, these individuals will now be eligible to apply for the June, 2021 due date.

The purpose of this Request for Information (RFI) is to solicit public comment on the use of Common Data Elements (CDEs) in NIH-funded research, particularly in the context of research on COVID-19.

The purpose of this Notice is to inform the extramural community that as a result of disruptions caused by the COVID-19 pandemic, the BRAIN Initiative will be providing up to a two-receipt cycle extension (roughly eight additional months) of eligibility for prospective applicants meeting the requirements for submission of an application to the BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00) through the February/March 2021 due dates.

Notice Change: Late Application Policy September 28, 2020, Application Due Date RFA-NS-21-001 NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research P50 Clinical Trial Optional)" Notice Number: NOT-NS-20-097 Key Dates Release Date: August 11, 2020 Related Announcements RFA-NS-21-001 - NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research P50 Clinical Trial Optional) Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to inform applicants a change the late application policy the September 28, 2020, Application Due Date RFA-NS-21-001 "NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research P50 Clinical Trial Optional)". NINDS understands the public health emergency related the Coronavirus Disease 2019) adversely affect applicants' ability submit applications a timely manner.  Late applications be accepted through 5:00 PM local time October 13, 2020, RFA-NS-21-001 "NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research P50 Clinical Trial Optional)".  late applications submitted after October 13, 2020 be considered. cover letter citing Notice NOT-NS-20-097) be submitted, it not required. the September 28, 2021, September 28, 2022, application due date(s), NIH Policy Late Submission Grant Applications NOT-OD-15-039 applies. RFA modified no longer state, "No late applications be accepted this Funding Opportunity Announcement."  Application Due Date(s) September 28, 2020, September 28, 2021, September 28, 2022 applications due 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due the listed date(s). late applications be accepted this Funding Opportunity Announcement. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Application Due Date(s) September 28, 2020, September 28, 2021, September 28, 2022 applications due 5:00 PM local time applicant organization. All types non-AIDS applications allowed this funding opportunity announcement due the listed date(s). Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Beth-Anne Sieber, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email: Beth-Anne.Sieber@nih.gov