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NIH Announces Availability Recovery Act Funds Administrative Supplements Support Core Consolidation Notice Number: NOT-RR-10-001 Catalog Federal Domestic Assistance Number(s)93.701, 93.702 Key DatesRelease Date:  November 6, 2009Receipt Date: January 13, 2010(NIH administrative supplements paper PHS398 application forms.) Issued byNational Institutes Health NIH), http://www.nih.gov) Participating Institutes CentersNational Center Research Resources NCRR) http://www.ncrr.nih.gov)National Cancer Institute NCI) http://www.cancer.gov)National Center Complementary Alternative Medicine NCCAM) http://www.nccam.nih.gov)National Institute Allergy Infectious Disease NIAID) http://www.niaid.nih.gov)National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) http://www.niams.nih.gov)National Institute Dental Craniofacial Research NIDCR) http://www.nidcr.nih.gov)National Institute Diabetes Digestive Kidney Disease NIDDK) http://www.niddk.nih.gov)National Institute Drug Abuse NIDA) http://www.nida.nih.gov)National Institute Environmental Health Sciences NIEHS) http://www.niehs.nih.gov)National Institute Nursing Research NINR) http://www.ninr.nih.gov)National Institute Mental Health NIMH) http://www.nimh.gov)National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose National Institutes Health NIH) announces opportunity investigators United States institutions/organizations certain active NIH Research Grants support core facilities request administrative supplements the purpose consolidating multiple cores a single, efficient core.  Support these supplements come funds provided NIH through American Recovery Reinvestment Act 2009 (“Recovery Act” ARRA”), Public Law 111-5.  Consistent the intent the Recovery Act, purpose this program to promote job creation economic development along accelerating pace achievement scientific research.  Approximately 15 million ARRA funds be obligated September 30, 2010 support requests submitted response this notice.  Support be requested up 1 year qualified grants eligibility section below).  is expected this be one-time opportunity.Background Recovery Act signed law February 17, 2009 the purpose stimulating American economy through job preservation creation, infrastructure investment, energy efficiency science, other means.  Recovery Act provides NIH up 10.4 billion be obligated over years a variety biomedical research research support activities.  administrative supplement opportunity one part the overall NIH Recovery Act investment strategy, described www.hhs.gov/recovery.For purposes this Notice, core facility defined a centralized shared resource provides access instruments, technologies, services, well expert consultation biomedical behavioral investigators.  is broad definition covers instrument intensive facilities well facilities offer advice concerning experimental design data interpretation.The National Center Research Resources the Office Extramural Research co-sponsored meeting Core Facilities July, 2009 http://www.ncrr.nih.gov/news_&_events/#past_events ).  Attendees included core facility managers, institutional officials responsible core facilities, representatives interested professional organizations.  common point discussion the meeting the difficulty consolidating multiple similar core facilities the same institution in same geographic area.  cores have set by different NIH Institutes Centers ICs) by different departments the institution.  Increasingly, institutions discovering multiple similar cores lead high costs the institution well decreased quality services the users relative what be achieved a single core facility high quality staff resources.The goal this Notice to allow institutions have multiple cores consolidate those facilities a single, efficient, core.  Notice allow cores supported multiple ICs the same institution consolidate the ICs agree this action appropriate. Examples situations are responsive this Notice include: Merging biomedical/behavioral core facilities different departments on different campuses the same institution a single core.  cores have initiated the institution created a result NIH awards. Moving equipment acquired a single investigator used a small cadre biomedical/behavioral researchers a core facility where would accessible a much larger group investigators. Consolidating cores two different technologies cell sorting sequencing, example) a larger single facility.  Such move should allow cross training staff multiple techniques would allow cores share centralized billing scheduling infrastructure. Merging core facilities different institutions a single facility served needs both institutions. list exemplary rather exhaustive prescriptive.Eligibility LimitationsInstitutes Centers NIH support core facilities using different activity codes.  Unless qualified below, Program Project P) Cooperative Agreement U) awards a core facility funded a participating IC eligible apply.  Supplements request more 500,000 equipment.  addition, supplements request more 500,000 alteration renovation.  Supplements also request more 200,000 direct costs) other costs such personnel supplies.  particular supplement contain request equipment, renovations, other costs although supplements not require three categories support.  questions concerning eligibility, contact assigned Program Officer. National Center Research Resources:  G12 awards eligible apply addition all P U awards.  National Cancer Institute:  Only NCI-designated Cancer Centers a P30 Cancer Center Support Grant eligible apply a supplement.  National Institute Allergy Infectious Disease:  Only CFAR P30 awards eligible apply a supplement.  National Institute Arthritis Musculoskeletal Skin Diseases:   Only P30 awards eligible apply a supplement.  National Institute Diabetes Digestive Kidney Disease: Only P30 P60 awards eligible apply a supplement.  budget limitations listed above apply all supplement requests. National Institute Drug Abuse  NIDA particularly interested consolidation results synergistic enhancement existing research capabilities, while continuing current services. National Institute Environmental Health Sciences: Only Environmental Health Science Center Grants P30) eligible apply.  budget eligibility limitations above apply all supplement requests. be eligible, parent grant must active the core consolidation activities proposed the supplement must accomplished within current competitive segment.  proposed supplement MUST within general scope the peer-reviewed activities aims approved within parent grant.  Projects currently a cost extension not eligible apply.Only administrative supplement be permitted an eligible award.  NIH intends issue only administrative per consolidation.  Costs the ongoing core well the retiring core(s) should submitted part a single administrative supplement.  are limits the number administrative supplement requests may submitted an institution Project Director/Principal Investigator.NIH encourages participation individuals racial ethnic groups underrepresented biomedical behavioral research, individuals disabilities individuals disadvantaged backgrounds.  Applications foreign institutions not permitted.  Consistent the goals the Recovery Act preserve create jobs promote economic recovery the United States, applicant must domestic United States) institutions/organizations i.e., located the 50 states, territories possessions the United States, Commonwealth Puerto Rico, Trust Territory the Pacific Islands, District Columbia).  addition, domestic U.S. institutions planning submit supplement requests include foreign components should aware requested funding any foreign components should exceed 10% the total requested direct costs 25,000 per year per subcontract/subaward in aggregate multiple subcontracts/subawards), whichever less.IMPORTANT:  funds requested the NIH grantee the supplement application must within general scope the peer-reviewed activities aims approved within parent grant.  request support new research objectives aims are outside the scope the approved parent grant not appropriate under administrative supplement.  of FundsAdministrative supplements request support facilitate consolidation core facilities.  Examples allowable expenses include: Personnel needed plan implement core consolidation.  Examples implementation activities include merging billing, purchasing, tracking, scheduling systems.  Salary support such personnel be requested no than year. Equipment purchases under 500,000) facilitate operations the consolidated core facility. Minor alteration renovation under 500,000) reconfigure space the core facility. Funds not used support personnel providing services users the core facility. Consolidated expanded core facilities must made widely available although facility must operate within scope the parent grant.  Awardees agree share best practices core consolidation the research community.  Such sharing involve participation a national meeting publication a summary the consolidation process their web site.Preparing Administrative Supplement RequestRequests under notice should the PHS 398 forms rev. 11/2007; available at:    http://grants1.nih.gov/grants/funding/phs398/phs398.html) and include following elements the request packet. Font size restrictions apply designated within PHS398 instructions. 1) Cover Letter - Citing Notice NOT-RR-10-001), specify request a Recovery Act Administrative Supplement, including following information: Project Director/Principal Investigator PD/PI) name Parent grant number title Amount the requested supplement Name title the authorized institutional official, Phone, email, address information both PD/PI the institutional official.  cover letter must signed the authorized organizational representative. 2) PHS 398 Form Page 1 Face page) MS Word  PDF title the project Box 1) should the title the parent award. Notice number title, Notice Availability Recovery Act Funds Administrative Supplements”) should cited Box 2, the yes” box should checked. Project Director/Principal Investigator PD/PI) must the same the PD/PI the parent award.  Multiple PD/PI parent awards, Contact PD/PI must the PD/PI listed the supplement request. Administrative supplements cannot change Multiple PD/PI team convert grant a single PD/PI a multiple PD/PI grant.  remaining items the face page should filled in accordance the PHS 398 application instructions. 3) PHS 398 Form page 2 MS Word  PDF Note: project summary” that the administrative supplement, the parent grant.  other information requested Form Page 2 should provided.4) brief proposal describing project, including: a) Scope the overall project the anticipated contribution the requested supplement to exceed five pages). Summarize activities were included the parent grant encompass those proposed the supplemental request.  Include description the supplement's purpose including anticipated steps involved consolidation the cores, justification requested alteration renovation space, a justification requested equipment.  Describe way the consolidated core serve biomedical/behavioral researchers.  description should estimate whether larger different group investigators use consolidated core.  the affected core facilities currently supported different NIH ICs, letter/e-mail the Program Officer each award should included indicating approval the plans change existing core.b) research project plan should discuss business plan the consolidated core facility to exceed page).  plan should address plans publicize existence the consolidated facility, sources funds operate staff consolidated facility, how current users existing facilities access consolidated core facility.c) research project plan should discuss the supplement accelerate tempo scientific research and/or allow job creation retention and/or green/sustainable technologies design approaches to exceed page).  order ensure all expenditures support an administrative supplement advance objectives the Recovery Act, applications must address Recovery Act justifications, including the supplement expected stimulate economy creating maintaining jobs the merged core facility and/or green/sustainable technologies design approaches be used the merged core facility.d) Budget the supplement a justification details items requested, including Facilities Administrative costs a justification all personnel their role(s) this project.  Note budget should appropriate the work proposed the supplement request. Applicants encouraged discuss budgets their NIH Program Officer. meet various transparency, accountability, reporting requirements Recovery Act, applications under notice must include detailed budgets the PHS 398 Form Pages 4 MS PDF) 5 MS PDF).  Modular budget pages not accepted even the parent grant funded a modular grant. Budget Funding Information below additional information. e) Biographical Sketch all new Senior/Key Personnel. is need repeat information previously provided other Senior/Key Personnel. MS PDFf) Human Subjects/Vertebrate Animal Documentation.  significant changes the approved of human subjects vertebrate animals be considered administrative supplements.   g) PHS 398 Checklist Form MS Word  PDFReview Selection FactorsAdministrative supplement requests first reviewed administratively NIH Program Grants Management staff expertise relevant the supplement request.  evaluation consider merit the supplement request its applicability the goals the Recovery Act.  recommendation awards the program be determined a trans-NIH group representation each IC participating this Notice.  final evaluation this group include merit the supplement request, applicability the goals the Recovery Act, the availability funds.Selection factors include following: Relevance the goals creating fewer higher quality core facilities will serve wider range biomedical/behavioral researchers. Relevance the proposed activities the parent grant determination the proposed activities within existing peer-reviewed approved scope the project. Adequate progress the parent grant appropriate the current stage the project. Appropriate well-described plan accomplish goals the supplement within timeframe proposed. Appropriateness the request achieve Recovery Act goals promoting job creation, economic development, accelerating pace achievement scientific research. While geographic variation be considered awarding Recovery Act funding, proposal’s scientific merit always the prevailing criterion. Budget Funding Information Funding administrative supplements existing grants be available Recovery Act funds FY2010, Therefore, supplements selected funding be limited one year the budget project period.In addition, domestic U.S. institutions planning submit supplement requests include foreign components should aware requested funding any foreign components should exceed 10% the total requested direct costs 25,000 per year per subcontract/subaward in aggregate multiple subcontracts/subawards), whichever less.How Apply be considered an administrative supplement, submit request writing the Institute/Center, to Division Receipt Referral, NIH Center Scientific Review.  Applications must signed the authorized institutional official submitted the appropriate IC Grants Management Specialist referenced the Notice Award).  NIAID prefer the supplement request directly the assigned Program Officer rather the Grants Management Specialist).  all ICs except NIAID, providing Program Officer the award copy the supplement encouraged, not required.  Applicants strongly encouraged submit applications electronically an e-mail attachment PDF format; however signature the institutional official must clearly visible.  Applicants also submit applications paper format the appropriate IC Grants Management contact. e-mail address the Grants Management Specialist the Program Officer be found the Notice Award.  Full address information those individuals available http://ned.nih.gov.Applications must received later January 13, 2010.  Timeline January 13, 2010 – Receipt dateFebruary 2010 – Administrative review supplements completed each participating ICMarch 2010 – Trans-NIH committee composed a representative each participating IC meets recommends supplements fundingMay 2010 – Supplements to appropriate Advisory Councils appropriate)June 2010 – Earliest date Notices Grant Award be releasedTerms Award formal notification the form a Notice Award NoA) be provided the grantee organization. NoA signed the grants management officer the authorizing document. Once administrative programmatic issues been resolved, NoA be generated via email notification the awarding component the grantee business official. terms the NoA reference requirements the Recovery Act.In addition the standard NIH terms award, funding provided under Recovery Act be subject the HHS Standard Terms Conditions American Recovery Reinvestment Act 2009 Recovery Act ARRA).  full text these terms approved NIH awards be found the following document: Standard Terms Conditions ARRA Awards.Selection an application award not authorization begin performance. Any costs incurred before receipt the NoA at recipient's risk. costs be reimbursed only the extent considered allowable pre-award costs. Administrative National Policy Requirements Program Official be assigned each funded application will assume responsibility normal stewardship the awards. NIH grant cooperative agreement awards include NIH Grants Policy Statement part the NoA. these terms award, the NIH Grants Policy Statement Part II: Terms Conditions NIH Grant Awards, Subpart A: General and NIH Grants Policy Statement Part II: Terms Conditions NIH Grant Awards, Subpart B: Terms Conditions Specific Types Grants, Grantees, Activities.In addition, recipients Recovery Act funds reminded such funds must separately tracked monitored independently any non-Recovery Act funding. Reporting Grantees must comply the requirements set forth the Recovery Act, including, not limited to, quarterly reporting requirements Section 1512 the Recovery Act specified HHS Standard Terms Conditions American Recovery Reinvestment Act 2009.  full text these terms approved NIH awards be found the following document: Standard Terms Conditions AARA Awards. Recovery Act-related reporting requirements be incorporated a special term award. Inquiries Inquiries discussion plans responding this Notice strongly encouraged. scientific technical questions relating research would supported this solicitation, contact Program Administrator assigned the parent grant.  administrative questions related this solicitation, contact Grants Management Specialist noted the Notice Award the parent grant.Questions the overall program should addressed any the following contacts:Dr. Gregory FarberOffice Extramural ActivitiesNational Center Research Resources6701 Democracy Boulevard, Room 904Bethesda, MD   20892-4874 Telephone: 301) 435-0778FAX: 301) 480-3658Email:  farberg@mail.nih.gov Dr. Jaswant S. BhorjeeNational Cancer Institute6116 Executive Boulevard, Room 700Rockville, MD   20892-8335 Telephone:  301) 435-9035FAX:  301) 402-0181Email:  bhorjeej@mail.nih.gov Dr. Barbara C. SorkinNational Center Complementary Alternative Medicine6707 Democracy Boulevard, Room 401Bethesda, MD   20892-5475 Telephone:  301) 594-8018FAX:  301) 480-3621Email:  sorkinb@mail.nih.gov Ms. Ann N. LeeNational Institute Allergy Infectious Disease NIAID)6700 B Rockledge Drive, Room 4211Bethesda, MD   20892-7626 Telephone:  301) 496-9176FAX 301) 402-3211Email:  anamkung@niaid.nih.gov Mrs. Justine F. BuschmanNational Institute Arthritis Musculoskeletal Skin Diseases NIAMS)6701 Democracy Boulevard, Room 877Bethesda, MD   20892-2350 Telephone: 301) 496-4811FAX: 301) 480-1284Email: buschmanj@mail.nih.gov Dr. Alicia DombroskiNational Institute Dental Craniofacial Research6701 Democracy Boulevard, Room 660Bethesda, MD   20892-4874 Telephone: 301) 594-4805Email:  adombroski@nidcr.nih.gov Dr. James HydeNational Institute Diabetes Digestive Kidney Disease6707 Democracy Boulevard, Room 789Bethesda, MD   20892-5460 Telephone:  301) 594-7692FAX:  301) 480-0475Email:  jh486z@nih.gov Dr. Christine ColvisNational Institute Drug Abuse 6001 Executive Boulevard, Room 5261Rockville, MD   20892-9581 Telephone:  301) 443-6480Email:  ccolvis@nida.nih.gov Dr. Leslie ReinlibNational Institute Environmental Health Sciences Division Extramural Research Training530 Davis Drive, Room 3072Research Triangle Park, NC   27713 Telephone:  919-541-4998FAX:  919-316-4606Email:  reinlib@niehs.nih.gov Dr. Jeanette HosseiniNational Institute Nursing Research6701 Democracy Boulevard, Room 718Bethesda, MD   20892-4870 Telephone: 301) 594-5972FAX:  301) 480-8260Email:  jeanetteh@mail.nih.gov Dr. Roger LittleNational Institute Mental Health6001 Executive Boulevard, Room 8211Rockville, MD   20892-9667 Telephone:  301) 402-5844FAX:  301) 443-1328Email:  alittle@mail.nih.gov Dr. Thomas MillerNational Institute Neurological Disorders Stroke6001 Executive Boulevard, Room 2139Rockville, MD   20892-9527 Telephone:  301) 496-1779FAX:  301) 402-1501Email:  millert@ninds.nih.gov  

Clarification Genotype Data Collection Project Management RFA MH-10-020 - Human Connectome Project U54) Notice Number: NOT-MH-10-004 Key Dates Release Date: October 28, 2009 Application Receipt Date:  November 24, 2009 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Center Complementary Alternative Medicine NCCAM) http://nccam.nih.gov/) National Center Research Resources NCRR) http://www.ncrr.nih.gov/) National Eye Institute NEI) http://www.nei.nih.gov/) National Institute Aging NIA) http://www.nia.nih.gov/) National Institute Alcohol Abuse Alcoholism NIAAA) http://www.niaaa.nih.gov/) National Institute Biomedical Imaging Bioengineering NIBIB) http://www.nibib.nih.gov/) National Institute Child Health Human Development NICHD) http://www.nichd.nih.gov/) National Institute Deafness Other Communication Disorders NIDCD) http://www.nidcd.nih.gov/) National Institute Dental Craniofacial Research NIDCR) http://www.nidcr.nih.gov/) National Institute Drug Abuse NIDA) http://www.nida.nih.gov/) National Institute Environmental Health Sciences NIEHS) http://www.niehs.nih.gov/) National Institute General Medical Sciences NIGMS) http://www.nigms.nih.gov/) National Institute Mental Health NIMH) http://www.nimh.nih.gov/) National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov/) National Institute Nursing Research NINR) http://www.ninr.nih.gov/) Office Behavioral Social Sciences Research OBSSR) http://obssr.od.nih.gov/) Purpose purpose this Notice to clarify issues regarding collection genotype data the of professional project management RFA-MH-10-020 ldquo;The Human Connectome Project,” was issued July 15, 2009.  Technological advances have transpired since RFA-MH-10-020 written made possible larger numbers subjects be imaged was envisioned that FOA.  Images represent principle data type be collected this project; ancillary data be collected includes genotyping using chip technology.  Since cost chips genotyping not insignificant, requirement genotype subject presents budgetary trade-off increases more more subjects included the project.  mitigate effect this trade-off the ability image large numbers subjects, rather requiring each subject genotyped, only 500 subjects be required be genotyped.  an applicant wishes genotype subjects, even beyond 500, is also acceptable.  other ancillary data collection e.g., demographic, behavioral assessment) expected all subjects described RFA-MH-10-020.  And, blood samples expected be collected all subjects described RFA-MH-10-020. Professional project management paramount the performance the Human Connectome Project.  Applicants have questions what constitutes professional project management, roles principal investigator project manager compare each other, other issues related this important aspect the project encouraged contact program officer listed below. Inquiries Specific questions this Notice should directed to: Michael F. Huerta, Ph.D. National Institute Mental Health 6001 Executive Boulevard, Room 7202, MSC 9645 Bethesda, MD 20892-9645 Telephone: 301) 443-1815 FAX: 301) 443-1731 Email: mhuert1@mail.nih.gov

Notice Intent Publish Request Applications the Blueprint Neuroscience Grand Challenge: New Drugs Diseases Disorders the Nervous System U01) Notice Number: NOT-NS-10-002 Key Dates Release Date:  October 16, 2009 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov/) its member institutes, offices, centers: National Center Complementary Alternative Medicine NCCAM) http://nccam.nih.gov/) National Center Research Resources NCRR) http://www.ncrr.nih.gov/) National Eye Institute NEI) http://www.nei.nih.gov/) National Institute Aging NIA) http://www.nia.nih.gov/) National Institute Alcohol Abuse Alcoholism NIAAA) http://www.niaaa.nih.gov/) National Institute Biomedical Imaging Bioengineering NIBIB) http://www.nibib.nih.gov/) National Institute Child Health Human Development NICHD) http://www.nichd.nih.gov/) National Institute Drug Abuse NIDA) http://www.nida.nih.gov/) National Institute Deafness Other Communication Disorders NIDCD) http://www.nidcd.nih.gov/) National Institute Dental Craniofacial Research NIDCR) http://www.nidcr.nih.gov/) National Institute Environmental Health Sciences NIEHS) http://www.niehs.nih.gov/) National Institute General Medical Sciences NIGMS) http://www.nigms.nih.gov/) National Institute Mental Health NIMH) http://www.nimh.nih.gov/) National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov/) National Institute Nursing Research NINR) http://www.ninr.nih.gov/) Office Behavioral Social Sciences Research OBSSR) http://obssr.od.nih.gov) Purpose NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov/) intends issue Request Applications RFA) solicit projects the Blueprint Grand Challenge New Drugs Diseases Disorders the Nervous System. goal to support development new small molecule drugs will transform treatment neurological, psychiatric, other nervous system diseases conditions. awards provide 1) funding support biological testing compounds during development 2) access technical, infrastructure, advisory resources enable investigators translate promising lead small molecule compounds drugs have completed phase 1 clinical trials. Applicants this RFA must have: least small molecule compound strong evidence biological activity relevant the intended indication a starting point medicinal chemistry optimization. robust, moderate throughput assay biological activity suitable testing compounds generated an iterative medicinal chemistry effort. assay should capable providing robust dose-response data 20-40 compounds a 1-2 week cycle. Secondary bioassays models sufficient evaluate potential a drug candidate the intended indication. Resources conduct drug development activities than bioactivity testing be provided the successful applicants the NIH Blueprint. include medicinal chemistry optimization, pharmacology toxicology testing Phase 1 clinical testing. Successful applicants retain ownership the intellectual property compounds develop through program. notice being provided allow potential applicants sufficient time develop responsive projects necessary collaborations. The RFA expected be published the NIH Guide Grants Contracts April 2010 an anticipated receipt date August 2010. RFA use U01 cooperative agreement mechanism. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Interested parties contact: Jill Heemskerk Ph.D. National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Boulevard, Room 2229 Bethesda, MD 20892-9525 EXPRESS/COURIER:  Rockville, MD 20852 Email: jill_heemskerk@nih.gov

Notice Intent Publish Request Applications Enhancing Neuroscience Diversity through Undergraduate Research Education Experiences R25) Notice Number: NOT-MH-10-003 Key Dates Release Date: October 9, 2009 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Center Complementary Alternative Medicine NCCAM), http://www.nccam.nih.gov) National Center Research Resources NCRR), http://www.ncrr.nih.gov) National Eye Institute NEI), http://www.nei.nih.gov) National Institute Aging NIA), http://www.nia.nih.gov) National Institute Alcohol Abuse Alcoholism NIAAA), http://www.niaaa.nih.gov) National Institute Biomedical Imaging Bioengineering NIBIB), http://www.nibib.nih.gov) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), http://www.nichd.nih.gov) National Institute Deafness Other Communication Disorders NIDCD), http://www.nidcd.nih.gov) National Institute Dental Craniofacial Research NIDCR), http://www.nidcr.nih.gov) National Institute Drug Abuse NIDA), http://www.nida.nih.gov) National Institute Environmental Health Sciences NIEHS), http://www.niehs.nih.gov) National Institute General Medical Sciences NIGMS), http://www.nigms.nih.gov) National Institute Mental Health NIMH), http://www.nimh.nih.gov) National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov) National Institute Nursing Research NINR), http://www.ninr.nih.gov) Office Behavioral Social Sciences Research OBSSR), http://obssr.od.nih.gov) Purpose National Institute Mental Health, behalf the Institutes Centers ICs) the NIH Blueprint Neuroscience Research intends promote new initiative publishing Request Applications RFA) solicit applications will support development collaborative, multi-institutional undergraduate research education research training programs the purpose increasing number students are well-prepared motivated enter Ph.D. degree programs the neurosciences. initiative focus junior senior undergraduate students are groups underrepresented the biomedical behavioral sciences individuals underrepresented racial ethnic groups, individuals disabilities, individuals disadvantaged backgrounds). APPLICATIONS NOT BEING SOLICITED THIS TIME.  Notice to encourage investigators expertise the areas neuroscience research, research education, research training consider applying this new RFA to allow potential applicants sufficient time develop meaningful collaborations responsive projects. RFA, will utilize Research Education Projects R25) award mechanism, expected be published the Fall 2009 an expected receipt date Winter Spring 2010. Research Initiative Details RFA support development collaborative research education partnerships will increase participants’ awareness interest the neurosciences, develop participants’ scientific knowledge research skills will allow to progress transition more advanced neuroscience related research education research training activities, to establish networks Ph.D. degree granting NIH-supported Predoctoral Institutional Research Training T32) programs the neurosciences. Components the collaborative research education programs should include: research-intensive institution, defined having existing neuroscience neuroscience related program, a significant number potential mentors NIH R01 equivalent extramural research support; or institutions have substantial enrollment undergraduates backgrounds underrepresented the biomedical behavioral sciences majoring areas relevant the neurosciences; Curriculum academic enhancement activities integrated across partnering institutions are uniquely designed increase students interest preparation enter Ph.D. degree programs the neurosciences; Part-time neuroscience research training experiences extramurally funded laboratories during academic year be carried within of partnering institutions; Full-time summer neuroscience research training experiences laboratories are part existing neuroscience-focused NIH Predoctoral Institutional Research Training T32) programs; Formal alliances neuroscience-focused NIH Predoctoral Institutional Research Training T32) programs agree provide summer research training experiences students participating this initiative. alliances expected facilitate early communication interaction between participating students NIH Predoctoral Institutional Research Training program directors. Inquiries Interested parties contact: Mark Chavez, Ph.D. Division Adult Translational Research amp; Treatment Development National Institute Mental Health 6001 Executive Boulevard, Room 7107 Bethesda, MD nbsp;20892-9632 Rockville, MD nbsp;20852 express/courier service) Telephone: 301); 443-8942 FAX: 301) 443-4611 Email:  mchavez1@mail.nih.gov

Notice Change Receipt Dates NINDS Institutional Center Core Grants Support Neuroscience Research P30) Notice Number: NOT-NS-10-001 Key Dates Release Date: October 7, 2009 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose purpose this notice to change multiple receipt dates per year PAR-08-116, NINDS Institutional Center Core Grants Support Neuroscience Research P30),” one receipt date per year. receipt schedule NINDS Center Core Grants P30) changed January 25, 25, September 25 a once year receipt date January 25.  new receipt date policy becomes effective the January 25, 2010 receipt date. NINDS not accept new, renewal, resubmission, revision applications under PAR-08-116 the 25 September 25, 2010 receipt dates. Inquiries Inquiries concerning policy should sent to: Thomas Miller, Ph.D. Office Translational Research National Institute Neurological Disorders Stroke 6001 Executive Boulevard, Room 2139 Bethesda, MD 20892 Telephone: 301-496-1779 FAX: 301-402-1501 Email: tm208y@nih.gov

Notice Intent Publish Program Announcement Countermeasures Against Chemical Threats CounterACT) Exploratory/Developmental Projects Translational Research R21) Notice Number: NOT-NS-09-018 Key Dates Release Date: September 22, 2009 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose nbsp; National Institute Neurological Disorders Stroke NINDS) intends issue Program Announcement Special Referral Considerations PAR) the fall 2009 provide support exploratory developmental translational research therapeutics reducing mortality morbidity caused acute exposures chemical threat agents.  Chemical threat agents toxic chemicals could released a deliberate terrorist attack against civilians, by accident natural disaster causing mass casualties.  NIH CounterACT Research Program supports basic, translational, clinical research aimed the discovery and/or identification better therapeutic medical countermeasures against chemical threat agents, facilitates movement through regulatory process www.ninds.nih.gov/counteract).  CounterACT Exploratory/Developmental Projects Translational Research R21) be utilized support 1-2 year pilot studies generate tools proof-of-principle data therapeutics treat exposures chemical threats.  Chemical threats include traditional chemical warfare nerve agents such sarin VX, toxic industrial chemicals such cyanide chlorine, toxic agricultural chemicals such parathion sodium fluoroacetate.  Pilot studies include creation validation screening assays therapy development, identification candidate therapeutics, development preliminary proof-of-principle data the efficacy candidate therapeutics.  Four six awards anticipated, with direct costs limit 250,000 per year.  is anticipated several NIH Institutes, including National Eye Institute NEI), National Institute Allergy Infectious Diseases NIAID), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Environmental Health Sciences NIEHS), the National Institute General Medical Sciences NIGMS), also participate this funding opportunity announcement. notice being provided allow potential applicants sufficient time develop responsive projects.  APPLICATIONS NOT BEING REQUESTED THIS TIME. Inquiries Direct inquiries regarding Notice to: David A. Jett, Ph.D. Program Director, NIH CounterACT Research National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2177, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-6035 Fax: 301-402-1501 jettd@ninds.nih.gov

Notice Additional Information Applicants the Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers U54) Program Notice Number: NOT-HD-09-023 Key Dates Release Date: September 16, 2009 Issued Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), http://www..nichd.nih.gov) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), http://www.niams.nih.gov) National Heart, Lung, Blood Institute NHLBI) http://www.nhlbi.nih.gov) National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov) Purpose purpose this Notice to alert potential applicants RFA-HD-09-027, ldquo;Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers U54)”, additional guidance available regarding content organization the applications.  Questions Answers document been posted the Wellstone Center website: http:// wellstonemdcenters.nih.gov . Potential applicants encouraged review document it provides clarification a number scientific technical issues the application process. Inquiries Additional questions be directed to: James W. Hanson, M.D. Director, Center Developmental Biology Perinatal Medicine Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) 6100 Executive Boulevard, Room 4A05A  Bethesda, MD 20892-7510 Telephone: 301) 496-8535 Email: hansonj@mail.nih.gov Glen H. Nuckolls, Ph.D. Director, Muscle Disorders Therapies Program Musculoskeletal Diseases Branch National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Democracy Plaza 6701 Democracy Boulevard, Suite 800 Bethesda, MD 20892-4872 Telephone: 301) 594-4974 Email: nuckollg@mail.nih.gov   John D. Porter, Ph.D. Program Director, Neurogenetics Cluster National Institute Neurological Disorders Stroke NINDS) 6001 Executive Blvd., Room 2142 Bethesda, MD 20892 Rockville, MD 20852 express/courier service) Telephone: 301) 496-5739 FAX: 301) 402-1501 Email: porterjo@ninds.nih.gov  Jonathan R. Kaltman, M.D. Heart Development Structural Diseases Branch Division Cardiovascular Diseases National Heart, Lung, Blood Institute NHLBI) Rockledge Center 6701 Rockledge Drive, Room 8222 Bethesda, MD 20892-7940 Zip Code 20817 express/courier service) Telephone: 301) 435-0510 FAX: 301-480-1454 Email: kaltmanj@nhlbi.nih.gov

RFA AMMENDMENT: Revised Review Criteria Ancillary Studies Immunomodulation Clinical Trials RFA–AI-08-011) Notice Number: NOT-AI-09-054 Key Dates Release Date: September 16, 2009 Issued National Institute Allergy Infectious Diseases NIAID) http://www.niaid.nih.gov) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) http://www.niams.nih.gov) National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) National Institute Diabetes Digestive Kidney Diseases NIDDK) http://www.niddk.nih.gov) Purpose purpose this notice to clarify the criteria below be used review applications submitted response RFA-AI-08-011 was extended a final receipt date January 9, 2010 NOT-AI-09-044): Overall Impact. Reviewers provide overall priority/impact score reflect assessment the likelihood the project exert sustained, powerful influence the research field(s) involved, consideration the following five core review criteria, additional review criteria applicable the project proposed).  Core Review Criteria.  Reviewers consider of five review criteria below the determination scientific technical merit, give separate score each.  application does need be strong all categories be judged likely have major scientific impact.  example, project by nature not innovative be essential advance field. Significance.  Does project address important problem a critical barrier progress the field?  the aims the project achieved, will scientific knowledge, technical capability, and/or clinical practice improved?  will successful completion the aims change concepts, methods, technologies, treatments, services, preventative interventions drive field? Investigator(s).  the PD/PIs, collaborators, other researchers well suited the project?  Early Stage Investigators New Investigators, they appropriate experience training?  established, they demonstrated ongoing record accomplishments have advanced field(s)?  the project collaborative multi-PD/PI, the investigators complementary integrated expertise; their leadership approach, governance organizational structure appropriate the project? Innovation. Does application challenge seek shift current research clinical practice paradigms utilizing novel theoretical concepts, approaches methodologies, instrumentation, interventions?  the concepts, approaches methodologies, instrumentation, interventions novel one field research novel a broad sense?  a refinement, improvement, new application theoretical concepts, approaches methodologies, instrumentation, interventions proposed? Approach.  the overall strategy, methodology, analyses well-reasoned appropriate accomplish specific aims the project?  potential problems, alternative strategies, benchmarks success presented?   the project in early stages development, the strategy establish feasibility will particularly risky aspects managed? the project involves clinical research, the plans 1) protection human subjects research risks, 2) inclusion minorities members both sexes/genders, well the inclusion children, justified terms the scientific goals research strategy proposed? there high likelihood the samples needed the proposed studies become available? Environment.  the scientific environment which work be done contribute the probability success?  the institutional support, equipment other physical resources available the investigators adequate the project proposed?  the project benefit unique features the scientific environment, subject populations, collaborative arrangements?  Additional Review Criteria. applicable the project proposed, reviewers consider following additional items the determination scientific technical merit, will give separate scores these items. Protections Human Subjects. research involves human subjects does involve of six categories research are exempt under 45 CFR Part 46, committee evaluate justification involvement human subjects the proposed protections research risk relating their participation according the following five review criteria: 1) risk subjects, 2) adequacy protection against risks, 3) potential benefits the subjects others, 4) importance the knowledge be gained, 5) data safety monitoring clinical trials. research involves human subjects meets criteria one more the six categories research are exempt under 45 CFR Part 46, committee evaluate: 1) justification the exemption, 2) human subjects involvement characteristics, 3) sources materials. Inclusion Women, Minorities, Children. the proposed project involves clinical research, committee evaluate proposed plans inclusion minorities members both genders, well the inclusion children. Vertebrate Animals. committee evaluate involvement live vertebrate animals part the scientific assessment according the following five points: 1) proposed of animals, species, strains, ages, sex, numbers be used; 2) justifications the of animals for appropriateness the species numbers proposed; 3) adequacy veterinary care; 4) procedures limiting discomfort, distress, pain injury that is unavoidable the conduct scientifically sound research including use analgesic, anesthetic, tranquilizing drugs and/or comfortable restraining devices; 5) methods euthanasia reason selection not consistent the AVMA Guidelines Euthanasia. Biohazards. Reviewers assess whether materials procedures proposed potentially hazardous research personnel and/or environment, if needed, determine whether adequate protection proposed. Inquiries Inquiries discussion plans responding RFA–AI-08-011 strongly encouraged. Interested parties contact: 1. Scientific/Research Contact(s): Annette L. Rothermel, Ph.D. Division Allergy, Immunology Transplantation National Institute Allergy Infectious Diseases 6610 Rockledge Drive Room 6617, MSC-6601 Bethesda, MD 20892- 6601 Telephone: 301) 496-7104 Fax: 301) 480-1450 Email: arothermel@niaid.nih.gov   Yan Wang, M.D., Ph.D. Division Skin Rheumatic Diseases, Extramural Program National Institute Arthritis Musculoskeletal Skin Diseases National Institute Health, DHHS Democracy Plaza, Suite 800 6701 Democracy Blvd, MSC 4872 Bethesda, MD 20892 Phone: 301-594-5032 Fax: 301-480-1284 Email: wangy1@mail.nih.gov Ursula Utz, Ph.D. Program Director National Institute Neurological Disorders Stroke Room 2134 6001 Executive Boulevard Bethesda, MD 20892-9521 Phone: 301-496-1431 FAX: 301-402-1501 Email: utzu@mail.nih.gov Beena Akolkar, Ph.D. Division Diabetes, Endocrinology, Metabolic Diseases National Institute Diabetes Digestive Kidney Diseases Room 6105 6707 Democracy Boulevard Bethesda, MD 20892-5460 Phone: 301-594-8812 FAX: 301-480-3503 Email: akolkarb@niddk.nih.gov 2. Peer Review Contact(s): Paul Amstad, Ph.D. Division Extramural Activities National Institute Allergy Infectious Diseases Room 3121, MSC-7616 6700B Rockledge Drive Bethesda, MD 20892-7616 Bethesda, MD 20817 express mail) Telephone: 301) 402-7098 Fax: 301) 480-2408 Email: pamstad@niaid.nih.gov

Administrative Changes the Joint NIH-NSF Initiative - Collaborative Research Computational Neuroscience CRCNS) Notice Number: NOT-NS-09-017 Key Dates Release Date:  September 4, 2009 Receipt Date: nbsp; November 17, 2009 Issued National Science Foundation NSF) http://www.nsf.gov) Directorate Computer Information Science Engineering Directorate Biological Sciences Directorate Social, Behavioral, Economic Sciences Directorate Mathematical Physical Sciences National Institutes Health NIH) http://www.nih.gov) National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) National Institute Mental Health NIMH) http://www.nimh.nih.gov) National Institute Drug Abuse NIDA) http://www.nida.nih.gov) National Institute Deafness Other Communication Disorders NIDCD) http://www.nidcd.nih.gov) National Institute Alcohol Abuse Alcoholism NIAAA) http://www.niaaa.nih.gov) National Eye Institute NEI)  http://www.nei.nih.gov) National Institute Biomedical Imaging Bioengineering NIBIB) http://www.nibib.nih.gov) Notice an amendment NOTICE: NOT-NS-08-008 Purpose nbsp; Notice announces several administrative changes the joint initiative, Collaborative Research Computational Neuroscience CRCNS), among four National Science Foundation NSF) Directorates seven participating National Institutes Health NIH) Institutes. CRCNS announcement released under NSF 08-514 http://www.nsf.gov/pubs/2008/nsf08514/nsf08514.htm).  new NOTICE incorporates following administrative changes please note the goal the program, scientific areas, budget limits, review criteria funding process NSF NIH remain same): 1. DEADLINE CHANGE deadline proposals changed October 30, 2009, November 17, 2009. 2. POSTDOCTORAL MENTORING PLANS proposal requests funding support postdoctoral researchers must include description the mentoring activities will provided such individuals. Proposals do comply this requirement be returned without review. nbsp;Please http://www.nsf.gov/pubs/policydocs/pappguide/nsf09_29/gpg_2.jsp#IIC2j further information. 3. FASTLANE, GRANTS.GOV announced May 21st, investigators must prepare submit proposals the NSF using NSF FastLane system http://www.fastlane.nsf.gov/.  NSF continue collaborate institutions have invested system-to-system submission functionality their preferred proposal submission method.  NSF plans provide web services interface those institutions want use existing grants management systems directly submit proposals NSF. 4. GERMAN-USA COLLABORATION COMPUTATIONAL NEUROSCIENCE NSF the German Federal Ministry Education Research BMBF) entered an agreement will enable US-German collaborative research proposals be considered through common review process.  more information, please NSF Dear Colleague Letter 09-60 http://www.nsf.gov/publications/pub_summ.jsp?ods_key=nsf0960) the Collaborative Research Computational Neuroscience program page http://www.nsf.gov/crcns/). Inquiries Prior the submission your proposal, written telephone inquiries NSF NIH program staff highly encouraged.  Please the NSF program announcement names contact information each the participating NSF Directorates and/or NIH Institutes http://www.nsf.gov/crcns/.

Notice Deadline Extension Program Announcement Bioengineering Research Grants Notice Number: NOT-EB-09-003 Update: following update relating this announcement been issued: September 29, 2009 - Notice NOT-CA-09-036 National Cancer Institute NCI) informs interested applicants it re-joined will continue participate this FOA. Key Dates Release Date: August 14, 2009 Issued National Eye Institute NEI), http://www.nei.nih.gov/) National Human Genome Research Institute NHGRI), http://www.genome.gov)  National Institute Alcohol Abuse Alcoholism NIAAA), http://www.niaaa.nih.gov) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), http://www.niams.nih.gov) National Institute Biomedical Imaging Bioengineering NIBIB), http://www.nibib.nih.gov)  National Institute Deafness Communication Disorders NIDCD), http://www.nidcd.nih.gov)  National Institute Dental Craniofacial Research NIDCR), http://www.nidcr.nih.gov)  National Institute Drug Abuse NIDA), http://www.nida.nih.gov) National Institute Environmental Health Sciences NIEHS), http://www.niehs.nih.gov)  National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), http://www.nichd.nih.gov) Purpose purpose this Notice to extend Expiration Date PA-07-279: Bioengineering Research Grants R01) until January 8, 2010.  following institutes no longer participating: National Cancer Institute NCI), http://www.nci.nih.gov) National Heart, Lung, Blood Institute NHLBI), http://www.nhlbi.nih.gov/) National Institute Allergy Infectious Diseases NIAID), http://www.niaid.nih.gov) National Institute Mental Health NIMH), http://www.nimh.nih.gov/) other aspects PA-07-279 remain unchanged. Inquiries Inquiries concerning Notice directed to: Albert Lee, Ph.D. National Institute Biomedical Imaging Bioengineering National Institutes Health 6707 Democracy Blvd., Suite 200 Bethesda, MD 20892-5477 Phone: 301) 451-4781 Email:  alee@mail.nih.gov