Find Funding Opportunities

NINDS Support M.D./Ph.D. Students Now the F31 Ruth L. Kirschstein National Research Service Award Mechanism Notice Number: NOT-NS-10-010 Key Dates Release Date:  March 4, 2010 Issued National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/) Background National Institute Neurological Disorders Stroke NINDS) considers training outstanding predoctoral M.D./Ph.D. students neuroscience research be critical the mission reducing burden neurological diseases. nbsp;For last 9 years, NINDS supported M.D./Ph.D. students the F30 Ruth Kirschstein National Research Service Award NRSA).  enhance support time devoted research training during M.D./Ph.D., NINDS now an F31 NRSA mechanism, PAR-10-091 http://grants.nih.gov/grants/guide/pa-files/PAR-10-091.html) specifically designed M.D./Ph.D. students, place the F30 mechanism. F31 mechanism M.D./Ph.D students being implemented NINDS support students starting early the research portion their training, eliminating requirement graduate research publications and/or preliminary data the grant review process. F31 applications M.D./Ph.D. students be reviewed an NINDS study section. Purpose NINDS remains firmly committed the support M.D./Ph.D. students. F31 NRSA fellowship provide individuals integrated M.D./Ph.D. programs up 5 years predoctoral NRSA support. nbsp;It differs the F30 mechanism that will provide support research leading the Ph.D. degree, not training is associated obtaining M.D. degree.  the change mechanism, NINDS instituting changes the review requirements will enhance ability students submit successful applications much earlier their M.D./Ph.D. training.  is suggested students submit F31 applications soon they chosen dissertation laboratory, could as early the end the medical school year prior the start full time dissertation research.  Taken together, changes preclude need preliminary data, increase support students during research years, potentially provide support immediately upon entering research laboratory. intent the NINDS to foster development independent M.D./Ph.D. investigators neuroscience advance Institute’s mission decrease burden neurological disorders.  High quality, creative research an essential element training a successful research career.  NINDS also regards development a comprehensive training plan outstanding mentoring critical a successful outcome.  Therefore, F31 FOA used NINDS support M.D./Ph.D. students places heavy emphasis only the opportunity doing high quality neuroscience research also the quality the overall training mentoring plan. nbsp;As described the funding opportunity announcement PAR-10-091), applicants should at least closely involved mentor an excellent track record training M.D./Ph.D. students should contact NINDS staff before preparing application ensure their research fits within NINDS mission. Applicants should sure reference correct program announcement applying fellowship support ensure proposals reviewed the appropriate NINDS study section. Inquiries Direct questions this Notice to: Stephen J. Korn, Ph.D. Director Training Career Development NIH/NINDS Neuroscience Center, Room 2186 6001 Executive Blvd MSC 9531 Bethesda, MD 20892-9531 E-mail: korns@ninds.nih.gov

Notice Availability Administrative Supplements Roadmap Assay Development HTS Awards National Institute Neurological Disorders & Stroke) Notice Number: NOT-NS-10-012 Key Dates Release Date: nbsp;March 3, 2010 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Background NIH Molecular Libraries Imaging Roadmap Initiative http://nihroadmap.nih.gov/molecularlibraries/index.asp) a major NIH effort broaden access rapid assay technologies.  overall goal the Initiative to facilitate creation a public database biological information small molecule chemical structures, then seeds further development small molecule pharmacological tools biological research.  Assay Development HTS Program one component this Initiative, funds development adaptation biological assays use automated high throughput molecular screening HTS).  is intended this Program promote development automated screening projects can submitted the Molecular Libraries Probe Production Centers Network MLPCN: www.mli.nih.gov), employs library chemical compounds are part the Molecular Libraries Small Molecule Repository.  Purpose 2010, administrative supplements be provided NINDS-relevant projects funded the Roadmap Molecular Libraries Assay Development HTS Program.  Investigators successfully submitting new, HTS-ready projects this Program the MLPCN, via ldquo;Fast Track direct entry” process described the RM-08-024 announcement http://grants.nih.gov/grants/guide/rfa-files/RFA-RM-08-024.html), request supplement up 50,000 total cost) NINDS.  Submitting Administrative Supplement Request Investigator required clarify a letter the funds be used support collaboration the assigned MLSCN Center.  is expected the funds enable Investigator participate probe development activities are related their project.  activities include, are limited to, direct secondary screening support, the provision specialty reagents required the HTS.  activities complement, not directly overlap, those proposed funded other sources. Qualifying Investigators must an active grant award, are encouraged file no-cost extension this award needed permit administrative supplementation during HTS collaboration.  IMPORTANT:  research proposed the NIH grantee the supplement application must within original scope the NIH-supported grant project.  funding mechanism being used support program, administrative supplements, be used cover cost increases are associated achieving certain new research objectives long they within original scope the project.  Any cost increases need result making modifications the project order take advantage opportunities would increase value the project consistent its originally approved objectives purposes. Requests be accepted until end August, 2010, will reviewed a monthly basis. Inquiries further information, contact: Mark Scheideler, Ph.D. Senior Scientific Officer Program Director, Molecular Libraries Assay Diversity Office Translational Research, NINDS National Institutes Health 6001 Executive Blvd., Room nbsp;2107 Bethesda, Maryland 20892-9527, U.S.A.  Phone: 301-496.1779 Fax: 301-402.1501 Email: scheidelerm@ninds.nih.gov

NINDS Administrative Supplements Collaborative Activities Promote Translational Research CAPTR) Notice Number: NOT-NS-10-008 Key Dates Release Date:  February 23, 2010          Receipt Date:  April 26, 2010 Earliest Anticipated Start Date:  August 1, 2010   Issued National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/) Purpose National Institute Neurological Disorders Stroke NINDS) announces availability one-year administrative supplements NINDS-funded grantees stimulate new interdisciplinary collaborations translational research.  proposed studies must within scope the peer-reviewed activities specified within NINDS parent award collaborators not a significant history joint interactions. Background Collaborative activities are, nature, difficult coordinate oversee activities led a single investigator.  fiscal constraints the current climate it increasingly difficult individual investigators advance their careers remain productive without outside collaborations.  2007, NIH implemented new policy recognize multiple principal investigators grant submissions http://grants.nih.gov/grants/guide/notice-files/NOT-OD-07-017.html) support team-led science.  wealth basic research discoveries numerous neurological disorders makes an opportune time stimulate translation these discoveries clinical applications.  success this type collaboration often dependent upon pairing investigators different backgrounds expertise.  program seeks support new interactions this type will move basic research activities towards translational outcomes.  is anticipated these administrative supplements be successful generating pilot data translational R21s, U01s, U54s, such those overseen NINDS’ Office Translational Research http://www.ninds.nih.gov/funding/areas/technology_development/index.htm), for new R01 P01 grant submissions the NIH. the end the activity, supported investigators be required submit brief 1-2 page) summary the findings, relevant publications, future plans the collaboration.  Sharing any resource developed these funds should also described within summary. CAPTR program initiated 2007 http://grants.nih.gov/grants/guide/notice-files/NOT-NS-07-003.html) continued 2008 2009.  is fourth solicitation the program.  Eligibility Before submitting application a collaborative administrative supplement, grantees should communicate their Program Director(s) discuss planned application.  proposed collaboration must new.  Investigators a significant history collaboration including co-authored publications, excepting review articles) not eligible apply jointly this supplement.  Likewise, collaboration should already apparent supported through funded NIH activity.  new, collaborating investigator must an independent appointment his her own laboratory space not a postdoctoral fellow other research personnel within laboratory the NINDS funded Program Director/Principal Investigator PD/PI).  pairing a basic an applied clinical, epidemiologic) investigator encouraged, not required.  pairing a senior a junior investigator also required; investigators all stages their careers encouraged participate.  application should propose either functional, mechanistic, pre-clinical activities designed move basic discovery towards translational endpoint the near future.  Proposals focused understanding biological mechanism underlying clinical observation also responsive.  Importantly, clinical relevance should well-defined movement towards goal should supported within proposal.  uniqueness interdisciplinary nature the research activity should also highlighted, well its relationship the parent grant.  proposed studies must within scope the peer-reviewed activities specified the parent award.  Proposals should be designed recover funds review-recommended administrative cuts the parent award provide cost extensions activities failed re-compete the peer review process, change parent grant a single PD/PI Multiple PD/PI award.  addition, should be used support incremental basic advances a field e.g., refinement a signaling pathway), technology development, generation a standard transgenic animal model without immediate translational impact.  supplements also intended support clinical interventions.  Imaging studies involving human subjects allowed long the clinical protocol Institutional Review Board IRB)-approved under IRB review the time submission. program support administrative supplements Research Project R00 R01), conditional seven-year Javits award highly meritorious applications R37), Program Project P01) awards NINDS grantees.  Parent awards must actively funded through July 31, 2011 order be eligible.  Grants are a no-cost extension period beginning or before August 1, 2011) not considered support under supplement program.  Only CAPTR supplement request be submitted per PD/PI per year.  both collaborating investigators PD/PIs independent NINDS R00, R01, R37 P01 grants, can submit joint supplement application requests support both awards ldquo;How Apply”, ldquo;Submitting Application”, ldquo;Budget Information” sections below). Resubmitted CAPTR applications encouraged long the applicant discussed the weaknesses the original submission be addressed their NINDS Program Director.  should noted the cover letter the application a resubmission. IMPORTANT:  research proposed the NIH grantee the supplement application must within original scope the NIH-supported grant project.  funding mechanism being used support program, administrative supplements, be used cover cost increases are associated achieving certain new research objectives long they within original scope the project.  Any cost increases need result making modifications the project order take advantage opportunities would increase value the project consistent its originally approved objectives purposes. to Apply is one-time announcement.  Applications must received or before April 26, 2010.  not send applications the Center Scientific Review.  Applicants strongly encouraged submit applications electronically an e-mail attachment PDF format clearly visible signatures the PD/PI Authorized Organizational Representative AOR)] the individual address below.  Applications be submitted paper format electronic submission not available.  Collaborative activities involve than administrative supplement request associated different NINDS grants and, potentially, different institutions) should note clearly the submission.  these cases, only complete application should submitted along a separate cover letter, budget page justification, face page, any biosketches/letters/resource pages pertinent the additional site.  role each site should clearly delineated within body the application.   nbsp;   Dr. Timothy Lavaute National Institute Neurological Disorders Stroke Neuroscience Center, Room 2141 6001 Executive Blvd Rockville, MD 20892 Email: lavautetm@ninds.nih.gov Submitting Application Applications an administrative supplement under program should the PHS 398 form rev. 6/2009; available http://grants.nih.gov/grants/funding/phs398/phs398.html), must include following: 1. Cover letter requesting supplement, identifying notice, number title the parent grant, providing full contact information the PD/PI.  separate title the collaborative activity should also provided this letter.  the activity involves submission two independent administrative supplement requests, name, institution, NINDS grant number the collaborating PD/PI should also provided, well the additional documents listed under ldquo;How Apply” above.) 2. Face page Form Page 1). title the project Box 1) should the title the parent award. Notice number title) should cited Box 2, the ldquo;yes” box should checked. Program Director/Principal Investigator PD/PI) must the same the PD/PI the parent award.  grants awarded Multiple PD/PI, current contact PD/PI must listed the administrative supplement application.  Subproject PIs P01 awards not eligible apply these supplements. remaining items the face page should filled according the PHS 398 application instructions. 3. Form Page 2 Summary, Relevance, Project/Performance Sites, Senior/Key Personnel, Significant Contributors, Human Embryonic Stem Cells) PHS 398. project description that the administrative supplement, the parent grant.  new co-investigator(s) collaborator(s) should noted within Additional Project/Performance Site Location applicable) Scientific/Key Personnel sections.  4. Biosketch(es) any new key co-investigator(s) collaborator(s) should provided are listed within parent grant(s).  NIH encourages applicants limit list selected peer-reviewed publications manuscripts press no than 15.  letter commitment the new participant(s) should also included indicated below.  5. Resources page(s) new key personnel named the parent grant(s). 6. Proposed budget the supplement a budget justification details items requested.  ldquo;Budget Information” section below. 7. Proposed research activities performed under supplement should consist items 2-3 Specific aims Research Strategy) delineated under PHS 398 Research Plan should exceed five pages.  Font size restrictions apply designated the PHS 398 rev. 6/2009) instructions. research plan the supplement should include Specific Aims Section 2 the PHS 398 Research Plan), Research Strategy Section 3, includes Significance, Innovation, Approach).  relationship the collaborative activity the parent grant should included under research strategy.  the collaboration involves than administrative supplement request, contribution each laboratory should clearly delineated within section. Bibliography References Cited Section 5 the PHS 398 Research Plan) should included.  of human subjects the proposed research should discussed detail, adhering instructions under Sections 6-9 the PHS 398 Research Plan.  Any differences the of human subjects specimens between administrative supplement activity the parent grant should noted.  appropriate, details should provided the protection human subjects inclusion women, children, minorities.  Additional guidance Human Subjects Research provided under Part II the PHS 398 instructions http://grants.nih.gov/grants/funding/phs398/phs398.pdf).  non-exempt human subject analyses proposed, clinical study protocol associated consent forms should provided along the status IRB approval. Vertebrate Animals: follow Section 10 the PHS 398 Research Plan instructions. Select Agent Research, Consortium/Contractual Arrangements, Letters Support, Resource Sharing Plan sections should completed described the PHS 398 instructions.  letter the new, collaborating investigator should provided include discussion his/her involvement the activity. Multiple Program Directors/Principal Investigators PDs/PIs) Leadership Plan not required.  Appendices supplemental material excluding clinical protocols consent forms) not accepted.  nbsp;Review Criteria Applications be reviewed administratively a committee NIH staff.  Awards be determined the basis scientific merit, translational impact, potential promote new interdisciplinary interactions, innovation, programmatic relevance, availability funds.  added value the underlying activity the parent grant(s) its realistic scope given one year commitment also taken consideration.  funding decisions final not subject appeal.  anticipated awards be no later September 30, 2010. appropriate IRB IACUC approvals must in place prior a supplement award being made.  Budget Funding Information Applicants request to 50,000 direct costs excluding consortium Facilities Administrative F&A) costs] the one-year duration an administrative supplement under program.  least investigator within collaboration must the Program Director/Principal Investigator an NINDS supported grant.  PD/PI either the funds support or part the collaborative activity, participation a collaborator/co-investigator their home institution, subcontract an outside investigator(s) support his/her involvement.  maximum direct cost request an individual NINDS grantee 50,000.  two NINDS grantees submitting joint CAPTR application, can request to 50,000 direct costs an administrative supplement each two independent grants.  maximum direct cost request a joint CAPTR application cannot exceed 100,000; each individual PD/PI only participate one CAPTR submission per year.  duration each award limited one year.  Facilities Administrative F&A) costs be paid the full, negotiated rate.  Applicants should provide detailed budget justification personnel costs, supplies, other expenses.  Salary support the PD/PI, co-investigators, collaborators not permitted can requested technicians, graduate students, postdoctoral associates, and/or research personnel.  purchase equipment not allowed.  fiscal year 2010, NINDS plans commit to 1,000,000 total costs towards administrative supplement program, a maximum 13 awards anticipated.    Inquiries Applicants encouraged discuss plans responding this Notice phone e-mail.  Scientific inquiries should directed the NINDS Program Director oversees parent grant associated the administrative supplement request.  General inquiries the CAPTR supplement program be directed to: Dr. Jane W. Fountain Program Director National Institute Neurological Disorders Stroke Neuroscience Center, Room 2110 6001 Executive Blvd Rockville, MD 20892 301) 496-1431 Email: fountai@ninds.nih.gov

Notice Intent Publish Program Announcement Research Grant Applications Supporting Validation Novel Therapeutic Targets Huntington’s Disease R01) Notice Number: NOT-NS-10-006 Key Dates Release Date: January 29, 2010 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose nbsp; National Institute Neurological Disorders Stroke NINDS) intends issue Program Announcement set-aside funds February/March 2010 provide support R01 research project grant applications directed the validation novel molecular targets disease-modifying therapeutic intervention Huntington’s disease. program announcement Validation Novel Therapeutic Targets Huntington’s Disease HD), represents collaborative effort between NINDS CHDI Foundation, Inc. CHDI) directed further characterizing novel molecular targets HD therapeutic development.  CHDI provide funds NINDS extend NINDS’ ability support awards under PAS.  anticipate will sufficient funds make 8-9 R01 awards fiscal year 2011 assuming average direct costs 250,000 per year an average length four years). nbsp; Research proposals responsive the FOA have following characteristics: target(s) a demonstrated direct causal relationship HD manipulated genetically pharmacologically an vitro orinvertebrate model HD. Application a minimum set best-practice guidelines genetic and/or pharmacological manipulation the target rodent other vivo mammalian models HD. notice being provided allow potential applicants sufficient time develop responsive projects.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Direct inquiries regarding Notice to: Margaret Sutherland, Ph.D. Program Director, Neurodegeneration National Institutes Health, NINDS 6001 Executive Blvd. NSC, Room 2222, MSC 9527 Bethesda, MD 20892-9527 Telephone: 301-496-5680 Fax: 301-480-1080 E-mail: sutherlandm@ninds.nih.gov

Notice Availability Administrative Supplements R25 Science Education Grants Notice Number: NOT-DA-10-007 Key Dates Release Date:  January 26, 2010 Receipt Date: April 2, 2010 Earliest Anticipated Start Date: June 1, 2010 Issued National Institutes Health Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov/) National Center Complementary Alternative Medicine http://www.NCCAM.gov) National Center Research Resources http://www.NCRR.gov) National Eye Institute http://www.NEI.gov) National Institute Aging http://www.NIA.gov) National Institute Alcohol Abuse Alcoholism http://www.NIAAA.gov) National Institute Biomedical Imaging Bioengineering http://www.NIBIB.gov) National Institute Child Health Human Development http://www.NICHD.gov) National Institute Drug Abuse http://www.NIDA.gov) National Institute Deafness Other Communication Disorders http://www.NIDCD.gov) National Institute Dental Craniofacial Research http://www.NIDCR.gov) National Institute Environmental Health Sciences http://www.NIEHS.gov) National Institute General Medical Sciences http://www.NIGMS.gov) National Institute Mental Health http://www.NIMH.gov) National Institute Neurological Disorders Stroke http://www.NINDS.gov) National Institute Nursing Research http://www.NINR.gov) Office Behavioral Social Sciences Research http://obssr.od.nih.gov) Purpose National Institutes Health Blueprint Neuroscience Research announces administrative supplement program 600,000 Fiscal Years 2010 2011 provide funds Blueprint Institute-supported research education projects Eligibility section below). purpose this program to create broadly disseminate materials/programs inform students teachers kindergarten-12th grade the field neuroscience. Background NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov/) a collaborative framework includes NIH Office the Director the NIH Institutes Centers support research the nervous system. pooling resources expertise, Blueprint identifies cross-cutting areas research, confronts challenges too large any single Institute Center. Since inception 2004, Blueprint supported development new tools, training opportunities other resources assist neuroscientists. 2009, Blueprint Grand Challenges launched catalyze research the potential transform our basic understanding the brain our approaches treating brain disorders.  addition promoting cutting edge neuroscience research, Blueprint recognizes importance improving science education order maintain U.S. competitiveness meet future demands the international technology marketplace.  order NIH fulfill mission, is need ensure adequate numbers students entering science education tracks eventually pursuing careers biomedical sciences.  science literacy should only include basic science knowledge, also understanding the process biomedical research an ability evaluate quality research studies are reported the media. is also important the NIH Blueprint Neuroscience Research all members society understand role science, biology, technology they relate neuroscience. is lack public understanding research general, including role research improving health.  educating school children, is likely we reach adults their lives well. address areas, initiative provides Administrative Supplement support innovative novel activities will promote neuroscience learning the kindergarten-12th grade through NIH funded R25 grants, including Science Education Drug Abuse Partnership Award SEDAPA) Science Education Partnership Award SEPA). Eligibility current announcement for supplements NIH Blueprint Neuroscience Institutes R25 science education grants. be eligible, parent grant must active, the science education project proposed the supplement must accomplished within competitive segment. proposed supplement MUST within general scope the peer-reviewed activities aims approved within parent grant, including projects a no-cost extension; while supplemental funds be awarded grants during no-cost extension, period support cannot extend beyond award period the additional time was granted.  Note while NIH recommends a no-cost extension already in place before administrative supplement request submitted, is a requirement all administrative supplement requests. Institutions submit than supplement request only supplement be funded each NIH funded R25 grant. IMPORTANT:  research proposed the NIH grantee the supplement application must within original scope the NIH-supported grant project.  funding mechanism being used support program, administrative supplements, be used cover cost increases are associated achieving certain new research objectives long they within original scope the project.  Any cost increases need result making modifications the project order take advantage opportunities would increase value the project consistent its originally approved objectives purposes. funding method being used support program, administrative supplements, be used cover cost increases are associated increasing speed projects funded under parent grant and/or achieving certain new science education objectives long they within scope the parent project.  examples the types supplements could appropriate include, are limited to, hiring additional personnel funding investments equipment technology leverage goals the project to enhance energy efficiency the conduct the project. Any cost increases need result making modifications the parent project order take advantage opportunities would increase value the project consistent its originally approved objectives purposes to accelerate tempo science education activities.  nbsp; Areas Interest NIH intends accept applications supplements under notice order promote science education the field neuroscience children grades K-12.  Examples responsive projects include, are limited to: Support specific neuroscience focused components curricula developed through NIH R25 grant such a SEPA/SEDAPA. nbsp; Develop neuroscience education programs low literacy students. Develop new expand existing Teacher Professional Development programs neuroscience content pedagogy.  Develop interactive inquiry-based neuroscience curricula elementary school students. Develop web based education material educational games middle and/or high school students based neuroscience. Expand content existing SEPA/SEDAPA-funded science museum exhibits develop traveling versions their existing SEPA/SEDAPA exhibits include neuroscience related topics. Submitting Administrative Supplement Request be considered an administrative supplement, submit request writing the Institute/Center, to Division Receipt Referral, Center Scientific Review. request must signed the authorized Business Official describe need additional funding the categorical costs. Requests under notice should the PHS 398 forms; available http://grants.nih.gov/grants/funding/phs398/phs398.html) include following elements the request packet.  1) Cover Letter - Citing Notice NOT-DA-10-007), specify request a NIH Blueprint Neuroscience Research Administrative Supplement R25 Science Education, the following information: Project Director/Principal Investigator PD/PI) name; Parent grant number title; Amount the requested supplement; Name title the institutional official; Phone, email, address information both PD/PI institutional official.  cover letter must signed the authorized organizational representative/institutional official. 2) PHS 398 Form Page 1 Face page) title the project Box 1) should the title the parent award. Notice number title, ldquo;Notice Availability Administrative Supplements R25 Science Education Grants) should cited Box 2, the ldquo;yes” box should checked. Project Director(s)/Principal Investigator(s) PDs/PIs) must the same the PD/PI the parent award.   remaining items the face page should filled in accordance the PHS 398 application instructions. 3) PHS 398 Form page 2 Note: project ldquo;summary” that the administrative supplement, the parent grant. 4) brief proposal describing project, including: a) Scope the overall project the anticipated contribution the requested supplement to exceed five pages). Provide brief description the scope the overall project which supplemental request based.  section should include description the supplement’s purpose, including proposed science education activities how improve neuroscience education/knowledge.  Describe relationship the supplement request the parent grant.  b) Budget the supplement a justification details items requested, including Facilities Administrative costs.  Budget Funding Information below. c) Biographical Sketch all new key personnel those are additions the supplemental project) d) Human Subjects/ Vertebrate Animal documentation applicable). Include current Human Subjects/IRB Vertebrate Animals/IACUC approval letter, available. Otherwise, will required the time funding. appropriate IRB IACUC approvals must in place prior a supplement award being made.  Any differences the involvement use human subjects specimens, use vertebrate animals, between administrative supplement activity the parent grant should noted.  appropriate, details should provided the protection human subjects inclusion women, children, minorities.  Additional guidance Human Subjects Research Vertebrate Animals provided under Part II the PHS 398 instructions http://grants1.nih.gov/grants/funding/phs398/phs398.html).   e) PHS 398 Checklist Form Selection Factors Administrative supplement requests be reviewed administratively NIH Program Grants Management staff expertise relevant the supplement request.  Awards be determined the basis the merit the supplement request, applicability the goals the NIH Blueprint Neuroscience, the availability funds. Awards be determined a review committee convened the Blueprint institutes. Applicants be notified regarding review outcome. nbsp;Selection factors include following: Relevance the proposed activities the parent grant. Adequate progress the parent grant appropriate the current stage the project. Appropriate well-described plan accomplish goals within timeframe proposed. Expertise the education/scientific team proposed conduct achieve goals supplemental study. Relevance target areas/priorities the NIH Blueprint Neuroscience Research. While geographic variation be considered awarding supplemental funding, proposal’s educational/scientific merit always the prevailing criterion. Budget Funding Information FY 2010 FY 2011 600,000 be available administrative supplements existing research projects.  administrative supplements limited no than 25 percent the Council-approved direct costs the current budget year the project, to maximum 75,000. Supplements be requested up two years may extend beyond FY 2011.  is anticipated supplemental funding begin FY 2010. to Apply is one-time announcement.  Applications must received or before April 2, 2010.  not send applications the NIH Center Scientific Review.  Submit original, hard copy the request packet original signatures the authorized business official) the Grants Management Specialist noted the Notice Award the parent grant. addition, applicants encouraged send electronic copy the submitted supplement request an e-mail attachment PDF format the program grants management contacts listed below under ldquo;Inquiries.” Inquiries Inquiries discussion plans responding this Notice strongly encouraged. Cathrine Sasek, Ph.D. National Institute Drug Abuse National Institutes Health Address: 6001 Executive Blvd Bethesda, MD 20892-9591 EXPRESS/COURIER:  Rockville, MD 20852 Phone: 301); 443-6071 Fax: 301) 443-6277 Email: csasek@nih.gov nbsp;   Grants Management Contact: grants management specialist appropriate funding institute the parent grant.

Participation NINDS PAR-10-038: Dissemination Implementation Research Health R01), PAR-10-039: Dissemination Implementation Research Health R03), PAR-10-040: Dissemination Implementation Research Health R21) Notice Number: NOT-NS-10-007 Key Dates Release Date:  January 15, 2010 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose purpose this Notice to inform applicants the NINDS announces intention participate, effective the February 5, 2010 receipt date, the following NIH Funding Opportunity Announcements FOAs): PAR-10-038: Dissemination Implementation Research Health R01) PAR-10-038) PAR-10-039: Dissemination Implementation Research Health R03) PAR-10-039) PAR-10-040: Dissemination Implementation Research Health R21) PAR-10-040) other aspects these FOAs remain unchanged participation other NIH Institutes continues, unaffected this Notice. Inquiries Scientific/research inquiries regarding Notice should directed the contact listed below: Deborah Hirtz M.D. Program Director, Office Clinical Research National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Blvd. Rockville, Md. 20892 Phone: 301-496-5821 Fax: 301 402-1080        Email: hirtzd@ninds.nih.gov

Request Information: Soliciting Input Huntington’s Disease Best Practice Guidelines Therapeutic Target Validation Notice Number: NOT-NS-10-005 Key Dates Release Date:    December 9, 2009 Response Due By: January 29, 2010 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov Purpose is time-sensitive Request Information RFI) issued the National Institute Neurological Disorders Stroke. purpose this RFI to solicit recommendations the best practices animal studies Huntington’s disease could advance knowledge validation therapeutic targets disease treatment. Institute envisions standardization animal studies through identification common protocols, outcome measures breeding practices enable comparison results across studies targets. Best practice guidelines should inclusive in vivo target manipulation through either genetic pharmacological interventions. responses the RFI be collected evaluated a group Institute staff assess best meet needs researchers the field. Results that evaluation be available the public will part a larger effort NINDS develop best practice guidelines target discovery validation neurological diseases. Background Huntington’s disease a rare neurodegenerative disorder, like neurodegenerative diseases, currently no treatment options modify disease progression. gene Huntington’s disease discovered 1993, genetic testing now identify individuals carrying pathological expansion the CAG repeat exon1 the gene, prior the onset motor symptoms. Knowledge the genetic basis the disease enabled development numerous animal models Huntington’s disease the discovery multiple cellular pathways associated disease pathogenesis. nbsp;The field currently faces challenge determining effective criteria identify best targets therapy development, taking consideration number potential targets, expense associated preclinical drug development, the limited patient population available clinical trials. RFI meant solicit input the extramural research community, scientific medical organizations, Federal Agencies, other interested parties well-versed Huntington’s disease the challenges facing therapeutic target identification validation this disease. Responses this RFI be reviewed NINDS staff will help inform complement assessment best practice guidelines will utilized the development initiatives review criteria involving standardized animal studies Huntington’s disease therapeutic target validation. Following publication the results this RFI, through ongoing interactions the Huntington’s disease research community, is anticipated development these guidelines help advance transform field overall. Best practice guidelines not meant limit number outcome measures studied, rather standardize core set outcome measures can applied all studies focused therapeutic target validation Huntington’s disease. RFI for planning purposes only, should be construed a solicitation applications proposals and/or an obligation any on part the United States Federal Government. Information Requested mission NIH to support biomedical discoveries will improve health save lives. further development therapeutic target validation Huntington’s disease, NINDS like input the following questions: Best Practice Guidelines nbsp;Animal Models there animal models Huntington’s disease best represent disease phenotype seen clinical practice?  so, please describe model including genetic background, length time onset disease, the behavior disease pathology relevant human Huntington’s disease.  reporting results, information should required regarding Huntington’s disease animal model used? example, reporting commercial source reference original paper describing model, catalog number, strain background, average life expectancy, range CAG repeat length across generations, differences disease phenotype between males females) breeding procedures husbandry standardized across studies, investigators institutes? example, of enriched cage environment, maintenance HD mouse models through breeding specific background strains). breeding recommendations exist specific Huntington’s disease models, please provide details. Study Design the experimental design, should Power analysis a requirement the determination group sizes each experiment? Should assumptions in Power analysis included reporting data conclusions the study? Should studies conducted a blinded fashion, that person administering tests and/or drugs blinded the genotypes and/or compounds administered? Blinding genotype feasible the beginning a study prior symptom onset). pharmacologically manipulating target, calculations should study design include? example, determination plasma target tissue exposure, determination maximum tolerated dose MTD) each genotyped studied, verifying compound activity the target e.g. pharmacodynamic data), etc) Outcome measures common outcome measures be applied target validation studies regardless HD rodent model chosen? example, measurement weight, rotarod performance, change regional e.g. striatal) brain volume, life expectancy, etc.) common drug characteristics/properties should reported pharmacological manipulation the target used? example, MTD, target tissue exposure, route administration, formulation details the compound, pharmacodynamic data target activity),timing intervention, etc) Standardized protocols a standardized protocol measurement CAG repeat length applied all studies? so please provide protocol(s). a standardized protocol measurement motor function such rotarod, open field grip strength) applied all studies? so, please provide protocol(s), any known variation background strain response. a standardized protocol measurement regional e.g. striatal) brain volume applied all studies? so please provide protocol. a standardized protocol measurement medium spiny neuron loss applied all studies applicable Huntington’s disease models demonstrating neuronal loss)? so please provide protocol. a standardized protocol measurement huntingtin protein aggregates applied all studies? so please provide protocol. a standardized protocol measurement soluble huntingtin protein levels applied all studies? so please provide protocol. Should standardized protocols considered? so, please provide protocol. General Information Please identify nature your interest the area databases repositories i.e. you biomedical clinical researcher, member an advocacy community group, other?). you a member a particular advocacy professional organization, please indicate name the organization. Please indicate main area research interest. name. email address. Responses Responses must submitted electronically using web-based format http://www.ninds.nih.gov/funding/areas/neurodegeneration/RFI-for-Hungti…), will accepted through January 29, 2010.  Replies individual questions optional, the site permit anonymous responses. information provided be analyzed may appear various reports. Inquiries Specific questions this RFI should directed the contact listed below: Margaret Sutherland, PhD Program Director, Neurodegeneration NINDS / NIH 6001 Executive Blvd., Rm 2222 Bethesda, MD 20892 Phone: 301-496-5680 Fax: 301-480-1080 E-mail: sutherlandm@ninds.nih.gov nbsp;

Administrative Supplement Extend Human Tissue Banking Efforts Distribute CNS Tissues Collected the NIH Roadmap GTEx Project Notice Number: NOT-MH-10-007 Key Dates Release Date: December 9, 2009 Receipt Date: January 19, 2010 Earliest Anticipated Start Date: April 2, 2010 Issued National Institute Mental Health NIMH), http://www.nimh.nih.gov/) National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov/) National Institute Drug Abuse NIDA) http://www.nida.nih.gov/) Purpose National Institute Mental Health NIMH), National Institute Neurological Diseases Stroke NINDS), National Institute Drug Abuse NIDA) announce availability funds support single administrative supplement an NIH grantee, currently funded human brain banking, extend brain collection efforts include receipt, processing, storage adult human normal control postmortem brains spinal cords the NIH Roadmap Genotype-Tissue Expression GTEx) Project.  proposed effort must within scope the peer-reviewed activities specified within parent grant.  length the supplement be limited the duration the parent grant, to five years.  is one-time solicitation. Background Genotype-Tissue Expression GTEx) project, NIH Roadmap Initiative http://nihroadmap.nih.gov/GTEx), aims provide resource the scientific community which study relationship between genetic variation regulation gene expression.  project collect analyze multiple human tissues donors have characterized germline genetic variation through dense genotyping.  treating global RNA expression levels quantitative traits, loci polymorphisms are highly correlated variations expression be identified expression quantitative trait loci, eQTLs.  GTEx Pilot Project comprises main initiatives: 1) Biospecimen Acquisition, 2) Laboratory, Data Analysis Coordinating Center LDACC), the latter established through separate contract mechanism NHLBI GTEx RFP NHLBI-HG-10-01. Biospecimen Acquisition be organized under National Cancer Institute’s NCI) cancer Human Biobank caHUB) initiative.  diagrammatic view the functional areas the GTEx project shown Figure 1. Tissue Source Sites TSS) be contracted recruit donors collect biospecimens.   Figure 1.  Schematic showing functional organization the GTEx pilot program GTEx project begin a 2.5-year pilot FY10.  developed a June 2008 GTEx Workshop http://nihroadmap.nih.gov/GTEx/workshop0608), primary goal the pilot to assess feasibility enrolling 160 donors identified through low post-mortem-interval PMI) autopsy organ transplant settings collecting high-quality RNA multiple tissues per donor.  precise number tissues yield high-quality RNA can collected each donor not known. aim this project to collect many different tissue types is practical, ideally 50 70, to analyze gene expression at least 50 tissues per donor. this Notice, NIMH, NINDS, NIDA intend capitalize the GTEx effort receiving, storing, dissecting postmortem human brains spinal cords collected GTEx donors the GTEx pilot phase future studies.  purpose this initiative to supplement existing CNS tissue storage facility store distribute brain spinal cords collected the GTEx project.  Donors be recruited tissue be collected the GTEx tissue source sites shipped the successful applicant further processing.  successful applicant be expected to: provide GTEx TSS a standardized protocol CNS tissue removal stabilization shipment; perform basic neuropathology quality control tissue collected shortly after receipt; dissect defined brain areas ship to GTEx Laboratory, Data Analysis Coordinating Center LDACC) using provided, standardized containers tracking procedures, within defined time period; store remaining brain spinal cord tissue associated clinical other phenotype data using LIM system allow tracking repeated sample dissection the same donor brain; provide requested tissues qualified investigators. GTEx project in pilot stage 2010-2011.  Depending the success the pilot available funds, GTEx project scale in subsequent years collect to 800 additional postmortem tissue donors.  Applicants should address ability scale brain storage sample handling the event the full GTEx project approved funded. Eligibility Before submitting application an administrative supplement, grantees strongly encouraged communicate the Program Officer(s) their funded NIH grant discuss planned application. program support administrative supplement an existing R01 R24 grant. parent grant must at least year active funding remaining the time award order be eligible.  Post-mortem brain processing must included the scope the parent grant.  Only supplement request be submitted per grant. Post-Award Requirements awardee be required participate GTEx Steering Committee teleconferences, well one in-person meeting.  two-page progress report addressing progress the supplement-funded activities be required annually.  should included an addition the progress report the parent grant included the final progress report a part the grant close-out process there no non-competing application.  Submitting Application Applications must received or before January 19, 2010. not send applications the Center Scientific Review.  Applicants encouraged submit electronic copy an e-mail attachment PDF format one hard copy original signatures the PI institutional official) the application to: Tiffany Yates Division Neuroscience Basic Behavioral Science National Institute Mental Health 6001 Executive Boulevard, Room 7194, MSC 9641 Bethesda, MD 20892-9641 Rockville, MD 20852 express/courier service) Email: yatest@mail.nih.gov Requests an administrative supplement under program must submitted the PHS 398 rev. 11/2007), available at:  http://grants.nih.gov/grants/funding/phs398_ver1107/phs398.html) must include following: 1.  Cover letter requesting supplement, identifying notice, number title the parent grant, providing full contact information the PI.  separate title the supplement activity should also provided this letter. 2.  Face page. title the project Box 1) should the title the parent grant. Notice number title) should cited Box 2, the yes” box should checked. Principal Investigator PI) must the same the PI the parent grant.  remaining items the face page should filled according the PHS 398 application instructions. 3.  Form page 2 Description, Performance Sites, Key Personnel, Significant Contributors, Human Embryonic Stem Cells) PHS 398. project description that the administrative supplement, the parent grant.  Any new co-investigator(s) collaborator(s) should noted under performance sites, along their institution(s). 4.  Biosketch(es) any new key co-investigator(s) collaborator(s), are listed within parent grant, should provided.. Letters commitment these new participants should included section 16 Consultants) the Research Plan. 5.  Resources page(s) new key personnel named the parent grant(s). 6.  Proposed budget the supplement a budget justification details items requested.  Budget Information” section below. 7.  Research Plan the supplement, items 2-5 to exceed five pages.  Font size restrictions apply designated within PHS398 instructions. section should include description the aims the parent grant the supplement's specific aims 2), background significance 3), preliminary studies 4), research design methods 5).  relationship the proposed studies the parent grant should included under background significance section 3. Items 13 Select Agent Research), 7 Bibliography References Cited), 15 Consortium/Contractual Arrangements), 17 Resource Sharing) 16 Consultants) should completed described the PHS 398 Instructions. Item 14 Multiple PDs/PI Leadership Plan not required. Appendices supplemental material not accepted. Review Award Criteria Applications are complete responsive the goals the supplement announcement be evaluated scientific technical merit a committee NIH staff.  Incomplete applications not reviewed.  Awards be determined the basis technical feasibility, experience the applicant managing post-mortem tissue, sophistication the pathology core staff the track record the applicant managing distributing post-mortem tissue.  Preference be given supplement requests where likelihood success highest.  added value the activity the parent grant(s) also taken consideration.  funding decisions final not subject appeal.  Resubmission applications not considered. Budget Information Applicants request to 250,000 direct costs the duration the administrative supplement under program.  Principal Investigator the parent NIH grant must the supplemental funds support work within scope the parent grant include collected GTEx CNS tissue.  duration the award limited the duration the parent grant, to exceed five years.  Facilities Administrative F&A) costs be paid the full, negotiated rate.  Applicants should provide detailed budget justification personnel costs, equipment, supplies, other expenses. purchase equipment allowed.  fiscal year 2010, participating Institutes plan commit approximately 400,000 total costs towards administrative supplement program, 1 award anticipated. Inquiries Applicants strongly encouraged discuss plans responding this Notice phone e-mail.  Scientific inquiries should directed the NIH Program Officer oversees parent grant associated the administrative supplement request.  General inquiries the supplement program be directed to: Susan Koester, Ph.D. Division Neuroscience Basic Behavioral Science National Institute Mental Health 6001 Executive Boulevard, Room 7205, MSC 9645 Bethesda, MD 20892-9645 Telephone:  301) 443-3563 Email: koesters@mail.nih.gov

NINDS Notice Intent Participate the High Priority, Short-Term Project Award R56) NOT-OD-04-047 Notice Number: NOT-NS-10-004 Key Dates Release Date: November 27, 2009 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose National Institute Neurological Disorders Stroke NINDS) announces intent participate, effective immediately, the High Priority, Short-Term Project Award R56), NOT-OD-04-047 http://grants.nih.gov/grants/guide/notice-files/NOT-OD-04-047.html). Additional information the R56 program available at: http://grants.nih.gov/grants/funding/r56.htm. Inquiries Direct inquiries regarding Notice to: Emmeline Edwards Deputy Director, Division Extramural Research National Institute Neurological Disorders amp; Stroke NSC 3305 6001 Executive Boulevard Bethesda, MD 20892 9531 Phone: 301-496-9248 Fax: 301-402-4370 Email: ee48r@nih.gov

Notice Intent Publish Request Applications a Parkinson’s Disease Data Organizing Center PD-DOC] U24) Notice Number: NOT-NS-10-003 Key Dates Release Date: November 13, 2009 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose National Institute Neurological Disorders Stroke NINDS) intends issue Request Applications RFA) provide support a redesigned enhanced Parkinson’s Disease Data Organizing Center PD-DOC). NINDS committed facilitating collection sharing data related clinical translational research Parkinson’s disease, the active development a centralized repository clinical data both observational studies clinical trials strengthen data sharing efforts the Parkinson’s disease research community establish important links between research efforts. main objectives this resource include: Serve an enduring repository data large clinical research studies PD, including clinical trials well epidemiological genetic studies, academia, non-profit disease organizations, industry. Data include clinical well genetic, imaging, neuropathology data elements. Link clinical data other data sets including imaging, pathology, genetic, biospecimens an easily searchable format. N.B. resource not house specimens, rather link clinical data other data sets.) Develop flexible, open source, web-based data entry system facilitate design, implementation, harmonization new clinical research studies PD. Serve a centralized listing PD related resources e.g., standard operating procedures SOPs) sample collection, antibodies, animal models, etc.). Outreach promote data standardization, data sharing, usefulness the PD-DOC resource well oversight data access. NINDS seeks applicants the expertise resources design maintain resource capable achieving aims. award anticipated a total budget 5.5 million total costs) over 5 years. Notice being provided allow potential applicants sufficient time develop responsive projects. RFA expected be published the NIH Guide Grants Contracts December 2009/January 2010 an anticipated receipt date April 30, 2010. RFA use U24 cooperative agreement mechanism. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Direct inquiries regarding Notice to: Wendy R. Galpern, MD, PhD Office Clinical Research NINDS / NIH 6001 Executive Blvd., 2225 Bethesda, MD 20892 Telephone: 301) 496-9135 Email: galpernw@ninds.nih.gov