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Participation NINDS PAR-10-266, Support NIGMS Program Project Grants P01) Notice Number: NOT-NS-10-029 Key Dates Release Date:   September 16, 2010 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants the National Institute Neurological Disorders Stroke announces participation, effective immediately, the Program Announcement PAR-10-266, titled quot;Support NIGMS Program Project Grants P01)." Components Participating Organizations section PAR-10-266 been revised include NINDS: Components Participating Organizations National Institute General Medical Sciences NIGMS), http://www.nigms.nih.gov/) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), http://www.niams.nih.gov/   National Institute Diabetes Digestive Kidney Diseases NIDDK), http://www2.niddk.nih.gov/ National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/   NINDS supports biomedical behavioral research the causes, treatment, prevention neurological disorders stroke. nbsp;The NINDS Program Project Center Grant Guidelines, including direct cost limitations, apply http://www.ninds.nih.gov/funding/ppg_guidelines.htm). Applications assigned the NINDS receive second level review the National Advisory Neurological Disorders Stroke Council NANDSC). CFDA number NINDS is: 93.853. other aspects this FOA remain same. Inquiries Please direct inquiries to: Chief, Scientific Review Branch National Institute Neurological Disorders Stroke Room 3201, MSC 9529 6001 Executive Blvd. Bethesda, MD 20892-9529 Rockville, MD 20852 express/courier service) Telephone: 301) 496-9223 Fax: 301) 402-0182 Email: nindsreview.nih.gov@mail.nih.gov

Notice Correction RFA-AG-11-010, Basic Research Self-Regulation R21) Notice Number:  NOT-AG-10-011 Key Dates: Release Date: September 7, 2010    Issued National Institutes Health NIH) Basic Behavioral Social Science Opportunity Network OppNet http://oppnet.nih.gov/) its member institutes, centers offices: National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Minority Health Health Disparities NCMHD) National Library Medicine NLM) Fogarty International Center FIC) National Center Complementary Alternative Medicine NCCAM) National Center Research Resources NCRR) Office AIDS Research OAR) http://www.oar.nih.gov/) Office Behavioral Social Sciences Research OBSSR) Office Dietary Supplements ODS) Office Disease Prevention ODP) http://prevention.nih.gov/) Office Research Women’s Health ORWH) Purpose purpose this Notice to correct Opening Date RFA-AG-11-010, Basic Research Self-Regulation R21) http://grants.nih.gov/grants/guide/rfa-files/RFA-AG-11-010.html issued the National Institute Aging behalf the NIH Behavioral Social Science Opportunity Network OppNet http://oppnet.nih.gov/) its member institutes, centers offices. Correction Under” Key Dates,” Opening Date Earliest date application be submitted Grants.gov) this FOA incorrectly listed December 6, 2011.  correct opening date December 6, 2010. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Lis Nielsen, Ph.D. Division Behavioral Social Research National Institute Aging 7201 Wisconsin Ave., 533 Bethesda, MD 20892-9205 Telephone: 301) 402-4156 Fax: 301) 402-0051 Email: nielsenli@nia.nih.gov

Notice Intent Publish Request Applications Clinical Research Centers establish Network Excellence Neuroscience Clinical Trials NEXT Sites - U10) Notice Number:  NOT-NS-10-025 Key Dates Release Date:   September 7, 2010 Related Notices NOT-NS-10-026 NOT-NS-10-027 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends issue Request Applications RFA) U10 grant applications support clinical research sites establish Network Excellence Neuroscience Clinical Trials NEXT). clinical research network develop conduct multiple early stage clinical trials research studies enable efficient testing the most promising therapies academia industry.  Examples include proof-of concept trials preparatory studies aimed validating biomarkers clinical outcomes neurological disorders including pediatric patients rare diseases. network provide robust, standardized, accessible infrastructure rapidly develop protocols will coordinate cadre specialist investigators implement studies efficiently. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  companion RFAs be concomitantly released, requesting U01 grant applications support a data coordinating center DCC) NOT-NS-10-027] U01 grant applications support a clinical coordinating center CCC) NOT-NS-10-026].  Note the currently planned RFAs establish collaborating Coordinating Centers Clinical Research Sites.  Separate FOAs be published the future invite applications Phase II clinical trials preparatory research studies will conducted within network. RFA expected be published fall 2010 an expected receipt date winter 2011. Clinical Research Sites RFA utilize U10 mechanism. Details the planned Funding Opportunity Announcement FOA) provided below. Research Initiative Details Notice encourages investigators expertise clinical trials consider applying this new RFA. Successful applicants the Clinical Sites RFA U10) have track record collaborative experienced neuroscience clinical trialists well institutional support.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Petra Kaufmann, MD National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Blvd., Room 2116 Bethesda, MD 20892-9520 Express/Courier:  Rockville, MD 20852 Telephone: 301) 496-9135 Fax: 301) 401-5301 Email: Petra.Kaufman@nih.gov http://www.ninds.nih.gov/

Notice Intent Publish Request Applications a Clinical Coordinating Center establish Network Excellence Neuroscience Clinical Trials NEXT-CCC) U01) Notice Number:  NOT-NS-10-026 Key Dates Release Date:   September 7, 2010 Related Notices NOT-NS-10-025 NOT-NS-10-027 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends issue Request Applications RFA) U01 grant applications support a clinical coordinating center CCC) establish Network Excellence Neuroscience Clinical Trials NEXT). clinical research network develop conduct multiple early stage clinical trials research studies enable efficient testing the most promising therapies academia industry.  Examples include proof-of concept trials preparatory studies aimed validating biomarkers clinical outcomes neurological disorders including pediatric patients rare diseases. network provide robust, standardized, accessible infrastructure rapidly develop protocols will coordinate cadre specialist investigators implement studies efficiently. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  companion RFAs be concomitantly released, requesting U10 grant applications support clinical research sites NOT-NS-10-025] U01 grant applications support a data coordinating center DCC) NOT-NS-10-027]. Note the current planned RFAs establish collaborating Coordinating Centers Clinical Research Sites.  Separate FOAs be published the future invite applications Phase II clinical trials preparatory research studies will conducted within network. RFA expected be published fall 2010 an expected receipt date winter 2011. Clinical Coordinating Center RFA utilize U01 mechanism activity code. Details the planned Funding Opportunity Announcement FOA) provided below. Research Initiative Details Notice encourages investigators expertise clinical trials consider applying this new RFA. Successful applicants the Clinical Coordinating Center U01) have proven track record successful clinical project management neuroscience trials including, not limited to: protocol development adherence GCP all regulatory requirements efficient contracting IRB procedures development implementation recruitment plans, safety monitoring reporting plans APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Petra Kaufmann, MD National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Blvd., Room 2116 Bethesda, MD 20892-9520 Express/Courier:  Rockville, MD 20852 Telephone: 301) 496-9135 Fax: 301) 401-5301 Email: Petra.Kaufman@nih.gov http://www.ninds.nih.gov/

Notice Intent Publish Request Applications a Data Coordinating Center establish Network Excellence Neuroscience Clinical Trials NEXT-DCC) U01) Notice Number:  NOT-NS-10-027 Key Dates Release Date:   September 7, 2010 Related Notices NOT-NS-10-025 NOT-NS-10-026 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) intends issue Request Applications RFA) U01 grant applications support a data coordinating center DCC) establish Network Excellence Neuroscience Clinical Trials NEXT). clinical research network develop conduct multiple early stage clinical trials research studies enable efficient testing the most promising therapies academia industry.  Examples include proof-of concept trials preparatory studies aimed validating biomarkers clinical outcomes neurological disorders including pediatric patients rare diseases. network provide robust, standardized, accessible infrastructure rapidly develop protocols will coordinate cadre specialist investigators implement studies efficiently. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  companion RFAs be concomitantly released, requesting U10 grant applications support clinical research sites NOT-NS-10-025] U01 grant applications support a clinical coordinating center CCC) NOT-NS-10-026].  Note the current planned RFAs establish collaborating Coordinating Centers Clinical Research Sites.  Separate FOAs be published the future invite applications Phase II clinical trials preparatory research studies will conducted within network. RFA expected be published fall 2010 an expected receipt date winter 2011. Data Coordinating Center RFA utilize U01 mechanism activity code. Details the planned Funding Opportunity Announcement FOA) provided below. Research Initiative Details Notice encourages investigators expertise clinical trials consider applying this new RFA. Successful applicants the Data Management Center U01) have proven capability manage large clinical trials efficiently to provide statistical support.  Expertise activities including, not limited to, following expected: web-based data management multicenter clinical trials is compliant regulatory requirements data quality assurance data sharing including and/or development common data elements CDEs, http://www.commondataelements.ninds.nih.gov/) APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Petra Kaufmann, MD National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Blvd., Room 2116 Bethesda, MD 20892-9520 Express/Courier:  Rockville, MD 20852 Telephone: 301) 496-9135 Fax: 301) 401-5301 Email: Petra.Kaufman@nih.gov http://www.ninds.nih.gov/

Notice Intent Publish Request Applications a Parkinson Disease Biomarkers Identification Network Coordinating Center U01) Notice Number: NOT-NS-10-024 Key Dates Release Date:  August 3, 2010 Issued National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/) Purpose National Institute Neurological Disorders Stroke NINDS) intends issue Request Applications RFA) grant applications support a data coordinating center DCC) clinical coordinating center CCC) focused initially the discovery validation biological markers Parkinson’s disease PD). nbsp;The NINDS convened conference May 2010 discuss current state biomarker development PD how development validation biomarkers most effectively fostered.  Based the insights recommendations provided the conference, effort being developed part the NINDS response the critical need biomarker development PD. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  RFA expected be published the Fall 2010 a receipt date early 2011.  RFA utilize U01 Cooperative Agreement Research Project funding mechanism. nbsp; Notice encourages investigators expertise Parkinson’s Disease begin consider applying this new RFA.  Additional expertise subject recruitment, clinical site identification, coordination standardized biospecimen collection, operation a public database standardized data collection dissemination also highly desirable. nbsp;One more separate FOAs be published invite discovery validation other biomarker projects be performed within network. APPLICATIONS NOT BEING SOLICITED THIS TIME.  Inquiries Interested parties contact: Katrina Gwinn MD National Institute Neurological Disorders Stroke National Institutes Health 6001 Executive Blvd Room 2143 Bethesda, MD  20892 Express/Courier: Rockville, MD  20852 Phone: 301) 496-5745 Fax: 301) 401-5301 Email: gwinnk@ninds.nih.gov

Request Information RFI): Tools Resources Neuroscience Research Notice Number: NOT-NS-10-023 Key Dates Release Date:  July 22, 2010 Response Due By: September 23, 2010 Issued National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/) Purpose is time-sensitive Request Information RFI), purpose which to assess scientific needs opportunities tool resource development neuroscience neurology. Background NINDS-funded research resources support development dissemination tools, collections, service facilities advance basic, translational clinical neuroscience research http://www.ninds.nih.gov/research/scientific_resources/index_research.h… selected examples).  planning future investments research resources, NINDS soliciting input the neuroscience neurological disease research advocacy communities identify areas greatest need. Information Requested Identify areas research could accelerated the development specific research resources. Describe 2-3 highest priority tools resources needed capitalize scientific opportunities overcome obstacles progress research. Describe NINDS might best facilitate development these tools/resources. Name Institutional Affiliation Email address Responses Responses must submitted electronically using web-based form http://www.ninds.nih.gov/research/scientific_resources/rfi.htm, will accepted through 09/23/2010.  Responses individual questions voluntary may anonymous.  Proprietary, classified, confidential, sensitive information should be included your response.  Government reserves right use any non-proprietary technical information any resultant solicitation(s).  Request Information RFI) for information planning purposes only should be construed a solicitation as obligation the part the Federal Government, National Institutes Health NIH), and/or National Institute Neurological Disorders Stroke NINDS). NIH does intend award grant contract pay the preparation any information submitted for NIH’s of such information.  Respondents not notified the NIH evaluation the information received.  basis claims against NIH shall arise a result a response this request information the NIH’s of such information either part our evaluation process in developing specifications any subsequent announcement.  Responses be held confidential. nbsp;Proprietary information should be sent. Inquiries Specific questions this RFI should directed the contact listed below: Anna Taylor, PhD 6001 Executive Boulevard, Room 3303 Bethesda, MD 20892 Phone: 301) 496-9248 Email: taylorann@mail.nih.gov

Extension Expiration Date Additional Receipt Dates RFA AI-10-014: Ancillary Studies Immunomodulation Clinical Trials R01) Notice Number: NOT-AI-10-035 Key Dates Release Date:  June 28, 2010 Opening Date:   Thirty days prior Letter intent Date. Letters Intent Receipt Date(s): Thirty days prior application receipt date Application Due Date(s): September 9, 2010; December 9, 2010, March 9, 2011 Peer Review Date(s): approximately twelve weeks after receipt date Council Review Date(s): Special Electronic Council Earliest Anticipated Start Date(s): approximately 17 weeks after receipt Expiration Date: March 10, 2011 Issued National Institute Allergy Infectious Diseases NIAID) http://www.niaid.nih.gov) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) http://www.niams.nih.gov) National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) National Institute Diabetes Digestive Kidney Diseases NIDDK) http://www2.niddk.nih.gov) Purpose purpose this notice to extend expiration date RFA-AI-10-014 Ancillary Studies Immunomodulation Clinical Trials R01) March 10, 2011, to add following additional receipt dates: September 9, 2010; December 9, 2010; March 9, 2011. participating NIH Institutes intend commit approximately 2M FY2011 fund 4-5 new grants support ancillary immune mechanistic studies conjunction independently supported clinical trials immunomodulatory interventions immune system mediated diseases vaccine clinical trials non-HIV/AIDS infectious diseases. than changes noted above, aspects RFA-AI-10-014 remain unchanged. Inquiries encourage inquiries concerning funding opportunity welcome opportunity answer questions potential applicants. Inquiries fall three areas: scientific/research program), peer review, financial grants management issues. Interested parties contact: 1. Scientific/Research Contact(s): Annette L. Rothermel, Ph.D. Division Allergy, Immunology Transplantation National Institute Allergy Infectious Diseases Room 3020, MSC-6601 6610 Rockledge Drive Bethesda, MD 20892- 6601 Telephone: 301-496-7104 Fax: 301-480-1450 Email: arothermel@niaid.nih.gov   Yan Wang, M.D., Ph.D. Division Skin Rheumatic Diseases, Extramural Program National Institute Arthritis Musculoskeletal Skin Diseases Democracy Plaza, Suite 800, MSC-4872 6701 Democracy Boulevard Bethesda, MD 20892-4872 Phone: 301-594-5032 Fax: 301-480-1284 Email: wangy1@mail.nih.gov  Ursula Utz, Ph.D. Neural Environment Program National Institute Neurological Disorders Stroke Room 213, MSC-9521 6001 Executive Boulevard Bethesda, MD 20892-9521 Phone: 301-496-1431 FAX: 301-402-1501Email: utzu@ninds.nih.gov  Beena Akolkar, Ph.D. Division Diabetes, Endocrinology, Metabolic Diseases National Institute Diabetes Digestive Kidney Diseases Room 681, MSC-5460 6707 Democracy Boulevard Bethesda, MD 20892-5460 Phone: 301-594-8812 FAX: 301-480-3503 Email: akolkarb@niddk.nih.gov 2. Peer Review Contact(s): Paul Amstad, Ph.D. Division Extramural Activities National Institute Allergy Infectious Diseases Room 3121, MSC-7616 6700B Rockledge Drive Bethesda, MD 20892-7616 Bethesda, MD 20817 express mail) Telephone: 301-402-7098 Fax: 301-480-2408 Email: pamstad@niaid.nih.gov 3. Financial/Grants Management Contact(s): Victoria P. Connors Division Extramural Activities National Institute Allergy Infectious Diseases Room 2122, MSC-7614 6700 B Rockledge Drive Bethesda, MD 20892-7614 Phone: 301) 402-5065 Fax: 301) 493-0597 Email: vp14v@nih.gov  

Request Information: Scientific Collaborative Considerations Associated the NINDS Epilepsy Centers without Walls Program Notice Number: NOT-NS-10-020 Key Dates Release Date:  June 25, 2010 Response Due By:  August 6, 2010 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose National Institute Neurological Disorders amp; Stroke NINDS) considering issuing series Funding Opportunity Announcements FOAs) the NINDS Epilepsy Centers without Walls Program Promote Collaborative Research the Epilepsies, newly envisioned cooperative agreement program will engage epilepsy research community collaborations solve challenges related the Epilepsy Research Benchmarks http://www.ninds.nih.gov/research/epilepsyweb/2007_benchmarks.htm). purpose this Request Information RFI) to solicit input will help guide development this new program.  Background epilepsies a diverse group chronic neurological disorders characterized spontaneous, recurring seizures. Collectively, disorders estimated affect approximately 3 million Americans all ages ethnic groups, a lifetime risk age 80 3%. highest incidence epilepsy in early childhood, the population the fastest growing incidence the elderly. a majority people epilepsy, medicines and/or surgical interventions control seizures, yet seizures continue about one-third cases even the best available treatment, sometimes leading devastating consequences.  Moreover, anti-epileptic treatments adverse side effects, no effective interventions exist prevent development epilepsy those risk.  Beyond seizures, sudden unexplained death epilepsy SUDEP) comorbid conditions, such depression cognitive behavioral impairments, increasingly recognized part a broader spectrum problems associated epilepsy. NINDS the lead NIH Institute research the epilepsies has supported important contributions past recent advances.  However, challenges remain epilepsy research.  further accelerate progress toward goals no seizures, side effects, the prevention epilepsy those risk, NINDS implementing new initiatives epilepsy research, including NINDS Epilepsy Centers without Walls Program Promote Collaborative Research the Epilepsies. program support multicenter, multidisciplinary consortia solve specific research challenges will lead advances prevention, diagnosis, treatment the epilepsies related comorbidities. program bring together best investigators, regardless geographic location, is novel innovative approach harnessing best research address difficult needs a particular field. NINDS expects issue first a series Request Applications RFA) this program fall 2010.  first RFAs likely focus human epilepsy genetics animal models epileptogenesis pharmacoresistance translational drug development. RFA soliciting planning grant applications a Center without Walls Sudden Unexpected Death Epilepsy SUDEP) also anticipated fall 2010. Recent planned NINDS workshops these topics be source input the key challenges Centers without Walls program should address.  NINDS hold workshops the areas human epilepsy genetics animal models epileptogenesis pharmacoresistance late summer, 2010.  NINDS previously held workshop SUDEP November 2008.  summary the meeting, includes research priorities identified during proceedings, in preparation. first workshop focus the state the science current large scale epilepsy genetic efforts. workshop assess readiness broad collaboration a US-based consortium how remove barriers collaboration this area. is hoped consensus begin be reached topics such as: priorities, phenotyping standards, retroactive of samples data, informatics data systems issues, informed consent future studies, functional validation studies, data sharing publication policies.  second workshop expected focus animal models epileptogenesis pharmacoresistance suitable translational research studies. purpose this workshop to assess utility available models developing testing new therapies prevent epileptogenesis, modify course epilepsy, to control seizures conditions remain resistant currently available treatment options.  workshop explore relevance these models specific clinical populations i.e., people develop epilepsy after traumatic brain injury, stroke, prolonged status epilepticus, etc.), regulatory barriers trial design, validation requirements candidate criteria preclinical intervention studies.  Information Requested NINDS seeking information will useful developing upcoming workshops the Epilepsy Center without Walls solicitations. Specifically, NINDS requests input the following areas please note it not required address areas order respond; feel free focus those items which are most interested addressing): Challenges exist investigators institutions establishing effective, large-scale, geographically dispersed collaborations.  Unique challenges collaboration the areas human genetics, animal models epileptogenesis pharmacoresistance, and/or Sudden Unexpected Death Epilepsy SUDEP). Lessons learned collaborative experiences other disorders are applicable the epilepsies. your experience, approaches models fostering collaborative research find be most effective, why. Approaches models have worked well. Key questions are currently obstacles further progress human genetics, translation therapies epileptogenesis pharmacoresistant epilepsy, and/or SUDEP. questions that  should asked the upcoming workshops human epilepsy genetics animal models epileptogenesis pharmacoresistance.  Recent advances emerging research should included. topic areas should considered an Epilepsy Center without Walls solicitation future years. Responses Responses should submitted electronically via web-based form available http://www.ninds.nih.gov/research/epilepsyweb/feedback.htm. Replies individual questions optional, the site permit anonymous responses.  Responses be accepted through August 6, 2010.  Confidentiality Responses this RFI voluntary may anonymous.  Any identifiers e.g., names, institutions, e-mail addresses, etc) be removed responses compiled.  Only processed, anonymized results be shared internally scientific working groups convened the NIH, appropriate. Proprietary, classified, confidential, sensitive information should be included your response.  Government reserves right use any non-proprietary technical information any resultant solicitation(s).  RFI for information planning purposes only should be construed a solicitation as obligation the part the Federal Government, National Institutes Health NIH), and/or National Institute Neurological Disorders Stroke NINDS). NIH does intend award grant contract pay the preparation any information submitted for NIH’s of such information.  Respondents be notified the NIH evaluation the information received.  basis claims against NIH shall arise a result a response this request information the NIH’s of such information either part our evaluation process in developing specifications any subsequent announcement.  Responses be held confidential. Proprietary information should be sent. Inquiries Specific questions this RFI should directed the contact listed below: Brandy Fureman, PhD Program Director, Epilepsies National Institute Neurological Disorders Stroke National Institutes Health furemanb@ninds.nih.gov Phone: 301-496-1917

Notice Intent Publish Series Request Applications the NINDS Epilepsy Centers without Walls Program U54) Notice Number: NOT-NS-10-022 Key Dates Release Date:  June 25, 2010 Issued National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov) Purpose NINDS announcing plans the Epilepsy Centers without Walls Program Promote Collaborative Research the Epilepsies.  program support multicenter, multidisciplinary consortia solve specific research challenges will lead advances prevention, diagnosis, treatment the epilepsies related comorbidities. program bring together best investigators, regardless geographic location, is novel innovative approach harnessing best research address difficult needs a particular field.  fall 2010, NINDS expects issue first a series Request Applications RFA) targeting specified challenges will support to five Centers without Walls, beginning FY2011 adding new center year.  Because nature scope the proposed research vary application application, is anticipated the size duration each award also vary.  Although actual support depend the scope a Center’s proposed goals, NINDS anticipates supporting Center up 3 million direct costs per year five years.  Progress toward measurable goals determine eligibility a single competitive renewal. NINDS currently working develop challenge topics be addressed the first Centers without Walls RFAs.  Toward end, NINDS hold workshops summer 2010 assess readiness broad collaboration research human epilepsy genetics, on model therapy development pharmacoresistant epilepsy the prevention epileptogenesis. addition, NINDS held workshop fall 2008 research needs opportunities sudden unexpected death epilepsy SUDEP).   three workshops provide important information the current state the science potential opportunities accelerate progress through collaborative approaches.         parallel this Notice Intent Publish, NINDS issuing Request Information: Scientific Collaborative Considerations Associated the NINDS Epilepsy Centers without Walls Program NOT-NS-10-020).  NINDS seeking information will useful developing upcoming workshops the Epilepsy Center without Walls solicitations. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Direct inquiries regarding Notice to: Brandy Fureman, PhD Program Director, Epilepsies National Institute Neurological Disorders Stroke National Institutes Health furemanb@ninds.nih.gov Phone: 301-496-1917