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Research on Current Topics in Alzheimer's Disease and Its Related Dementias (R01 Clinical Trial Optional)

PAR
Friday, November 16, 2018
Clinical Trials Research
Saturday, November 13, 2021
R01
PAR-19-070

Funding Opportunity Purpose

The purpose of this Funding Opportunity Announcement (FOA) is to invite applications proposing research on current topics in Alzheimer's disease and its related dementias. Further information on the high-priority topics of interest will be announced through a series of Notices published subsequent to this FOA.

Small Research Grants for Analyses of Data for the Gabriella Miller Kids First Data Resource (R03 - Clinical Trial Not Allowed)

PAR
Friday, November 16, 2018
Sunday, September 8, 2019
R03
PAR-19-069

Funding Opportunity Purpose

REISSUE of PAR-18-733 The NIH Common Fund has established the Gabriella Miller Kids First Pediatric Research Program (Kids First) to develop a pediatric research data resource populated by genome sequence and phenotype data that will be of high value for the communities of investigators who study the genetics of childhood cancers and/or structural birth defects. The overall goal of the Gabriella Miller Kids First Pediatric Data Resource is to help researchers understand the underlying mechanisms of these conditions, leading to more refined diagnostic capabilities and ultimately more targeted therapies, as well as to develop an integrated pediatric research data resource by obtaining and aggregating genome sequence and phenotype data for as many relevant structural birth defects and pediatric cancer cohorts as possible and to advance research in this area through the broad sharing of these data with the research community. This FOA is intended to promote meritorious small research projects focused on the development and analyses of childhood cancer and/or structural birth defects datasets that are part of the Kids First Data Resource or could be included in the Kids First Data Resource. Development of statistical methodology appropriate for analyzing genome-wide data relevant to childhood cancer and/or structural birth defects may also be proposed.

NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed)

PA
Monday, November 5, 2018
Saturday, January 8, 2022
R03
PA-19-052

Funding Opportunity Purpose

The NIH Small Research Grant Program supports small research projects that can be carried out in a short period of time with limited resources. This program supports different types of projects including pilot and feasibility studies; secondary analysis of existing data; small, self-contained research projects; development of research methodology; and development of new research technology.

Optimization of Non-addictive Therapies [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Not Allowed)

RFA
Monday, November 5, 2018
Translational Research
Thursday, March 7, 2019
UG3/UH3
RFA-NS-19-010

Funding Opportunity Purpose

The purpose of this funding opportunity announcement (FOA) is to support preclinical optimization and development of safe, effective, and non-addictive small molecule and biologic therapeutics to treat pain. The goal of the program is to accelerate the optimization and development of promising small molecule and biologic hits/leads towards clinical trials. Applicants must have a promising hit/lead, robust biological rationale for the intended approach, and identified assays for optimization of the agent. The scope of this program includes optimization and early development activities, IND-enabling studies, and assembly of Investigational New Drug (IND) application. This is a milestone-driven phased cooperative agreement program involving participation of NIH program staff in the development of the project plan and monitoring of research progress.

Research Project Grant (Parent R01 Clinical Trial Not Allowed)

PA
Monday, November 5, 2018
Saturday, January 8, 2022
R01
PA-19-056

Funding Opportunity Purpose

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. This Funding Opportunity Announcement does not accept applications proposing clinical trial(s)

Research Project Grant (Parent R01 Clinical Trial Required)

PA
Monday, November 5, 2018
Saturday, January 8, 2022
R01
PA-19-055

Funding Opportunity Purpose

The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions. Applicants should note that some ICs (see Related Notices) only accept applications proposing mechanistic studies that meet NIH's definition of a clinical trial through this funding opportunity announcement.

Emerging Global Leader Award (K43 Independent Clinical Trial Required)

PAR
Friday, November 2, 2018
Thursday, November 5, 2020
K43
PAR-19-051

Funding Opportunity Purpose

This is a reissue of the Emerging Global Leader Program (K43) to align with the clinical trials policy.

Promoting Research on Music and Health: Fundamentals and Applications (R01 Clinical Trials Optional)

RFA
Tuesday, October 30, 2018
Friday, March 1, 2019
R01
RFA-NS-19-008

Funding Opportunity Purpose

The purpose of this FOA is to promote research to both understand the mechanisms by which music is uniquely processed in the brain and optimize music medicine to enrich our lives and treat illness. This FOA encourages a broad variety of R01 research projects from basic to applied approaches, across the lifespan, and in both healthy and diseased individuals. It encourages partnerships and collaborations among basic researchers, technological development researchers, music intervention experts, and/or other clinical researchers.

Promoting Research on Music and Health: Fundamentals and Applications (R21 Clinical Trials Optional)

RFA
Tuesday, October 30, 2018
Friday, March 1, 2019
R21
RFA-NS-19-009

Funding Opportunity Purpose

This FOA is intended to encourage exploratory studies to : (1) increase our understanding of how music affects the brain, body, and behavior and (2) use that knowledge to develop evidence-based music interventions to enhance health or treat specific diseases and disorders. Proposed R21 projects can investigate how music is processed by or modifies the brain, or how it affects specific biological functions during childhood development and learning, adulthood, and aging. Projects can also include preliminary interventions that provide a basis for therapeutic interventions. When appropriate, collaborations among basic researchers, technology developers, music intervention experts, or other clinical researchers are highly encouraged.

Promoting Research on Music and Health: Phased Innovation Award for Music Interventions (R61/R33 Clinical Trial Optional)

RFA
Tuesday, October 30, 2018
Friday, March 1, 2019
R61/R33
RFA-AT-19-001

Funding Opportunity Purpose

The purpose of this FOA is to promote innovative research on music and health with an emphasis on developing music interventions aimed at understanding their mechanisms of action and clinical applications with little or no preliminary data. Because of the need for a multidisciplinary approach, collaborations among basic researchers, translational science researchers, music intervention experts, other clinical researchers, music health professionals, and technology development researchers are encouraged. The FOA utilizes a phased R61/R33 funding mechanism to support mechanistic research and to evaluate the clinical relevance of music interventions. The R61 phase will provide funding for up to two years to either investigate the biological mechanisms or behavioral processes underlying music interventions in relevant animal models, healthy human subjects, and/or clinical populations, or can be used to develop innovative technology or approaches to enhance music intervention research. The second R33 phase will provide up to three years of support for further mechanistic investigations, intervention development, or pilot clinical studies. The pilot clinical studies may focus on intervention optimization/refinement, feasibility, adherence, and/or identification of appropriate outcome measures to inform future clinical research. Transition from the R61 to the R33 phase of the award will depend on successful completion of pre-specified milestones established in the R61.

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