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Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44)

PAR
Thursday, March 9, 2017
Translational Research
Friday, May 8, 2020
U44
PAR-17-201
Charles Cywin

Funding Opportunity Purpose

The Blueprint Neurotherapeutics Network (BPN) encourages applications from small businesses seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry, or at the Development stage, to advance a development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Projects that enter at the Discovery stage and meet their milestones may continue on through Development. BPN awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (UG3/UH3)

PAR
Thursday, March 9, 2017
Translational Research
Friday, May 8, 2020
UG3/UH3
PAR-17-205
Charles Cywin

Funding Opportunity Purpose

The Blueprint Neurotherapeutics Network (BPN) invites applications from neuroscience investigators seeking support to advance their small molecule drug discovery and development projects into the clinic. Participants in the BPN are responsible for conducting all studies that involve disease- or target-specific assays, models, and other research tools and receive funding for all activities to be conducted in their own laboratories. In addition, applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in medicinal chemistry, pharmacokinetics, toxicology, formulations development, chemical synthesis including under Good Manufacturing Practices (GMP), and Phase I clinical testing. Projects can enter either at the Discovery stage, to optimize promising hit compounds through medicinal chemistry, or at the Development stage, to advance a development candidate through Investigational New Drug (IND)-enabling toxicology studies and phase I clinical testing. Projects that enter at the Discovery stage and meet their milestones may continue on through Development. BPN awardee Institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN contractors (and thereby control the patent prosecution and licensing negotiations) for drug candidates developed in this program.

NINDS Postdoctoral Mentored Career Development Award (K01)

PAR
Tuesday, January 31, 2017
Wednesday, January 8, 2020
K01
PAR-17-145

Funding Opportunity Purpose

The purpose of the NINDS Postdoctoral Mentored Career Development Award is to support the ability of outstanding, mentored postdoctoral researchers to develop a potentially impactful research project with a comprehensive career development plan that will enable them to launch an independent research program. Candidates are encouraged to apply for support from this NINDS K01 any time between the second through fourth year of cumulative mentored postdoctoral research experience, and may be supported by this NINDS K01 within the first 6 years of cumulative postdoctoral research experience. Because the completion of a strong, well-planned, thorough career development plan, in addition to development of an impactful research project, is a critical aspect of this K01, applications are strongly encouraged early in the postdoctoral eligibility window. By the end of the proposed K01 award period, the candidate should be poised to begin an independent research career with a well-developed, impactful research project and the expertise required to become a leader in the field.

Zika Virus (ZIKV) Complications (R21)

PA
Tuesday, January 17, 2017
Thursday, January 25, 2018
R21
PA-17-085

Funding Opportunity Purpose

The purpose of this Funding Opportunity Announcement (FOA) is to provide support for research on Zika virus (ZIKV) and its complications. This FOA replaces PAR-16-106 which had used rolling application due dates to facilitate the rapid review and award of particularly urgent or time-sensitive projects. The last date for submitting an application to PAR-16-106 is January 13, 2017.

HIV-1 infection of the Central Nervous System (R01)

PA
Thursday, January 5, 2017
Wednesday, January 8, 2020
R01
PA-17-100

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) invites research grant applications focused on defining and understanding the pathogenic mechanisms involved in Human Immunodeficiency Virus (HIV)-1 induced CNS dysfunction, but within the context of viral suppression and Antiretroviral therapy (ART). The FOA further supports research to identify therapeutic targets against which treatments may be developed to prevent the neurobehavioral and neurological co-morbidities in HIV-1 infected individuals. Basic and translational research in domestic and international settings are of interest. Multidisciplinary research teams and collaborative alliances are encouraged but not required.

Jointly Sponsored Ruth L. Kirschstein National Research Service Award for Institutional Predoctoral Training Programs in the Neurosciences (T32)

PAR
Thursday, December 22, 2016
Sunday, May 26, 2019
T32
PAR-17-096

Funding Opportunity Purpose

The Jointly Sponsored NIH Predoctoral Training Program in the Neurosciences (JSPTPN) is an institutional program that supports broad and fundamental research training in the neurosciences. In addition to a broad education in the neurosciences, a key component will be a curriculum that provides a strong foundation in experimental design, statistical methodology and quantitative reasoning. . JSPTPN programs are intended to be two years in duration, and students may only be appointed to this training grant during the first 2 years of their graduate research training. The primary objective is to prepare individuals for careers in neuroscience that will have a significant impact on our understanding of nervous system function and the health-related research needs of the nation.

Eradication of HIV-1 from Central Nervous system Reservoirs (R01)

PA
Tuesday, December 13, 2016
Wednesday, January 8, 2020
R01
PA-17-084

Funding Opportunity Purpose

This Funding Opportunity Announcement (FOA) invites research grant applications studying mechanisms of HIV-1 persistence and eradication strategies specifically focused on the central nervous system (CNS) in the context of viral suppression. Basic and translational research in domestic and international settings are of interest. Multidisciplinary research teams and collaborative alliances are encouraged but not required.

Common Mechanisms and Interactions Among Neurodegenerative Diseases (R01)

PAS
Friday, October 21, 2016
Tuesday, May 8, 2018
R01
PAS-17-028

Funding Opportunity Purpose

This FOA encourages preclinical and clinical research to study whether, and how, different neurodegenerative disease processes interact with one another to initiate and/or hasten progression of neuropathology and dementia.

BD2K Support for Meetings of Data Science Related Organizations (U13)

RFA
Friday, October 7, 2016
Saturday, December 1, 2018
U13
RFA-CA-16-020

Funding Opportunity Purpose

The purpose of this Funding Opportunity Announcement (FOA) is to support high quality and impactful conferences/scientific meetings that are convened by data science related organizations whose missions focus on biomedical data science. This FOA, which uses the NIH conference cooperative agreement program (U13), is part of the NIH-wide initiative, Big Data to Knowledge (BD2K). Data science related organizations have a critical role in advancing biomedical data science but often depend on meetings to carry out their work. This FOA will support high quality conferences or meetings that are relevant to the biomedical data science needs of the participating Institutes and Centers of the National Institutes of Health. For the purpose of this FOA, a conference is defined as a gathering, such as in the form of a symposium, seminar, scientific meeting, workshop, or any other organized and formal meeting where persons assemble to coordinate, exchange, and disseminate information, or to explore or clarify a defined subject, problem, or area of knowledge. Applicants representing data science related organizations may request support for one or a series of meetings over multiple years that address areas of data science aligned with the goals of the NIH BD2K program.

Emerging Global Leader Award (K43)

PAR
Tuesday, October 4, 2016
Saturday, December 15, 2018
K43
PAR-17-001

Funding Opportunity Purpose

The purpose of the Fogarty Emerging Global Leader Award is to provide research support and protected time (three to five years) to an early career research scientist from a low- or middle-income country (LMIC) who holds a junior faculty position at an LMIC academic or research institution, as defined by the World Bank (http://data.worldbank.org/about/country-classifications/country-and-lending-groups, including low-income, lower-middle-income, and upper-middle-income countries). This intensive, mentored research career development experience is expected to lead to an independently funded research career at the LMIC institution or in another LMIC. This Funding Opportunity Announcement (FOA) invites applications from LMIC scientists from any health-related discipline who propose career development activities and a research project that is relevant to the health priorities of their country under the mentorship of LMIC and U.S. mentors.

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