The National Institute of Neurological Disorders and Stroke (NINDS) and the
National Institute of Dental Research (NIDR), serving as the lead Institutes
for the National Institutes of Health (NIH) Pain Research Consortium, together
with the National Cancer Institute (NCI), National Institute on Aging (NIA),
National Institute of Allergy and Infectious Diseases (NIAID), National
Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National
Institute on Deafness and Other Communication Disorders (NIDCD), National
Institute on Drug Abuse (NIDA), National Institute of General Medical Sciences
(NIGMS), National Institute of Nursing Research (NINR), and the Office of
Research on Women"s Health (ORWH), encourage investigator-initiated research
project grant applications to study mechanisms underlying analgesic response
and pain to advance the development of novel pain interventions, treatments
and management strategies. The purpose of this New Directions in Pain
Research: I program announcement (PA) is to inform the scientific community
of broad, shared interests in pain research encompassing the various
components of the NIH, and to stimulate and foster a wide range of basic,
translational and patient-oriented clinical studies on pain. Applications are
particularly encouraged to study pain throughout the lifespan from the
perspectives of molecular genetics, transcriptional controls, signal
transduction, including cellular/molecular mechanisms, innovative imaging
technologies, plasticity and from hormonal or gender influences. The pain
experience needs to be examined at all levels of analysis from the gene,
molecule, cell, tissue, and organ, to the individual, family and community,
with the ultimate goal of developing new insights into pain intervention,
treatment and management.
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Expiration Date: Tuesday, September 4, 2001 NOFO Number: PA-98-102 Release Date: Friday, September 4, 1998 Notice Type: PA
Expiration Date: Saturday, December 12, 1998 NOFO Number: RFA-NS-99-002 Release Date: Friday, September 4, 1998 Notice Type: RFA
The National Institute of Neurological Disorders and Stroke (NINDS), the
National Institute of Drug Abuse (NIDA), and the National Institute of Mental
Health (NIMH) invite investigator-initiated research grant applications that
address the potential role of the central nervous system (CNS) as a reservoir
for HIV. HIV can penetrate the CNS, and a subset of HIV-infected individuals
develop motor and/or cognitive impairments to varying degrees. The mechanisms
responsible for this CNS dysfunction are not well known. Direct injury by the
virus or viral components and the abnormal secretion of cytokines likely
damage nervous system cells. It is assumed that halting HIV replication
and/or elimination of virus would prevent CNS damage. This Request for
Applications (RFA) solicits research applications to study mechanisms of HIV
trafficking through the blood brain barrier (BBB), CNS viral localization,
control and eradication, and the CNS as a potential virus reservoir.
Applications addressing the anti-HIV CNS drug discovery, drug delivery and
pharmacology are especially encouraged.
Expiration Date: Sunday, August 5, 2001 NOFO Number: PA-98-097 Release Date: Wednesday, August 5, 1998 Notice Type: PA
The purpose of this program announcement (PA) is to solicit applications for
multidisciplinary, methodologically rigorous programs of neuroscience research
that will use advanced techniques for statistical and molecular genetic
analysis in human and animal populations to elucidate the genetic basis of
complex behaviors. This PA is issued in response to the growing evidence that
complex behaviors of relevance to human health and disease show varying
degrees of genetic influence. Examples include complex behaviors associated
with memory, activity level, harm avoidance, reward dependence, emotionality,
contextual fear conditioning, sensorimotor gating, drug seeking, pain
perception and reactivity, and analgesic response. The goals of this PA are
to quantify genetic and environmental effects and gene-environment
interactions and to locate and characterize genes affecting complex behaviors
in humans and animals.
Expiration Date: Sunday, July 29, 2001 NOFO Number: PA-98-094 Release Date: Wednesday, July 29, 1998 Notice Type: PA
The National Institute of Neurological Disorders and Stroke (NINDS), and the
National Cancer Institute (NCI) invite applications for support of research that
will increase our knowledge of the genetic, molecular, cellular, and
physiological mechanisms of radiation-induced cell injury and recovery, and the
sensitizing and protective mechanisms in the central nervous system under
radiation treatment conditions for brain tumors. The intent of this program
announcement (PA) is to encourage investigator-initiated applications to study
tumor and normal brain cell injury and repair mechanisms induced by brain tumor
radiotherapy including stereotactic radiosurgery procedures such as the Gamma
Knife, altered fractionation and/or radioenhancing agents, using state-of-the-art
neurobiological and neuroimaging approaches.
Expiration Date: Monday, May 21, 2001 NOFO Number: PA-98-074 Release Date: Thursday, May 21, 1998 Notice Type: PA
The purpose of this Program Announcement (PA) is to solicit applications as part
of a National Institutes of Health (NIH) initiative to increase our support of
the zebrafish as an animal model for research. This PA is intended to continue
stimulation of a trans-NIH initiative that was started with RFA: DK-98-006,
entitled "Genomic Resources for the Zebrafish," NIH Guide for Grants and
Contracts, Vol. 26, No. 39, December 5, 1997.
Expiration Date: Thursday, February 11, 1999 NOFO Number: RFA-NS-99-001 Release Date: Thursday, May 14, 1998 Notice Type: RFA
The National Institute of Neurological Disorders and Stroke (NINDS), in
collaboration with the National Center for Research Resources (NCRR) and the
Office of Research on Minority Health (ORMH), invites applications for
Specialized Neuroscience Research Programs at Minority Institutions (SNRP)
awards. The purpose of this Request for Applications (RFA) is to augment and
strengthen the research capabilities of faculty, students, and fellows at
minority institutions by supporting the development of new, and/or the
enhancement of ongoing, basic and clinical neuroscience research projects and
programs.
Expiration Date: Saturday, October 10, 1998 NOFO Number: RFA-AI-98-006 Release Date: Monday, May 11, 1998 Notice Type: RFA
The National Institute of Allergy and Infectious Diseases (NIAID), the National
Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the
National Heart, Lung and Blood Institute (NHLBI), the National Institute of
Neurological Disorders and Stroke (NINDS), and the Office of Research on Women"s
Health (ORWH) invite investigator-initiated research applications for mechanistic
studies in clinical trials of immunomodulatory interventions for immune system
mediated diseases, including asthma and allergy, graft failure in solid organ and
stem cell transplantation, and autoimmune diseases. Specifically, this Request
for Applications (RFA) focuses on the utilization of patients and patient
materials from such trials for the evaluation of immunologic and other relevant
parameters in order to study the mechanisms underlying the intervention, the
mechanisms of disease pathogenesis, surrogate markers of disease activity and
therapeutic effect, and mechanisms of human immunologic function. The parent or
core clinical trial must have independent financial support and will NOT receive
support under this RFA. Mechanistic studies in clinical trials supported by
industry are particularly encouraged but clinical trials supported by any source,
public or private, are eligible.
Expiration Date: Friday, April 6, 2001 NOFO Number: PA-98-052 Release Date: Monday, April 6, 1998 Notice Type: PA
The purpose of the Mentored Patient-oriented Research Career Development Award
(K23) is to support the career development of investigators who have made a
commitment to focus their research endeavors on patient-oriented research. This
mechanism provides support for a period of supervised study and research for
clinically trained professionals who have the potential to develop into
productive, clinical investigators focussing on patient-oriented research.
Expiration Date: Friday, April 6, 2001 NOFO Number: PA-98-053 Release Date: Monday, April 6, 1998 Notice Type: PA
The purpose of the Midcareer Investigator Award in Patient-Oriented Research
(K24) is to provide support for clinicians to allow them protected time to devote
to patient-oriented research and to act as mentors for beginning clinical
investigators. The target candidates are outstanding clinical scientists engaged
in patient-oriented research who are within 15 years of their specialty training,
who can demonstrate the need for a period of intensive research focus as a means
of enhancing their clinical research careers, and who are committed to mentoring
the next generation of clinical investigators focussing on patient-oriented
research. The award is intended to further the research and mentoring endeavors
of outstanding patient-oriented investigators, enable them to expand their
potential to make significant contributions to their field of patient-oriented
research, and to act as mentors for beginning clinicians.
Expiration Date: Tuesday, March 27, 2001 NOFO Number: PA-98-050 Release Date: Friday, March 27, 1998 Notice Type: PA
The purpose of this Program Announcement (PA) is to encourage submission of new
research project grant (R01) and exploratory/developmental research grant (R21)
applications to develop innovative technologies, methodologies, or
instrumentation for the study of the biology of the brain. Research is solicited
that will explore new approaches, test imaginative new ideas, and challenge
existing paradigms in technologies to study the development, structure, function,
and aging of the brain in both human and animal models. Also solicited is
research that will develop significant enhancements to existing technologies
important to neuroscience, and research that will translate a scientific concept
into the basis for a future technology that may advance understanding of
important neuroscience research problems. It is emphasized that the research
solicited can include tools and approaches that relate to any and all aspects of
neuroscience.