In response to recent research progress and opportunity, the excellent response
to the initial request, and in recognition of continuing Congressional interest
to intensify and to expand basic and clinical research in Parkinson"s Disease,
the National Institute of Neurological Disorders and Stroke (NINDS) invites
qualified investigators to submit grant applications for the establishment of
NINDS Parkinson"s Disease Research Centers of Excellence. The purpose of
reissuing this Request for Applications (RFA) is to encourage additional research
opportunities and discoveries that will lead to improved diagnosis and treatment
of patients with Parkinson"s Disease and related neurodegenerative disorders,
based on a better understanding of the fundamental cause(s) of the disease. It
is expected that these Centers will foster an environment that will enhance the
research effectiveness of investigators in a multi-disciplinary setting,
utilizing specialized methods relevant to the study of these disorders. The
original RFA was published in the NIH Guide, Volume 26, Number 38, November 21,
1997.
Find Funding Opportunities
COVID-19 Funding Notices | Approved Initiative Concepts | Research Opportunity Announcements
All NINDS-related notices of funding opportunities (NOFOs), request for applications (RFAs), program announcements (PAs), and other NIH Guide announcements are listed. Search the Closed Opportunities tab to find expired opportunities. Search the Notices tab to find all Notices.
Learn more about award types and program directors and managers.
NINDS has a number of open positions for researchers and clinicians to contribute to exciting neuroscience programs - APPLY NOW!
For more focused results add quotes to indicate parameters. Example format: "search term".
Expiration Date: Wednesday, April 28, 1999 NOFO Number: RFA-NS-99-004 Release Date: Friday, December 18, 1998 Notice Type: RFA
Expiration Date: Saturday, February 27, 1999 NOFO Number: RFA-HL-99-001 Release Date: Friday, December 18, 1998 Notice Type: RFA
The primary goal of this initiative is to advance our understanding of sleep and
wakefulness by developing improved molecular, cellular, and systems approaches
to investigate sleep and circadian phenotypes in mice. Better and more
extensively-characterized mouse models will help determine the genetic
underpinnings of sleep and wakefulness, elucidate the physiological role of
sleep, and develop new directions for the treatment of sleep disorders.
Establishing inbred mice strains as a platform for sleep studies will advance our
understanding of normal sleep phenotypes, facilitate the use of targeted and
transgenic gene modification approaches, and lead to a refinement in the
definition of sleep state in molecular and genomic terms.
Expiration Date: Friday, March 19, 1999 NOFO Number: RFA-NS-99-003 Release Date: Friday, December 11, 1998 Notice Type: RFA
The purpose of this Request for Applications (RFA) is to solicit applications for
research grants to develop new technologies or refine established technologies
for gene discovery and gene expression analysis in the nervous system. The
nervous system poses unique challenges to gene expression analysis because of its
extreme cellular heterogeneity and complex distributions of messenger RNAs within
individual cells. In addition, the nervous system is unusual in the degree to
which it uses alternative splicing and RNA editing as mechanisms for regulating
the spatial and temporal specificity of gene function. The development of
methods suited to the anatomical and molecular complexities of the nervous system
is therefore critical for quantifying gene expression in this system, and for
understanding how changes in gene expression may correlate with different
developmental, pathological, or functional states. Methods of interest would
include, but are not limited to: 1) isolation of mRNA from single cells or small
cell populations, 2) creation of high quality cDNA libraries from small amounts
of tissue, 3) high throughput methods for quantifying the expression of large
numbers of genes, 4) methods for quantifying multiple spliced or edited variants
of a given transcript, 5) methods for comparing protein levels to corresponding
mRNA levels for a given transcript within a cell or tissue sample, and 6)
techniques for visualizing RNA distribution within cells and tissues. The
development of these methods is expected to improve our understanding of nervous
system function in normal and disease conditions, and will aid in the diagnosis
and treatment of neurological disorders.
Expiration Date: Tuesday, December 4, 2001 NOFO Number: PA-99-024 Release Date: Friday, December 4, 1998 Notice Type: PA
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS), the National Institute on Aging (NIA), the National Institute for Child
Health and Human Development (NICHD), the National Institute of Dental and
Craniofacial Research (NIDCR), the National Institute on Deafness and Other
Communication Disorders (NIDCD), the National Institute of Diabetes, Digestive,
and Kidney Diseases (NIDDK), the National Institute of General Medical Sciences
(NIGMS), the National Institute of Mental Health (NIMH), the National Institute
of Neurological Disorders and Stroke (NINDS), the National Heart, Lung, and Blood
Institute (NHLBI), and the National Center for Research Resources (NCRR)
encourage investigator-initiated research grant applications to study tissue
engineering. The purpose of this Tissue Engineering Program Announcement (PA)
is to inform the scientific community of the NIH"s interests, and to stimulate
and foster a wide range of basic and translational studies to: (1) develop
optimal materials/designs for matrices/scaffolds, (2) better understand how
matrices/scaffolds interact with cells and their surrounding tissues, (3) develop
better animal models, and (4) validate and standardize the criteria for a
successful repair/replacement of tissues and organs.
Expiration Date: Tuesday, November 27, 2001 NOFO Number: PA-99-021 Release Date: Friday, November 27, 1998 Notice Type: PA
The purpose of this biobehavioral pain research program announcement (PA) is to
inform the scientific community of the interests of the various institutes at the
National Institutes of Health (NIH) and to stimulate and foster a wide range of
basic and clinical studies on pain as they relate to the missions of these
Institutes.
Expiration Date: Monday, October 29, 2001 NOFO Number: PAS-99-010 Release Date: Thursday, October 29, 1998 Notice Type: PAS
Participating Institutes and Centers (ICs) of the National Institutes of Health
(NIH) invite applications for R24 awards to support Bioengineering Research
Partnerships (BRPs) to support basic bioengineering research addressing important
biological or medical research problems. A BRP is a multidisciplinary research
team applying an integrative, systems approach to developing knowledge and/or
methods to prevent, detect, diagnose, and treat disease and understand health and
behavior, and must include bioengineering expertise in combination with basic
and/or clinical investigators. A BRP may propose design-directed or hypotheses-
driven research in universities, national laboratories, medical schools, private
industry and other public and private entities.
Expiration Date: Monday, October 29, 2001 NOFO Number: PAR-99-009 Release Date: Thursday, October 29, 1998 Notice Type: PAR
Participating Institutes and Centers (ICs) of the National Institutes of Health
(NIH) invite applications for Bioengineering Research Grants (BRG) to support
basic bioengineering research whose outcomes are likely to advance health or
health-related research within the mission of the NIH. A BRG application should
propose to apply basic bioengineering design-directed or hypothesis-driven
research to an important medical or biological research area.
Expiration Date: Tuesday, October 16, 2001 NOFO Number: PA-99-004 Release Date: Friday, October 16, 1998 Notice Type: PA
The purpose of this program announcement (PA) is to encourage basic
research on the structures of membrane proteins at (or near) atomic
resolution. Considerable research is on-going in the area of
membrane protein structure and function, particularly with respect
to sequences, topology, and the effects of mutations, however, much
of this work is somewhat speculative in that the interpretations
depend upon the very limited number of structures that have
actually been solved by direct biophysical measurements. Despite
several recent landmark solutions of membrane protein structures,
there remains a significant gap between the understanding of
membrane proteins and that of their soluble counterparts. This gap
will likely increase as the facility with which soluble protein
structures can be solved continues to increase. Therefore, it is
clear that a special effort is needed to promote studies of
membrane protein structures. An increase in the number of known
membrane protein structures will contribute to an enhanced
understanding of many basic phenomena underlying cellular functions
essential to human health.
Expiration Date: Monday, September 24, 2001 NOFO Number: PA-98-108 Release Date: Thursday, September 24, 1998 Notice Type: PA
The purpose of this program announcement is to encourage grant applications for
the support of research designed to elucidate the diagnosis, epidemiology,
etiology, genetics, treatment, and optimal means of service delivery in relation
to Autistic Disorder ("autism") and autism spectrum disorders (Rett"s Disorder,
Childhood Disintegrative Disorder, Asperger"s Disorder, Pervasive Developmental
Disorder-Not Otherwise Specified, or "Atypical Autism").
Expiration Date: Saturday, January 23, 1999 NOFO Number: RFA-OD-98-008 Release Date: Thursday, September 24, 1998 Notice Type: RFA
In order to promote high-quality research of CAM, the Office of Alternative
Medicine (OAM), the National Cancer Institute (NCI), the National Heart, Lung and
Blood Institute (NHLBI), the National Institute of Arthritis and Musculoskeletal
and Skin Disorders (NIAMS), the National Institute of Dental Research (NIDR),
National Institute of Neurological Disorders and Stroke (NINDS), and the National
Institute on Aging (NIA) invite applications for Centers for CAM Research using
the Specialized Center (P50) grant mechanism. Such Centers will provide the
resources necessary for the rigorous scientific investigation of CAM. It is
expected that research conducted at these Centers will examine the potential
efficacy, effectiveness, safety and validity of CAM practices, as well as the
physiological or psychological mechanisms underlying these practices.