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 COVID-19 Funding Notices | Approved Initiative Concepts | Research Opportunity Announcements

All NINDS-related notices of funding opportunities (NOFOs), request for applications (RFAs), program announcements (PAs), and other NIH Guide announcements are listed. Search the Closed Opportunities tab to find expired opportunities. Search the Notices tab to find all Notices.

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Research Category: Neural Exposome, ONETOX Expiration Date: Thursday, January 1, 2026 NOFO Number: NOT-NS-23-087 Release Date: Monday, June 5, 2023 Notice Type: NOT Contact: David Jett

The goal of this initiative is to increase our knowledge of how environmental stressors such as heat, crowding, air quality, noise, violence, and adverse childhood experiences in lower resourced communities affect Alzheimers Disease Related Dementias (ADRD). These and other noninheritable factors are collectively known as the exposome and includes environmental stress which is a major factor in racial and ethnic health inequities. ADRD is more prevalent and severe in people who live in lower resourced environments, and there is a need to identify the most important risk factors and determine their mechanistic underpinnings.

Research Category: Neural Exposome, ONETOX Expiration Date: Wednesday, January 1, 2025 NOFO Number: NOT-NS-22-114 Release Date: Wednesday, August 10, 2022 Notice Type: NOT

The purpose of this notice is to clarify which Funding Opportunity Announcements (FOAs) NINDS will use to solicit applications in response to NOT-ES-22-006 "Notice of Special Interest (NOSI): Climate Change and Health". As stated in the NOSI, NINDS will accept applications from the following announcements: PA-20-184 Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required), PA-20-185 NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed), PA-20-196 NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required), PA-20-195 NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed).

Research Category: Neural Exposome, ONETOX Expiration Date: Thursday, May 8, 2025 NOFO Number: NOT-ES-22-006 Release Date: Wednesday, June 1, 2022 Notice Type: Notice of Special Interest Contact: David Jett

The National Institute of Environmental Health Science (NIEHS), in partnership with Fogarty International Center (FIC), National Institute of Minority Health and Health Disparities (NIMHD), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institute of Mental Health (NIMH), National Institute of Nursing Research (NINR), National Heart Blood and Lung Institute (NHBLI) and National Institute of Allergy and Infectious Disease (NIAID) is leading an NIH-wide Climate Change and Health Initiative (CCHI) with the goals of: reducing the health threats posed by climate change across the lifespan; improving the health of people who are at increased risk from or disparately affected by climate change impacts; and building health resilience among individuals, communities, nations around the world, thereby increasing health equity. As a part of this CCHI, this NOSI encourages applications that address the impact of climate change on health and well-being over the life course, including the health implications of climate change in the United States and globally.

Research Category: Neural Exposome, ONETOX Expiration Date: Wednesday, January 1, 2025 NOFO Number: NOT-NS-22-088 Release Date: Wednesday, March 23, 2022 Notice Type: NOT

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Aging (NIA) intend to publish a Funding Opportunity Announcement (FOA) to solicit applications for basic and translational research on the impact of the microbiome gut-brain axis on Alzheimers Disease Related Dementias (ADRD). While there is growing evidence that the microbiome is an important factor that contributes to overall health and a variety of diseases and disorders, the role of intestinal microbiota dysfunction in specific ADRDs has not been adequately addressed. Furthermore, there is a need for more engagement of the ADRD research community to better understand the mechanistic relationship between the gut-brain axis and dementia-related diseases. This FOA will support mechanistic and early translational research focused on a more rigorous in-depth examination of the potential interactions between the gut microbiome and genetic and non-genetic molecular targets that influence ADRD. It is expected that these studies will address the clinical relevance of the gut microbiome on disease initiation, progression, or modification that will lead ultimately to better therapeutic interventions. This Notice is being provided to allow potential applicants sufficient time to develop integrated multidisciplinary collaborations and responsive projects. The FOA is expected to be published in Summer 2022 with an expected application due date in Fall 2022. This FOA will utilize the R01 (Clinical Trials Not Allowed) activity code.

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