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Notice Announcing Limited Number Travel Fellowship Awards Innovative Analysis Applications NeuroLINCS Data Notice Number: NOT-NS-16-004 Key Dates Release Date: January 14, 2016 Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) announcing availability a limited number travel fellowship awards innovative analysis applications NeuroLINCS data new existing research studies neurological related disorders.  Travel fellowships for undergraduate graduate students currently enrolled accredited U.S. educational institutions postdoctoral fellows are within three years their terminal degree of December 31, 2015. travel fellowship support attendance the LINCS meeting be held the University California, Irvine UCI) March 10-11, 2016.  Travel fellowship awardees present NeuroLINCS data analysis approach results this meeting. Background 2014, National Institutes Health NIH) awarded six cooperative agreement grants U54) support Data Signature Generating Centers DSGCs) are part the NIH Library Integrated Network-based Cellular Signatures LINCS) program.  LINCS program aims catalog analyze cellular function molecular activity response perturbing agents, such drugs, toxicants, genetic factors, can alter cellular signature.            of DSGCs, NeuroLINCS, focused characterizing induced pluripotent stem cell iPSC) lines differentiated cell types derived healthy control) subjects patients neurological disorders such Amyotrophic Lateral Sclerosis ALS) Spinal Muscular Atrophy SMA). Technologies employed the NeuroLINCS center include transcriptomics RNA-Seq), proteomics SWATH-MS), epigenomics ATAC-Seq) robotic imaging.  cell lines studied date include iPSCs healthy control subjects 0000iCTR, 0014iCTR, 0025iCRT, 0083iCTR) iPSC lines ALS patients a C9ORF72 pathogenic hexanucleotide repeat expansion 0028iALS, 0029iALS, 0030iALS, 0052iALS), SMA patients SMA type 1 disease 0032iSMA, 0077iSMA 0083iSMA).  Additional de-identified clinical information the iPSC lines used NeuroLINCS be found the Cedars-Sinai iPSC core site.  Data Available of January 3, 2016, three data releases September, 2015, June 2015 December 2015) available the NeuroLINCS center include data iPSC lines motor neurons differentiated several these lines.  Metadata describing experimental conditions assays employed, cell line growth, motor neuron differentiation quality assurance measures also available. Tools apps developed the BD2k-LINCS data coordination integration center available to assist analysis of NeuroLINCS data.  to Apply Only domestic travel be supported only US citizens permanent residents apply. Applicants travel fellowships should complete online registration form upload proposal, the time registration.  proposal should include applicants name, email address, Institutional affiliation, abstract the research proposal, list NeuroLINCS datasets be used, a research hypothesis analysis strategy, February 12, 2016. Awardees be notified February 19th, 2016. Please contact program official listed below further information.   Inquiries Please direct inquiries to: Margaret Sutherland, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email: sutherlandm@ninds.nih.gov

Notice Clarifying SBIR Direct-to-Phase II Eligibility Criteria Notice Number: NOT-OD-16-052 Key Dates Release Date:   January 12, 2016 Related Announcements PAR-14-088     Issued National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Minority Health Health Disparities NIMHD) National Center Advancing Translational Sciences NCATS) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Purpose purpose this Notice to clarify types applications can submitted the National Institutes Health Small Business Innovation Research NIH SBIR) Direct-to-Phase II pilot funding opportunity announcement PAR-14-088. NIH Direct-to-Phase II program accept Phase II submissions regardless the funding source the Phase I-like proof principle work which proposed Phase II research based. NIH strongly encourages small businesses contact appropriate Institute Center early their application planning process ensure technology of priority the Institute/Center. Information regarding funding opportunity submission information changed follows:  Part 2. Section I. Funding Opportunity Description following text deleted:  goal this FOA to enable small business has accomplished objectives a Phase SBIR grant through non-SBIR funds initiate Phase II SBIR stage development, without needing perform early stage, Phase-I-SBIR-type research. FOA also accept lsquo;regular’ Phase II submissions SBCs have received Phase SBIR STTR award NIH any agency participates the SBIR/STTR programs projects which applicants seek follow-on research development funding.  following text added:  NIH Direct-to-Phase II program accept Phase II submissions regardless the funding source the Phase I-like proof principle work which proposed Phase II research based, the following exception:  Small business concerns SBCs) eligible submit Phase II applications projects were supported a Phase SBIR STTR award NIH any agency expected submit regular Phase II application through SBIR/STTR solicitations quot;Renewal" applications based the awarded Phase SBIR STTR project. Only Phase II application be awarded a specific project supported a Phase award. NIH policies regarding overlapping applications still apply NOT-OD-14-082). A Phase II awardee receive additional, sequential Phase II award called NIH Phase IIB) continue work an initial Phase II award. nbsp; other aspects these FOAs remain unchanged. Inquiries Please direct inquiries to: NIH SBIR/STTR Program Office Telephone: 301-435-2688 Email: sbir@od.nih.gov Website: http://sbir.nih.gov

Notice Information: Parallel Funding Initiative Collaborative Research Between Investigators the USA in State São Paulo, Brazil Notice Number: NOT-TW-16-001 Key Dates Release Date: January 12, 2016 Related Announcements PA-16-160 PA-13-302     Issued Fogarty International Center FIC) National Cancer Institute NCI) National Eye Institute NEI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Library Medicine NLM) National Center Complementary Integrative Health NCCIH) Purpose National Institute Health NIH) the São Paulo Research Foundation FAPESP), Brazil, signed memorandum understanding MOU) encourage collaborative international research between investigators the US in State São Paulo. two funding agencies intend jointly support parallel funding) successful R01 applications the NIH fall within research areas mutual interest, including single disciplinary cross-disciplinary approaches topics. areas interest include mission areas the participating NIH Institutes Centers ICs), named above. Descriptions their areas interest be found the website links provided. Any application falling outside areas undergo standard review process NIH will be eligible parallel funding. Inquiries the suitability proposed projects each IC be directed the Point Contact each participating IC, listed below. Only applications the NIH parent R01 PA-13-302 subsequent reissuances) be considered this opportunity this time. Instructions Applicants 1. Applications eligible parallel funding under initiative must include least Program Director/Principal Investigator PD/PI) an institution the State São Paulo is eligible funding FAPESP one PD/PI the US is eligible funding NIH. multiple PD/PI MPI) option should used. Any MPI submit application the contact PD/PI. the application chosen parallel support, US PD/PI their institution become contact PD/PI NIH, the São Paulo PD/PI become contact PD/PI FAPESP. may also other collaborators anywhere the world. 2. Applicants should send summary the proposed project such the abstract the NIH application) FAPESP Science Manager Dr. Simone Godoi chamada_nih@fapesp.br confirm eligibility least four weeks prior submission the application NIH. 3. Applicants should indicate interest being considered this opportunity acknowledge understanding any award NIH be split funded parallel through linked FAPESP award writing would this application be considered under NIH-FAPESP Funding Initiative. FAPESP confirmed the São Paulo PD/PI eligible this initiative." the end the Specific Aims. 4. Processing the application NIH follow standard NIH receipt referral guidelines review.  the application referred one the participating NIH ICs, will considered parallel support after both levels NIH peer review just prior award. application only undergo review the NIH. Applicants should follow normal guidance an NIH application, including rules regarding foreign applications applications foreign components. 5. applicant be asked forward NIH summary statement full application FAPESP following peer review, within week receiving summary statement, they wish be further considered parallel support. an award made, additional documents, reformatting, re-budgeting be required either agency. 6. Applicants be notified per normal NIH procedure whether are being considered an NIH award the administering NIH IC indicate whether award be funded parallel FAPESP. Inquiries General inquiries this initiative should directed to: Kevin Bialy, MAA Fogarty International Center FIC) Telephone: 301-496-6273 Email: Kevin.Bialy@nih.gov Subject matter inquiries should directed the Point Contact the relevant Institute Center. Paul C Pearlman, PhD National Cancer Institute NCI) Telephone: 240-276-5354 Email: paul.pearlman@nih.gov Lisa Neuhold, PhD National Eye Institute NEI) Telephone: 301-451-2020 Email: Lisa.Neuhold@nih.gov Jeffery Schloss, PhD National Human Genome Research Institute NHGRI) Telephone: 301-496-7531 Email: Jeffery.Schloss@nih.gov            John Haaga, PhD National Institute Aging NIA) Telephone: 301-496-3131 Email: John.Haaga@nih.gov Margaret M. Murray, PhD National Institute Alcohol Abuse Alcoholism NIAAA) Telephone: 301-443-2594 Email: pmurray@mail.nih.gov Margarita R. Ossorio Goldman, M.Sc National Institute Allergy Infectious Diseases NIAID) Telephone: 301-451-2597 Email: Margarita.Ossorio@niaid.nih.gov Laura K. Moen, PhD National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Telephone: 301-451-6515 Email: moenl@mail.nih.gov Christine A. Kelley, PhD National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4778 Email: kelleyc@mail.nih.gov Rohan Hazra, MD Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone: 301-435-6868 Email: Rohan.Hazra@nih.gov Lana Shekim, PhD National Institute Deafness Other Communication Disorders NIDCD) Telephone: 301-496-5061 Email: shekiml@nidcd.nih.gov Emily L. Harris, PhD, MPH National Institute Dental Craniofacial Research NIDCR) Telephone: 301-594-4846 Email: emily.harris@nih.gov Andrew Bremer, MD, PhD National Institute Diabetes Digestive Kidney Diseases NIDDK) Telephone: 301-402-7886 Email: Andrew.Bremer@nih.gov Steve Gust, PhD National Institute Drug Abuse NIDA) Telephone: 301-402-1118 Email: Steve.Gust@nih.gov Michael Humble, PhD National Institute Environmental Health Sciences NIEHS) Telephone: 919-316-4621 Email: humble@niehs.nih.gov Charles G. Edmonds, PhD National Institute General Medical Sciences NIGMS) Telephone: 301-594-4428 Email: edmondsc@nigms.nih.gov Andrea Horvath Marques, PhD National Institute Mental Health NIMH) Telephone: 301-443-3945 Email: andrea.horvathmarques@nih.gov Claudia Moy, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email:  MoyC@ninds.nih.gov Mary Roary, PhD National Institute Nursing Research NINR) Telephone: 301) 594-2154 Email: mary.roary@mail.nih.gov Rick Berzon, DrPH, PA National Institute Minority Health Health Disparities NIMHD) Telephone: 301-594-8949 Email: rick.berzon@nih.gov Valerie Florance, PhD National Library Medicine NLM) Telephone: 301-496-4621 Email: florancev@mail.nih.gov Flora Katz, PhD Fogarty International Center FIC) Telephone: 301-402-9591 Email: Flora.Katz@nih.gov John S. Williamson, PhD National Center Complementary Integrative Health NCCIH) Telephone: 301-496-2583 Email: john.williamson@nih.gov

Notice Correct Submission Instructions the Number Scientific Cores Allowed PAR-15-146 Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)" Notice Number: NOT-NS-16-002 Key Dates Release Date:   January 8, 2016 Related Announcements PAR-15-146     Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this notice to correct information the number Scientific Cores allowed PAR-15-146 quot;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)". Section IV. 2. Content Form Application Submission Currently FOA reads: application should consist the following components: Overall: required Administrative Core: required Scientific Core: optional; Maximum 2 Research Education Core: required Project: Minimum 3 required; Maximum 5 nbsp; FOA modified read: application should consist the following components: Overall: required Administrative Core: required Scientific Core: optional; Maximum 3 Research Education Core: required Project: Minimum 3 required; Maximum 5 nbsp; other aspects the FOA remain unchanged Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-6035 Email: jettd@ninds.nih.gov

Notice Updates the National Robotics Initiative NRI) Notice Number: NOT-EB-15-008 Key Dates Release Date: December 22, 2015 Related Announcements NOT-EB-14-008     Issued National Eye Institute NEI) National Institute Aging NIA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Office Behavioral Social Sciences Research OBSSR) National Science Foundation NSF ) National Aeronautics Space Administration NASA) U.S. Department Agriculture USDA) Defense Advanced Research Projects Agency DARPA) Air Force Office Scientific Research AFOSR) U.S. Department Energy DOE) Purpose Notice updates supersedes previous Guide Notice, NOT-EB-14-008, published the NIH Guide, October 23, 2014. NIH collaborating a multi-agency funding opportunity, National Robotics Initiative NRI), whose goal to accelerate development use robots the United States work beside, cooperatively with, people http://www.nsf.gov/pubs/2016/nsf16517/nsf16517.htm), carry work people dangerous environments.  Innovative robotics research applications emphasizing realization such co-robots working symbiotic relationships human partners supported multiple agencies the federal government including National Science Foundation NSF), National Aeronautics Space Administration NASA), National Institutes Health NIH), U.S. Department Agriculture USDA), U.S. Department Defense DOD) the U.S. Department Energy DOE). purpose this program the development this next generation robotics, advance capability usability such systems artifacts, to encourage existing new communities focus innovative application areas. will address entire life cycle fundamental research development manufacturing deployment. Collaboration between academic, industry, non-profit other organizations strongly encouraged establish better linkages between fundamental science technology development, deployment use. NIH encourages robotics research technology development enhance health, lengthen life reduce illness disability. NIH also supports non-hypothesis driven applications, includes technology-driven problem-driven applications. Specifically, participating NIH Institutes Centers ICs) this solicitation interested targeting solicitation support development assistive robotic technology achieve functional independence humans; improve quality life; assist behavioral therapy personalized care; promote wellness/health. most significant challenges be addressing safety issues, especially applications be used home-based long-term care settings where integration complex systems be required. Additionally, assistive robots need quickly adapt changes the user the environment. Human assistive devices should designed assist healthcare providers as well the individuals needing care. Development robotic applications important NIH because their potential significant impact healthcare the future. Human assistive devices revolutionize healthcare the next 20 years much personal electronics changed our daily lives the past decades. Affordable accessible robotic technology facilitate wellness personalized healthcare. Continual health assessment personalized intervention the potential offset shrinking size the healthcare workforce the growing elderly disabled population. the future, assistive robotics enable people engage all aspects human life endurance dignity. Examples assistive robotic technology development include are limited to: - Homecare long-term personalized care robots - Robotic wellness/health promotion maintenance - Robotic behavioral therapy - Robotic aids mobility, manipulation, human communication cognition, vision non-sighted persons - Assistive robotics eliminate health disparities across populations developing appropriate assistive co-robotic technologies, applicants should consider following basic characteristics: effectiveness, affordability, cultural acceptability, accessibility those need them. Applicants should describe these technologies address healthcare needs the end user healthy individuals, persons disability, or health disparity populations). proposer should compellingly describe healthcare problem being addressed the technology solution being proposed.  is strongly encouraged a healthcare expert included the research team a consultant collaborator, appropriate). robotic applications promoted this solicitation for non-operative settings.  NIH still interested supporting robotics surgical health interventions, robotic exoskeletons, prosthetics, however, in response solicitation. Applicants interested these areas should send inquiries the NIH contacts listed below.  Award Information NIH awards under solicitation be R01 grants.  Award sizes NIH funded research projects expected range approximately 100,000 250,000 per year direct costs, durations one three years. No award exceed 250,000 per year direct costs. Applicants wish submit application NIH more 250,000 direct costs any year should contact Program staff an NIH Institute/Center directly alternate proposal mechanisms.  Estimated program budget, number awards average award size duration subject the availability funds.  Determination awards based three criteria: 1) availability funds, 2) program priorities, 3) scientific merit. Subsequent grant administration procedures be accordance the policies the awarding Institute. Application Preparation Submission Instructions Applications submitted response this solicitation should prepared submitted accordance the general guidelines contained the NSF Grant Proposal Guide GPG).  Applications must submitted the NSF, to NIH.  the full solicitation, are additional instructions listed applicants interested NIH consideration funding e.g. Human/Animal Subjects Protections, Review Criteria, etc.). Applicants reminded identify NSF program announcement number the program announcement block the NSF Cover Sheet Proposal the National Science Foundation.  Compliance this announcement critical determining relevant application processing guidelines. Failure submit information delay processing. Budgetary Information Cost sharing not required applications submitted this funding opportunity. Budgets should include travel funds the PD/PI team members attend annual NRI Principal Investigators' meeting.  NIH Process mission the NIH to support science pursuit knowledge the biology behavior living systems to apply knowledge enhance health, lengthen life reduce illness disability. While of NIH NSF review criteria based the same standards scientific evaluation, scoring mechanisms programmatic emphases vary. example: proposals under consideration NIH be scored their respective review panels using NIH 1-9 scoring system, does include consideration broader impacts. Applicants should pay particular attention NIH evaluation standards represented criteria human protections, inclusion women, minorities, children the study population, animal subjects’ protections, well biohazards. general, NIH funding priorities be directed toward applications best address criteria are used NIH. goal this activity to involve multiple agencies using application one review. meet NIH requirements, those applications are identified potential funding participating NIH ICs, applicant organization be required submit R01 application an NIH-approved format.  PDs/PIs invited submit NIH receive further information submission procedures the NIH. NIH application not allowed increase alter proposed budget change scientific content the application the converted submission the NIH. The summary statement be presented the involved IC's National Advisory Council the second level review. Subsequent the Council review, NIH ICs make funding determinations selected awards. Grant administration procedures NIH awardees, including those related New Early Stage Investigators be accordance the policies NIH. Please note applications be submitted review the NSF March 7, 2016. PDs/PIs applications selected potential funding the participating NIH ICs be notified the end June 2016.  converted submission NIH be due July 15, 2016.  PD/PI should work closely their Sponsored Programs Office assure timely submission during submission window. earliest project start date be September30, 2016. Inquiries Written telephone inquiries encouraged.  NIH Program contacts listed below. Please the NSF NRI website names contact information each the participating NSF Directorates, USDA, NASA, DARPA, AFOSR, DOE.  Grace C.Y. Peng, Ph.D., National Institute Biomedical Imaging Bioengineering NIBIB) Telephone: 301-451-4778;  Email: pengg@mail.nih.gov Tom Greenwell, Ph.D. National Eye Institute NEI) Telephone: 301-451-2020 Email:  greenwellt@nei.nih.gov Lyndon Joseph, Ph.D National Institute Aging NIA) Telephone: 301-496-6926 Email: Josephlj@nia.nih.gov Louis Quatrano, Ph. D. Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Telephone:  301-402-4221 Email: Quatranl@mail.nih.gov Roger L. Miller, Ph.D. National Institute Deafness Other Communication Disorders NIDCD) Telephone: 301-402-3458 Email:  millerr@nidcd.nih.gov Daofen Chen, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: daofen.chen@nih.gov Augie Diana, Ph.D. National Institute Nursing Research NINR) Telephone: 301-402-6423 Email: dianaa@mail.nih.gov

Notice Extend PAR-13-055 Dissemination Implementation Research Health R01)" Notice Number: NOT-CA-16-006 Key Dates Release Date: December 14, 2015 Related Announcements PAR-13-055     Issued National Cancer Institute NCI) National Center Complementary Integrative Health NCCIH formerly NCCAM) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) Clarification per NOT-AI-13-034) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Institute Mental Health NIMH) National Institute Minority Health Health Disparities NIMHD) National Institute Nursing Research NINR) Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to extend PAR-13-055 quot;Dissemination Implementation Research Health R01)", encourages investigators submit research grant applications will identify, develop, evaluate refine effective efficient methods, systems, infrastructures, strategies disseminate implement research-tested health behavior change interventions, evidence-based prevention, early detection, diagnostic, treatment management, quality life improvement services, data monitoring surveillance reporting tools public health clinical practice settings focus patient outcomes. current expiration date January 8, 2016. new expiration date May 10, 2016. other aspects this FOA remain same. Inquiries Please direct inquiries to: David A. Chambers, D.Phil. National Cancer Institute NCI) Telephone: 240-276-5090 Email: dchamber@mail.nih.gov

Notice Extend PAR-13-054 Dissemination Implementation Research Health R21)" Notice Number: NOT-CA-16-007 Key Dates Release Date:   December 14, 2015 Related Announcements PAR-13-054     Issued National Institute Mental Health NIMH) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) Clarification per NOT-AI-13-035) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH formerly NCCAM) Office Behavioral Social Sciences Research OBSSR) Fogarty International Center FIC) Purpose purpose this Notice to extend PAR-13-054 quot;Dissemination Implementation Research Health R21)", encourages investigators submit research grant applications will identify, develop, evaluate refine effective efficient methods, systems, infrastructures, strategies disseminate implement research-tested health behavior change interventions, evidence-based prevention, early detection, diagnostic, treatment management, quality life improvement services, data monitoring surveillance reporting tools public health clinical practice settings focus patient outcomes. current expiration date January 8, 2016. new expiration date May 10, 2016. other aspects this FOA remain same. Inquiries Please direct inquiries to: David A. Chambers, D.Phil. National Cancer Institute NCI) Telephone: 240-276-5090 Email: dchamber@mail.nih.gov

Notice Correct Application Review Date, the Phased Activity Description RFA-NS-16-013 Innovation Grants Nurture Initial Translational Efforts IGNITE): Development Validation Model Systems and/or Pharmacodynamic Markers Facilitate Discovery Neurotherapeutics R21/R33)" Notice Number: NOT-NS-16-001 Key Dates Release Date:   December 2, 2015 Related Announcements RFA-NS-16-013       Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to correct review date the activity description section NINDS RFA-NS-16-013 Innovation Grants Nurture Initial Translational Efforts IGNITE): Development Validation Model Systems and/or Pharmacodynamic Markers Facilitate Discovery Neurotherapeutics R21/R33)". Part 1. Overview Information Key Dates FOA currently reads: Scientific Merit Review June 2016; October 2106; February 2017; June 2017; October 2107; February 2018    FOA now changed read: Scientific Merit Review June 2016; October 2016; February 2017; June 2017; October 2017; February 2018    Part 2. Full Text Announcement Section I. Funding Opportunity Description FOA currently reads: Activities the R21 Phase Initial development the model, testing paradigm, ex vivo system PD measure Any optimization the above related feasibility, endpoint range sensitivity, potential scale for validation studies breeding, aging, etc.), specificity the model system/PD measure it relates the disease endpoint measures, identification confounding variables, etc. Activities the R33 Phase Complete internal validation endpoints used the model system PD measure Scale-up external validation studies external validation studies, including comparisons phenotype human disease, comparisons disease etiology preclinical species what known the human disease efficacy clinically tested therapeutic agents available) the new model system FOA now changed read:             Activities the R21 Phase: Initial development the model, testing paradigm, ex vivo system PD measure Any optimization the above related feasibility, endpoint range sensitivity, potential scale for validation studies breeding, aging, etc.), specificity the model system/PD measure it relates the disease endpoint measures, identification confounding variables, etc. Activities the R33 Phase: Complete internal validation endpoints used the model system PD measure Scale-up external validation studies external validation studies, including comparisons phenotype human disease, comparisons disease etiology preclinical species what known the human disease efficacy clinically tested therapeutic agents available) the new model system other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Mary Ann Pelleymounter, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: mary.pelleymounter@mail.nih.gov

Notice Correction Review Locus PAR-15-278 NINDS Exploratory Clinical Trials Small Business R42)" Notice Number: NOT-NS-15-049 Key Dates Release Date:   November 19, 2015 Related Announcements PAR-15-278     Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to correct information regarding locus review applications submitted PAR-15-278 quot;NINDS Exploratory Clinical Trials Small Business R42)". Part 2. Section V. 2. Review Selection Process FOA currently reads: Applications be evaluated scientific technical merit an) appropriate Scientific Review Group(s) convened Center Scientific Review, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. FOA modified read: Applications be evaluated scientific technical merit an appropriate Scientific Review Group(s) convened NINDS, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. Part 2. Section VII. Agency Contacts FOA currently reads: Peer Review Contact(s) Joseph Rudolph, PhD Center Scientific Review CSR) Telephone: 301-408-9098 Email: josephru@mail.nih.gov FOA modified read: Peer Review Contact(s) Chief, Scientific Review Branch National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9223 Email: nindsreview.nih.gov@mail.nih.gov other aspects the FOA remain unchanged Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov

Notice Correction Review Locus PAR-15-277 NINDS Exploratory Clinical Trials Small Business R44)" Notice Number: NOT-NS-15-050 Key Dates Release Date:   November 19, 2015 Related Announcements PAR-15-277 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to correct information regarding locus review applications submitted PAR-15-277 quot;NINDS Exploratory Clinical Trials Small Business R44)". Part 2. Section V. 2. Review Selection Process FOA currently reads: Applications be evaluated scientific technical merit an) appropriate Scientific Review Group(s) convened Center Scientific Review, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. FOA modified read: Applications be evaluated scientific technical merit an appropriate Scientific Review Group(s) convened NINDS, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. Part 2. Section VII. Agency Contacts FOA currently reads: Peer Review Contact(s) Joseph Rudolph, PhD Center Scientific Review CSR) Telephone: 301-408-9098 Email: josephru@mail.nih.gov . FOA modified read: Peer Review Contact(s) Chief, Scientific Review Branch National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9223 Email: nindsreview.nih.gov@mail.nih.gov other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov