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Notice Pre-application Informational Webinar RFA-NS-16-002 NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research Program P50)" Notice Number: NOT-NS-15-040 Key Dates Release Date:   September 4, 2015 Related Announcements NOT-NS-15-041 RFA-NS-16-002 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants RFA-NS-16-002 a webinar provide related information the NINDS Morris K. Udall Centers Excellence Parkinson's Disease Research Program. intent the webinar to provide overview the initiative to address questions pertinent the preparation responsive applications. webinar directed primarily toward applicants the December 15, 2015 application due date; investigators considering future application the NINDS Udall Centers program also welcome participate. webinar optional not required application submission. Webinar Information Date: Monday, September 21, 2015 Time: 2:00pm EDT Duration: 1 hour register the webinar, to submit advance questions, please e-mail sieberb@ninds.nih.gov  Friday, September 18, 2015; please include Udall Webinar" the subject line. Every effort be to answer questions during webinar itself; however, due time constraints responses be provided after webinar concludes. Applicants strongly encouraged discuss proposals the Program Officer early the application development process. Inquiries Please direct programmatic inquiries to: Beth-Anne Sieber, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email: sieberb@ninds.nih.gov Please direct review-related inquiries to: Birgit Neuhuber, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-3562 Email: neuhuber@ninds.nih.gov

NINDS Announces Interest Large Randomized Emergency Care Clinical Trials Notice Number: NOT-NS-15-039 Key Dates Release Date:   August 27, 2015  Related Announcements NOT-HL-15-262  PAR-13-278 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) announces interest applications large, simple, randomized clinical trials neurologic related emergency care adults, address significant public health issues. trials must take place the pre-hospital and/or emergency department settings. NINDS particularly interested multi-site clinical trial applications simple pragmatic trials assessing novel interventions comparative effectiveness.  funded, proposed clinical trials be implemented a planned trans-federal emergency care network entitled Strategies Innovate Emergency Care Clinical Trials Network SIREN) NOT-NS-15-021, NOT-NS-15-022, NOT-NS-15-023) estimated start date March 2017). Since emergency care stroke incorporated the NIH StrokeNet program PAR-14-220), NINDS interested trials addressing neurologic emergencies than stroke the SIREN program.     Applications emergency care clinical trials should submitted the funding opportunity announcement PAR-13-278, NINDS PHASE III Investigator-Initiated Multi-Site Clinical Trials U01). Potential applicants strongly encouraged contact NINDS further information discussion. Inquiries Please direct inquiries to: Dr. Robin Conwit National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: conwitr@ninds.nih.gov

Notice Participation Additional NIH Components PAR-15-292 " Emerging Global Leader Award K43)" Notice Number: NOT-TW-15-004 Key Dates Release Date:   August 26, 2015  Related Announcements PAR-15-292     Issued Fogarty International Center FIC) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women’s Health ORWH) Purpose Notice to inform potential applicants additional NIH components participate Program Announcement PAR-15-292 to detail additional interest NHGRI. following changes been to reflect participation NIDCR, NINDS ORWH this FOA to detail additional interest NHGRI: Part 1. Overview Information Components Participating Organizations Fogarty International Center FIC) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women’s Health ORWH) Part 2. Section 1. Funding Opportunity Description Interests Participating NIH Institutes, Centers Offices: National Human Genome Research Institute NHGRI) interested applications individuals pursuing careers researchers the area the ethical, legal, social implications ELSI) genetics genomics research the of genetics clinical settings.  specific research topic proposed should apply across broad spectrum diseases conditions should be specific just disease, except the extent a particular disease serve a model broader applicability.  Examples topics appropriate exploration be found the ELSI Research Priorities website at: http://www.genome.gov/27543732. NHGRI also support applications individuals are developing methods research resources that support, or conducting basic translational research in: genomic sciences, informatics, implementation genomics clinical care genomic medicine), cost-effectiveness genomic interventions. specific research topic proposed should apply across broad spectrum diseases and health conditions should be specific just disease, except the extent a particular disease serve a model broader applicability.  Projects that capitalize unique opportunities use, models, diseases conditions are difficult study the U.S. because prevalence other factors will considered.  Examples such conditions might include, are limited to, sickle cell disease thalassemias, apoA associated kidney disease, and severe adverse drug reactions higher frequency outside U.S., such Stevens Johnson Syndrome SJS). National Institute Dental Craniofacial Research NIDCR) interested applications a research focus dental, oral, craniofacial conditions occur frequently the LMIC are a high public health burden; research addressing health disparities dental, oral, craniofacial conditions; research achieve national regional goals oral dental health such those articulated the World Health Organization. Examples include, are limited to: working local communities establish best means delivering preventive oral health care; establishing successful approaches deliver fluoride a local population, particularly areas without potable water; studying oral pre-malignant lesions associated betel nut use; studying interplay genes environment dental, oral, craniofacial health leveraging environments specific the country. program these topics responsive goals 2, 3, 4 the NIDCR Strategic Plan http://www.nidcr.nih.gov/research/ResearchPriorities/StrategicPlan/). National Institute Neurological Disorders Stroke NINDS) interested supporting mechanistic, epidemiological, prevention, translational clinical research across spectrum neurological, neuromuscular neurovascular diseases disorders all ages. addition prevalent neurological disorders stroke, NINDS also interested supporting research areas rare neglected neurological diseases are relevant the Low- Middle-Income Countries NINDS Disorder Index http://www.ninds.nih.gov/disorders/disorder_index.htm). Office Research Women’s Health ORWH) mission to improve health women, has strides doing by ensuring women diverse populations included all clinical studies, sex gender influences health disease explored, that women the opportunity advance biomedical careers. ORWH assess applications their ability directly fulfill goals 4.0 6.0 the NIH Strategic Plan Women’s Health Sex Differences Research, can found at: http://orwh.od.nih.gov/research/strategicplan/ORWH_StrategicPlan2020_Vo…. Section VII. Agency Contacts other aspects the FOA remain unchanged. Scientific/Research Contacts: Jean E. McEwen, J.D., Ph.D. National Human Genome Research Institute NHGRI) Telephone: 301-402-4997 Email: mcewenj@mail.nih.gov Jeff Schloss, Ph.D. National Human Genome Research Institute NHGRI) Telephone: 301-496-7531 Email: schlossj@exchange.nih.gov Lynn King, Ph.D. National Institute Dental Craniofacial Research NIDCR) Telephone: 301-594-5006 Email: Lynn.King@nih.gov Claudia S. Moy, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: moyc@ninds.nih.gov Jennifer Plank-Blazinet, Ph.D. Office Research Women’s Health ORWH) Telephone: 301-496-8931 Email: Jennifer.plank@nih.gov Financial/Grants Management Contact(s) Diana Rutberg National Institute Dental Craniofacial Research NIDCR) Telephone: 301-504-4798 Email: rutbergd@mail.nih.gov Tijuanna E. DeCoster, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9231 Email: decostert@mail.nih.gov Inquiries Please direct inquiries to: Christine Jessup, Ph.D. Fogarty International Center FIC) Telephone: 301-496-1653 Email: Christine.Jessup@nih.gov

Request Information: Input the Development the Federal Pain Research Strategy Notice Number: NOT-NS-16-038 Key Dates Release Date: August 12, 2015 Response Date: September 18, 2015 Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS)   Purpose behalf HHS, in response provisions the Patient Protection Affordable Care Act, NIH established Interagency Pain Research Coordinating Committee IRPCC) coordinate pain research efforts within HHS across Federal Agencies. IPRCC developing strategic plan pain research across federal agencies.  panel experts convene provide recommendations key pain research areas move field forward the ultimate goal relieve pain improve pain care through evidence based studies enhancing federal research agenda.  key areas prevention acute chronic pain, acute pain acute pain management, transition acute chronic pain, chronic pain chronic pain management, disparities pain pain care provide framework development the strategy upon important cross-cutting elements be addressed. Background information the IPRCC, membership, responsibilities details the planning process develop research strategy, themes the working groups, cross cutting elements be addressed each working group be found http://iprcc.nih.gov/. Information Requested Request Information RFI) invites public comment input the development the federal pain research strategy.  your comments any all these specific areas, ask you consider broad research opportunities needs could the greatest benefit advancing pain research the ultimate goal relieving pain improving pain care. Such broad research opportunities needs include, are limited to: major challenges opportunities revolutionizing we understand, prevent, assess, diagnose manage acute chronic pain. Transformative areas research where new discoveries related areas research have greatest benefit advancing pain research. Transformative areas research where new discoveries related areas research have greatest benefit developing new therapies pharmacologic non-pharmacologic therapies innovative approaches pain management scientific advances could result a quantum leap the care acute chronic pain conditions. New technical capabilities tools can a significant impact pain research clinical practice the next ten years. potential collaborative efforts between relevant non-pain researchers pain researchers. potential expansion the pain research community. potential collaboration within across federal agencies. role potential federal agencies support pain research expanding enhancing pipeline new basic, translational, clinical researchers. Potential areas Public-Private Partnerships – partnerships will allow federal agencies support pain research work collaboratively both public private entities advance research improve public health. inform development the strategic plan, input being sought broad research opportunities, including those listed above they relate research priorities each the following specific thematic areas across continuum pain for disparities pain pain care, the task force address: Prevention acute chronic pain Acute pain acute pain management transition acute chronic pain Chronic pain chronic pain management Disparities pain pain care To Submit Response Click following link access RFI form submit response: http://iprcc.nih.gov/FPRS/RFI assure consideration, responses must received Friday, September 18, 2015. Responses this RFI voluntary. Any personal identifiers be removed responses compiled. Proprietary, classified, confidential, sensitive information should be included your response. RFI for planning purposes only is a solicitation applications an obligation the part the United U.S.) Government provide support any ideas identified response it. Please note the U.S. government not pay the preparation any comment submitted for use that comment. Inquiries Please direct inquiries to: Linda Porter, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-4460 Email: porterl@ninds.nih.gov

Notice Cancelation the Final Receipt Date PAR-13-362 Neurological Sciences Academic Development Award K12)” Notice Number: NOT-NS-15-037 Key Dates Release Date:   August 10, 2015  Related Announcements PAR-13-362     Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform scientific community the cancelation the final application due date PAR-13-362 quot;Neurological Sciences Academic Development Award K12)”. nbsp; Part 1. Key Dates Currently reads: Posted Date September 23, 2013 Open Date Earliest Submission Date) November 11, 2013 Letter Intent Due Date(s) Applicable Application Due Date(s) December 11, 2013, October 12, 2014, October 12, 2015 5:00 PM local time applicant organization. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Applicable Scientific Merit Review February, 2014 Advisory Council Review May, 2014 Earliest Start Date July 2014 Expiration Date October 13, 2015 Due Dates E.O. 12372 Applicable now modified read: Posted Date September 23, 2013 Open Date Earliest Submission Date) November 11, 2013 Letter Intent Due Date(s) Applicable Application Due Date(s) December 11, 2013, October 12, 2014 5:00 PM local time applicant organization. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Applicable Scientific Merit Review February, 2014 Advisory Council Review May, 2014 Earliest Start Date July 2014 Expiration Date August 14, 2015 Due Dates E.O. 12372 Applicable nbsp; other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice NINDS Programmatic Priority PAR-13-208 Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects U01)" Notice Number: NOT-NS-15-035 Key Dates Release Date:   August 6, 2015 Related Announcements PAR-13-208     Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants PAR-13-208 quot;Countermeasures Against Chemical Threats CounterACT) Cooperative Research Projects (U01)" priority be given research applications clearly describe goal developing or therapeutic candidates is ready advanced development the end the proposed project periods to 5 years).  Projects proposed will given priority should culminate the submission a Pre-Investigational New Drug Pre-IND) Application Package the FDA, should very close securing the data planning needed submission the Pre-IND package.  such, applicants encouraged address regulatory strategy necessary achieve goal. Research supported under FOA to prepare advanced development after filing Pre-IND package.  Most the advanced development activities required regulatory approval include GMP GLP level efforts) not usually covered under FOA, could potentially supported other federal agencies industry once NIH-supported research completed.  HHS advanced development agency relevant this FOA the Biomedical Advanced Research Development Authority BARDA). Once research funded under FOA completed, should the following before exploring possibility additional funding through BARDA advanced development. least lead compound. Lead compounds biologically active compounds hits where affinity, potency, selectivity been established. Efficacy an appropriate animal model Initial pharmacology toxicology studies Stable scalable synthesis the lead compound Preliminary regulatory strategy including Target Product Profile regulatory expertise Commercialization plan other indications applicable Intellectual Property Rights Applications focus specifically the above goal be deemed high programmatic priority. applicants strongly encouraged discuss applications the Scientific/Research contact listed the FOA early the application development process. Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-443-8189 Email: jettd@ninds.nih.gov

Notice Programmatic Priority NINDS PAR-15-146 Countermeasures Against Chemical Threats CounterACT) Centers Excellence U54)" Notice Number: NOT-NS-15-036 Key Dates Release Date:   August 6, 2015 Related Announcements PAR-15-146 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants PAR-15-146 quot;Countermeasures Against Chemical Threats CounterACT) Centers Excellence (U54)" priority be given research applications clearly describe goal developing or therapeutic candidates is ready advanced development the end the proposed project periods to 5 years).  Projects proposed response this FOA will given programmatic priority should culminate the submission a Pre-Investigational New Drug Pre-IND) Application Package the FDA, should very close securing the data planning needed submission the Pre-IND package.  such, applicants encouraged address regulatory strategy necessary achieve goal. Research supported under FOA to prepare advanced development after filing Pre-IND package.  Most the advanced development activities required regulatory approval include GMP GLP level efforts) not usually covered under FOA, could potentially supported other federal agencies industry once NIH-supported research completed.  HHS advanced development agency relevant this FOA the Biomedical Advanced Research Development Authority BARDA). Once research funded under FOA completed, should the following before exploring possibility additional funding through BARDA advanced development. least lead compound. Lead compounds biologically active compounds hits where affinity, potency, selectivity been established. Efficacy an appropriate animal model Initial pharmacology toxicology studies Stable scalable synthesis the lead compound Preliminary regulatory strategy including Target Product Profile regulatory expertise Commercialization plan other indications applicable Intellectual Property Rights Applications focus specifically the above goal be deemed high programmatic priority. applicants strongly encouraged discuss applications the Scientific/Research contact early the application development process. Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-443-8189 Email: jettd@ninds.nih.gov

Participation Canadian Researchers the NIH BRAIN Initiative Notice Number: NOT-MH-15-020 Key Dates Release Date:   August 6, 2015 Related Announcements None     Issued National Institute Mental Health NIMH) National Eye Institute NEI)National Institute Aging NIA) National Inistitute Alcohol Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Brain Canada Foundation Brain Canada) Purpose 10 NIH Institutes are part the NIH BRAIN Initiative announce new partnership, formalized a letter agreement, the Brain Canada Foundation Brain Canada) support involvement Canadian researchers the NIH BRAIN Initiative.  Both NIH the Brain Canada Foundation believe the ambitious goals the BRAIN Initiative best attained collaboration across disciplinary boundaries well geographic boundaries.  Brain Canada seek partners provide grant support Canadian researchers through Canada Brain Research Fund provides 1:1 match funds raised other sources. Supplemental Funding NIH a number BRAIN Initiative awards FY14 http://braininitiative.nih.gov/nih-brain-awards.htm) many are expected be in FY15.  Canadian researchers are interested participating funded awards advised contact Program Director/Principal Investigator the NIH award inquire there mutual interest collaboration.  there interest, Canadian researcher apply directly the Brain Canada Foundation funding the work be performed Canada. each approved project an added Canadian collaboration, funding administration the work performed Canada shall managed Brain Canada. Matching Funding most the NIH BRAIN Initiative Funding Opportunity Announcements, foreign institutions been permitted participate either submitting applications directly as subcontractors an application a domestic institution.  Canadian researchers submit applications either role BRAIN Initiative awards should contact Brain Canada will seek partners provide grant support through Canada Brain Research Fund. addition providing funds, representatives the Brain Canada Foundation join those the National Science Foundation, Food Drug Administration, Defense Advanced Research Projects Agency, Australian National Health Medical Research Council, the Intelligence Advanced Research Projects Agency meetings the BRAIN Multi-Council Working Group http://braininitiative.nih.gov/Brain_multi_council_working_group.htm). Inquiries Please direct inquiries to: Gregory K. Farber, Ph.D. National Institute Mental Health NIMH) Telephone:  301-435-0778 Email:  farberg@mail.nih.gov Ned Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1917 Email:  talleye@mail.nih.gov Inez Jabalpurwala Brain Canada Foundation Telephone: 514-989-2989 Email:  programs@braincanada.ca

Notice Correction the Renegotiation Multiple PD/PI Grants Awards Policy NINDS RFA-NS-16-001 Research Program Award R35)" Notice Number: NOT-NS-15-034 Key Dates Release Date: July 28, 2015   Related Announcements RFA-NS-16-001 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to correct description the anticipated terms award Section VI. Award Administration Information, Subsection 1. Award Notices, related the renegotiation current NINDS awards. Investigators receive Research Program Award RPA) be required relinquish other NINDS funding. the case multiple-PD/PI awards, will relinquish formal involvement the award will able continue collaboration support the RPA. transition be at end the current budget period. similar process be followed subprojects P01s P50s. Investigators supported an RPA expected continue associated investigators the continuing P01 P50 thus expected interact the subproject investigators to access the P01 P50 cores. Section VI. Award Administration Information 1. Award Notices Currently reads: is expected the RPA replace current NINDS funding other grants. Renegotiation current NINDS funds be expected.  Multiple PD/PI grants be excluded. Modified read: is expected the RPA replace current NINDS funding other grants. Renegotiation current NINDS funds be expected. other aspects the FOA remain unchanged. additional information the RPA program, please review Frequently Asked Questions http://www.ninds.nih.gov/funding/NINDS-Research-Program-Award-FAQ.htm. Inquiries Please direct inquiries to: Dr. David Owens National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9248 Email: David.Owens@.nih.gov

Notice Intent Publish Funding Opportunity Announcement BRAIN Initiative: Foundations Non-Invasive Human Brain Imaging Neuro-Recording Techniques R01) Participation the Australian National Health Medical Research Council Notice Number: NOT-MH-15-022 Key Dates Release Date:   July 21, 2015 Estimated Publication Date Announcement: October 2015   First Estimated Application Due Date: December 2015  Earliest Estimated Award Date: June 2016  Earliest Estimated Start Date: June 2016 Related Announcements RFA-MH-16-750     Issued National Institutes Health NIH) National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Australian National Health Medical Research Council NHMRC) Purpose NIMH, other NIH Institutes Centers ICs) are part the BRAIN Initiative, intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications research the foundations non-invasive human brain imaging neuro-recording techniques.  goal this FOA be support integrative, multidisciplinary efforts will revolutionize our understanding the meaning the data collected non-invasive human brain imaging functional evaluation techniques.   Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published fall 2015 an expected application due date winter 2015. FOA utilize R01 activity code. Research Initiative Details Notice encourages investigators expertise insights this area non-invasive human brain imaging neuro-recording begin consider applying this new FOA.  Studies supported this new FOA move beyond simply observing signal collected using non-invasive imaging recording techniques a level more directly informs our understanding the cellular- circuit-bases these signals. Such studies greatly improve our knowledge dynamic brain function both normal pathological conditions. addition, collaborative investigations combining expertise physics, computational information science, engineering, biology, neuroscience, clinical science, behavioral science be encouraged investigators such expertise should also begin considering applying this application. NIH Institutes Centers are part the NIH BRAIN Initiative announce new partnership, formalized a letter agreement, the Australian National Health Medical Research Council NHMRC) support involvement Australian researchers specific NIH BRAIN Initiative programs.  Both NIH the NHMRC believe the ambitious goals the BRAIN Initiative best attained collaborating across disciplinary boundaries well geographic boundaries.  Details NHMRC application procedures, funding rules, eligibility requirements be available the NHMRC website. Foreign institutions be permitted submit applications the FOA described this Notice either submitting applications directly as subcontractors an application a domestic institution.  addition providing funds, representatives the NHMRC join those the National Science Foundation, Food Drug Administration, Defense Advanced Research Projects Agency, the Intelligence Advanced Research Projects Agency meetings the BRAIN Multi-Council Working Group http://braininitiative.nih.gov/Brain_multi_council_working_group.htm). APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Gregory K. Farber, Ph.D. National Institute Mental Health NIMH) Telephone: 301-435-0778 Email: farberg@mail.nih.gov Ned Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1917 Email:  talleye@mail.nih.gov National Health Medical Research Council NHMRC) Telephone: 61 2 6217 9450 Email: brain@nhmrc.gov.au