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Notice the Extension the Expiration Date PAR-13-281 NINDS Exploratory Clinical Trials R01)" Notice Number: NOT-NS-16-029 Key Dates Release Date: 25, 2016 Related Announcements PAR-13-281  Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice inform interested applicants the expiration date PAR-13-281 NINDS Exploratory Clinical Trials R01)" be extended one funding cycle. Key Dates table updated accordingly: Part 2. Key Dates Posted Date July 22, 2013 Open Date Earliest Submission Date) September 5, 2013 Letter Intent Due Date(s) Applicable Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2017 Due Dates E.O. 12372 Applicable Inquiries Please direct inquiries to: Peter Gilbert National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-0870 Email: gilbertp@ninds.nih.gov  

Request Information: Soliciting Input New Research Strategies Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS) Notice Number: NOT-NS-16-024 Key Dates Release Date: 24, 2016 Response Date: June 24, 2016   Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) National Heart, Lung, Blood Institute NHLBI) National Institute Aging NIA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Library Medicine NLM) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS)  Purpose Trans-National Institutes Health NIH) ME/CFS Working Group developing new strategies guide NIH's research efforts priority setting research ME/CFS.  Seeking input the planning process through Request Information RFI) critical identification consideration research areas topics be included future efforts.  members the Trans-NIH ME/CFS Working Group review consider comments received under RFI regard current future needs direction ME/CFS research research training. Information Requested Through RFI, Trans-NIH ME/CFS Working Group invites input researchers, health care providers, patient advocates health advocacy organizations, scientific professional organizations, Federal agencies, other interested parties.  Organizations strongly encouraged submit single response reflects views their organization membership a whole. Please provide perspective the following issues they relate the Working Group's planning efforts: Emerging needs opportunities should considered new ME/CFS research strategies developed. Challenges barriers progress research ME/CFS. Gaps opportunities across research continuum basic through clinical studies. commenting a research need scientific opportunity, Working Group suggests your comments contain following our full consideration: Description the need opportunity Scientific rationale potential public health impact Anticipated challenges will need be addressed Appropriate benchmarks evaluating progress. this RFI, NIBIB interested the ideas the development new imaging bioengineering technologies could the potential a significant impact ME/CFS research. Trans-NIH ME/CFS Working Group also welcomes general comments. Responses Responses this RFI must submitted via email MECFSRFI@mail.nih.gov  Responses be accepted through June 24, 2016. Responses voluntary may submitted anonymously.  Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted.  Please not include any personally identifiable other information you not wish make public.  proprietary, classified, confidential, sensitive information should included your response. request for information planning purposes only should be construed a solicitation as obligation the part the United States Government.  Trans-NIH ME/CFS Working Group not any awards based responses this RFI pay the preparation any information submitted for Government's of such information. Inquiries Please direct inquiries to: Vicky Whittemore, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: vicky.whittemore@nih.gov

Notice the Extension the Expiration Date PAR-13-278 NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)" Notice Number: NOT-NS-16-028 Key Dates Release Date: 24, 2016 Related Announcements PAR-13-278     Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice inform interested applicants the expiration date PAR-13-278 quot;NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)" be extended one funding cycle. Key Dates table updated accordingly: Part 1. Key Dates Posted Date July 22, 2013 Open Date Earliest Submission Date) September 5, 2013 Letter Intent Due Date(s) Applicable Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2017 Due Dates E.O. 12372 Applicable nbsp; Inquiries Please direct inquiries to: Peter Gilbert National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-0870 Email: gilbertp@ninds.nih.gov  

Notice Travel Support PDs/PIs NINDS-Funded Institutional Training T32) Programs Attend NINDS T32 Regional Meetings Notice Number: NOT-NS-16-025 Key Dates Release Date:   May 10, 2016 Related Announcements NOT-NS-14-026 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice supersedes NOT-14-NS-026, establishes maximum travel support NINDS award T32 PDs/PIs cover costs associated attending T32 Regional Meetings. NINDS supports institutional training programs T32s) both predoctoral postdoctoral fellows are intended develop strong next generation neuroscientists engaged research NINDS-mission relevant research-associated occupations. programs expected facilitate development a highly qualified, diverse workforce. purpose this Notice to inform awardees NINDS T32 training programs it continue holding periodic meetings among PDs/PIs, to offset costs associated attendance these meetings, NINDS provide to 700 direct cost directly the T32 grants grant PDs/PIs their designees attend meetings.  meetings scheduled, Director, NINDS Office Training, Career Development Workforce Diversity notify PDs/PIs additional information, including instructions requesting funds. Inquiries Please direct inquiries to: Letitia Weigand, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-4188 Email: letitia.weigand@nih.gov

Notice Clarify PAR-15-146 Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)" Notice Number: NOT-NS-16-026 Key Dates Release Date: 5, 2016 Related Announcements PAR-15-146    Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to amend Award Information section, the Application Submission section PAR-15-146 quot;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)". Part 2. Section II. Award Information Award Budget FOA currently reads: Application budgets not limited need reflect actual needs the proposed project. most studies within scope this FOA, anticipated direct cost individual awards 2-3 million per year a total 10-15 million over maximum five-year project period. is modified read: Application budgets not exceed 2.5 million direct costs per year over. applications not need request maximum budget the size duration the awards vary depending upon nature scope research programs. Section IV. Application Submission Information 6. Submission Requirements Information FOA currently reads: Requests 500,000 more direct costs any year Applicants requesting 500,000 more direct costs any year excluding consortium F&A) must contact NIH program staff least 6 weeks before submitting application follow Policy the Acceptance Review Unsolicited Applications Request 500,000 More Direct Costs described the SF424 R&R) Application Guide. is modified read: Applicable nbsp; other aspects this FOA remain same. Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-6035 Email: jettd@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement NINDS Postdoctoral Training F32) Includes Specific Eligibility Requirements Notice Number: NOT-NS-16-012 Key Dates Release Date:   May 2, 2016 Estimated Publication Date Announcement: August 2016  First Estimated Application Due Date: December 2016 Earliest Estimated Award Date: 2017  Earliest Estimated Start Date: June 2017 Related Announcements NOT-NS-16-013 NOT-NS-17-002 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institutes Neurological Disorders Stroke NINDS) intends restructure support postdoctoral researchers publishing Funding Opportunity Announcements FOAs) solicit applications support postdoctoral research training career development. FOA described this Notice utilize F32 activity code another FOA utilize K01 activity code NOT-NS-16-013) NINDS F32 FOA intended facilitate early planning creative, innovative projects well-designed training experiences conceived discussions between excellent candidates outstanding mentors. aid the early planning support highly significant, creative innovative projects, preliminary data be expected the application. Starting the first application due date this FOA estimated be December, 2016), NINDS only accept F32 applications candidates who, the due date, within year prior joining postdoctoral laboratory are within first year their research experience the laboratory which training proposed. F32 only support postdoctoral fellows while are within first 3 years research training any specific laboratory research environment candidates apply an F32 a second postdoctoral laboratory experience, must apply prior to, within first year of, joining second postdoctoral laboratory). Simultaneously the first due date this FOA, NINDS cease accepting F32 applications response the omnibus NIH F32 FOA. NINDS also intends issue FOA solicit K01 applications candidates a Ph.D. equivalent research doctoral degree NOT-NS-16-013 details). Candidates be eligible apply this K01 anytime within second through fourth year cumulative postdoctoral research experience, may supported the NINDS K01 within first 6 years cumulative postdoctoral research experience. Notice being provided allow potentially eligible applicants sufficient time develop plans their upcoming postdoctoral training. Similarly, Notice informs postdoctoral fellows will been their current postdoctoral laboratory more a year December, 2016 their final opportunity apply support an NINDS F32 that laboratory, response PA-14-149 its reissue , expected be August, 2016 receipt date. new NINDS F32 FOA expected be published the fall 2016, an expected initial application due date December, 2016. Research Initiative Details Notice encourages graduate students postdoctoral fellows have identified postdoctoral research mentor who within time window spans year before one year after entering postdoctoral laboratory the December 2016 application due date begin consider applying this new FOA. research areas within NINDS mission, all types research fundamental basic research, disease-related basic research, clinical research translational research), encouraged. key aspect the F32 FOA the expectation NO preliminary data be required. NINDS seek applications propose highly significant highly innovative projects excellent candidates working outstanding mentors. Consequently, applications should contain carefully planned, well-integrated research training plans, devised prepared close collaboration between applicant mentor(s). Applications should contain clearly described plans accomplish highly significant research critical training goals. unique aspect this FOA the goal supporting innovative, creative perhaps bold research ideas without delay associated the need the applicant collect high quality data prior obtaining support. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:301-496-4188 Email: korns@ninds.nih.gov

Notice Intent Publish Funding Opportunity Announcement an NINDS Postdoctoral Research Career Development Award K01) Notice Number: NOT-NS-16-013 Key Dates Release Date:   May 2, 2016 Estimated Publication Date Announcement: October 2016  First Estimated Application Due Date: February 2017 Earliest Estimated Award Date: October 2017  Earliest Estimated Start Date: October 2017 Related Announcements NOT-NS-16-012 NOT-NS-17-002      Issued National Institute Neurological Disorders Stroke NINDS)  Purpose National Institutes Neurological Disorders Stroke NINDS) intends restructure support postdoctoral researchers publishing Funding Opportunity Announcements FOAs) solicit applications support postdoctoral research. FOA described this notice utilize K01 activity code another FOA utilize F32 activity code NOT-NS-16-012) Notice being provided allow potential applicants time develop, their mentors, plans a research project will belong the applicant, is based preliminary data collected the applicant the mentor's laboratory. new NINDS K01 FOA expected be published the Fall 2016, an anticipated initial application due date Winter 2017. Research Initiative Details NINDS K01 intended candidates a Ph.D. equivalent research doctoral degree. Candidates be eligible apply the K01 anytime within second through fourth year cumulative mentored, postdoctoral research experience, may supported the NINDS K01 within first 6 years cumulative postdoctoral research experience. Successful K01 applications be designed facilitate continuation outstanding, innovative projects, combined career development activities will prepare outstanding postdoctoral, mentored investigators an independent research career. K01 application describe project that, demonstrated preliminary data collected the applicant, holds promise result highly significant results future discoveries. K01 candidate continue be guided a postdoctoral mentor, will primarily responsible oversight conduct the research project. the end the proposed K01 award period, candidate be poised begin independent research career will a well-developed, highly significant project he/she take him/her an independent research position. NINDS K01 intended only candidates a research doctorate Ph.D. equivalent), not postdoctoral researchers have clinical doctorate M.D. equivalent). Candidates a clinical degree either alone in combination a research doctorate) apply a K08 K23 award, if eligible, K99/R00 award. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-4188 Email: korns@ninds.nih.gov

Notice Extend PA-13-216 Research Autism Spectrum Disorders R01)" Notice Number: NOT-MH-16-009 Key Dates Release Date:   May 2, 2016 Related Announcements PA-13-216     Issued National Institute Mental Health NIMH) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Environmental Health Sciences NIEHS) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to extend PA-13-216 “Research Autism Spectrum Disorders R01)" invites applications support research designed elucidate etiology, epidemiology, diagnosis, treatment, optimal means service delivery relation autism spectrum disorders ASD).  current expiration date May 8, 2016. new expiration date September 8, 2016. other aspects this FOA remain same. Inquiries Please direct inquiries to: Lisa Gilotty, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3825 Email: gilottyl@mail.nih.gov

Notice National Institute Neurological Disorders Stroke NINDS) Participation PA-16-164 Administrative Supplements Research Sleep Disturbances Impact Chronic Pain Admin Supp)" Notice Number: NOT-NS-16-020 Key Dates Release Date: April 26, 2016 Related Announcements PA-16-164     Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to inform potential applicants the National Institute Neurological Disorders Stroke NINDS) participating, effective immediately, PA-16-164 ldquo;Administrative Supplements Research Sleep Disturbances Impact Chronic Pain Admin Supp)” to detail additional interest NINDS.   following sections PA-16-164 been updated reflect participation NINDS this FOA. Part 1. Overview Information Components Participating Organizations National Center Complementary Integrative Health NCCIH) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Catalog Federal Domestic Assistance CFDA) Number(s) 93.213; 93.865; 93.279; 93.853 Part 2. Full Text Announcement Section I. Funding Opportunity Description Scope Work NINDS particularly interested research related the neural mechanisms sleep disturbances impact chronic pain.   Part 2. Section VII. Agency Contacts the participation NINDS, following contacts added the FOA. Scientific/Research Contact(s) Janet He, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: hey@ninds.nih.gov Michael Oshinsky, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: michael.oshinsky@nih.gov Financial/Grants Management Contact(s) Tijuana Decoster, PhD National Institute Neurological Disorders amp; Stroke NINDS) Telephone: 301-496-9531 Email: decostert@mail.nih.gov other aspects this FOA remain unchanged. Inquiries Please direct inquiries to:

Notice Extension the Response Date NOT-HL-16-312 Request Information RFI): Input Revisions the NIH Sleep Disorders Research Plan" Notice Number: NOT-HL-16-316 Key Dates Release Date:   April 15, 2016 Related Announcements NOT-HL-16-312     Issued National Heart, Lung, Blood Institute NHLBI) National Institute Neurological Disorders Stroke NINDS) National Institute Diabetes Digestive Kidney Diseases NIDDK) Purpose Notice extends response date NOT-HL-16-312 quot;Request Information RFI): Input Revisions the NIH Sleep Disorders Research Plan". Notice also informs intended participants National Cancer Institute NCI), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), National Institute Mental Health NIMH), National Institute Nursing Research NINR), National Center Complementary Integrative Health NCCIH) also participate this RFI. following sections NOT-HL-16-312 been updated: Issued National Heart, Lung, Blood Institute NHLBI) National Institute Neurological Disorders Stroke NINDS) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Cancer Institute NCI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) Current Response Date:  8, 2016 New Response Date:  16, 2016 other aspects the RFI remain same. Inquiries Please direct inquiries to: Michael Twery, PhD National Heart, Lung, Blood Institute NHLBI)   Telephone: 301-435-0199 Email: TweryM@nhlbi.nih.gov