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Notice Intent Publish Funding Opportunity Announcement Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS) Data Management Coordinating Center DMCC) U01) Notice Number: NOT-NS-17-004 Key Dates Release Date: October 21, 2016 Estimated Publication Date Announcement: December 2016  First Estimated Application Due Date: April 2017 Earliest Estimated Award Date: September 2017  Earliest Estimated Start Date: September 2017    Related Announcements RFA-NS-17-022 NOT-NS-17-003 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS), along other NIH Institutes Centers ICs), intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications a Data Management Coordinating Center DMCC) facilitate coordinate research the Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Collaborative Research Centers ME/CFS CRC). overarching goal this initiative be establish data management coordinating center will support work a network ME/CFS CRCs will work independently collaboratively define causes and discover improved treatments ME/CFS will coordinate activities through DMCC. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published December 2016 an expected application due date April 2017. NIH anticipates holding pre-application web-based teleconference which interested prospective applicants invited. Information this pre-application web-based teleconference call be available the FOA. FOA utilize U01 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators expertise insights this area data management coordination begin consider applying this new FOA. Clinical basic data management efficient data collection well data mining data sharing be addressed through FOA the Data Management Coordinating Center DMCC) component support ME/CFS CRCs.  DMCC support collaborative research teams the ME/CFS CRCs manage coordinate research data collection the Data Management Coordinating Center. Applicants encouraged, not required use multiple program director/principal investigator PD/PI) mechanism facilitate collaborations.  Multidisciplinary teams diverse areas expertise be represented.  Foreign components allowed, applications foreign institutions not accepted. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Vicky Whittemore, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: vicky.whittemore@nih.gov

Notice Clarification Regarding Country Eligibility PAR-17-001 Emerging Global Leader Award K43)" Notice Number: NOT-TW-17-002 Key Dates Release Date: October 21, 2016 Related Announcements NOT-TW-17-008 PAR-17-001 NOT-TW-12-011 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Human Genome Research Institute NHGRI) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Research Women’s Health ORWH) Purpose purpose this Notice to clarify eligibility PAR-17-001 Emerging Global Leader Award K43)". Specifically, Notice clarifies country eligibility requirements institutions individuals reflect Country Eligibility Fogarty International Training Grants. Part 2. Section III. Eligibility Information 1. Eligible Applicants Foreign Institutions Currently reads Only non-domestic non-U.S.) Entities Foreign Institutions) Low- Middle-Income Countries eligible apply. LMICs defined the World Bank classification system according Gross National Income GNI) per capita low-income,” lower-middle-income,” upper-middle-income” http://data.worldbank.org/about/country-classifications/country-and-len…). Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement, allowed. Modified read sentence added italicized below) Only non-domestic non-U.S.) Entities Foreign Institutions) Low- Middle-Income Countries eligible apply. LMICs defined the World Bank classification system according Gross National Income GNI) per capita low-income,” lower-middle-income,” upper-middle-income” http://data.worldbank.org/about/country-classifications/country-and-len…). Country Eligibility Fogarty International Training Grants additional information.  Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement, allowed. Part 2. Section III. Eligibility Information 1. Eligible Applicants Eligible Individuals Program Director/Principal Investigator) Currently reads Any candidate the skills, knowledge, resources necessary carry the proposed research the Program Director/Principal Investigator PD/PI) invited work his/her primary mentors U.S.-based one LMIC-based) organization develop application support. Individuals underrepresented racial ethnic groups well individuals disabilities always encouraged apply NIH support. Multiple PDs/PIs not allowed. applicant must an LMIC citizen and, the time award, not a citizen a non-citizen national the United States have lawfully admitted permanent residence i.e., possess currently valid Permanent Resident Card USCIS Form I-551, other legal verification such status). Modified read sentence added italicized below) Any candidate the skills, knowledge, resources necessary carry the proposed research the Program Director/Principal Investigator PD/PI) invited work his/her primary mentors U.S.-based one LMIC-based) organization develop application support. Individuals underrepresented racial ethnic groups well individuals disabilities always encouraged apply NIH support. Multiple PDs/PIs not allowed. applicant must an LMIC citizen and, the time award, not a citizen a non-citizen national the United States have lawfully admitted permanent residence i.e., possess currently valid Permanent Resident Card USCIS Form I-551, other legal verification such status). Country Eligibility Fogarty International Training Grants additional information.  other aspects this FOA remain same. Inquiries Please direct inquiries to: Christine Jessup, Ph.D. Fogarty International Center FIC) Telephone: 301-496-1653 Email: christine.jessup@nih.gov

Notice the Discontinuation Participation NINDS PA-16-307 Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship Parent F32)" Notice Number: NOT-NS-17-002 Key Dates Release Date: October 17, 2016 Related Announcements PA-16-307 NOT-NS-16-012 NOT-NS-16-013     Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice informs community the National Institute Neurological Disorders Stroke NINDS) discontinue participation PA-16-307 quot;Ruth L. Kirschstein National Research Service Award NRSA) Individual Postdoctoral Fellowship Parent F32)".  NINDS not accept either new resubmission applications PA-16-307 the December 8, 2016 application due date beyond. NINDS now accepting applications F32 support exclusively via PAR-16-458. previously described NOT-NS-16-012 NOT-NS-16-013, NINDS restructuring funding support postdoctoral researchers.  Beginning the December 8, 2016 due date, research training support postdoctoral fellows under F32 activity code be available through NINDS using PAR-16-458 quot;NINDS Ruth L. Kirschstein National Research Service Award NRSA) Training Postdoctoral Fellows F32)."  NINDS F32 support postdocs are within first 3 years research training the sponsor's laboratory, includes several key differences the parent F32. Most notably, applicants only eligible the NINDS F32 prior starting, within first 12 months starting, postdoctoral training the sponsor's laboratory research environment. Because the very early application, preliminary data expected.  is anticipated another Funding Opportunity Announcement postdocs, utilizes K01 activity code, be published time the February 12, 2017 initial receipt date. will available applicants their second through fourth year cumulative postdoctoral research experience NOT-NS-16-013).  Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institutes Neurological Disorders Stroke Telephone: 310-496-4188 Email: korns@ninds.nih.gov

Notice Correction the Application Due Date RFA-NS- 17-002 High Impact Neuroscience Research Resource Grants R24)" Notice Number: NOT-NS-17-001 Key Dates Release Date: October 6, 2016 Related Announcements RFA-NS-17-002 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to correct Application due date RFA-NS-17-002, quot;High Impact Neuroscience Research Resource Grants R24)". application due date the FOA, February 14, 2016 incorrect. correct date February 14, 2017. nbsp; current version the FOA reads: Part 1. Key Dates Open Date Earliest Submission Date):          January 14, 2016 Letter Intent Due Date(s):                            January 14, 2016 Application Due Date(s):                                  February 14, 2016 FOA corrected read: Part 1. Key Dates Open Date Earliest Submission Date):           January 14, 2017 Letter Intent Due Date(s):                            January 14, 2017 Application Due Date(s):                                  February 14, 2017, nbsp; other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Randall R. Stewart, Ph.D.  National Institute Neurological Disorder Stroke NINDS) Telephone: 301-496-1917  Email: stewartr@mail.nih.gov

Notice Extend RFA-MH-17-245 BRAIN Initiative: Non-Invasive Neuromodulation - Mechanisms Dose/Response Relationships Targeted CNS Effects R01)" Notice Number: NOT-MH-16-023 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-245 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-245 ldquo;BRAIN Initiative: Non-Invasive Neuromodulation - New Tools Techniques Spatiotemporal Precision R01)" invites application encourage optimization existing electrical magnetic stimulation methods. Part 1. Key Dates Currently reads:  Application Due Date(s): November 23, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 24, 2016 Modified read: Application Due Date(s): November 23, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects this FOA remain same. Inquiries Please direct inquiries to: Fred Friedman, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-4058 Email: ffriedma@mail.nih.gov

Notice Extend RFA-MH-17-240 BRAIN Initiative: Non-Invasive Neuromodulation - New Tools Techniques Spatiotemporal Precision R01)" Notice Number: NOT-MH-16-024 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-240 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-240 ldquo;BRAIN Initiative: Non-Invasive Neuromodulation - New Tools Techniques Spatiotemporal Precision R01)" invites application develop test novel tools methods neuromodulation go beyond existing variations. Part 1. Key Dates Currently reads:  Application Due Date(s): November 23, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 24, 2016 Modified read: Application Due Date(s): November 23, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects this FOA remain same. Inquiries Please direct inquiries to: Fred Friedman, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-4058 Email: ffriedma@mail.nih.gov

Notice Extend RFA-MH-17-235 BRAIN Initiative: Foundations Non-Invasive Functional Human Brain Imaging Recording-Bridging Scales Modalities R01)" Notice Number: NOT-MH-16-025 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-235 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-235 ldquo;BRAIN Initiative: Foundations Non-Invasive Functional Human Brain Imaging Recording - Bridging Scales Modalities R01)" invites application support effort will revolutionize our understanding the biological activity underlying, bioinformatic content data collected using contemporary non-invasive functional brain imaging techniques.  Part 1. Key Dates Currently reads:   Application Due Date(s): November 23, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 24, 2016 Modified read: Application Due Date(s): November 23, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects this FOA remain same. Inquiries Please direct inquiries to: Jay Churchill, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3621 Email: churchillj@mail.nih.gov

Notice Extend RFA-MH-17-220 BRAIN Initiative: Development Validation Novel Tools Analyze Cell-Specific Circuit-Specific Processes the Brain R01)" Notice Number: NOT-MH-16-026 Key Dates Release Date: September 16, 2016 Related Announcements RFA-MH-17-220 Issued National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose purpose this Notice to extend RFA-MH-17-220 ldquo;BRAIN Initiative: Development Validation Novel Tools Analyze Cell-Specific Circuit-Specific Processes the Brain R01)" invites application develop validate novel tools facilitate detailed analysis complex circuits provide insights cellular interactions underlie brain function. Part 1. Key Dates Currently reads: Application Due Date s): November 2, 2016 Scientific Merit Review: March 2017 Advisory Council Review: 2017 Earliest Start Date: September 2017 Expiration Date: November 3, 2016 Modified read: Application Due Date(s): November 2, 2016 October 13, 2017 Scientific Merit Review: March 2017 March 2018 Advisory Council Review: 2017 May 2018 Earliest Start Date: September 2017 September 2018 Expiration Date: October 14, 2017 other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Michelle Freund, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-1815 Email: BRAIN-info-NIMH@mail.nih.gov

BRAIN Initiative Multi-Council Working Group Clearance Initiative Concepts FY2017 Notice Number: NOT-NS-16-041 Key Dates Release Date: September 6, 2016 Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Integrative Health NCCIH) Purpose Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative an ambitious multi-agency effort announced President Obama April 2013. Specific goals NIH contributions the Initiative formulated over year-long planning process culminated the release BRAIN 2025: Scientific Vision, seminal planning document produced a working committee the Advisory Council the NIH Director. NIH continues be guided this document by input the BRAIN Multi-Council Working Group MCWG), committee includes Advisory Council members each the ten NIH Institutes Centers ICs) contributing the BRAIN Initiative.  upcoming fiscal year represents transition point the BRAIN Initiative, goals scaling efforts a number specific areas: 1.  Census Brain Cell Types 2.  Tools Cells Circuits 3.  Technologies Neural Recording Modulation 4.  Human Imaging Neuromodulation 6.  Technology Dissemination Training 7.  Small Business Awards 8.  Data Coordination 9.  Neuroethics fund ambitious goals this transition, President’s budget calls a total appropriation 195 million, has matched exceeded proposals House Senate appropriations subcommittees.  its most recent meeting August 2, 2016, MCWG provided clearance BRAIN FY 2017 initiatives.  Investigators interested particular research areas encouraged review listing cleared initiatives, includes contact information NIH Program staff each area.  Links this information be found the following url:  https://braininitiative.nih.gov/about/multi-council-working-group. Interested parties also encouraged subscribe the BRAIN Update post https://brainupdate.nih.gov/), issues periodic announcements including new funding opportunities.  Inquiries Please direct inquiries to: Edmund Ned) Talley, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: Edmund.Talley@nih.gov email strongly preferred) Gregory K. Farber, Ph.D. National Institute Mental Health NIMH) Telephone:  301-435-0778 Email: farberg@mail.nih.gov

Notice Discontinuation PAR-14-340 Request Access Parkinson's Disease Related-Biospecimens X01)" Notice Number: NOT-NS-16-040 Key Dates Release Date: August 2, 2016 Related Announcements PAR-14-340 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants NINDS discontinue PAR-14-340 quot;Request Access Parkinson's Disease Related-Biospecimens X01)" of August 12, 2016. Information the Parkinson's Disease Biomarkers Program PDBP), the continued coordination biosample access various Parkinson's Disease cohorts including PDBP, BioFIND NINDS/Michael J. Fox Foundation MJFF) collaboration), Harvard Biomarker Study, and  MJFF supported resources including DATATOP, LRRK2 cohort the 24 hour biofluid sampling study available the PDBP biospecimen website. Inquiries Please direct inquiries to: Margaret Sutherland, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5680 Email: sutherlandm@ninds.nih.gov nbsp;