The National Institute of Allergy and Infectious Diseases
(NIAID), the National Institute of Neurological Disorders and Stroke
(NINDS), the National Institute of Arthritis and Musculoskeletal and
Skin Diseases (NIAMS), the Office of Research on Womens Health (ORWH)
of the National Institutes of Health (NIH) and the National Multiple
Sclerosis Society (NMSS) invite applications to identify, characterize,
and define differences in the immune response between males and females,
including responses to exogenous and self-antigens, the innate and
adaptive immune response, systemic and mucosal immune response, and
regulation of the immune system by hormonal and non-hormonal sex
differences. The intent of this Request for Applications (RFA) is to
support multidisciplinary research on sex-based differences in immune
responses that may be important in autoimmune diseases, including
multiple sclerosis (MS), rheumatic diseases such as rheumatoid arthritis
(RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc),
as well as other immune mediated diseases, and the underlying mechanisms
and clinical significance of such differences. Collaborative
multidisciplinary research, involving investigators with expertise in
various scientific disciplines and clinical specialties is encouraged.
Both human studies and animal models with relevance to human disease are
appropriate. Research that expands basic and clinical knowledge of the
effect of sex, including hormonal and non-hormonal differences, on the
immune response will facilitate development of improved therapeutic and
preventive strategies for autoimmune diseases and other immune-mediated
disorders. The focus of this RFA is the biological or physiological sex
differences between males and females, studies of the cultural, social,
and historical differences between males and females ("gender
differences") are not responsive to this RFA.
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Expiration Date: Wednesday, July 11, 2001 NOFO Number: RFA-AI-01-005 Release Date: Monday, February 12, 2001 Notice Type: RFA
Expiration Date: Thursday, July 12, 2001 NOFO Number: RFA-HD-01-008 Release Date: Wednesday, January 31, 2001 Notice Type: RFA
This Request for Applications (RFA) solicits research grant applications to
examine the feasibility of using Xenopus tropicalis for standard genetic
manipulations. The research proposed should optimize the conditions required
to perform efficient, large-scale mutagenesis, and should use the optimized
parameters to perform small-scale mutagenesis, phenotyping, and gene cloning,
identification, and characterization. Mutant animals, protocols, and data
produced by these projects should be made available to the scientific
community. We anticipate that the mutants, data and procedures developed by
the projects funded under this RFA will enable Xenopus tropicalis to play a
significant role in identifying and characterizing genes that regulate
cellular and developmental processes.
Expiration Date: Thursday, April 12, 2001 NOFO Number: RFA-DA-01-011 Release Date: Thursday, January 25, 2001 Notice Type: RFA
This RFA solicits proposals for development of tools and techniques for
the establishment of random and targeted sequence-tagged insertion
libraries of embryonic stem (ES) cells that can be used to generate
mutant mice in which the expression of the tagged gene could be
controlled temporally and spatially. The development of such a
resource for wide distribution to the scientific community would make
it possible to scan the sequence database for any gene of interest and
order the corresponding targeted ES cell line. Ideally, the
insertional mutagenesis system developed would permit a wide range of
genetic analyses and manipulations, including enhancer-trapping,
conditional knockouts, conditional expression or overexpression, etc.
It also would permit the larger community of investigators to utilize
genomic resources efficiently.
Expiration Date: Thursday, April 12, 2001 NOFO Number: RFA-DA-01-012 Release Date: Thursday, January 25, 2001 Notice Type: RFA
This Request for Applications (RFA) solicits proposals for development of
tools and techniques for the establishment of random and targeted sequence-
tagged insertion libraries of embryonic stem (ES) cells that can be used to
generate mutant mice in which the expression of the tagged gene could be
controlled temporally and spatially. The development of such a resource for
wide distribution to the scientific community would make it possible to scan
the sequence database for any gene of interest and order the corresponding
targeted ES cell line. Ideally, the insertional mutagenesis system developed
would permit a wide range of genetic analyses and manipulations, including
enhancer-trapping, conditional knockouts, conditional expression or
overexpression, etc. It also would permit the larger community of
investigators to utilize genomic resources efficiently.
Expiration Date: Sunday, February 1, 2004 NOFO Number: PA-01-043 Release Date: Thursday, January 18, 2001 Notice Type: PA
The overall goal of this initiative is to invite qualified researchers to
submit new research grant applications to conduct mechanistic studies using
patients, patient materials or information from multi-site pediatric drug
trials sponsored by the National Institute of Child Health and Human
Development (NICHD), National Institute of Diabetes and Digestive and Kidney
Diseases (NIDDK), National Institute of Mental Health (NIMH), and the
National Institute of Neurological Disorders and Stroke (NINDS).
Expiration Date: Sunday, January 4, 2004 NOFO Number: PAS-01-041 Release Date: Thursday, January 4, 2001 Notice Type: PAS
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS) and the National Institute of Neurological Disorders and Stroke
(NINDS) encourage investigator-initiated research grant applications of
therapeutic and pathogenic approaches for the muscular dystrophies.
Responses to this program announcement may include studies in appropriate
animal models or preclinical or clinical studies in patients with Duchenne
muscular dystrophy (DMD), Becker muscular dystrophy (BMD),
facioscapulohumeral dystrophy (FSHD), limb-girdle muscular dystrophy (LGMD),
myotonic dystrophy (DM), congenital muscular dystrophy (CMD), Emery-Dreifuss
muscular dystrophy (EMD), or other forms of muscular dystrophy.
Expiration Date: Wednesday, February 21, 2001 NOFO Number: RFA-AG-01-003 Release Date: Wednesday, December 6, 2000 Notice Type: RFA
In July of 2000 it was announced that the NIH would set aside $50
million over five years to support research on new ways to treat
Alzheimer's disease, an ongoing commitment, by targeting the production
of disease-associated processes, such as formation of amyloid plaques
and neurofibrillary tangles with a special emphasis on the development
of a vaccine to prevent the disease. This RFA is intended to assist in
the development of immunological preventive and treatment strategies
for Alzheimers disease. As part of the overall initiative, several
related program announcements, with set-asides, are also being
developed.
Expiration Date: Friday, February 23, 2001 NOFO Number: RFA-RR-01-001 Release Date: Friday, December 1, 2000 Notice Type: RFA
The National Gene Vector Laboratories (NGVL) were established in 1995
to produce clinical grade vectors for human gene transfer protocols.
The purpose of this Request for Applications (RFA) is to continue the
support of the NGVL to produce and distribute such vectors and to
perform related toxicology studies for Phase I and II human clinical
gene transfer protocols.
Expiration Date: Wednesday, August 15, 2001 NOFO Number: PA-01-024 Release Date: Friday, December 1, 2000 Notice Type: PA
Participating Institutes and Centers (ICs) of the National Institutes of Health
(NIH) invite applications for R01 awards to support Bioengineering Research
Partnerships (BRPs) for basic multidisciplinary research addressing important
biological or medical research problems. A BRP is a multidisciplinary research
team applying an integrative, systems approach to develop knowledge and/or
methods to prevent, detect, diagnose, or treat disease or to understand health
and behavior. The partnership must include appropriate bioengineering expertise
in combination with basic and/or clinical investigators. A BRP may propose
discovery-driven, developmental, non-hypothesis-driven, design-directed, or
hypothesis-driven research at universities, national laboratories, medical
schools, large or small businesses, or other public and private entities.
Expiration Date: Friday, March 23, 2001 NOFO Number: RFA-MH-01-010 Release Date: Wednesday, November 29, 2000 Notice Type: RFA
This Request for Applications (RFA) solicits applications to study the
development or refinement of behavioral, pharmacological or other innovative
treatment interventions for individuals with autism or other autism-spectrum
disorders.