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The participating Institutes and Centers invite qualified researchers to submit research grant applications on methodology and measurement in the behavioral and social sciences. Methodology and measurement issues include the processes that underlie research design, data collection techniques, measurement, and data analysis techniques in the social and behavioral sciences. The goal of this program announcement is to encourage research that will improve the quality and scientific power of data collected in the behavioral and social sciences, relevant to the missions of the NIH Institutes and Centers. Research that addresses methodology and measurement issues in diverse populations, issues in studying sensitive behaviors, issues of ethics in research, issues related to confidential data and the protection of research subjects, and issues in developing multidisciplinary, multimethod, and multilevel approaches to behavioral and social science research is particularly encouraged. Applicants are strongly encouraged to contact the Program Contact for Scientific/Research issues (listed under WHERE TO SEND INQUIRES) of the IC that most closely matches their research focus to determine the IC's interest in the research topic.

The National Institutes of Health Autism Coordinating Committee (NIH/ACC) is implementing the aspects of the Children"s Health Act of 2000 that relate to support of autism research by NIH. The NIH/ACC is composed of the NIH Institutes currently funding autism research: NIMH, NICHD, NINDS, NIDCD, and NIEHS. An important aspect of these activities is the establishment of Centers of Excellence in Autism Research, and in this RFA the participating institutes invite research grant applications for such Centers. The first round of competition for this type of center support was initiated by RFA-MH- 02-001 (http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-02-001.html). This RFA initiates a second round of competition under the same guidelines, except for deadlines, that governed the first round. These Centers will constitute a cohesive program, operating under an NIH cooperative agreement, which will be called the STAART Centers Program (Studies to Advance Autism Research and Treatment).

The purpose of this initiative is to provide short-term interim support for institutional activities that will strengthen oversight of human subjects research at institutions that receive significant NIH support for clinical research. While there is considerable flexibility in the types of activities that could be supported under this program, it is important that these enhance the protection of research subjects by means that will be sustained by the institution after the award period ends. This is a one-time solicitation, it is not anticipated that this RFA will be reissued. While all NIH components supporting clinical research are providing support for this program, it will be administered by the National Center for Research Resources.

The National Institute of Neurological Disorders and Stroke (NINDS) invites applications for Center Core Grants to support neuroscience research. The purpose of this program is to advance the NINDS mission to promote understanding and treatment of neurological disorders by providing core research facilities that are not otherwise available. Each Center Core Grant will support shared resources and facilities used by investigators with research projects funded by NINDS. This support, by providing more accessible resources, is expected to assure a greater productivity than would be possible from the separate projects. An institution is eligible for a maximum of one NINDS Center Core Grant. These awards will support basic, translational, and clinical research, but will not be used to support clinical trials or to provide patient services.

The purpose of this program announcement (PA) is to encourage basic research on the structures of membrane proteins at atomic resolution. It replaces and updates previous program announcements (PA-99-004 and PA-95-035), which were issued under the same title. Considerable research is ongoing in the area of membrane protein structure and function, yet relatively few investigators have applied the techniques of x-ray crystallography, electron diffraction, or nuclear magnetic resonance (NMR) spectroscopy to study directly the structures of their proteins. During the past decade, approximately 30 membrane protein structures have been solved and each structure has been a major contribution in its area of science (see: http://blanco.biomol.uci.edu/Membrane_Proteins_xtal.html). This progress clearly demonstrates that obtaining membrane protein structures is feasible. However, during this same decade the rate of soluble protein structure solution has accelerated greatly and there remains a gap between the understanding of membrane proteins and their soluble protein counterparts.

The National Institutes of Health (NIH) invites applications for grants to develop, conduct, evaluate, and disseminate short-term courses on laboratory research techniques for human embryonic stem cell lines. The courses should include hands-on experience to improve the knowledge and skills of biomedical researchers to maintain, characterize, and utilize human embryonic stem cells in basic research studies and be made available to investigators in research areas of interest to all of the institutes and centers of the NIH.

This RFA is intended to promote productive re-entry of NIH-trained foreign investigators into their home countries as part of a broader program to enhance the scientific research infrastructure in developing countries, to stimulate research on a wide variety of high priority health-related issues in these countries, and to advance NIH efforts to address health issues of global import.

The purpose of this RFA is to encourage the use of high throughput drug screening and chemical genetics in Neurodegeneration research by funding the development of assays that may be adapted for high throughput approaches.

The National Institute of Mental Health (NIMH), National Institute on Neurological Disorders and Stroke (NINDS), National Institute on Drug Abuse (NIDA), and National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) request research grant applications to study neuroimmune molecules and mechanisms involved in regulating normal and pathological central nervous system (CNS) function. Areas of research interest include those raised in discussions at the recent workshop "Strategies for Identifying Functional Links Between the Immune System, Brain Function, and Behavior" http://www.nimh.nih.gov/research/linkssummary.cfm. This program announcement (PA) also incorporates topics explored at the "Research Roundtable on Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS)" http://www.nimh.nih.gov/research/pandassummary.cfm.

Functional magnetic resonance imaging (fMRI) is increasingly important for understanding human brain function. As with other imaging modalities, informatics tools are used at all stages of fMRI studies. As fMRI has evolved in neuroscience laboratories, investigators have created informatics tools to allow them to address particular research questions. This has resulted in a relatively small number of informatics tools that are both useful and widely used.