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- This funding opportunity announcement (FOA) solicits Small Business Innovation Research (SBIR) grant applications that propose research and development of probes useful in imaging the structure and function of the brain and other parts of the nervous system, with award duration and amounts greater than those routinely allowed under the SBIR programs. Specifically this FOA solicits SBIR applications that propose research and development of probes that generate signals detectable by one or more imaging modality. Such probes should indicate the structure or function of molecules or subcellular elements of neurons or other cells of the nervous system. Of special interest are applications that propose research and development of novel probes, although significant enhancements of already existing probes are also solicited. Grant applications may propose projects that will result in probes solely intended for use in research or probes that might have clinical utility. It is expected that this initiative will require expertise from a variety of disciplines, including neuroscience, biology, chemistry, physics, engineering, biotechnology, and bioengineering. Moreover, it is anticipated that these types of expertise will be brought together in various combinations in individual proposed projects. - Budgets up to $200,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $400,000 total costs per year and up to 3 years may be requested for Phase II. - No funds have been specifically set aside for this program; the number of awards and the amount of funds provided for awards have not been predetermined. - This funding opportunity will be run in parallel with a funding opportunity of identical scientific scope, Probes for Microimaging The Nervous System (PA-06-022) that will utilize the Small Business Technology Transfer (STTR [R41/R42]) grant mechanisms. - Only United States SBCs are eligible to submit SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. I.A. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an SBIR application, the Project Director/Principal Investigator (PD/PI) must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: - http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (MS Word) - http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (PDF) - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- This Funding Opportunity Announcement (FOA) solicits Small Business Technology Transfer Research (STTR) grant applications that propose research and development of probes useful in imaging the structure and function of the brain and other parts of the nervous system, with award duration and amounts greater than those routinely allowed under the STTR programs. Specifically this FOA solicits STTR applications that propose research and development of probes that generate signals detectable by one or more imaging modality. Such probes should indicate the structure or function of molecules or subcellular elements of neurons or other cells of the nervous system. Of special interest are applications that propose research and development of novel probes, although significant enhancements of already existing probes are also solicited. Grant applications may propose projects that will result in probes solely intended for use in research or probes that might have clinical utility. It is expected that this initiative will require expertise from a variety of disciplines, including neuroscience, biology, chemistry, physics, engineering, biotechnology, and bioengineering. Moreover, it is anticipated that these types of expertise will be brought together in various combinations in individual proposed projects. - Budgets up to $ 200,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $ 400,000 total costs per year and up to 3 years may be requested for Phase II. - No funds have been specifically set aside for this program; the number of awards and the amount of funds provided for awards have not been predetermined. - This funding opportunity will be run in parallel with a funding opportunity of identical scientific scope, “Probes for Microimaging The Nervous System” (PA-06-021), that will utilize the Small Business Innovation Research (SBIR [R43/R44]) grant mechanism. - Only United States SBCs are eligible to submit STTR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. I.A. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: - http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2…;(MS Word) - http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2…;(PDF) - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088.

- The purpose of this FOA is to invite applications by small businesses for the commercial development of technologies for high throughput data acquisition and analysis that could aid the research fields of basic behavioral science or neuroscience relevant to the mission of the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS).  - Only Small Business Innovation Research (SBIR) Phase I, Phase II, and Fast Track grant applications are solicited by this FOA. - This funding opportunity will be run in parallel with a funding opportunity of identical scientific scope, “HIGH THROUGHPUT TOOLS FOR BRAIN AND BEHAVIOR” (PA-06-024) that will utilize the Small Business Technology Transfer (STTR [R41/R42]) grant mechanism. - Budgets up to $ 200,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $ 450,000 total costs per year and up to 3 years may be requested for Phase II. - No funds have been specifically set aside for this program; the number of awards and the amount of funds provided for awards have not been predetermined. - Only United States SBCs are eligible to submit SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. I.A. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an SBIR application, the Project Director/Principal Investigator (PD/PI) must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (MS Word) http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (PDF) - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088.

- The purpose of this FOA is to invite applications by small business concerns (SBC) for the commercial development of technologies for high throughput data acquisition and analysis that could aid the research fields of basic behavioral science or neuroscience relevant to the mission of the National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS).  - Only STTR Phase I, Phase II, and Fast Track grant applications are solicited by this FOA. - This funding opportunity will be run in parallel with a funding opportunity of identical scientific scope, “HIGH THROUGHPUT TOOLS FOR BRAIN AND BEHAVIOR” (PA-06-023) that will utilize the Small Business Innovation Research (SBIR [R43/R44] grant mechanisms. - Budgets up to $200,000 total costs per year and time periods up to 2 years for Phase I may be requested. Budgets up to $450,000 total costs per year and up to 3 years may be requested for Phase II. - No funds have been specifically set aside for this program; the number of awards and the amount of funds provided for awards have not been predetermined. - Only United States SBCs are eligible to submit STTR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III.I.A. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an STTR application, the Project Director/Principal Investigator (PD/PI) may be employed with the small business concern or the participating non-profit research institution as long as he/she has a formal appointment with or commitment to the applicant small business concern, which is characterized by an official relationship between the small business concern and that individual. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct.·  - See Section IV for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (MS Word) http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (PDF) - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- This FOA requests applications using the SBIR Cooperative Agreement (U44) mechanism to provide support for Phase II, and Fast-Track projects that directly address identification and pre-clinical testing of new therapeutics. - Only Aims required for therapy development can be supported in this program. No basic/mechanistic Aims may be included in the research plan. - There is no specific limit on the total funds that will be awarded under this FOA or on the number of awards. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. - This FOA employs the SBIR (U44) cooperative agreement mechanism. Applications may be submitted for support as Phase II or Fast-Track grants. Phase II applicants may request a project period of up to three years and a budget of up to $750,000 total costs per year, or $1 million total costs per year if studies required for IND or IDE filing with the FDA are included. Applicants may request a project period of up to two years and a budget of up $300,000 total costs per year for the Phase I part of a Fast-Track application.  - Initial merit review is convened by the NINDS Scientific Review Branch. - Only U.S. small business concerns are eligible to submit SBIR applications. A small business concern is one that, on the date of award, meets ALL of the criteria as described in Section III. I.A. of this announcement. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. The Project Director/Principal Investigator (PD/PI) must have his/her primary employment (more than 50%) with the small business at the time of award and for the duration of the project, which precludes full-time employment elsewhere. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (MS Word) http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (PDF) - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088.

- This Funding Opportunity Announcement (FOA), issued as an initiative of the trans-NIH Bioengineering Consortium (BECON) on behalf of the participating Institutes and Centers, invites Small Business Technology Transfer (STTR) grant applications for projects for developing and applying nanotechnology to biomedicine.Nanotechnology is defined as the creation of functional materials, devices and systems through control of matter at the scale of 1 to 100 nanometers, and the exploitation of novel properties and phenomena at the same scale.Nanotechnology is emerging as a field critical for enabling essential breakthroughs that may have tremendous potential for affecting biomedicine.Moreover, nanotechnologies developed in the next several years may well form the foundation of significant commercial platforms that shift the paradigms of clinical applications. - Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. - This funding opportunity will use the STTR (R41/R42) grant mechanism. - This funding opportunity will be run in parallel with a FOA of identical scientific scope, (PA-06-009) that will utilize the Small Business Innovation Research (SBIR [R43/R44]) grant mechanism. - Only United States SBCs are eligible to submit SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. I.A. -Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2…(MS Word) http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088.

- This funding opportunity will utilize the Small Business Technology Transfer (STTR) mechanism, but will be run in parallel with a funding opportunity announcement of identical scientific scope (RFA-DK-05-016) that will utilize the Small Business Innovation Research (SBIR) grant mechanism. - The National Institute of Diabetes, Digestive and Kidney diseases (NIDDK), National Eye Institute (NEI), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of Child Health and Human development (NICHD) invite the small business community to apply cutting edge technology to investigate the development of new approaches to predict, prevent, treat, and cure type 1 Diabetes (T1D) and its complications. - The total funds available will be approximately $500,000 in FY2006. - The participating institutes intend to fund 2-4 Phase I, Phase II or Fast Track STTR projects. - Eligibility requirements are described in Section III. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her institution to develop an application for support. Individuals for underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an STTR application, the Project Director/Principal Investigator (PD/PI) may be employed with the small business concern or the participating non-profit research institution as long as he/she has a formal appointment with or commitment to the applicant small business concern, which is characterized by an official relationship between the small business concern and that individual. - Applicants may submit more than one application, provided they are scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR.doc&n…;(MS Word) http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR.pdf&n…;(PDF) - Applicants are encouraged to return to these links for the most current version of these instructions. - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- This funding opportunity will utilize the Small Business Innovation Research (SBIR) mechanism, but will be run in parallel with a program announcement of identical scientific scope (RFA-DK-05-015) that will utilize the Small Business Technology Transfer (STTR) grant mechanism. - The National Institute of Diabetes, Digestive and Kidney diseases (NIDDK), National Eye Institute (NEI), National Heart, Lung, and Blood Institute (NHLBI), National Institute of Allergy and Infectious Diseases (NIAID), National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of Child Health and Human development (NICHD) invite the small business community to apply cutting edge technology to investigate the development of new approaches to predict, prevent, treat, and cure type 1 Diabetes (T1D) and its complications. - The total funds available will be approximately $3.5 million in FY2006. - The participating institutes intend to fund 6-8 Phase I, Phase II or Fast Track SBIR projects.  - Eligibility requirements are described in Section III. Only small business concerns are eligible to submit SBIR applications. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her institution to develop an application for support. Individuals for underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an SBIR application, the Project Director/Principal Investigator (PD/PI) must have his/her primary employment (more than 50%) with the small business at the time of award and for the duration of the project. - Applicants may submit more than one application, provided they are scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR.doc&n…;(MS Word) http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR.pdf&n…;(PDF) Applicants are encouraged to return to these links for the most current version of these instructions. - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- The participating institutes of the National Institutes of Health invite the small business community to apply cutting edge-technology to develop new approaches and chemical modifications that will increase the long term stability, delivery and targeting of siRNAs in cells and tissues for laboratory and therapeutic applications. - The number of awards made under this solicitation will depend on the overall scientific merit of the applications and the availability of funds. - This PA uses the SBIR mechanisms. - Only small business concerns are eligible to submit applications. - This funding opportunity will utilize the Small Business Innovation Research (SBIR) mechanism, but will be run in parallel with a program announcement of identical scientific scope (PA-06-004) that will utilize the Small Business Technology Transfer (STTR) grant mechanism. - Only United States SBCs are eligible to submit SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. I.A. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an SBIR application, the Project Director/Principal Investigator (PD/PI) must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2…;(MS Word) http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2…;(PDF) - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - SF424 (R&R) Application and Electronic Submission Information: http://grants.nih.gov/grants/funding/424/index.htm - General information on Electronic Submission of Grant Applications: http://era.nih.gov/ElectronicReceipt/ - Telecommunications for the hearing impaired is available at: TTY 301-451-0088

- The participating institutes of the National Institutes of Health invite the small business community to apply cutting edge-technology to develop new approaches and chemical modifications that will increase the long term stability, delivery and targeting of siRNAs in cells and tissues for laboratory and therapeutic applications. - The number of awards made under this solicitation will depend on the overall scientific merit of the applications and the availability of funds. - This PA uses the STTR (R41/R42) mechanisms. - This funding opportunity will utilize the Small Business Technology Transfer (STTR) mechanism, but will be run in parallel with a program announcement of identical scientific scope (PA-06-003) that will utilize the Small Business Innovation Research (SBIR) grant mechanism. - Only United States SBCs are eligible to submit SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III. I.A. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an SBIR application, the Project Director/Principal Investigator (PD/PI) must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (MS Word) and http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (PDF). Applicants are encouraged to return to these links for the most current version of these instructions. - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: http://grants.nih.gov/grants/funding/424/index.htm http://era.nih.gov/ElectronicReceipt. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088