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This Program Announcement with review (PAR) invites applications for the Morris K. Udall Parkinsons Disease Centers of Excellence Program.

- The National Cancer Institute (NCI), the National Institute of Environmental Health Sciences (NIEHS), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute of Neurological Disorders and Stroke (NINDS) invite Small Business Technology Transfer (STTR) applications from small business concerns (SBCs) for the development and delivery of novel in vivo image acquisition or enhancement technologies and methods for biomedical imaging and image-guided interventions and therapy (applications may incorporate limited pilot or clinical feasibility evaluations using either pre-clinical models or clinical studies). - This funding opportunity is primarily intended to facilitate the proof-of-feasibility, development, and delivery of novel imaging technologies for early detection, screening, diagnosis, image-guided interventions and treatments of various diseases, and, secondarily, to facilitate limited evaluation studies to show proof-of-concept and functionality. - Research partnerships among investigators in both academia and device and drug industries are encouraged to more rapidly translate and deliver completed imaging system developments.

This funding opportunity announcement (FOA) from the National Cancer Institute (NCI), the National Institute of Environmental Health Sciences (NIEHS), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute of Neurological Disorders and Stroke (NINDS) invites Small Business Innovation Research (SBIR) applications from small business concerns (SBCs) for the development and delivery of novel in vivo image acquisition or enhancement technologies and methods for biomedical imaging and image-guided interventions and therapy (applications may incorporate limited pilot or clinical feasibility evaluations using either pre-clinical models or clinical studies).

- The goal of this Initiative is to create a clinical research network of emergency medicine physicians, neurologists, and neurosurgeons who will work together to efficiently develop more and better treatments for patients with acute neurological disorders through execution of NINDS-sponsored clinical trials - Funding of the clinical sites (hubs) and funding of the statistical coordinating center will be through separate RFAs. The statistical center RFA will follow the clinical coordinating center RFA by 6-12 months.

The Fogarty International Center (FIC) invites applications for International Research Ethics Education and Curriculum Development awards to develop graduate level curricula and provide opportunities for developing country academics, researchers and health professionals in international research ethics related to performing research involving human subjects.  New applications focusing on research ethics education/training for Mexico, Central America, China, Brazil, Thailand, Vietnam, Nigeria, Russia and the countries of the former Soviet Union are especially encouraged. U.S. and foreign applicants can request up to four years of support for up to $250,000 total costs (direct and F and A) per year for comprehensive curriculum development and training programs. Developing country applicants can request up to two years of support to $25,000 total costs (direct and F and A) per year for program planning and curriculum development in preparation to apply for comprehensive research educational program support in the future.

This funding opportunity provides updated guidelines for National Institutes of Health (NIH) support of conferences and scientific meetings. Because the nature and scope of the proposed activities will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the number of applications, quality, duration, and costs of the applications received. This funding opportunity announcement (FOA) will use the NIH conference grant (R13) and conference cooperative agreement (U13) award mechanisms.

The purpose of the Academic Research Enhancement Award (AREA) program is to stimulate research in educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation's research scientists, but that have not been major recipients of NIH support. These AREA grants create opportunities for scientists and institutions otherwise unlikely to participate extensively in NIH programs, to contribute to the Nation's biomedical and behavioral research effort.

- This Funding Opportunity Announcement (FOA), issued as an initiative of the trans-NIH Bioengineering Consortium (BECON) on behalf of the participating Institutes and Centers, invites Small Business Innovation Research (SBIR) grant applications for projects for developing and applying nanotechnology to biomedicine. Nanotechnology is defined as the creation of functional materials, devices and systems through control of matter at the scale of 1 to 100 nanometers, and the exploitation of novel properties and phenomena at the same scale. Nanotechnology is emerging as a field critical for enabling essential breakthroughs that may have tremendous potential for affecting biomedicine. Moreover, nanotechnologies developed in the next several years may well form the foundation of significant commercial platforms that shift the paradigms of clinical applications. - Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. - This funding opportunity will use the SBIR (R43/R44) grant mechanisms. - This funding opportunity will be run in parallel with a program announcement of identical scientific scope (PA-06-008) that will utilize the Small Business Technology Transfer (STTR) grant mechanism. - Only United States SBCs are eligible to submit SBIR applications. A SBC is one that, on the date of award for both Phase I and Phase II funding agreements, meets ALL of the criteria as described in Section III.I.A. - Any individual with the skills, knowledge, and resources necessary to carry out the proposed research is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs. On an SBIR application, the Project Director/Principal Investigator (PD/PI) must have his/her primary employment (more than 50%) with the SBC at the time of award and for the duration of the project. - Applicant SBCs may submit more than one application, provided each application is scientifically distinct. - See Section IV.1 for application materials. The application instructions for this Funding Opportunity Announcement (FOA) are located at the following links: http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (MS Word) and http://grants.nih.gov/grants/funding/424/SF424_RR_Guide_SBIR_STTR_Ver2… (PDF). Applicants are encouraged to return to these links for the most current version of these instructions. - For general information on SF424 (R&R) Application and Electronic Submission, see the following Web sites: - http://grants.nih.gov/grants/funding/424/index.htm - http://era.nih.gov/ElectronicReceipt. - Telecommunications for the hearing impaired is available at: TTY 301-451-0088.

On February 26, 2004, Executive Order 13329 (http://a257.g.akamaitech.net/7/257/2422/14mar20010800/edocket.access.gp…) was signed by President George W. Bush requiring agencies with Small Business Innovation Research (SBIR) and Small Business Technology Transfer (STTR) programs, to the extent permitted by law and in a manner consistent with the mission of the Department, to give high priority within the SBIR and STTR programs to manufacturing-related research and development (R&D).In response to this Executive Order, NIH is expanding its focus by encouraging eligible United States small business concerns to submit STTR Phase I, Phase II, and Fast-Track grant applications whose biomedical research is related to advanced processing, manufacturing processes, equipment and systems, and manufacturing workforce skills and protection.

On February 26, 2004, Executive Order 13329 (http://a257.g.akamaitech.net/7/257/2422/14mar20010800/edocket.access.gp…) was signed by President George W. Bush requiring SBIR/STTR agencies, to the extent permitted by law and in a manner consistent with the mission of the Department, to give high priority within the SBIR and STTR programs to manufacturing-related research and development (R&D).In response to this Executive Order, NIH is expanding its focus by encouraging eligible United States small business concerns to submit SBIR Phase I, Phase II, and Fast-Track grant applications whose biomedical research is related to advanced processing, manufacturing processes, equipment and systems, and manufacturing workforce skills and protection.