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The National Institute on Neurological Disorders and Stroke (NINDS) Research Education grant is a flexible and specialized mechanism designed to foster the development of neuroscience researchers through creative and innovative educational programs. The overall goal of the NINDS research training and research education programs is to ensure that highly trained scientists will make future advances that lead to a reduction in the burden of neurological disease.These research education grants will create an opportunity for medical residents and fellows to participate in an intensive 9 to 24 months of mentored research education experience during residency and fellowship years. This opportunity will include the necessary training for successful competition for independent mentored research awards and will facilitate the transition from fellow/resident to clinician-scientist.In addition to laboratory research skills, participants in the program will develop the critical skills necessary to design and conduct research experiments and write competitive grant applications.

-Purpose. To solicit research applications proposing preclinical studies using multi-drug therapies to attenuate neurological injury and/or to enhance recovery after traumatic brain injury (TBI). -Mechanism of Support. This Funding Opportunity Announcement (FOA) will utilize the Research Project (R01) grant mechanism. -Funds Available and Anticipated Number of Awards. The NICHD intends to commit approximately $2 million in total costs (direct plus Facilities and Administrative costs) in FY 2009. The NINDS intends to commit 750,000 in total costs (direct plus Facilities and Administrative costs) in FY2009. It is anticipated that up to 5 new grants will be made in response to this FOA.

-The goals of NIH-supported career development programs are to help ensure that diverse pools of highly trained scientists are available in adequate numbers and in appropriate research areas to address the Nation's biomedical, behavioral, and clinical research needs. -Purpose: The purpose of the Midcareer Investigator Award in Patient-Oriented Research is to provide support to mid-career health-professional doctorates or equivalent who are typically at the Associate Professor level or the equivalent (see Section III. Eligible Individuals) for protected time to devote to patient-oriented research (POR) and to act as research mentors primarily for clinical residents, clinical fellows and/or junior clinical faculty. The intent of this award is two-fold: 1) to enable mid-career clinician scientists to devote more time and to augment their capabilities in patient-oriented research; and 2) to enable mid-career clinical scientists to mentor new clinical investigators in the conduct of patient-oriented research. An award recipient who continues to have an independent peer-reviewed patient-oriented research program and continues to provide mentoring to new investigators can continue to contribute to the overall goals of the program after being promoted to Full professor.

-Purpose. The NIH Blueprint for Neuroscience Research is a framework to enhance cooperative activities among the NIH Office of the Director and 15 NIH Institutes and Centers that support research on the nervous system (for further information, see http://neuroscienceblueprint.nih.gov/). This Funding Opportunity Announcement (FOA) is released in affiliation with the Neuroscience Blueprint, with Institutes and Centers participating independently. This Funding Opportunity Announcement (FOA) encourages Small Business Innovation Research (SBIR) grant applications from small business concerns (SBCs) that propose to focus on the development of tools or techniques that will significantly advance the current state of the art in neuroplasticity research. Although applications will not be restricted to a particular type of technology, NIH is especially interested in applications that seek to harness the ability to assess and manipulate activity with exquisite subcellular resolution, and in cells specified by their circuit connectivity and/or transmitter phenotype. -Mechanism of Support. This FOA will utilize the NIH SBIR (R43/R44) grant mechanisms for Phase I, Phase II, and Fast-Track applications and runs in parallel with an FOA of identical scientific scope,RFA-MH-09-030, which encourages R01 applications.

-urpose: The purpose of the NIH Research Conference Grant Program (R13 and U13) is to support high quality conferences/scientific meetings that are relevant to the scientific mission of the NIH and to the public health. A conference/scientific meeting is defined as a gathering, symposium, seminar, scientific meeting, workshop or any other organized, formal meeting where persons assemble to coordinate, exchange, and disseminate information or to explore or clarify a defined subject, problem, or area of knowledge. Each NIH Institute and Center (IC) has a scientific purview and different program goals and initiatives that evolve over time. Prior to preparing an application, it is critical that all applicants consult the appropriate IC representative listed in the R13/U13 Website (http://grants.nih.gov/grants/funding/r13/) to obtain current information about IC specific program priorities and policies. This action is of utmost importance because applications with marginal or no relevance to the participating Institutes will not be accepted for review or possible funding. In addition, applicants are encouraged to consult the Frequently Asked Questions Website for more detailed information about this program: http://grants.nih.gov/grants/funding/r13/index.htm -Mechanism of Support: This FOA will utilize the NIH conference grant (R13) and conference cooperative agreement (U13) award mechanisms. -Funds Available and Anticipated Number of Awards: Because the nature and scope of the proposed activities will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the number of applications, quality, duration, and costs of the applications received.

-Purpose. The National Institute of Allergy and Infectious Diseases (NIAID), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) the National Institute of Neurological Disorders and Stroke (NINDS), and the Office of Research on Women's Health (ORWH) invite applications from institutions that propose to accelerate the discovery and development of therapies for autoimmune diseases through their participation in the Autoimmunity Centers of Excellence (ACE) program. The ACE network of biomedical research centers will foster collaborations among basic and clinical scientists and facilitate cooperative clinical trials in autoimmune diseases. Each application in response to this FOA must include: (1) a clinical component, (2) a research component, (3) a pilot research project, and (4) cores that participate in cooperative and collaborative projects within each Center and among the Centers. -Mechanism of Support. This FOA will use the multi-project NIH U19 Cooperative Agreement award mechanism. -Funds Available and Anticipated Number of Awards. NIAID, NIDDK, NIAMS, NINDS, and ORWH anticipate awarding $7.2 million in total costs in FY 2009 to fund up to 9 new or competing renewal grants. An additional $4.9 million in total costs per year will be available in a Discretionary Fund to support clinical trials and other group activities as described be

-Purpose. This FOA encourages investigator-initiated applications designed to exploit the power of the zebrafish as a vertebrate model for biomedical and behavioral research.Applications proposing to develop new genetic screens of high priority to the zebrafish community that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development and aging, organ formation, neural processes, behavior, sensory processes, physiological processes, and disease processes are welcome.This effort stems from an NIH initiative developed by the Institutes and Centers of the Trans-NIH Zebrafish Coordinating Committee (TZCC) under the co-chairmanship of NICHD and NIDDK. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

-Purpose. This FOA encourages investigator-initiated applications designed to exploit the power of the zebrafish as a vertebrate model for biomedical and behavioral research.Applications proposing to develop new research tools or techniques that are of high priority to the zebrafish community and that will advance the detection and characterization of genes, pathways, and phenotypes of interest in development and aging, organ formation, neural processes, behavior, sensory processing, physiological processes, and disease processes are welcome.This effort stems from an NIH initiative developed by the Institutes and Centers of the Trans-NIH Zebrafish Coordinating Committee (TZCC) under the co-chairmanship of NICHD and NIDDK. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

-Purpose. This Funding Opportunity Announcement (FOA) is issued as an initiative of the NIH Blueprint for Neuroscience Research. The Neuroscience Blueprint is a collaborative framework through which 16 NIH Institutes, Centers and Offices jointly support neuroscience-related research, with the aim of accelerating discoveries and reducing the burden of nervous system disorders (for further information, see http://neuroscienceblueprint.nih.gov/). Applications are solicited for support of projects that will develop probes, instrumentation, and other tools for understanding, monitoring, and manipulating nervous system plasticity. This FOA will focus on the development of tools or techniques that will significantly advance the current state of the art in neuroplasticity research. Although applications will not be restricted to a particular type of technology, we are especially interested in applications that seek to harness the ability to assess and manipulate activity with exquisite subcellular resolution, and in cells specified by their circuit connectivity and/or transmitter phenotype. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an SBIR FOA that will be posted at a later date.

-Purpose.NINDS Center Core Grants will support centralized resources and facilities shared by investigators with existing NINDS-funded research projects.Each Center will be composed of one or more research cores, each of which will enrich the effectiveness of ongoing research, and promote new research directions.There should be no overlap between the requested core facilities and other pre-existing core facilities. -Mechanism of Support.This Funding Opportunity Announcement (FOA) will use the NIH Center Core Grants (P30) award mechanism. -Funds Available and Anticipated Number of Awards.Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary.NINDS has not specified a maximum number of awards or a maximum total amount of funding that will be awarded under this FOA.