CounterACT Publications 2018

 

 

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Neurotoxic Agents

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, De Araujo Furtado M, Braga MFM. Full Protection Against Soman-Induced Seizures and Brain Damage by LY293558 and Caramiphen Combination Treatment in Adult Rats. Neurotox Res. 2018 Oct;34(3):511-524. doi: 10.1007/s12640-018-9907-1. Epub 2018 Apr 30. PubMed PMID: 29713995.

Aroniadou-Anderjaska V, Pidoplichko VI, Figueiredo TH, Braga MFM. Oscillatory Synchronous Inhibition in the Basolateral Amygdala and its Primary Dependence on NR2A-containing NMDA Receptors. Neuroscience. 2018 Mar 1;373:145-158. doi: 10.1016/j.neuroscience.2018.01.021. Epub 2018 Jan 13. PubMed PMID: 29339324.

Bever CS, Barnych B, Hnasko R, Cheng LW, Stanker LH. A New Conjugation Method Used for the Development of an Immunoassay for the Detection of Amanitin, a Deadly Mushroom Toxin. Toxins (Basel). 2018 Jun 28;10(7). doi: 10.3390/toxins10070265. PubMed PMID: 29958410; PubMed Central PMCID: PMC6070930.

Chao CK, Balasubramanian N, Gerdes JM, Thompson CM. The inhibition, reactivation and mechanism of VX-, sarin-, fluoro-VX and fluoro-sarin surrogates following their interaction with HuAChE and HuBuChE. Chem Biol Interact. 2018 Aug 1;291:220-227. doi: 10.1016/j.cbi.2018.06.019. Epub 2018 Jun 18. PubMed PMID: 29920286; PubMed Central PMCID: PMC6061941.

Chuang SH, Reddy DS. 3β-Methyl-Neurosteroid Analogs Are Preferential Positive Allosteric Modulators and Direct Activators of Extrasynaptic δ-Subunit γ-Aminobutyric Acid Type A Receptors in the Hippocampus Dentate Gyrus Subfield. J Pharmacol Exp Ther. 2018 Jun;365(3):583-601. doi: 10.1124/jpet.117.246660. Epub 2018 Mar 30. PubMed PMID: 29602830; PubMed Central PMCID: PMC5941194.

Chuang SH, Reddy DS. Genetic and Molecular Regulation of Extrasynaptic GABA-A Receptors in the Brain: Therapeutic Insights for Epilepsy. J Pharmacol Exp Ther. 2018 Feb;364(2):180-197. doi: 10.1124/jpet.117.244673. Epub 2017 Nov 15. Review. PubMed PMID: 29142081; PubMed Central PMCID: PMC5771312.

Dhir A, Rogawski MA. Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats. Epilepsia. 2018 May;59(5):935-944. doi: 10.1111/epi.14069. Epub 2018 Apr 6. PubMed PMID: 29682729; PubMed Central PMCID: PMC5934328.

Figueiredo TH, Apland JP, Braga MFM, Marini AM. Acute and long-term consequences of exposure to organophosphate nerve agents in humans. Epilepsia. 2018 Oct;59 Suppl 2:92-99. doi: 10.1111/epi.14500. Epub 2018 Aug 29. Review. PubMed PMID: 30159887; PubMed Central PMCID: PMC6172147.

González EA, Carty DR, Tran FD, Cole AM, Lein PJ. Developmental exposure to silver nanoparticles at environmentally relevant concentrations alters swimming behavior in zebrafish (Danio rerio). Environ Toxicol Chem. 2018 Dec;37(12):3018-3024. doi: 10.1002/etc.4275. Epub 2018 Nov 8. PubMed PMID: 30242895; PubMed Central PMCID: PMC6457247.

Hagstrom D, Zhang S, Ho A, Tsai ES, Radić Z, Jahromi A, Kaj KJ, He Y, Taylor P, Collins ES. Planarian cholinesterase: molecular and functional characterization of an evolutionarily ancient enzyme to study organophosphorus pesticide toxicity. Arch Toxicol. 2018 Mar;92(3):1161-1176. doi: 10.1007/s00204-017-2130-7. Epub 2017 Nov 22. PubMed PMID: 29167930; PubMed Central PMCID: PMC6413736.

Hampe AE, Li Z, Sethi S, Lein PJ, Seker E. A Microfluidic Platform to Study Astrocyte Adhesion on Nanoporous Gold Thin Films. Nanomaterials (Basel). 2018 Jun 21;8(7). doi: 10.3390/nano8070452. PubMed PMID: 29933551; PubMed Central PMCID: PMC6070884.

Hayes TR, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF. Radiosynthesis of O-(1-[18 F]fluoropropan-2-yl)-O-(4-nitrophenyl)methylphosphonate: A novel PET tracer surrogate of sarin. J Labelled Comp Radiopharm. 2018 Dec;61(14):1089-1094. doi: 10.1002/jlcr.3688. Epub 2018 Nov 4. PubMed PMID: 30347484; PubMed Central PMCID: PMC6661111.

Hobson BA, Rowland DJ, Supasai S, Harvey DJ, Lein PJ, Garbow JR. A magnetic resonance imaging study of early brain injury in a rat model of acute DFP intoxication. Neurotoxicology. 2018 May;66:170-178. doi: 10.1016/j.neuro.2017.11.009. Epub 2017 Nov 26. PubMed PMID: 29183789; PubMed Central PMCID: PMC5940565.

Hossain MM, Weig B, Reuhl K, Gearing M, Wu LJ, Richardson JR. The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6. Exp Neurol. 2018 Oct;308:111-119. doi: 10.1016/j.expneurol.2018.07.005. Epub 2018 Jul 12. PubMed PMID: 30017881.

Klein P, Dingledine R, Aronica E, Bernard C, Blümcke I, Boison D, Brodie MJ, Brooks-Kayal AR, Engel J Jr, Forcelli PA, Hirsch LJ, Kaminski RM, Klitgaard H, Kobow K, Lowenstein DH, Pearl PL, Pitkänen A, Puhakka N, Rogawski MA, Schmidt D, Sillanpää M, Sloviter RS, Steinhäuser C, Vezzani A, Walker MC, Löscher W. Commonalities in epileptogenic processes from different acute brain insults: Do they translate?. Epilepsia. 2018 Jan;59(1):37-66. doi: 10.1111/epi.13965. Epub 2017 Dec 15. Review. PubMed PMID: 29247482; PubMed Central PMCID: PMC5993212.

Kuruba R, Wu X, Reddy DS. Benzodiazepine-refractory status epilepticus, neuroinflammation, and interneuron neurodegeneration after acute organophosphate intoxication. Biochim Biophys Acta Mol Basis Dis. 2018 Sep;1864(9 Pt B):2845-2858. doi: 10.1016/j.bbadis.2018.05.016. Epub 2018 May 23. PubMed PMID: 29802961; PubMed Central PMCID: PMC6066461.

Lauková M, Velíšková J, Velíšek L, Shakarjian MP. Developmental and sex differences in tetramethylenedisulfotetramine (TMDT)-induced syndrome in rats. Dev Neurobiol. 2018 Apr;78(4):403-416. doi: 10.1002/dneu.22582. Epub 2018 Feb 14. PubMed PMID: 29411537; PubMed Central PMCID: PMC5867264.

Liang LP, Pearson-Smith JN, Huang J, McElroy P, Day BJ, Patel M. Neuroprotective Effects of AEOL10150 in a Rat Organophosphate Model. Toxicol Sci. 2018 Apr 1;162(2):611-621. doi: 10.1093/toxsci/kfx283. PubMed PMID: 29272548; PubMed Central PMCID: PMC5888936.

Marrero-Rosado B, de Araujo Furtado M, Schultz CR, Stone M, Kundrick E, Walker K, O'Brien S, Du F, Lumley LA. Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam. Epilepsia. 2018 Dec;59(12):2206-2218. doi: 10.1111/epi.14582. Epub 2018 Oct 25. PubMed PMID: 30368799; PubMed Central PMCID: PMC6334636.

Neal M, Richardson JR. Time to get Personal: A Framework for Personalized Targeting of Oxidative Stress in Neurotoxicity and Neurodegenerative Disease. Curr Opin Toxicol. 2018 Feb;7:127-132. doi: 10.1016/j.cotox.2018.02.003. Epub 2018 Feb 15. PubMed PMID: 30272040; PubMed Central PMCID: PMC6157269.

Neal M, Richardson JR. Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration. Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):432-443. doi: 10.1016/j.bbadis.2017.11.004. Epub 2017 Nov 4. Review. PubMed PMID: 29113750; PubMed Central PMCID: PMC5743548.

Neal ML, Boyle AM, Budge KM, Safadi FF, Richardson JR. The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor. J Neuroinflammation. 2018 Mar 8;15(1):73. doi: 10.1186/s12974-018-1100-1. PubMed PMID: 29519253; PubMed Central PMCID: PMC5842560.

Neumann KD, Blecha JE, Hayes TR, Huynh T, Chao CK, Guilloteau N, Zinn KR, VanBrocklin HF, Thompson CM, Gerdes JM. Radiosynthesis, ex Vivo Biodistribution, and in Vivo Positron Emission Tomography Imaging Evaluations of [11C]2-Pyridinealdoxime Methiodide ([11C]2-PAM): A First-In-Class Antidote Tracer for Organophosphate Intoxication. ACS Chem Neurosci. 2018 Dec 19;9(12):3007-3014. doi: 10.1021/acschemneuro.8b00212. Epub 2018 Aug 20. PubMed PMID: 30071719; PubMed Central PMCID: PMC6699170.

Patel M. A Metabolic Paradigm for Epilepsy. Epilepsy Curr. 2018 Sep-Oct;18(5):318-322. doi: 10.5698/1535-7597.18.5.318. PubMed PMID: 30464734; PubMed Central PMCID: PMC6224150.

Pressly B, Nguyen HM, Wulff H. GABAA receptor subtype selectivity of the proconvulsant rodenticide TETS. Arch Toxicol. 2018 Feb;92(2):833-844. doi: 10.1007/s00204-017-2089-4. Epub 2017 Oct 16. PubMed PMID: 29038840; PubMed Central PMCID: PMC5818616.

Pringle RB, Meek EC, Chambers HW, Chambers JE. Neuroprotection From Organophosphate-Induced Damage by Novel Phenoxyalkyl Pyridinium Oximes in Rat Brain. Toxicol Sci. 2018 Dec 1;166(2):420-427. doi: 10.1093/toxsci/kfy212. PubMed PMID: 30496567; PubMed Central PMCID: PMC6260155.

Reddy DS, Chuang SH, Hunn D, Crepeau AZ, Maganti R. Neuroendocrine aspects of improving sleep in epilepsy. Epilepsy Res. 2018 Nov;147:32-41. doi: 10.1016/j.eplepsyres.2018.08.013. Epub 2018 Aug 31. Review. PubMed PMID: 30212766; PubMed Central PMCID: PMC6192845.

Reddy DS. GABA-A Receptors Mediate Tonic Inhibition and Neurosteroid Sensitivity in the Brain. Vitam Horm. 2018;107:177-191. doi: 10.1016/bs.vh.2017.12.001. Epub 2018 Feb 9. Review. PubMed PMID: 29544630.

Rojas A, Wang W, Glover A, Manji Z, Fu Y, Dingledine R. Beneficial Outcome of Urethane Treatment Following Status Epilepticus in a Rat Organophosphorus Toxicity Model. eNeuro. 2018 Mar-Apr;5(2). doi: 10.1523/ENEURO.0070-18.2018. eCollection 2018 Mar-Apr. PubMed PMID: 29766039; PubMed Central PMCID: PMC5952304.

Thompson KW, Suchomelova L, Wasterlain CG. Treatment of early life status epilepticus: What can we learn from animal models?. Epilepsia Open. 2018 Dec;3(Suppl Suppl 2):169-179. doi: 10.1002/epi4.12271. eCollection 2018 Dec. PubMed PMID: 30564776; PubMed Central PMCID: PMC6293069.

Tu R, Armstrong J, Lee KSS, Hammock BD, Sapirstein A, Koehler RC. Soluble epoxide hydrolase inhibition decreases reperfusion injury after focal cerebral ischemia. Sci Rep. 2018 Mar 27;8(1):5279. doi: 10.1038/s41598-018-23504-1. PubMed PMID: 29588470; PubMed Central PMCID: PMC5869703.

Velíšková J, Silverman JL, Benson M, Lenck-Santini PP. Autistic traits in epilepsy models: Why, when and how?. Epilepsy Res. 2018 Aug;144:62-70. doi: 10.1016/j.eplepsyres.2018.05.009. Epub 2018 May 18. Review. PubMed PMID: 29783181; PubMed Central PMCID: PMC5978734.

Wang F, Zhang H, Ma AH, Yu W, Zimmermann M, Yang J, Hwang SH, Zhu D, Lin TY, Malfatti M, Turteltaub KW, Henderson PT, Airhart S, Hammock BD, Yuan J, de Vere White RW, Pan CX. COX-2/sEH Dual Inhibitor PTUPB Potentiates the Antitumor Efficacy of Cisplatin. Mol Cancer Ther. 2018 Feb;17(2):474-483. doi: 10.1158/1535-7163.MCT-16-0818. Epub 2017 Dec 28. PubMed PMID: 29284644; PubMed Central PMCID: PMC5824635.

Wu X, Kuruba R, Reddy DS. Midazolam-Resistant Seizures and Brain Injury after Acute Intoxication of Diisopropylfluorophosphate, an Organophosphate Pesticide and Surrogate for Nerve Agents. J Pharmacol Exp Ther. 2018 Nov;367(2):302-321. doi: 10.1124/jpet.117.247106. Epub 2018 Aug 16. PubMed PMID: 30115757; PubMed Central PMCID: PMC6193253.

Zolkowska D, Wu CY, Rogawski MA. Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus. Epilepsia. 2018 Oct;59 Suppl 2:220-227. doi: 10.1111/epi.13999. Epub 2018 Feb 17. PubMed PMID: 29453777.
 

Vesicating Agents

Achanta S, Chintagari NR, Brackmann M, Balakrishna S, Jordt SE. TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation. Toxicol Lett. 2018 Sep 1;293:140-148. doi: 10.1016/j.toxlet.2018.03.007. Epub 2018 Mar 10. PubMed PMID: 29535050; PubMed Central PMCID: PMC5975083.

Chang YC, Gordon MK, Gerecke DR. Expression of Laminin 332 in Vesicant Skin Injury and Wound Repair. Clin Dermatol (Wilmington). 2018;2(1). PubMed PMID: 30058002; PubMed Central PMCID: PMC6063082.

Chang YC, Soriano M, Hahn RA, Casillas RP, Gordon MK, Laskin JD, Gerecke DR. Expression of cytokines and chemokines in mouse skin treated with sulfur mustard. Toxicol Appl Pharmacol. 2018 Sep 15;355:52-59. doi: 10.1016/j.taap.2018.06.008. Epub 2018 Jun 20. PubMed PMID: 29935281; PubMed Central PMCID: PMC6438172.

Charkoftaki G, Jester JV, Thompson DC, Vasiliou V. Nitrogen mustard-induced corneal injury involves the sphingomyelin-ceramide pathway. Ocul Surf. 2018 Jan;16(1):154-162. doi: 10.1016/j.jtos.2017.11.004. Epub 2017 Nov 10. PubMed PMID: 29129753.

Das LM, Binko AM, Traylor ZP, Duesler L, Lu KQ. Defining the timing of 25(OH)D rescue following nitrogen mustard exposure. Cutan Ocul Toxicol. 2018 Jun;37(2):127-132. doi: 10.1080/15569527.2017.1355315. Epub 2017 Aug 8. PubMed PMID: 28737434; PubMed Central PMCID: PMC6025804.

Eveleth DD, Eveleth JJ, Subramaniam A, Hahn R, Zhou P, Gordon MK, Bradshaw RA. An Engineered Human Fibroblast Growth Factor-1 Derivative, TTHX1114, Ameliorates Short-term Corneal Nitrogen Mustard Injury in Rabbit Organ Cultures. Invest Ophthalmol Vis Sci. 2018 Sep 4;59(11):4720-4730. doi: 10.1167/iovs.18-24568. PubMed PMID: 30267094; PubMed Central PMCID: PMC6155473.

Joseph LB, Composto GM, Perez RM, Kim HD, Casillas RP, Heindel ND, Young SC, Lacey CJ, Saxena J, Guillon CD, Croutch CR, Laskin JD, Heck DE. Sulfur mustard induced mast cell degranulation in mouse skin is inhibited by a novel anti-inflammatory and anticholinergic bifunctional prodrug. Toxicol Lett. 2018 Sep 1;293:77-81. doi: 10.1016/j.toxlet.2017.11.005. Epub 2017 Nov 7. PubMed PMID: 29127031; PubMed Central PMCID: PMC5938161.

Moretti A, Li Q, Chmielowski R, Joseph LB, Moghe PV, Uhrich KE. Nanotherapeutics Containing Lithocholic Acid-Based Amphiphilic Scorpion-Like Macromolecules Reduce In Vitro Inflammation in Macrophages: Implications for Atherosclerosis. Nanomaterials (Basel). 2018 Feb 2;8(2). doi: 10.3390/nano8020084. PubMed PMID: 29393918; PubMed Central PMCID: PMC5853716.

Moretti A, Li Q, Chmielowski R, Joseph LB, Moghe PV, Uhrich KE. Nanotherapeutics Containing Lithocholic Acid-Based Amphiphilic Scorpion-Like Macromolecules Reduce In Vitro Inflammation in Macrophages: Implications for Atherosclerosis. Nanomaterials (Basel). 2018 Feb 2;8(2). doi: 10.3390/nano8020084. PubMed PMID: 29393918; PubMed Central PMCID: PMC5853716.

Srivastava RK, Traylor AM, Li C, Feng W, Guo L, Antony VB, Schoeb TR, Agarwal A, Athar M. Cutaneous exposure to lewisite causes acute kidney injury by invoking DNA damage and autophagic response. Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1166-F1176. doi: 10.1152/ajprenal.00277.2017. Epub 2018 Jan 17. PubMed PMID: 29361668; PubMed Central PMCID: PMC6032074.
 

Pulmonary Agents

Aggarwal S, Ahmad I, Lam A, Carlisle MA, Li C, Wells JM, Raju SV, Athar M, Rowe SM, Dransfield MT, Matalon S. Heme scavenging reduces pulmonary endoplasmic reticulum stress, fibrosis, and emphysema. JCI Insight. 2018 Nov 2;3(21). doi: 10.1172/jci.insight.120694. PubMed PMID: 30385726; PubMed Central PMCID: PMC6238745.

Brand JD, Lazrak A, Trombley JE, Shei RJ, Adewale AT, Tipper JL, Yu Z, Ashtekar AR, Rowe SM, Matalon S, Harrod KS. Influenza-mediated reduction of lung epithelial ion channel activity leads to dysregulated pulmonary fluid homeostasis. JCI Insight. 2018 Oct 18;3(20). doi: 10.1172/jci.insight.123467. PubMed PMID: 30333319; PubMed Central PMCID: PMC6237450.

Collawn JF, Bartoszewski R, Lazrak A, Matalon S. Therapeutic attenuation of the epithelial sodium channel with a SPLUNC1-derived peptide in airway diseases. Am J Physiol Lung Cell Mol Physiol. 2018 Feb 1;314(2):L239-L242. doi: 10.1152/ajplung.00516.2017. Epub 2018 Jan 4. PubMed PMID: 29351436; PubMed Central PMCID: PMC5866505.

Duerr MA, Palladino END, Hartman CL, Lambert JA, Franke JD, Albert CJ, Matalon S, Patel RP, Slungaard A, Ford DA. Bromofatty aldehyde derived from bromine exposure and myeloperoxidase and eosinophil peroxidase modify GSH and protein. J Lipid Res. 2018 Apr;59(4):696-705. doi: 10.1194/jlr.M083279. Epub 2018 Feb 14. PubMed PMID: 29444934; PubMed Central PMCID: PMC5880502.

Fukuda S, Enkhbaatar P, Nelson C, Cox RA, Wolfson MR, Shaffer TH, Williams RO 3rd, Surasarang SH, Sawittree S, Florova G, Komissarov AA, Koenig K, Sarva K, Ndetan HT, Singh KP, Idell S. Lack of durable protection against cotton smoke-induced acute lung injury in sheep by nebulized single chain urokinase plasminogen activator or tissue plasminogen activator. Clin Transl Med. 2018 Jun 18;7(1):17. doi: 10.1186/s40169-018-0196-3. PubMed PMID: 29916009; PubMed Central PMCID: PMC6006005.

Goswami DG, Agarwal R, Tewari-Singh N. Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite. Toxicol Lett. 2018 Sep 1;293:112-119. doi: 10.1016/j.toxlet.2017.11.011. Epub 2017 Nov 12. Review. PubMed PMID: 29141200; PubMed Central PMCID: PMC5949076.

Idell S, Rahman NM. Intrapleural Fibrinolytic Therapy for Empyema and Pleural Loculation: Knowns and Unknowns. Ann Am Thorac Soc. 2018 May;15(5):515-517. doi: 10.1513/AnnalsATS.201711-848PS. PubMed PMID: 29361235; PubMed Central PMCID: PMC5955053.

Jilling T, Ren C, Yee A, Aggarwal S, Halloran B, Ambalavanan N, Matalon S. Exposure of neonatal mice to bromine impairs their alveolar development and lung function. Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L137-L143. doi: 10.1152/ajplung.00315.2017. Epub 2017 Sep 14. PubMed PMID: 28912380; PubMed Central PMCID: PMC5866428.

Johnson CG, Stober VP, Cyphert-Daly JM, Trempus CS, Flake GP, Cali V, Ahmad I, Midura RJ, Aronica MA, Matalon S, Garantziotis S. High molecular weight hyaluronan ameliorates allergic inflammation and airway hyperresponsiveness in the mouse. Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L787-L798. doi: 10.1152/ajplung.00009.2018. Epub 2018 Sep 6. PubMed PMID: 30188746; PubMed Central PMCID: PMC6425518.

Logue BA, Zhang Z, Manandhar E, Pay AL, Croutch CR, Peters E, Sosna W, Rioux JS, Veress LA, White CW. Determination of methyl isopropyl hydantoin from rat erythrocytes by gas-chromatography mass-spectrometry to determine methyl isocyanate dose following inhalation exposure. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Sep 1;1093-1094:119-127. doi: 10.1016/j.jchromb.2018.07.004. Epub 2018 Jul 5. PubMed PMID: 30015309; PubMed Central PMCID: PMC6218199.

McGraw MD, Dysart MM, Hendry-Hofer TB, Houin PR, Rioux JS, Garlick RB, Loader JE, Smith R, Paradiso DC, Holmes WW, Anderson DR, White CW, Veress LA. Bronchiolitis Obliterans and Pulmonary Fibrosis after Sulfur Mustard Inhalation in Rats. Am J Respir Cell Mol Biol. 2018 Jun;58(6):696-705. doi: 10.1165/rcmb.2017-0168OC. PubMed PMID: 29314868; PubMed Central PMCID: PMC6002659.

Miao Y, Jing JC, Desai V, Mahon SB, Brenner M, Veress LA, White CW, Chen Z. Automated 3D segmentation of methyl isocyanate-exposed rat trachea using an ultra-thin, fully fiber optic optical coherence endoscopic probe. Sci Rep. 2018 Jun 7;8(1):8713. doi: 10.1038/s41598-018-26389-2. PubMed PMID: 29880863; PubMed Central PMCID: PMC5992171.

Okponyia OC, McGraw MD, Dysart MM, Garlick RB, Rioux JS, Murphy AL, Roe GB, White CW, Veress LA. Oxygen Administration Improves Survival but Worsens Cardiopulmonary Functions in Chlorine-exposed Rats. Am J Respir Cell Mol Biol. 2018 Jan;58(1):107-116. doi: 10.1165/rcmb.2016-0223OC. PubMed PMID: 28846437; PubMed Central PMCID: PMC5941308.

Poole LG, Beier JI, Torres-Gonzales E, Schlueter CF, Hudson SV, Artis A, Warner NL, Nguyen-Ho CT, Dolin CE, Ritzenthaler JD, Hoyle GW, Roman J, Arteel GE. Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung. Alcohol. 2018 Nov 14;. doi: 10.1016/j.alcohol.2018.10.008. [Epub ahead of print] PubMed PMID: 30445135; PubMed Central PMCID: PMC6513731.

Reeder KM, Dunaway CW, Blackburn JP, Yu Z, Matalon S, Hastie AT, Ampleford EJ, Meyers DA, Steele C. The common γ-chain cytokine IL-7 promotes immunopathogenesis during fungal asthma. Mucosal Immunol. 2018 Sep;11(5):1352-1362. doi: 10.1038/s41385-018-0028-1. Epub 2018 Jun 15. PubMed PMID: 29907867; PubMed Central PMCID: PMC6319622.

Tata A, Kobayashi Y, Chow RD, Tran J, Desai A, Massri AJ, McCord TJ, Gunn MD, Tata PR. Myoepithelial Cells of Submucosal Glands Can Function as Reserve Stem Cells to Regenerate Airways after Injury. Cell Stem Cell. 2018 May 3;22(5):668-683.e6. doi: 10.1016/j.stem.2018.03.018. Epub 2018 Apr 12. PubMed PMID: 29656943; PubMed Central PMCID: PMC5935539.

Zhou T, Song WF, Shang Y, Yao SL, Matalon S. Halogen Inhalation-Induced Lung Injury and Acute Respiratory Distress Syndrome. Chin Med J (Engl). 2018 May 20;131(10):1214-1219. doi: 10.4103/0366-6999.231515. Review. PubMed PMID: 29722341; PubMed Central PMCID: PMC5956773.

Zhou T, Yu Z, Jian MY, Ahmad I, Trempus C, Wagener BM, Pittet JF, Aggarwal S, Garantziotis S, Song W, Matalon S. Instillation of hyaluronan reverses acid instillation injury to the mammalian blood gas barrier. Am J Physiol Lung Cell Mol Physiol. 2018 May 1;314(5):L808-L821. doi: 10.1152/ajplung.00510.2017. Epub 2018 Jan 25. PubMed PMID: 29368549; PubMed Central PMCID: PMC6008127.
 

Metabolic/Cellular Poisons

Cheung JY, Wang J, Zhang XQ, Song J, Davidyock JM, Prado FJ, Shanmughapriya S, Worth AM, Madesh M, Judenherc-Haouzi A, Haouzi P. Methylene Blue Counteracts H2S-Induced Cardiac Ion Channel Dysfunction and ATP Reduction. Cardiovasc Toxicol. 2018 Oct;18(5):407-419. doi: 10.1007/s12012-018-9451-5. PubMed PMID: 29603116; PubMed Central PMCID: PMC6126975.

Cheung JY, Wang J, Zhang XQ, Song J, Tomar D, Madesh M, Judenherc-Haouzi A, Haouzi P. Methylene blue counteracts cyanide cardiotoxicity: cellular mechanisms. J Appl Physiol (1985). 2018 May 1;124(5):1164-1176. doi: 10.1152/japplphysiol.00967.2017. Epub 2018 Feb 8. PubMed PMID: 29420146; PubMed Central PMCID: PMC6050200.

Haouzi P, Gueguinou M, Sonobe T, Judenherc-Haouzi A, Tubbs N, Trebak M, Cheung J, Bouillaud F. Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication. Clin Toxicol (Phila). 2018 Sep;56(9):828-840. doi: 10.1080/15563650.2018.1429615. Epub 2018 Feb 16. PubMed PMID: 29451035; PubMed Central PMCID: PMC6086742.

Judenherc-HaouzI A, Sonobe T, Bebarta VS, Haouzi P. On the Efficacy of Cardio-Pulmonary Resuscitation and Epinephrine Following Cyanide- and H2S Intoxication-Induced Cardiac Asystole. Cardiovasc Toxicol. 2018 Oct;18(5):436-449. doi: 10.1007/s12012-018-9454-2. PubMed PMID: 29644580; PubMed Central PMCID: PMC6126935.

Kim DS, Anantharam P, Hoffmann A, Meade ML, Grobe N, Gearhart JM, Whitley EM, Mahama B, Rumbeiha WK. Broad spectrum proteomics analysis of the inferior colliculus following acute hydrogen sulfide exposure. Toxicol Appl Pharmacol. 2018 Sep 15;355:28-42. doi: 10.1016/j.taap.2018.06.001. Epub 2018 Jun 19. PubMed PMID: 29932956; PubMed Central PMCID: PMC6422160.

Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA. Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 2018;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018. PubMed PMID: 29879736; PubMed Central PMCID: PMC5991913.

Szilagyi JT, Fussell KC, Wang Y, Jan YH, Mishin V, Richardson JR, Heck DE, Yang S, Aleksunes LM, Laskin DL, Laskin JD. Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase. Toxicol Appl Pharmacol. 2018 Nov 15;359:102-107. doi: 10.1016/j.taap.2018.09.011. Epub 2018 Sep 15. PubMed PMID: 30222979; PubMed Central PMCID: PMC6528659.
 

Anticoagulant

Lindeblad M, Lyubimov A, van Breemen R, Gierszal K, Weinberg G, Rubinstein I, Feinstein DL. The Bile Sequestrant Cholestyramine Increases Survival in a Rabbit Model of Brodifacoum Poisoning. Toxicol Sci. 2018 Oct 1;165(2):389-395. doi: 10.1093/toxsci/kfy147. PubMed PMID: 29897553; PubMed Central PMCID: PMC6154278.

Rubinstein I, Weinberg G, van Breemen R, Hershow RC, Feinstein DL. Treatment for long acting anticoagulant rodenticide poisoning - beyond INR monitoring?. Toxicol Commun. 2018;2(1):59-61. doi: 10.1080/24734306.2018.1500152. Epub 2018 Aug 13. PubMed PMID: 30923779; PubMed Central PMCID: PMC6433158.

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