Current CounterACT Researchers & Projects

 

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Select project titles to get information on the abstracts, budgets, publications, patents, and contact information associated with each CounterACT-supported  grant from the NIH RePORTER database.

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Grant Type Toxidrome (category) Title PI / Project Lead Institution
U54 Metabolic/Cellular Poison Advancing novel cyanide countermeasures MACRAE, CALUM A BRIGHAM AND WOMEN'S HOSPITAL
U54 Nerve Agent Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication LEIN, PAMELA J UNIVERSITY OF CALIFORNIA AT DAVIS
U54 Pulmonary Agent Development of antidotes for toxic gases WHITE, CARL W UNIVERSITY OF COLORADO DENVER
U54 Vesicating Agent Rutgers University CounterACT Center of Excellence LASKIN, JEFFREY D RBHS-SCHOOL OF PUBLIC HEALTH
U54 Vesicating Agent Barrier Damage and The Immune Cascade Northwestern University CounterACT Center of Excellence (NUCCX) LU, KURT NORTHWESTERN UNIVERSITY AT CHICAGO
U54 Vesicating Agent UAB Research Center of Excellence in Arsenicals ATHAR, MOHAMMAD UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Metabolic/Cellular Poison Cyanide/Azide Detoxification by New Cobalt Complexes and NO Donors PETERSON, JAMES UNIVERSITY OF PITTSBURGH AT PITTSBURGH
U01 Metabolic/Cellular Poison Optimization of a Combined Drug and Delivery Device for Treatment of Cyanide Poisoning PATTERSON, STEVEN E UNIVERSITY OF MINNESOTA
U01 Nerve Agent Identification of Novel Brain-penetrating Phenoxyalkyl Pyridinium Oxime Countermeasures CHAMBERS, JANICE ELAINE MISSISSIPPI STATE UNIVERSITY
U01 Nerve Agent Saracatinib and 1400W Counteract Nerve Agents-induced Long-term Neurotoxicity THIPPESWAMY, THIMMASETTAPPA IOWA STATE UNIVERSITY
U01 Nerve Agent Antiglutamatergic Therapy to Protect the Immature Brain Against Nerve Agents BRAGA, MARIA F HENRY M. JACKSON FDN FOR THE ADV MIL/MED
U01 Nerve Agent Novel Water-Soluble Adjunct Anticonvulsants for Nerve Agents REDDY, DOODIPALA SAMBA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
U01 Nerve Agent Novel Antibody-Oxime Pairing to Reduce Circulating Organophosphate Levels. THOMPSON, CHARLES MARK HUMAN BIOMOLECULAR RESEARCH INSTITUTE
U01 Nerve Agent Anticholinergic and antiepileptic Therapies for Chlorine Toxicity VERESS, LIVIA AGNES UNIVERSITY OF COLORADO DENVER
U01 Nerve Agent Development of IM Formulation of (2S,3S)-SPD for Nerve Agent Seizures ROGAWSKI, MICHAEL A UNIVERSITY OF CALIFORNIA AT DAVIS
U01 Nerve Agent Novel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus DELORENZO, ROBERT JOHN VIRGINIA COMMONWEALTH UNIVERSITY
U01 Nerve Agent Novel pediatric anticonvulsants for nerve agents REDDY, DOODIPALA SAMBA TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR
U01 Nerve Agent Optimization of Substituted Phenoxyalkyl Pyridinium Oximes as Therapies for Organophosphate Poisoning CHAMBERS, JANICE ELAINE MISSISSIPPI STATE UNIVERSITY
U01 Nerve Agent Advanced Development of Drugs to Mitigate Parathion Intoxication LASKIN, JEFFREY D RBHS-SCHOOL OF PUBLIC HEALTH
U01 Nerve Agent Improved Therapeutics for the Resurrection of the Aged Form of Acetylcholinesterase HADAD, CHRISTOPHER M OHIO STATE UNIVERSITY
U01 Pharmaceutical-based Agent Immunotherapy to Counteract Lethal Doses of Carfentanil JANDA, KIM SCRIPPS RESEARCH INSTITUTE
U01 Pharmaceutical-based Agent Antibody-based countermeasures against fentanyl and its analogues PRAVETONI, MARCO UNIVERSITY OF MINNESOTA
U01 Pharmaceutical-based Agent Development of Agents for Synthetic Opioid Overdose PRISINZANO, THOMAS EDWARD UNIVERSITY OF KENTUCKY
U01 Pharmaceutical-based Agent Optimization of novel thioesters as a therapeutic strategy for combating opioid overdoses and abuse LEWIS, STEPHEN JOHN CASE WESTERN RESERVE UNIVERSITY
U01 Pulmonary Agent CIALIS® reverses halogen induced injury to pregnant animals and their offspring MATALON, SADIS UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Pulmonary Agent Optimization of AEOL10150 treatment of sulfur mustard-induced lung toxidrome in a pig model DAY, BRIAN J NATIONAL JEWISH HEALTH
U01 Pulmonary Agent Advanced TRPA1 Inhibitor for the Treatment of Chlorine Inhalation Injury JORDT, SVEN-ERIC DUKE UNIVERSITY
U01 Pulmonary Agent Identification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicity AGGARWAL, SAURABH UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Pulmonary Agent Functional Genomics of Chemical-Induced Acute Lung Injury LEIKAUF, GEORGE DOUGLAS UNIVERSITY OF PITTSBURGH AT PITTSBURGH
U01 Pulmonary Agent Antidotes against HCI-induced chronic lung injury CATRAVAS, JOHN D OLD DOMINION UNIVERSITY
U01 Vesicating Agent Optimization of Novel Molecular Target-based Drugs for Arsenical Skin Injury ATHAR, MOHAMMAD UNIVERSITY OF ALABAMA AT BIRMINGHAM
U01 Vesicating Agent Targeted Therapeutic Approaches to Counteract Toxicity from Phosgene Oxime Skin Exposure TEWARI-SINGH, NEERA MICHIGAN STATE UNIVERSITY
U01 Vesicating Agent Translation of novel and repurposed drugs to address the acute and late effects of mustard exposure LU, KURT NORTHWESTERN UNIVERSITY AT CHICAGO
U01 Vesicating Agent Identification of lead compounds to topically treat sulfur mustard injury to reduce ocular damage and improve vision. BAKER, SHENDA SYNEDGEN, INC.
U01 Vesicating Agent Dexamethasone as an Effective Therapy for Ocular Injuries by Vesicating Agents. AGARWAL, RAJESH UNIVERSITY OF COLORADO DENVER
U01 Vesicating Agent Turbo Eye Drops to Treat Ocular Toxicity and Blindness from Sulfur Mustard MOHAN, RAJIV RAVINDRA UNIVERSITY OF MISSOURI-COLUMBIA
T32 Metabolic/Cellular Poison Molecular Mechanisms of Environmental Injury AMEREDES, BILL T UNIVERSITY OF TEXAS MED BR GALVESTON
R21 Metabolic/Cellular Poison Novel therapeutic targets for fluoroacetate-induced toxicities. AHMAD, AFTAB UNIVERSITY OF ALABAMA AT BIRMINGHAM
R21 Metabolic/Cellular Poison Hydrogen sulfide toxicity to the cornea BALNE, PRAVEEN K UNIVERSITY OF MISSOURI-COLUMBIA
R21 Metabolic/Cellular Poison Treatment strategies for ocular toxicity from chloropicrin TEWARI-SINGH, NEERA MICHIGAN STATE UNIVERSITY
R21 Metabolic/Cellular Poison Novel Antidotes for H2S Poisoning ICHINOSE, FUMITO MASSACHUSETTS GENERAL HOSPITAL
R21 Metabolic/Cellular Poison The cyclic redox dye Azure B as a novel cyanide antidote: in vivo efficacy studies HAOUZI, PHILIPPE A PENNSYLVANIA STATE UNIV HERSHEY MED CTR
R21 Nerve Agent Saracatinib Mitigates OP nerve agent-induced Long-term Neurotoxicity THIPPESWAMY, THIMMASETTAPPA IOWA STATE UNIVERSITY
R21 Nerve Agent Soman-induced neuropathology in Gottingen minipig: large animal model assessment for MCM LANGE, LUCILLE GENEVA FOUNDATION
R21 Nerve Agent Mitoapocynin, a novel NOX2 inhibitor, mitigates nerve agents induced longterm neurotoxicity THIPPESWAMY, THIMMASETTAPPA IOWA STATE UNIVERSITY
R21 Nerve Agent Identifying Molecular Targets for the Proconvulsant Activity of TETS LEIN, PAMELA J UNIVERSITY OF CALIFORNIA AT DAVIS
R21 Pharmaceutical-based Agent Safer, Non-addicting Pain Management: Identification and Expression of Cyclic Peptides with Analgesic and Breathing Stimulant Properties COTTEN, JOSEPH F MASSACHUSETTS GENERAL HOSPITAL
R21 Pharmaceutical-based Agent Covalent Naloxone Nanoparticles for Next Generation Fentanyl Countermeasures AVERICK, SAADYAH ALLEGHENY-SINGER RESEARCH INSTITUTE
R21 Pharmaceutical-based Agent Microneedles for emergency treatment of synthetic opioid overdose NARAYAN, ROGER J NORTH CAROLINA STATE UNIVERSITY RALEIGH
R21 Pulmonary Agent Inhibition of soluble epoxide hydrolase protects against phosgene-induced lung injuries ACHANTA, SATYANARAYANA DUKE UNIVERSITY
R21 Pulmonary Agent Cannabinoid-2 receptor signaling in vesicant induced lung injury NAGRE, NAGARAJA EASTERN VIRGINIA MEDICAL SCHOOL
R21 Pulmonary Agent Mitigation of Chlorine Injury to Mitochondria MATALON, SADIS UNIVERSITY OF ALABAMA AT BIRMINGHAM
R21 Pulmonary Agent Esomeprazole counteracts chlorine toxicity in pregnant animals JILLING, TAMAS UNIVERSITY OF ALABAMA AT BIRMINGHAM
R21 Pulmonary Agent Airway stem cell activation in the mitigation of halogen-induced lung injury AHMAD, SHAMA UNIVERSITY OF ALABAMA AT BIRMINGHAM
R21 Pulmonary Agent Repurposing thiosulfate for chlorine gas exposure DAY, BRIAN J NATIONAL JEWISH HEALTH
R21 Pulmonary Agent Chlorinated lipid modification of proteins: Biomarkers of chlorine gas exposure FORD, DAVID A SAINT LOUIS UNIVERSITY
R21 Pulmonary Agent Specialized pro-resolving mediators as potential medical countermeasures in a pig model of chlorine gas-induced acute lung injury ACHANTA, SATYANARAYANA DUKE UNIVERSITY
R21 Vesicating Agent MicroRNAs in Skin Inflammation and Wounding by Mustard Vesicants. AGARWAL, RAJESH UNIVERSITY OF COLORADO DENVER
R21 Vesicating Agent Imaging the healing of ocular injury caused by vesicants to identify new therapies WOLLMAN, ROY UNIVERSITY OF CALIFORNIA LOS ANGELES
R21 Vesicating Agent Targeting Citrullination in Ocular Chemical Injury MOHAN, ROYCE UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
R03 Nerve Agent A novel mouse model for anxiety-induced seizures BRENNER, ROBERT UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
R01 Nerve Agent Functional analysis of the microRNA-induced silencing complex in epilepsy GROSS, CHRISTINA CINCINNATI CHILDRENS HOSP MED CTR
R01 Pulmonary Agent Novel ARNT-mediated Regulatory Paradigm of AHR Signaling WRIGHT, CASEY W UNIVERSITY OF TEXAS MED BR GALVESTON
R01 Pulmonary Agent COUNTERACT Supplement--ASPIRE: Air Pollution: Strategies for Personalized Intervention to Reduce Exposure RAJAGOPALAN, SANJAY CASE WESTERN RESERVE UNIVERSITY
R01 Vesicating Agent NOT-NS-20-030: Use of anchored biologics to treat vesicant induced neovascularization SHANKS, ROBERT M UNIVERSITY OF PITTSBURGH AT PITTSBURGH
R01 Vesicating Agent Clusterin at the Ocular Surface Administrative Supplement II FINI, M ELIZABETH TUFTS MEDICAL CENTER
F30 Vesicating Agent Characterization of an Ex Vivo Bioprinted Skin Model of Sulfur Mustard Injury JORGENSEN, ADAM WAKE FOREST UNIVERSITY HEALTH SCIENCES

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