CounterACT Publications 2017

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Neurotoxic Agents

Apland JP, Aroniadou-Anderjaska V, Figueiredo TH, Prager EM, Olsen CH, Braga MFM. Susceptibility to Soman Toxicity and Efficacy of LY293558 Against Soman-Induced Seizures and Neuropathology in 10-Month-Old Male Rats. Neurotox Res. 2017 Nov;32(4):694-706. doi: 10.1007/s12640-017-9789-7. Epub 2017 Aug 3. PubMed PMID: 28776308.

Aronica E, Bauer S, Bozzi Y, Caleo M, Dingledine R, Gorter JA, Henshall DC, Kaufer D, Koh S, Löscher W, Louboutin JP, Mishto M, Norwood BA, Palma E, Poulter MO, Terrone G, Vezzani A, Kaminski RM. Neuroinflammatory targets and treatments for epilepsy validated in experimental models. Epilepsia. 2017 Jul;58 Suppl 3:27-38. doi: 10.1111/epi.13783. Review. PubMed PMID: 28675563; PubMed Central PMCID: PMC5873599.

Barnych B, Rand AA, Cajka T, Lee KSS, Hammock BD. Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs. Org Biomol Chem. 2017 May 23;15(20):4308-4313. doi: 10.1039/c7ob00789b. PubMed PMID: 28470279; PubMed Central PMCID: PMC5527127.

Barnych B, Vasylieva N, Joseph T, Hulsizer S, Nguyen HM, Cajka T, Pessah I, Wulff H, Gee SJ, Hammock BD. Development of Tetramethylenedisulfotetramine (TETS) Hapten Library: Synthesis, Electrophysiological Studies, and Immune Response in Rabbits. Chemistry. 2017 Jun 22;23(35):8466-8472. doi: 10.1002/chem.201700783. Epub 2017 May 30. PubMed PMID: 28411375; PubMed Central PMCID: PMC5808876.

Brown BM, Shim H, Wulff H. Are there superagonists for calcium-activated potassium channels?. Channels (Austin). 2017 Nov 2;11(6):504-506. doi: 10.1080/19336950.2017.1376971. Epub 2017 Oct 5. PubMed PMID: 28876978; PubMed Central PMCID: PMC5786189.

Brown BM, Shim H, Zhang M, Yarov-Yarovoy V, Wulff H. Structural Determinants for the Selectivity of the Positive KCa3.1 Gating Modulator 5-Methylnaphtho[2,1-d]oxazol-2-amine (SKA-121). Mol Pharmacol. 2017 Oct;92(4):469-480. doi: 10.1124/mol.117.109421. Epub 2017 Jul 31. PubMed PMID: 28760780; PubMed Central PMCID: PMC5588545.

Cao Z, Xu J, Hulsizer S, Cui Y, Dong Y, Pessah IN. Influence of tetramethylenedisulfotetramine on synchronous calcium oscillations at distinct developmental stages of hippocampal neuronal cultures. Neurotoxicology. 2017 Jan;58:11-22. doi: 10.1016/j.neuro.2016.10.015. Epub 2016 Oct 29. PubMed PMID: 27984050; PubMed Central PMCID: PMC5303550.

Chapman CA, Zhu X, Chen H, Yanik AA, Lein PJ, Seker E. Nanostructure Introduces Artifacts in Quantitative Immunofluorescence by Influencing Fluorophore Intensity. Sci Rep. 2017 Mar 27;7(1):427. doi: 10.1038/s41598-017-00447-7. PubMed PMID: 28348397; PubMed Central PMCID: PMC5428417.

Chapman CAR, Wang L, Chen H, Garrison J, Lein PJ, Seker E. Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance. Adv Funct Mater. 2017 Jan 19;27(3). doi: 10.1002/adfm.201604631. Epub 2016 Dec 12. PubMed PMID: 28626362; PubMed Central PMCID: PMC5471629.

Clossen BL, Reddy DS. Catamenial-like seizure exacerbation in mice with targeted ablation of extrasynaptic δGABA-a receptors in the brain. J Neurosci Res. 2017 Oct;95(10):1906-1916. doi: 10.1002/jnr.24028. Epub 2017 Feb 25. PubMed PMID: 28236431; PubMed Central PMCID: PMC5561461.

Clossen BL, Reddy DS. Novel therapeutic approaches for disease-modification of epileptogenesis for curing epilepsy. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1519-1538. doi: 10.1016/j.bbadis.2017.02.003. Epub 2017 Feb 5. Review. PubMed PMID: 28179120; PubMed Central PMCID: PMC5474195.

Dingledine R, Coulter DA, Fritsch B, Gorter JA, Lelutiu N, McNamara J, Nadler JV, Pitkänen A, Rogawski MA, Skene P, Sloviter RS, Wang Y, Wadman WJ, Wasterlain C, Roopra A. Transcriptional profile of hippocampal dentate granule cells in four rat epilepsy models. Sci Data. 2017 May 9;4:170061. doi: 10.1038/sdata.2017.61. PubMed PMID: 28485718; PubMed Central PMCID: PMC5423390.

Green AL, Zhan L, Eid A, Zarbl H, Guo GL, Richardson JR. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1. Neuropharmacology. 2017 Oct;125:189-196. doi: 10.1016/j.neuropharm.2017.07.020. Epub 2017 Jul 22. PubMed PMID: 28743636; PubMed Central PMCID: PMC5585058.

Hobson BA, Sisó S, Rowland DJ, Harvey DJ, Bruun DA, Garbow JR, Lein PJ. From the Cover: MagneticResonance Imaging Reveals Progressive Brain Injury in Rats Acutely Intoxicated With Diisopropylfluorophosphate. Toxicol Sci. 2017 Jun 1;157(2):342-353. doi: 10.1093/toxsci/kfx049. PubMed PMID: 28329842; PubMed Central PMCID: PMC5458789.

Hossain MM, Liu J, Richardson JR. Pyrethroid Insecticides Directly Activate Microglia Through Interaction With Voltage-Gated Sodium Channels. Toxicol Sci. 2017 Jan;155(1):112-123. doi: 10.1093/toxsci/kfw187. Epub 2016 Sep 21. PubMed PMID: 27655349; PubMed Central PMCID: PMC6080855.

Hu P, Wu X, Khandelwal AR, Yu W, Xu Z, Chen L, Yang J, Weisbrod RM, Lee KSS, Seta F, Hammock BD, Cohen RA, Zeng C, Tong X. Endothelial Nox4-based NADPH oxidase regulates atherosclerosis via soluble epoxide hydrolase. Biochim Biophys Acta Mol Basis Dis. 2017 Jun;1863(6):1382-1391. doi: 10.1016/j.bbadis.2017.02.004. Epub 2017 Feb 7. PubMed PMID: 28185955; PubMed Central PMCID: PMC5608514.

Hwang SH, Wagner K, Xu J, Yang J, Li X, Cao Z, Morisseau C, Lee KS, Hammock BD. Chemical synthesis and biological evaluation of ω-hydroxy polyunsaturated fatty acids. Bioorg Med Chem Lett. 2017 Feb 1;27(3):620-625. doi: 10.1016/j.bmcl.2016.12.002. Epub 2016 Dec 2. PubMed PMID: 28025003; PubMed Central PMCID: PMC5584617.

Kodani SD, Barthélemy M, Kamita SG, Hammock B, Morisseau C. Development of amide-based fluorescent probes for selective measurement of carboxylesterase 1 activity in tissue extracts. Anal Biochem. 2017 Dec 15;539:81-89. doi: 10.1016/j.ab.2017.10.014. Epub 2017 Oct 18. PubMed PMID: 29054529; PubMed Central PMCID: PMC5696082.

Lee KS, Henriksen NM, Ng CJ, Yang J, Jia W, Morisseau C, Andaya A, Gilson MK, Hammock BD. Probing the orientation of inhibitor and epoxy-eicosatrienoic acid binding in the active site of soluble epoxide hydrolase. Arch Biochem Biophys. 2017 Jan 1;613:1-11. doi: 10.1016/ Epub 2016 Oct 29. PubMed PMID: 27983948; PubMed Central PMCID: PMC5172606.

McElroy PB, Liang LP, Day BJ, Patel M. Scavenging reactive oxygen species inhibits status epilepticus-induced neuroinflammation. Exp Neurol. 2017 Dec;298(Pt A):13-22. doi: 10.1016/j.expneurol.2017.08.009. Epub 2017 Aug 16. PubMed PMID: 28822838; PubMed Central PMCID: PMC5658247.

Miller SL, Aroniadou-Anderjaska V, Pidoplichko VI, Figueiredo TH, Apland JP, Krishnan JK, Braga MF. The M1 Muscarinic Receptor Antagonist VU0255035 Delays the Development of Status Epilepticus after Organophosphate Exposure and Prevents Hyperexcitability in the Basolateral Amygdala. J Pharmacol Exp Ther. 2017 Jan;360(1):23-32. doi: 10.1124/jpet.116.236125. Epub 2016 Oct 31. PubMed PMID: 27799295; PubMed Central PMCID: PMC5193080.

Neumann KD, Thompson CM, Blecha JE, Gerdes JM, VanBrocklin HF. An improved radiosynthesis of O-(2-[18 F]fluoroethyl)-O-(p-nitrophenyl)methylphosphonate: A first-in-class cholinesterase PET tracer. J Labelled Comp Radiopharm. 2017 Jun 15;60(7):337-342. doi: 10.1002/jlcr.3511. Epub 2017 May 15. PubMed PMID: 28406525; PubMed Central PMCID: PMC6031433.

Nguyen HM, Singh V, Pressly B, Jenkins DP, Wulff H, Yarov-Yarovoy V. Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Mol Pharmacol. 2017 Apr;91(4):392-402. doi: 10.1124/mol.116.108068. Epub 2017 Jan 26. PubMed PMID: 28126850; PubMed Central PMCID: PMC5363711.

Nik AM, Pressly B, Singh V, Antrobus S, Hulsizer S, Rogawski MA, Wulff H, Pessah IN. Rapid Throughput Analysis of GABAA Receptor Subtype Modulators and Blockers Using DiSBAC1(3) Membrane Potential Red Dye. Mol Pharmacol. 2017 Jul;92(1):88-99. doi: 10.1124/mol.117.108563. Epub 2017 Apr 20. PubMed PMID: 28428226; PubMed Central PMCID: PMC5452057.

Niquet J, Suchomelova L, Thompson K, Klitgaard H, Matagne A, Wasterlain C. Acute and long-term effects of brivaracetam and brivaracetam-diazepam combinations in an experimental model of status epilepticus. Epilepsia. 2017 Jul;58(7):1199-1207. doi: 10.1111/epi.13787. Epub 2017 Jun 9. PubMed PMID: 28597912; PubMed Central PMCID: PMC5508597.

Niquet J, Baldwin R, Norman K, Suchomelova L, Lumley L, Wasterlain CG. Simultaneous triple therapy for the treatment of status epilepticus. Neurobiol Dis. 2017 Aug;104:41-49. doi: 10.1016/j.nbd.2017.04.019. Epub 2017 Apr 29. PubMed PMID: 28461248; PubMed Central PMCID: PMC5504687.

Niquet J, Baldwin R, Suchomelova L, Lumley L, Eavey R, Wasterlain CG. Treatment of experimental status epilepticus with synergistic drug combinations. Epilepsia. 2017 Apr;58(4):e49-e53. doi: 10.1111/epi.13695. Epub 2017 Feb 22. PubMed PMID: 28225161; PubMed Central PMCID: PMC5386805.

Pearson JN, Warren E, Liang LP, Roberts LJ 2nd, Patel M. Scavenging of highly reactive gamma-ketoaldehydes attenuates cognitive dysfunction associated with epileptogenesis. Neurobiol Dis. 2017 Feb;98:88-99. doi: 10.1016/j.nbd.2016.11.011. Epub 2016 Dec 5. PubMed PMID: 27932305; PubMed Central PMCID: PMC5396543.

Pearson-Smith JN, Patel M. Metabolic Dysfunction and Oxidative Stress in Epilepsy. Int J Mol Sci. 2017 Nov 8;18(11). doi: 10.3390/ijms18112365. Review. PubMed PMID: 29117123; PubMed Central PMCID: PMC5713334.

Pearson-Smith JN, Liang LP, Rowley SD, Day BJ, Patel M. Oxidative Stress Contributes to Status Epilepticus Associated Mortality. Neurochem Res. 2017 Jul;42(7):2024-2032. doi: 10.1007/s11064-017-2273-1. Epub 2017 May 2. PubMed PMID: 28462450; PubMed Central PMCID: PMC5640323.

Reddy DS. Sex differences in the anticonvulsant activity of neurosteroids. J Neurosci Res. 2017 Jan 2;95(1-2):661-670. doi: 10.1002/jnr.23853. Review. PubMed PMID: 27870400; PubMed Central PMCID: PMC5120602.

Reddy DS. Do oral contraceptives increase epileptic seizures?. Expert Rev Neurother. 2017 Feb;17(2):129-134. doi: 10.1080/14737175.2016.1243472. Epub 2016 Oct 12. PubMed PMID: 27690666; PubMed Central PMCID: PMC5540161.

Reddy DS, Bhimani A, Kuruba R, Park MJ, Sohrabji F. Prospects of modeling poststroke epileptogenesis. J Neurosci Res. 2017 Apr;95(4):1000-1016. doi: 10.1002/jnr.23836. Epub 2016 Jul 25. Review. PubMed PMID: 27452210; PubMed Central PMCID: PMC5266751.

Reddy DS, Colman E. A Comparative Toxidrome Analysis of Human Organophosphate and Nerve Agent Poisonings Using Social Media. Clin Transl Sci. 2017 May;10(3):225-230. doi: 10.1111/cts.12435. Epub 2017 Feb 26. PubMed PMID: 28238224; PubMed Central PMCID: PMC5421825.

Rojas A, Ganesh T, Walker A, Dingledine R. Ethylatropine Bromide as a Peripherally Restricted Muscarinic Antagonist. ACS Chem Neurosci. 2017 Apr 19;8(4):712-717. doi: 10.1021/acschemneuro.6b00334. Epub 2017 Jan 6. PubMed PMID: 28044440; PubMed Central PMCID: PMC5872150.

Rotundo RL. Biogenesis, assembly and trafficking of acetylcholinesterase. J Neurochem. 2017 Aug;142 Suppl 2:52-58. doi: 10.1111/jnc.13982. Epub 2017 Mar 21. Review. PubMed PMID: 28326552; PubMed Central PMCID: PMC5550332.

Sharma S, Puttachary S, Thippeswamy T. Glial source of nitric oxide in epileptogenesis: A target for disease modification in epilepsy. J Neurosci Res. 2017 Dec 12;. doi: 10.1002/jnr.24205. [Epub ahead of print] Review. PubMed PMID: 29230865; PubMed Central PMCID: PMC6035106.

Sisó S, Hobson BA, Harvey DJ, Bruun DA, Rowland DJ, Garbow JR, Lein PJ. Editor's Highlight: Spatiotemporal Progression and Remission of Lesions in the Rat Brain Following Acute Intoxication With Diisopropylfluorophosphate. Toxicol Sci. 2017 Jun 1;157(2):330-341. doi: 10.1093/toxsci/kfx048. PubMed PMID: 28329845; PubMed Central PMCID: PMC6070115.

Torolira D, Suchomelova L, Wasterlain CG, Niquet J. Phenobarbital and midazolam increase neonatal seizure-associated neuronal injury. Ann Neurol. 2017 Jul;82(1):115-120. doi: 10.1002/ana.24967. Epub 2017 Jul 7. PubMed PMID: 28556259; PubMed Central PMCID: PMC5546097.

Tsai CS, Mao RW, Tsai SC, Shahverdi K, Zhu Y, Lin SK, Hsu YH, Boss G, Brenner M, Mahon S, Smaldone GC. Faraday Waves-Based Integrated Ultrasonic Micro-Droplet Generator and Applications. Micromachines (Basel). 2017;8(2). doi: 10.3390/mi8020056. Epub 2017 Feb 14. PubMed PMID: 29250438; PubMed Central PMCID: PMC5726552.

Vasylieva N, Barnych B, Rand A, Inceoglu B, Gee SJ, Hammock BD. Sensitive Immunoassay for Detection and Quantification of the Neurotoxin, Tetramethylenedisulfotetramine. Anal Chem. 2017 May 16;89(10):5612-5619. doi: 10.1021/acs.analchem.7b00846. Epub 2017 Apr 24. PubMed PMID: 28398746; PubMed Central PMCID: PMC5920647.

Vasylieva N, Barnych B, Wan D, El-Sheikh EA, Nguyen HM, Wulff H, McMahen R, Strynar M, Gee SJ, Hammock BD. Hydroxy-fipronil is a new urinary biomarker of exposure to fipronil. Environ Int. 2017 Jun;103:91-98. doi: 10.1016/j.envint.2017.03.012. Epub 2017 Mar 23. PubMed PMID: 28343720; PubMed Central PMCID: PMC5432128.

Wagner K, Gilda J, Yang J, Wan D, Morisseau C, Gomes AV, Hammock BD. Soluble epoxide hydrolase inhibition alleviates neuropathy in Akita (Ins2 Akita) mice. Behav Brain Res. 2017 May 30;326:69-76. doi: 10.1016/j.bbr.2017.02.048. Epub 2017 Mar 1. PubMed PMID: 28259677; PubMed Central PMCID: PMC5409858.

Wagner K, Lee KS, Yang J, Hammock BD. Epoxy fatty acids mediate analgesia in murine diabetic neuropathy. Eur J Pain. 2017 Mar;21(3):456-465. doi: 10.1002/ejp.939. Epub 2016 Sep 15. PubMed PMID: 27634339; PubMed Central PMCID: PMC5300894.

Wagner KM, McReynolds CB, Schmidt WK, Hammock BD. Soluble epoxide hydrolase as a therapeutic target for pain, inflammatory and neurodegenerative diseases. Pharmacol Ther. 2017 Dec;180:62-76. doi: 10.1016/j.pharmthera.2017.06.006. Epub 2017 Jun 19. Review. PubMed PMID: 28642117; PubMed Central PMCID: PMC5677555.

Younus I, Reddy DS. Epigenetic interventions for epileptogenesis: A new frontier for curing epilepsy. Pharmacol Ther. 2017 Sep;177:108-122. doi: 10.1016/j.pharmthera.2017.03.002. Epub 2017 Mar 6. Review. PubMed PMID: 28279785; PubMed Central PMCID: PMC5565684.

Zhang Y, Hong G, Lee KS, Hammock BD, Gebremedhin D, Harder DR, Koehler RC, Sapirstein A. Inhibition of soluble epoxide hydrolase augments astrocyte release of vascular endothelial growth factor and neuronal recovery after oxygen-glucose deprivation. J Neurochem. 2017 Mar;140(5):814-825. doi: 10.1111/jnc.13933. Epub 2017 Jan 23. PubMed PMID: 28002622; PubMed Central PMCID: PMC5310989.


Vesicating Agents

Chmielowski RA, Abdelhamid DS, Faig JJ, Petersen LK, Gardner CR, Uhrich KE, Joseph LB, Moghe PV. Athero-inflammatory nanotherapeutics: Ferulic acid-based poly(anhydride-ester) nanoparticles attenuate foam cell formation by regulating macrophage lipogenesis and reactive oxygen species generation. Acta Biomater. 2017 Jul 15;57:85-94. doi: 10.1016/j.actbio.2017.05.029. Epub 2017 May 15. PubMed PMID: 28522412; PubMed Central PMCID: PMC5546209.

Faig JJ, Moretti A, Joseph LB, Zhang Y, Nova MJ, Smith K, Uhrich KE. Biodegradable Kojic Acid-Based Polymers: Controlled Delivery of Bioactives for Melanogenesis Inhibition. Biomacromolecules. 2017 Feb 13;18(2):363-373. doi: 10.1021/acs.biomac.6b01353. Epub 2017 Jan 26. PubMed PMID: 28026947; PubMed Central PMCID: PMC5810376.

Francis M, Groves AM, Sun R, Cervelli JA, Choi H, Laskin JD, Laskin DL. Editor's Highlight: CCR2 Regulates Inflammatory Cell Accumulation in the Lung and Tissue Injury following Ozone Exposure. Toxicol Sci. 2017 Feb;155(2):474-484. doi: 10.1093/toxsci/kfw226. Epub 2016 Nov 11. PubMed PMID: 27837169; PubMed Central PMCID: PMC5291213.

Francis M, Sun R, Cervelli JA, Choi H, Mandal M, Abramova EV, Gow AJ, Laskin JD, Laskin DL. Editor's Highlight: Role of Spleen-Derived Macrophages in Ozone-Induced Lung Inflammation and Injury. Toxicol Sci. 2017 Jan;155(1):182-195. doi: 10.1093/toxsci/kfw192. Epub 2016 Oct 5. PubMed PMID: 27708193; PubMed Central PMCID: PMC6080856.

McGraw MD, Osborne CM, Mastej EJ, Di Paola JA, Anderson DR, Holmes WW, Paradiso DC, Garlick RB, Hendry-Hofer TB, Rancourt RC, Smith RW, Burns C, Roe GB, Rioux JS, White CW, Veress LA. Editor's Highlight: Pulmonary Vascular Thrombosis in Rats Exposed to Inhaled Sulfur Mustard. Toxicol Sci. 2017 Oct 1;159(2):461-469. doi: 10.1093/toxsci/kfx151. PubMed PMID: 28962529; PubMed Central PMCID: PMC5837673.

McGraw MD, Rioux JS, Garlick RB, Rancourt RC, White CW, Veress LA. From the Cover: Impaired Proliferation and Differentiation of the Conducting Airway Epithelium Associated With Bronchiolitis Obliterans After Sulfur Mustard Inhalation Injury in Rats. Toxicol Sci. 2017 Jun 1;157(2):399-409. doi: 10.1093/toxsci/kfx057. PubMed PMID: 28402575; PubMed Central PMCID: PMC6075598.

Scott JF, Das LM, Ahsanuddin S, Qiu Y, Binko AM, Traylor ZP, Debanne SM, Cooper KD, Boxer R, Lu KQ. Oral Vitamin D Rapidly Attenuates Inflammation from Sunburn: An Interventional Study. J Invest Dermatol. 2017 Oct;137(10):2078-2086. doi: 10.1016/j.jid.2017.04.040. Epub 2017 May 30. PubMed PMID: 28576736; PubMed Central PMCID: PMC5610950.

Tacastacas JD, Chan DV, Carlson S, Gerson SL, Dowlati A, Fu P, Lu K, Groft S, Rosenjack J, Honda K, McCormick TS, Cooper KD. Evaluation of O6-Benzylguanine-Potentiated Topical Carmustine for Mycosis Fungoides: A Phase 1-2 Clinical Trial. JAMA Dermatol. 2017 May 1;153(5):413-420. doi: 10.1001/jamadermatol.2016.5793. PubMed PMID: 28199478; PubMed Central PMCID: PMC5817489.

Tai Y, Wang C, Wang Z, Liang Y, Du J, He D, Fan X, Jordt SE, Liu B. Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone. Sci Rep. 2017 Aug 8;7(1):7532. doi: 10.1038/s41598-017-07651-5. PubMed PMID: 28790335; PubMed Central PMCID: PMC5548750.

Venosa A, Gow JG, Hall L, Malaviya R, Gow AJ, Laskin JD, Laskin DL. Regulation of Nitrogen Mustard-Induced Lung Macrophage Activation by Valproic Acid, a Histone Deacetylase Inhibitor. Toxicol Sci. 2017 May 1;157(1):222-234. doi: 10.1093/toxsci/kfx032. PubMed PMID: 28184907; PubMed Central PMCID: PMC6075217.

Pulmonary Agents

Achanta S, Jordt SE. TRPA1: Acrolein meets its target. Toxicol Appl Pharmacol. 2017 Jun 1;324:45-50. doi: 10.1016/j.taap.2017.03.007. Epub 2017 Mar 8. PubMed PMID: 28284857; PubMed Central PMCID: PMC5528158.

Ahmed KA, Nichols AL, Honavar J, Dransfield MT, Matalon S, Patel RP. Measuring nitrate reductase activity from human and rodent tongues. Nitric Oxide. 2017 Jun 1;66:62-70. doi: 10.1016/j.niox.2017.04.001. Epub 2017 Apr 5. PubMed PMID: 28390999; PubMed Central PMCID: PMC5484083.

Amdahl MB, DeMartino AW, Tejero J, Gladwin MT. Cytoglobin at the Crossroads of Vascular Remodeling. Arterioscler Thromb Vasc Biol. 2017 Oct;37(10):1803-1805. doi: 10.1161/ATVBAHA.117.310058. PubMed PMID: 28954806; PubMed Central PMCID: PMC5822687.

Amdahl MB, Sparacino-Watkins CE, Corti P, Gladwin MT, Tejero J. Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System. Biochemistry. 2017 Aug 1;56(30):3993-4004. doi: 10.1021/acs.biochem.7b00224. Epub 2017 Jul 19. PubMed PMID: 28671819; PubMed Central PMCID: PMC5555378.

George L, Mitra A, Thimraj TA, Irmler M, Vishweswaraiah S, Lunding L, Hühn D, Madurga A, Beckers J, Fehrenbach H, Upadhyay S, Schulz H, Leikauf GD, Ganguly K. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res. 2017 Aug 9;18(1):152. doi: 10.1186/s12931-017-0629-3. PubMed PMID: 28793908; PubMed Central PMCID: PMC5551015.

Ghosh M, Ahmad S, White CW, Reynolds SD. Transplantation of Airway Epithelial Stem/Progenitor Cells: A Future for Cell-Based Therapy. Am J Respir Cell Mol Biol. 2017 Jan;56(1):1-10. doi: 10.1165/rcmb.2016-0181MA. PubMed PMID: 27632244; PubMed Central PMCID: PMC5248965.

Honavar J, Doran S, Ricart K, Matalon S, Patel RP. Nitrite therapy prevents chlorine gas toxicity in rabbits. Toxicol Lett. 2017 Apr 5;271:20-25. doi: 10.1016/j.toxlet.2017.02.019. Epub 2017 Feb 22. PubMed PMID: 28237808; PubMed Central PMCID: PMC5580399.

Lambert JA, Carlisle MA, Lam A, Aggarwal S, Doran S, Ren C, Bradley WE, Dell'Italia L, Ambalavanan N, Ford DA, Patel RP, Jilling T, Matalon S. Mechanisms and Treatment of Halogen Inhalation-Induced Pulmonary and Systemic Injuries in Pregnant Mice. Hypertension. 2017 Aug;70(2):390-400. doi: 10.1161/HYPERTENSIONAHA.117.09466. Epub 2017 Jun 12. PubMed PMID: 28607126; PubMed Central PMCID: PMC5518712.

Li FJ, Surolia R, Li H, Wang Z, Liu G, Liu RM, Mirov SB, Athar M, Thannickal VJ, Antony VB. Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin. Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L80-L91. doi: 10.1152/ajplung.00087.2017. Epub 2017 Apr 27. PubMed PMID: 28450285; PubMed Central PMCID: PMC5538875.

Malaviya R, Laskin JD, Laskin DL. Anti-TNFα therapy in inflammatory lung diseases. Pharmacol Ther. 2017 Dec;180:90-98. doi: 10.1016/j.pharmthera.2017.06.008. Epub 2017 Jun 19. Review. PubMed PMID: 28642115; PubMed Central PMCID: PMC5693260.

Summerhill EM, Hoyle GW, Jordt SE, Jugg BJ, Martin JG, Matalon S, Patterson SE, Prezant DJ, Sciuto AM, Svendsen ER, White CW, Veress LA. An Official American Thoracic Society Workshop Report: Chemical Inhalational Disasters. Biology of Lung Injury, Development of Novel Therapeutics, and Medical Preparedness. Ann Am Thorac Soc. 2017 Jun;14(6):1060-1072. doi: 10.1513/AnnalsATS.201704-297WS. PubMed PMID: 28418689; PubMed Central PMCID: PMC5529138.

Sunil VR, Vayas KN, Fang M, Zarbl H, Massa C, Gow AJ, Cervelli JA, Kipen H, Laumbach RJ, Lioy PJ, Laskin JD, Laskin DL. World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung. Exp Mol Pathol. 2017 Feb;102(1):50-58. doi: 10.1016/j.yexmp.2016.12.005. Epub 2016 Dec 13. PubMed PMID: 27986442; PubMed Central PMCID: PMC5472054.

Trempus CS, Song W, Lazrak A, Yu Z, Creighton JR, Young BM, Heise RL, Yu YR, Ingram JL, Tighe RM, Matalon S, Garantziotis S. A novel role for primary cilia in airway remodeling. Am J Physiol Lung Cell Mol Physiol. 2017 Aug 1;313(2):L328-L338. doi: 10.1152/ajplung.00284.2016. Epub 2017 May 4. PubMed PMID: 28473325; PubMed Central PMCID: PMC5582939.

Yang S, Jan YH, Mishin V, Heck DE, Laskin DL, Laskin JD. Diacetyl/l-Xylulose Reductase Mediates Chemical Redox Cycling in Lung Epithelial Cells. Chem Res Toxicol. 2017 Jul 17;30(7):1406-1418. doi: 10.1021/acs.chemrestox.7b00052. Epub 2017 Jun 26. PubMed PMID: 28595002; PubMed Central PMCID: PMC5708134.

Zhou Y, Liu T, Duan JX, Li P, Sun GY, Liu YP, Zhang J, Dong L, Lee KSS, Hammock BD, Jiang JX, Guan CX. Soluble Epoxide Hydrolase Inhibitor Attenuates Lipopolysaccharide-Induced Acute Lung Injury and Improves Survival in Mice. Shock. 2017 May;47(5):638-645. doi: 10.1097/SHK.0000000000000767. PubMed PMID: 27753791; PubMed Central PMCID: PMC5382142.

Metabolic/Cellular Poisons

Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK. Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model. Ann N Y Acad Sci. 2017 Nov;1408(1):61-78. doi: 10.1111/nyas.13559. PubMed PMID: 29239480; PubMed Central PMCID: PMC5734662.

Anantharam P, Whitley EM, Mahama B, Kim DS, Imerman PM, Shao D, Langley MR, Kanthasamy A, Rumbeiha WK. Characterizing a mouse model for evaluation of countermeasures against hydrogen sulfide-induced neurotoxicity and neurological sequelae. Ann N Y Acad Sci. 2017 Jul;1400(1):46-64. doi: 10.1111/nyas.13419. Epub 2017 Jul 18. PubMed PMID: 28719733; PubMed Central PMCID: PMC6383676.

Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR. Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection. Ann Emerg Med. 2017 Jun;69(6):718-725.e4. doi: 10.1016/j.annemergmed.2016.09.034. Epub 2016 Dec 29. PubMed PMID: 28041825; PubMed Central PMCID: PMC5446299.

Brenner M, Azer SM, Oh KJ, Han CH, Lee J, Mahon SB, Du X, Mukai D, Burney T, Saidian M, Chan A, Straker DI, Bebarta VS, Boss GR. Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion. J Clin Toxicol. 2017 Jun;7(3). doi: 10.4172/2167-7972.1000355. Epub 2017 Jun 27. PubMed PMID: 28868209; PubMed Central PMCID: PMC5578424.

Haouzi P, Tubbs N, Rannals MD, Judenherc-Haouzi A, Cabell LA, McDonough JA, Sonobe T. Circulatory Failure During Noninhaled Forms of Cyanide Intoxication. Shock. 2017 Mar;47(3):352-362. doi: 10.1097/SHK.0000000000000732. PubMed PMID: 27513083; PubMed Central PMCID: PMC5303192.

Imamura F, Cooper TK, Hasegawa-Ishii S, Sonobe T, Haouzi P. Hydrogen Sulfide Specifically Alters NAD(P)H Quinone Dehydrogenase 1 (NQO1) Olfactory Neurons in the Rat. Neuroscience. 2017 Dec 16;366:105-112. doi: 10.1016/j.neuroscience.2017.10.014. Epub 2017 Oct 18. PubMed PMID: 29054567; PubMed Central PMCID: PMC5694374.

Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB. A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice. J Bone Miner Res. 2017 Jan;32(1):46-59. doi: 10.1002/jbmr.2909. Epub 2016 Sep 7. PubMed PMID: 27391172; PubMed Central PMCID: PMC5199609.

Kambale KJ, Ali ER, Sadiki NH, Kayembe KP, Mvumbi LG, Yandju DL, Boivin MJ, Boss GR, Stadler DD, Lambert WE, Lasarev MR, Okitundu LA, Mumba Ngoyi D, Banea JP, Tshala-Katumbay DD. Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning. Neurotoxicology. 2017 Mar;59:256-262. doi: 10.1016/j.neuro.2016.05.016. Epub 2016 May 28. PubMed PMID: 27246648; PubMed Central PMCID: PMC5125906.

Musah S, Schlueter CF, Humphrey DM Jr, Powell KS, Roberts AM, Hoyle GW. Acute lung injury and persistent small airway disease in a rabbit model of chlorine inhalation. Toxicol Appl Pharmacol. 2017 Jan 15;315:1-11. doi: 10.1016/j.taap.2016.11.017. Epub 2016 Nov 30. PubMed PMID: 27913141; PubMed Central PMCID: PMC5241700.

Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT. Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell Chem Biol. 2017 May 18;24(5):565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. Epub 2017 Apr 13. PubMed PMID: 28416275; PubMed Central PMCID: PMC5472353.


Kalinin S, Marangoni N, Kowal K, Dey A, Lis K, Brodsky S, van Breemen R, Hauck Z, Ripper R, Rubinstein I, Weinberg G, Feinstein DL. The Long-Lasting Rodenticide Brodifacoum Induces Neuropathology in Adult Male Rats. Toxicol Sci. 2017 Sep 1;159(1):224-237. doi: 10.1093/toxsci/kfx134. PubMed PMID: 28903499; PubMed Central PMCID: PMC5837443.