NINDS Office of Research Quality

Experimental and analytical rigor, measures to reduce bias, and transparency of reporting are the foundations for quality scientific research. Attention to principles of good study design and transparent reporting are essential to enable the scientific community as well as the community at large to assess the value of scientific findings. This is also important for peer reviewers to properly advise NINDS on grant applications. Please visit the resources referenced below or contact us for more information.


Rigor Champions and Resources

NINDS held a workshop in October 2018 on how better to instill the principles of rigorous research, which brought together subject matter experts capable of evaluating current educational practices. In light of this meeting, NINDS now calls for interested members of the scientific community to identify themselves as champions for scientific rigor. Please visit the Rigor Champions and Resources page for more information.

Funding Opportunities

NINDS has also launched a new initiative to improve training in the principles of rigorous research. Companion funding opportunities are now available for building, evaluating, and disseminating a user-friendly, harmonized, and openly accessible educational resource to promote awareness, understanding, and utilization of the principles of rigorous research: Creating an Educational Nexus for Training in Experimental Rigor (CENTER) and Materials to Enhance Training in Experimental Rigor (METER). Visit the links above or in the right sidebar to learn more.


NINDS Presentations about Rigor and Transparency

Scientific Rigor and Transparency Requirements

Dr. Maripierre Surpris released this video in March 2022 explaining the NIH requirements for rigor and transparency in grant applications. This video is part of a series about the Stephen I. Katz Early Stage Investigator Research Project Grant, but it is relevant to all NIH applications. See the NINDS page on Improving the Quality of NINDS-Supported Research through Rigorous Study Design and Transparent Reporting for additional NINDS guidance on rigor considerations in grant applications.

Rigor and Transparency in Research

In November 2020, Dr. Devon Crawford discussed rigor and transparency issues in the context of the virtual NINDS Metabolism-based Therapies for Epilepsy Workshop.

When Rigor Goes Wrong

On March 16, 2018, Dr. Shai Silberberg discussed some of the major rigor and transparency issues in biomedical research at a workshop for NINDS R25 grant recipients and trainees.

NINDS Historical Perspective on Research Rigor

Dr. Shai Silberberg presented a historical perspective of NINDS's involvement in the NIH rigor and transparency efforts as of September 2015. This 15-minute presentation was part of a larger NIH workshop on Reproducibility in Cell Culture Studies.


 

Publications


NIH Blog Posts

Related Topics 

NIH Rigor and Reproducibility

NIH Applicant Guidelines

NINDS Applicant Guidelines

NIH Reviewer Guidelines(pdf, 218 KB)

Experimental Design Tools and NIH Grant Examples

Training
NIH-Curated Training Modules and Online Course

NIH Office of Extramural Research Training and Resources

Contact

Shai Silberberg, Ph.D. | Director, Research Quality
SilberbS@ninds.nih.gov

Devon Crawford, Ph.D. | Program Director
devon.crawford@nih.gov

Related Announcements

Creating an Educational Nexus for Training in Experimental Rigor (CENTER) (RFA-NS-21-009)

Materials to Enhance Training in Experimental Rigor (METER) (RFA-NS-21-033)

NIH and AHRQ Announce Upcoming Changes to Policies, Instructions and Forms for Research Training Grant, Fellowship, and Career Development Award Applications (NOT-OD-20-033)

NIH & AHRQ Announce Upcoming Updates to Application Instructions and Review Criteria for Research Grant Applications (NOT-OD-18-228)

Improving the Quality of NINDS-Supported Preclinical and Clinical Research through Rigorous Study Design and Transparent Reporting (NOT-NS-11-023)

News and Events

NEWS

Good Science is Rigorous Science (NINDS Director's Message, August 9, 2021)

Rigor Not Mortis - Strengthening the Quality of Neuroscience Research (NINDS Director's Message, April 5, 2017)

EVENTS

NINDS Workshop on Catalyzing Communities of Research Rigor Champions (May 23-24, 2022)

NINDS Workshop: A Visionary Resource for Instilling Fundamental Principles of Rigorous Neuroscience Research (October 22-23, 2018)

NINDS Workshop: Optimizing the Predictive Value of Preclinical Research  (June 20-21, 2012)

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