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The Division of Translational Research funds programs to support new technology development and treatments for neurological disorders and prepares them for investor funding and corporate partnerships. We provide critical path funding and research resources for biotechnology companies and university researchers to advance early-stage neurological technologies, devices, and therapeutic programs to industry adoption (i.e., investor funding and corporate partnerships). In the last fiscal year, our division funded research projects covering a wide range of modalities (see chart).
Please find below a list of active projects that would welcome new partners.
Full List of Active Projects for Partnering
[contains sortable, interactive table of 255 projects]
Download All OTR Active Projects (Excel)
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| Title | Indications | Institution | Modality Category | PI | Programs |
|---|---|---|---|---|---|
| Orexin Receptor Antagonists for Drug Addiction and Panic Disorder | Addiction | Eolas Therapeutics, Inc. | Drug (small molecule) | Kenny, Paul J. | Blueprint |
| Small molecule drugs for treatment of dry age-related macular degeneration | Macular Degeneration | Columbia University | Drug (small molecule) | Petrukhin, Konstantin | Blueprint |
| Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy | Epilepsy | Mayo Clinic | Deep Brain Stimulation | Worrell, Gregory A. | BRAIN |
| High-Bandwidth Wireless Interfaces for Continuous Human Intracortical Recording | Multiple Indications | Massachusetts General Hospital; Brown University | Microelectrode Development | Hochberg, Leigh R.; Nurmikko, Arto | BRAIN |
| Central thalamic stimulation for traumatic brain injury | Traumatic Brain Injury (TBI) | Cornell | Deep Brain Stimulation | Schiff, Nicholas; Butson, Christopher R.; Giancino, Joseph Thomas; Henderson, Jaimie M.; Machado, Andre Guelman | BRAIN |
| Shape Memory Polymer Embolic Foams for Treating Cerebrovascular Aneurysms | Aneurysm | Texas Engineering Experiment Station | Therapeutic Device | Maitland, Duncan J. | NINDS Cooperative Program |
| Human EGFRvIII-specific BiTE for the treatment of Glioblastoma | Aneurysm | Duke University | Therapeutic Device | Sampson, John | NINDS Cooperative Program |
| Neural Stem Cell Mediated CE-CPT11 Therapy for Neuroblastoma | Nervous System Tumor | City of Hope/Beckman Research Institute | Cell Therapy | Aboody, Karen S. | NINDS Cooperative Program |
| Development of a next-generation PSD95 Inhibitor for the treatment of acute ischemia | Stroke | University Health Network | Peptide Therapy | Tymianski, Michael | NINDS Cooperative Program |
| Intralipid: A novel frontline countermeasure for brodifacoum poisoning | Anticoagulants | University of Illinois at Chicago | Drug (small molecule) | Feinstein, Douglas L | CounterACT |
| Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide Antidote | Metabolic/Cellular Poisons | University of California San Diego | Drug (small molecule) | Boss, Gerry R | CounterACT |
| Developing Drugs to Mitigate Parathion Intoxication | Neurotoxic Agents | RBHS - Robert Wood Johnson Medical School | Drug (small molecule) | Laskin, Jeffrey D | CounterACT |
| Neuroprotective effects of AEOL 10150 against organophosphate toxicity | Neurotoxic Agents | University of Colorado Denver | Drug (small molecule) | Patel, Manisha N | CounterACT |
| Accelerated AChE Reactivator Design by Mechanistic Neutron Scattering Studies | Neurotoxic Agents | University of California San Diego | Drug (small molecule) | Radic, Zoran | CounterACT |
| Brain-penetrating acetylcholinesterase reactivators for several organophosphates | Neurotoxic Agents | Mississippi State University | Drug (small molecule) | Chambers, Janice Elaine | CounterACT |
| Neurosteroid Treatment for OP Intoxication | Neurotoxic Agents | Texas A&M University Health Science Center | Drug (small molecule) | Reddy, Doodipala Samba | CounterACT |
| Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication | Neurotoxic Agents | University of California Davis | Drug (small molecule) | Lein, Pamela J | CounterACT |
| Targeting the Glutamatergic System to Counteract Soman Toxicity in Immature Rats | Neurotoxic Agents | Henry M. Jackson FDN for the ADV MIL/MED | Drug (small molecule) | Braga, Maria F | CounterACT |
| Formulation and Encapsulation of Enzymic Countermeasures Against Organophosphorus | Neurotoxic Agents | Ohio State University | Protein Therapy | Magliery, Thomas J | CounterACT |
| Amelioration of soman-induced neuropathology with NAAG-related compounds | Neurotoxic Agents | Henry M. Jackson FDN for the ADV MIL/MED | Drug (small molecule) | McCabe, Joseph T | CounterACT |
| Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment Strategies | Pulmonary Agents | University of Alabama at Birmingham | Drug (small molecule) | Matalon, Sadis | CounterACT |
| Nitrite dependent protection against Cl2 gas toxicity_role of chlorinated lipids | Pulmonary Agents | University of Alabama at Birmingham | Diagnostic Device | Patel, Rakesh Pravinchandra | CounterACT |
| Thioredoxin mimicry: novel treatment of toxicant-mediated inhalational lung injury | Pulmonary Agents | Radikal Therapeutics, Inc. | Drug (small molecule) | Southan, Garry John | CounterACT |
| Amelioration of Vesicant-Induced Skin Injury by High Dose 25-Hydroxyvitamin D | Vesicating Agents | Case Western Reserve University | Drug (small molecule) | Lu, Kurt | CounterACT |
| Extracellular RNA as therapeutic target after toxic chemical inhalation | Vesicating Agents | University of Alabama at Birmingham | Protein Therapy | Ahmad, Aftab | CounterACT |
| RNAI THERAPY FOR SPINOCEREBELLAR ATAXIA TYPE 1 | Spinocerebellar Ataxia | Children's Hosp of Philadelphia | Oligonucleotide Therapy | Davidson, Beverly L. | CREATE Bio |
| Preclinical Testing of a Novel Flow Diverting Stent for Treating Intracranial Aneurysms | Aneurysm | Neurosigma, Inc. | Therapeutic Device | Kealey, Colin | Small Business |
| Auto-Injectable Diazepam Formulation for Rapid Treatment of Uncontrolled Seizures | Epilepsy | Xeris Pharmaceuticals, Inc. | Drug (small molecule) | Kinzell, John | Small Business |
| Enzyme Replacement Therapy for Sanfilippo A Lysosomal Rare Disease | Lysosomal storage disorder | Biostrategies, LLC | Protein Therapy | Radin, David | Small Business |
| Highly efficient cerebral perfusion MRI | Multiple Indications | Advanced MRI Technology, LLC | Imaging Device | Feinberg, David Alan | Small Business |
| High-Field MR Compatible Dense Array EEG using Polymer Thick Film Technology | Multiple Indications | Electrical Geodesics, Inc. | Imaging Device | Poulsen, Catherine | Small Business |
| Microhook Nerve Tape: A Nerve Repair Coaptation Aid | Nerve Injury | Axion Biosystems, LLC. | Intraoperative Device | Clements, Isaac | Small Business |
| Development of selective Cav3 channel blockers for treatment of neuropathic pain | Pain | AFASCI, Inc. | Drug (small molecule) | Xie, Xinmin Simon | Small Business |
| DBS-Expert: Automated Deep Brain Stimulation Programming Using Functional Mapping | Parkinson's Disease | Great Lakes Neurotechnologies | Research Devices/Software | Heldman, Dustin A. | Small Business |
| Rapid Magnetomotive Thrombolysis for Stroke | Stroke | Pulse Therapeutics, Inc. | Drug Delivery | Creighton, Francis Milton | Small Business |
| Stroke Treatment by Chemically-induced Hypothermia | Stroke | JT Pharmaceuticals, Inc. | Peptide Therapy | Dix, Thomas | Small Business |
| Targeted Transcranial Electrotherapy to Accelerate Stroke Rehabilitation-Exploratory Trial on Aphasia | Stroke | Soterix Medical, Inc. | Therapeutic Device | Datta, Abhishek | Small Business |
| Multimodality Image-Based Assessment System for Traumatic Brain Injury | Traumatic Brain Injury (TBI) | Kitware, Inc | Imaging Device | Aylward, Stephen | Small Business |
| Optimization of Compounds that Stabilize the SMN Protein for Treatment of SMA | Spinal Muscular Atrophy (SMA) | Indiana Univ-Purdue Univ At Indianapolis | Drug (small molecule) | Androphy, Elliot | IGNITE |
| Neural Stem Cell Carriers for Glioblastoma Immunotherapy | Other | Northwestern University At Chicago | Cell Therapy | Balyasnikova, Irina | IGNITE |
| Red blood cell microparticles (RMPs) to reduce bleeding following hemorrhagic stroke | Stroke | University Of Miami School Of Medicine | Other | Dave, Kunjan | IGNITE |
| Inhibitors of TrkB Signaling | Epilepsy | Duke University | Drug (small molecule) | Mcnamara, James O. | IGNITE |
| Developing Novel RNA-Based Therapeutics for Parkinson's Disease | Parkinson's Disease | Robert Wood Johnson Medical School | Protein Therapy | Mouradian, Maral | IGNITE |
| New GAA expansion mouse for efficacy studies of treatments for Friedreich ataxia | Spinocerebellar Ataxia | University Of Alabama At Birmingham | Model Development | Napierala, Marek | IGNITE |
| Anticonvulsant screening using chronic epilepsy models | Epilepsy | Massachusetts General Hospital | Drug (small molecule) | Staley, Kevin J. | IGNITE |
| Development of Poly ICLC for neuroprotection against ischemic brain injury | Stroke | Oregon Health & Science University | Oligonucleotide Therapy | Stenzel-Poore, Mary P | IGNITE |
| Complement inhibitors targeted to the ischemic brain for the treatment of stroke | Stroke | Medical University Of South Carolina | Protein Therapy | Tomlinson, Stephen | IGNITE |
| Efficacies and Pharmacodynamic Assays for LRRK2 Small-Molecule Inhibitors | Parkinson's Disease | University Of Alabama At Birmingham | Drug (small molecule) | West, Andrew B | IGNITE |
| Modified neural stem cells for glycosylation-independent treatment of MPS IIIB | Lysosomal storage disorder | Los Angeles Biomedical Research Institute/ Harbor UCLA Medical Center | Cell Therapy | Iacovino, Michelina | IGNITE |
| Development of Therapeutic Antibody for Traumatic Brain Injury | Traumatic Brain Injury (TBI) | Beth Israel Deaconess Medical Center | Protein Therapy | Lu, Kun Ping | CREATE Bio |
| In vivo efficacy studies to support the development of DUX4-targeted RNAi therapy for FSHD | Muscular Dystrophy | Research Institute Nationwide Children's Hospital | Gene Therapy | Harper, Scott Q. | IGNITE |
| Development and validation of a genetically engineered model of neurofibromatosis type 2 to facilitate discovery of neurotherapeutics | Neurofibromatosis | SCRIPPS Florida | Model Development | Kissil, Joseph | IGNITE |
| The Rat Pre-Formed Alpha-Synuclein Fibril Model of Parkinsons Disease | Parkinson's Disease | Michigan State University | Model Development | Sortwell, Caryl | IGNITE |
| Discovery of Post-transcriptional utrophin upregulator small molecules for Duchenne Muscular Dystrophy therapeutics | Muscular Dystrophy | University of Pennsylvania | Drug (small molecule) | Khurana, Tejvir S. | IGNITE |
| Innovation Grant to Nurture Initial Translational Efforts (IGNITE) to Neurotherapeutic Approaches in Minipig Models of PKU Disorders | PKU Disorders | University of Pittburgh at Pittsburgh | Model Development | Nicholls, Robert D. | IGNITE |
| Allele-specific RNA-targeted lead compounds for Huntingtons disease | Huntington's Disease | Ribometrix, LLC | Drug (small molecule) | Warner, Katherine | IGNITE |
| Discovery of non-addictive KOR antagonists for migraine prophylaxis | Pain | BlackThorn Therapeutics, Inc | Drug (small molecule) | Jones, Robert M. | Blueprint |
| Discovery/Development of GABA-A α5 Positive Allosteric Modulators for Treatment of MCI due to AD | Alzheimer's Disease | AgeneBio, Inc. | Drug (small molecule) | Rozenzweig-Lipson, Sharon | Blueprint |
| Development of an Oral Analgesic for Neuropathic Pain | Pain | Eicosis, LLC | Drug (small molecule) | Buckpitt, Alan R. | Blueprint |
| Kv7.2/7.3 Activators for the Treatment of Epilepsy Disorders | Epilepsy | Knopp Biosciences, LLC | Drug (small molecule) | Bozik, Michael | Blueprint |
| Developing nonmuscle II inhibitors for substance use relapse | Addiction | Scripps Florida | Drug (small molecule) | Miller, Courtney A. | Blueprint |
| Disaggregation of Toxic Protein Oligomers in Brain with Electromagnetic Treatment | Alzheimer's Disease | NEUROEM THERAPEUTICS, INC. | Therapeutic Device | ARENDASH, GARY W | Small Business |
| Development of an information-rich assay for C9ORF72 as a test for ALS and FTD | Amyotrophic Lateral Sclerosis (ALS) | Asuragen, Inc. | Assay development | Bram, Eran | Small Business |
| Kinetic Phenotype Discovery Informatics for Neurological Diseases | Amyotrophic Lateral Sclerosis (ALS) | Drvision Technologies, LLC | Research tool | Lee, Shih-Jong J | Small Business |
| Phase 1 Clinical Evaluation of NP10679, a GluN2B Selective, Context-Dependent NMDA Receptor Inhibitor for Subarachnoid Hemorrhage | Aneurysm | Neurop, Inc. | Drug (small molecule) | Zaczek, Robert | Small Business |
| Development of BA-1049 for treatment of cerebral cavernous malformation | Aneurysm | Bioaxone Biosciences, INC. | Drug (small molecule) | Mckerracher, Lisa Joan | Small Business |
| Recombinant Silk Elastin-like Protein Polymers for the Embolization of Cerebral Aneurysms | Aneurysm | Theratarget | Protein Therapy | Ghandehari, Hamid | Small Business |
| Development of a Biochemical Diagnosis for Creutzfeldt-Jakob disease | Creutzfeldt-Jakob disease | AMPRION, INC. | Biomarker | Lebovitz, Russell M | Small Business |
| High Performance Seizure Monitoring and Alert System | Epilepsy | Optima Neuroscience, INC. | Diagnostic Device | Shiau, Deng-Shan | Small Business |
| EEG Patch | Epilepsy | Epitel, INC. | Diagnostic Device | Lehmkuhle, Mark J | Small Business |
| Development of a large area high resolution micro ECoG electrode array | Epilepsy | Bmseed, LLC | Research tool | Graudejus, Oliver | Small Business |
| Development and validation of therapy for mucopolysaccharidosis III | Lysosomal storage disorder | Phoenix Nest, INC. | Gene Therapy | Ekins, Sean | Small Business |
| Pharmacological Chaperone Therapy for the GM2 Gangliosidoses | Lysosomal storage disorder | Orphi Therapeutics, INC. | Drug (small molecule) | Sjoberg, Eric | Small Business |
| New Treatment of the Brain in Niemann Pick C | Lysosomal storage disorder | Lipogene Company, INC. | Gene Therapy | Pardridge, William M | Small Business |
| Brain DNA Therapeutics with Trojan Horse Liposomes | Lysosomal storage disorder | Lipogene Company, INC. | Gene Therapy | Partridge, William | Small Business |
| Enzyme replacement therapy for GM1 gangliosidosis lysosomal rare disease | Lysosomal storage disorder | Biostrategies, LC | Protein Therapy | Radin, David | Small Business |
| Improving MPS I ERT Efficacy through Lectin-Mediated Delivery | Lysosomal storage disorder | Biostrategies, LC | Protein Therapy | Radin, David | Small Business |
| High-quality compact portable low-field head MRI with ultra-fast gradients | Multiple Indications | Weinberg Medical Physics, LLC | Imaging | Weinberg, Irving | Small Business |
| MRI brain morphometry for computer-aided detection of neurological disorders | Multiple Indications | Corticometrics, LLC | Imaging | SCHMANSKY, NICHOLAS JOHN | Small Business |
| Modular antibody engineering to overcome the blood brain barrier | Multiple Indications | Abzyme Therapeutics, LLC | Protein/Antibody Therapy | Tran, Hiep T | Small Business |
| Platform for practical delivery of oral autoantigens as co-therapies for neurological disease | Myasthenia Gravis | Soymeds, INC. | Protein/Antibody Therapy | Piller, Kenneth J | Small Business |
| Development and Characterization of a Swine Model of Neurofibromatosis Type 2 | Neurofibromatosis | Recombinetics, INC. | Model Development | Watson, Adrienne Leigh | Small Business |
| Development of NSI-189, a novel neurogenic molecule, to prevent and treat diabetic neuropathy | Neuropathy | Neuralstem, INC. | Drug (small molecule) | Johe, Karl K | Small Business |
| Development of Pirenzepine for HIV-SN | Neuropathy | Winsantor, INC. | Drug (small molecule) | Mizisin, Andrew | Small Business |
| Cyanalyzer A Medical Laboratory Device for the Rapid Diagnosis of Cyanide Exposure | Metabolic/Cellular Poisons | Seacoast Science, INC. | Diagnostic Device | Jackson, Randy | Small Business |
| Cyanalyzer A Medical Laboratory Device for the Rapid Diagnosis of Cyanide Exposure | Neurotoxin exposure | SEACOAST SCIENCE, INC. | Diagnostic Device | Jackson, Randy | Small Business |
| The Bilayer Nanopore Integrated Assay for Complete Toxin Characterization, Phase II | Other | ELECTRONIC BIOSCIENCES, INC. | Assay development | ERVIN, ERIC | Small Business |
| NITRC Image Repository: A Commercial Solution to Advancing Data Sharing in Neuroscience | Other | TCG, INC. | Imaging | PREUSS, NINA | Small Business |
| A novel 3D-ultrasound platform using traditional 2D probes | Other | URSUS MEDICAL, LLC | Imaging | HAYES, THOMAS | Small Business |
| Software and hardware to study brain function during behavior using laser scanning microscopy. | Other | VIDRIO TECHNOLOGIES, LLC | Imaging | KIMMEL, BRUCE | Small Business |
| Development of technologies to advance fast and accurate tools for measuring fluorescence in living cells, with emphasis on developing assays optimized for screening in neuronal cells and brain tissue | Other | MONTANA MOLECULAR, LLC | Imaging | QUINN, ANNE MARIE | Small Business |
| High Speed Multiphoton Multifocal Whole Brain Imaging | Other | TISSUEVISION, INC. | Other | RAGAN, TIMOTHY M | Small Business |
| NeuroPET HD: A low-cost, high performance neuro-PET imaging system | Other | PET/X, LLC | Imaging | HUNTER, WILLIAM COULIS JASON | Small Business |
| Non-invasive integrated system for brain stimulation and magnetocorticography | Other | TRISTAN TECHNOLOGIES, INC. | Imaging | PAULSON, DOUGLAS N | Small Business |
| A Microneedle Array System for Transcutaneous Nerve Mapping | Other | AXION BIOSYSTEMS, LLC | Research tool | ROSS, JAMES | Small Business |
| Automated electrophysiological analysis of neural circuitry using a novel nano-electrode array for intracellular recording of membrane potential | Other | CYION TECHNOLOGIES, LLC | Research tool | JIANG, XIN | Small Business |
| A microfluidic platform for modeling drug transport and cell trafficking across the blood-brain barrier | Other | NORTIS, INC. | Research tool | NEUMANN, THOMAS | Small Business |
| An Implantable and High-Density, Multiplexed Micro-ECoG System | Other | MICRO-LEADS, INC. | Research tool | MCLAUGHLIN, BRYAN L | Small Business |
| A Unified System for Wireless Optogenetics and Brain Microdialysis for Small Molecules: Prototype Development and Validation | Other | EICOM USA | Research tool | AZUMA, SHINJI | Small Business |
| Prosthetic System for Large-Scale Recording and Manipulation of Neural Circuit Activity in Non-Human Primates | Other | GRAYMATTER RESEARCH | Research tool | GOODELL, ALBERT BALDWIN | Small Business |
| Enterprise Neuroinformatics for Interoperable Data Management and Dissemination | Other | ADVANCED BIOMEDICAL INFORMATICS GROUP | Research tool | BOCKHOLT, HENRY JEREMY | Small Business |
| Development of Selective Inhibitors of NaV1.7 as Therapeutics for Pain | Pain | SITEONE THERAPEUTICS, INC. | Drug (small molecule) | MULCAHY, JOHN VINCENT | Small Business |
| Peripheral nerve stimulation for amputee pain | Pain | SPR THERAPEUTICS, LLC | Therapeutic Device | BOGGS, JOSEPH WILDER | Small Business |
| Glycosaminoglycan-Interacting Small Molecule (GISMO) as Parkinsons Therapeutic | Parkinson's Disease | GISMO THERAPEUTICS, INC. | Drug (small molecule) | GREGOR, PAUL | Small Business |
| Advanced therapeutic for Parkinsons Disease | Parkinson's Disease | INHIBIKASE THERAPEUTICS | Drug (small molecule) | WERNER, MILTON H | Small Business |
| Improved Electrode Material for Deep Brain Stimulation and Neural Recording | Parkinson's Disease | PLATINUM GROUP COATINGS, LLC | Therapeutic Device | PETROSSIANS, ARTIN | Small Business |
| Improved Electrode Material for High-Density Closed-Loop DBS. | Parkinson's Disease | PLATINUM GROUP COATINGS, LLC | Therapeutic Device | PETROSSIANS, ARTIN | Small Business |
| Development of self-delivering RNAi targeted to PTEN for treatment of spinal cord injury | Spinal Cord Injury (SCI) | BIOAXONE BIOSCIENCES, INC. | Drug (small molecule) | MCKERRACHER, LISA JOAN | Small Business |
| Discovering Novel Drug Targets for CNS Edema by In Vitro Genetics | Stroke | PREDICTIVE BIOLOGY | Biomarker | CHOI, TED | Small Business |
| Human Neural Cell Exosomes as a therapeutic treatment for stroke | Stroke | ARUNA BIOMEDICAL, INC. | Cell Therapy | WEBB, ROBIN L | Small Business |
| Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment | Stroke | ZYMO RESEARCH CORPORATION | Drug (small molecule) | BOOHER, KEITH | Small Business |
| Identifying activators of interferon regulatory factors for neuroprotection. | Stroke | NEURALEXO, LLC | Drug (small molecule) | STENZEL-POORE, MARY P | Small Business |
| Human Apyrase Therapy for Acute Ischemic Stroke | Stroke | APT THERAPEUTICS, INC. | Protein Therapy | CHEN, RIDONG | Small Business |
| Reducing Brain Injury After Focal Ischemia Using a Nitric Oxide-Neutral Oxygen Carrier | Stroke | OMNIOX, INC. | Protein Therapy | CARY, STEPHEN | Small Business |
| Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury | Stroke | PROTHERA BIOLOGICS, LLC | Protein Therapy | LIM, YOW-PIN | Small Business |
| DRα1-MOG: A Novel Immunomodulatory Therapeutic for Stroke | Stroke | VIROGENOMICS BIODEVELOPMENT, INC. | Protein Therapy | ALKAYED, NABIL J | Small Business |
| A Combination Endovascular Device: Therapeutic Hypothermia with Stentriever Devices | Stroke | FOCALCOOL, LLC | Therapeutic Device | MERRILL, THOMAS L | Small Business |
| Establishing the Functional Viability and Dose-Response of Duck, Duck Punch: A Stroke Rehabilitation Computer Game | Stroke | RECOVR, INC. | Therapeutic Device | HAYES, AUSTEN LUKE | Small Business |
| Prediction Model for Incident Stroke for Early Screening of an Individual at Risk of Stroke | Stroke | IHEALTHSCREEN, INC. | Biomarker | BHUIYAN, ALAUDDIN | Small Business |
| Early Feasibility Clinical Study of the VitalFlow Stimulator, an Emergency Treatment for Ischemic Stroke | Stroke | NERVIVE, INC. | Therapeutic Device | SACRISTAN, EMILIO | Small Business |
| Bioimpedance-based Intracranial Mapping for Monitoring Evolving TBI | Traumatic Brain Injury (TBI) | RYTEK MEDICAL, INC. | Diagnostic Device | HALTER, RYAN JOSEPH | Small Business |
| Advanced morphological analysis of cerebral blood flow for acute concussion diagnosis and return-to-play determination | Traumatic Brain Injury (TBI) | NEURAL ANALYTICS, INC. | Diagnostic Device | HAMILTON, ROBERT | Small Business |
| Noninvasive scalp detection of cortical spreading depression for brain injury | Traumatic Brain Injury (TBI) | SCIENCEPLUSPLEASE, LLC | Diagnostic Device | JONES, STEPHEN CARTER | Small Business |
| Novel Treatment for Traumatic Brain Injury | Traumatic Brain Injury (TBI) | EPIGEN BIOSCIENCES, INC. | Drug (small molecule) | UTESHEV-GAARD, VICTOR V | Small Business |
| Advanced Bicycle Helmet Technology for Prevention of Traumatic Brain Injury | Traumatic Brain Injury (TBI) | APEX BIOMEDICAL COMPANY, LLC | Prevention device | BOTTLANG, MICHAEL | Small Business |
| Internal and external validation of a porcine dystrophinopathy model | Muscular Dystrophy | Iowa State University | Model Development | Selsby, Joshua | IGNITE |
| Use of CRISPR/Cas9 to treat Huntington disease | Huntington's Disease | Emory University | Gene Therapy | Li, Xiao-Jiang | IGNITE |
| High-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophy | Other | University of Pittsburgh at Pittsburgh | Protein Therapy | Vogt, Andreas | IGNITE |
| Long Acting Local Analgesics: HSV-CA8 Biotherapeutics | Pain | University Of Miami School Of Medicine | Protein Therapy | Levitt, Roy C. | IGNITE |
| A software tool for objective identification of concussion-related vision disorders using a novel eye-tracking device | Traumatic Brain Injury (TBI) | Oculogica, INC. | Diagnostic Device | Master, Christina | Small Business |
| Assessment of NOVO-118 as a regenerative therapeutic in acute spinal cord injury | Spinal Cord Injury (SCI) | Novoron Bioscience, INC. | Protein Therapy | Stiles, Travis Lee | Small Business |
| Commercialization of a Rapid Blood Test for Traumatic Brain Injury | Traumatic Brain Injury (TBI) | Fawkes Biotechnology, LLC | Diagnostic Device | Lovell, Mark Anthony | Small Business |
| Development of a syringe/sonication device employed to administer DDFPe in the prehospital setting | Traumatic Brain Injury (TBI) | Nuvox Pharma, LLC | Therapeutic Device | Unger, Evan Charles | Small Business |
| Development of a unified information-rich test for CNBP and DMPK to improve assessment of Myotonic Dystrophy Type 1 and 2 | Muscular Dystrophy | Asuragen, INC. | Diagnostic Device | Hall, Bradley | Small Business |
| Development of an Implantable Trigeminal Nerve Stimulation System for Drug Resist | Epilepsy | Neurosigma, INC. | Therapeutic Device | Cook, Ian | Small Business |
| Form factor determination for the Talon microIPG system to treat Chronic Migraine | Pain | Neogenesis Technologies, LLC | Therapeutic Device | Dulak, Gary | Small Business |
| Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury | Stroke | Mitovation, INC. | Therapeutic Device | Sanderson, Thomas | Small Business |
| MRI-compatible and integrated devices for simultaneous neural recording, stimulation, imaging | Other | Mr-Link, LLC | Research tool | Liu, Zhongming | Small Business |
| Nonsense Suppressing Drugs for Rett Syndrome | Other | Starwise Therapeutics, LLC | Drug (small molecule) | Kozikowski, Alan | Small Business |
| Preclinical Testing of Splice Modulating Oligonucleotides Targeting SCN8A to Treat Dravet Syndrome | Epilepsy | Lifesplice Pharma, LLC | Oligonucleotide Therapy | Tallent, Melanie | Small Business |
| Rapid Baseline Free Organophosphate Exposure Diagnostic Test | Neurotoxin exposure | Countervail Corporation | Diagnostic Device | Basinger, Bill | Small Business |
| Retinal eye-tracking for the prognosis and monitoring of multiple sclerosis | Multiple Sclerosis | C.Light Technologies, INC. | Diagnostic Device | Sheehy, Christy Kathleen | Small Business |
| Development of dendrimer-N-acetylcystein for the treatment of neonatal brain injury | Cerebral Palsy | Johns Hopkins University | Other | Rangaramanujam, Kannan | CREATE Bio |
| Antisense Oligonucleotides for Treating Spinocerebellar Ataxia Type 2 | Spinocerebellar Ataxia | Pulst, Stefan M. | Oligonucleotide Therapy | Pulst, Stefan M. | CREATE Bio |
| A Novel Myeloperoxidase Inhibitor for Treating Multiple Sclerosis | Multiple Sclerosis | RENEUROGEN, LLC | Peptide Therapy | Pritchard, Kirkwood | Small Business |
| An all-optical electrophysiology platform for the discovery of pain therapeutics | Pain | Q-STATE BIOSCIENCES, INC. | Drug (small molecule) | McManus, Owen B | Small Business |
| Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms | Stroke | GENTUITY, LLC | Intraoperative Device | Ughi, Giovanni J | Small Business |
| NeuroMAP System for Clinical Research | Multiple Indications | ALTEC, INC. | Research tool | De Luca, Gianluca | Small Business |
| Optimization and Assessment of a Biologic to Improve Cognitive Function After Traumatic Brain Injury | Traumatic Brain Injury (TBI) | ALCAMENA STEM CELL THERAPEUTICS, LLC | Peptide Therapy | Verdecia, Mark A | Small Business |
| Development of a novel bioabsorbable clip and applier for rapid closure of the dura mater in open and minimally invasive spine surgery | Spinal Cord Injury (SCI) | NEURAMEDICA, LLC | Therapeutic Device | Dreilinger, Rachel | Small Business |
| Development of immunoassays for highly sensitive diagnostic monitoring of traumatic brain injury using novel astroglial injury-defined biomarkers | Traumatic Brain Injury (TBI) | IMMUNARRAY USA, INC. | Assay development | Vanmeter, Timothy E | Small Business |
| MyoRegulator: A non-invasive neuromodulation device for treatment of spasticity in stroke patients | Stroke | PATHMAKER NEUROSYSTEMS, INC. | Therapeutic Device | Yaghoubi, Nader | Small Business |
| Noninvasive Seizure Screening in Preclinical Models of Epilepsy | Epilepsy | SIGNAL SOLUTIONS, LLC | Research Devices/Software | Sunderam, Sridhar | Small Business |
| Novel Highly Regenerative and Scalable Progenitor Cell Exosomes for Treating Stroke | Stroke | BIOTIME, INC. | Other | Larocca, Dana | Small Business |
| PIKFYVE antagonism as a therapy for C9ORF72-ALS/FTD | Multiple Indications | ACURASTEM, INC. | Assay development | Alworth, Samuel V | Small Business |
| TDP-43 aggregation inhibitors for the treatment of ALS | Amyotrophic Lateral Sclerosis (ALS) | AQUINNAH PHARMACEUTICALS, INC. | Drug (small molecule) | Larsen, Glenn | Small Business |
| Tolerability of SRX246 in Huntingtons Disease Patients | Huntington's Disease | AZEVAN PHARMACEUTICALS, INC. | Drug (small molecule) | Brownstien, Michael | Small Business |
| Topical selective T-type blockers for the treatment of neuropathic pain | Pain | DERMAXON, LLC | Drug (small molecule) | Astruc-Diaz, Fanny | Small Business |
| Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntingtons Disease | Huntington's Disease | BIOSENSICS, LLC | Monitoring Device | Gwin, Joseph T | Small Business |
| EP2 antagonists as novel anti-epileptogenic agents | Epilepsy | EMORY UNIVERSITY | Gene Therapy | GANESH, THOTA | IGNITE |
| Development and validation of small molecules to treat neurofibromatosis associated schwannoma | Neurofibromatosis | SCRIPPS FLORIDA | Drug (small molecule) | KISSIL, JOSEPH | IGNITE |
| Small molecule stabilizers of Hsp70 for treatment of spinal and bulbar muscular atrophy | Spinal and Bulbar Muscular Atrophy | UNIVERSITY OF MICHIGAN | Drug (small molecule) | LIEBERMAN, ANDREW P | IGNITE |
| Development of SK channel modulators as therapeutic agents for ataxia | Spinocerebellar Ataxia | CHAPMAN UNIVERSITY | Drug (small molecule) | ZHANG, MIAO | IGNITE |
| Development of Human 12/15-lioxygenase therapeutics for stroke | Stroke | Massachusetts General Hospital | Drug (small molecule) | van Leyen, Klaus | Blueprint |
| Phosgene Oxime Cutaneous Toxicity and Mechanisms to Identify Therapeutic Targets | Pulmonary Agents | University of Colorado Denver | Drug (small molecule) | Tewari-Singh, Neera | CounterACT |
| Functional Genomics of Chemical-Induced Acute Lung Injury | Pulmonary Agents | University of Pittsburgh at Pittsburgh | Drug (small molecule) | Leikauf, George | CounterACT |
| Treatment of persistent chlorine-induced small airway disease | Pulmonary Agents | University of Louisville | Drug (small molecule) | Hoyle, Gary | CounterACT |
| CIALIS® reverses halogen induced injury to pregnant animals and their offspring | Pulmonary Agents | University of Alabama at Birmingham | Drug (small molecule) | Matalon, Sadis | CounterACT |
| Development of antidotes for toxic gases | Pulmonary Agents | University of Colorado Denver | Drug (small molecule) | White, Carl | CounterACT |
| Targeting cardiopulmonary calpains to mitigate toxicity of halogen gases. | Pulmonary Agents | University of Alabama at Birmingham | Drug (small molecule) | Ahmad, Shama | CounterACT |
| TIE2 Activation for the Treatment of Chemical-Induced Acute Lung Injury | Pulmonary Agents | Duke University | Drug (small molecule) | Kontos, Christopher | CounterACT |
| Antidotes against Hydrochloric Acid-Induced Chronic Lung Injury | Pulmonary Agents | Old Dominion University | Drug (small molecule) | Catravas, John | CounterACT |
| An Approach toward Antidotes for Phosphine | Pulmonary Agents | University of Pittsburgh at Pittsburgh | Drug (small molecule) | Pearce, Linda | CounterACT |
| Methylene blue as an antidote against hydrogen sulfide intoxication | Metabolic/Cellular Poisons | Pennsylvania State Univ Hershey Med Ctr | Drug (small molecule) | Haouzi, Philippe | CounterACT |
| New Chelating (decorporating) Agents for Azide | Metabolic/Cellular Poisons | University of Pittsburgh at Pittsburgh | Drug (small molecule) | Pearce, Linda | CounterACT |
| Effects of acute administration of the Phenothiazinium Chromophore Methylene blue during life threatening cyanide intoxication | Metabolic/Cellular Poisons | Pennsylvania State Univ Hershey Med Ctr | Drug (small molecule) | Haouzi, Philippe | CounterACT |
| Overlay independent X-ray data analysis for enhanced oxime OP-ChE reactivation | Neurotoxic Agents | University of California San Diego | Research tool | Radić, Zoran | CounterACT |
| Toxin-specific and symptomatic drugs in combination with novel neuroprotectants effectively counteract DFP-induced long-term neurotoxicity | Neurotoxic Agents | Iowa State University | Drug (small molecule) | Thippeswamy, Thimmasettappa | CounterACT |
| Epigenetic Attenuation of Long-Term Effects of Nerve Agents | Neurotoxic Agents | Texas A&M University Health Science Ctr | Drug (small molecule) | Reddy, Samba | CounterACT |
| Anticholinergic and antiepileptic Therapies for Chlorine Toxicity | Neurotoxic Agents | University of Colorado Denver | Drug (small molecule) | Veress, Livia | CounterACT |
| Neurosteroids as a standard medical countermeasure for OP poisoning | Neurotoxic Agents | University of California Irvine | Drug (small molecule) | Gee, Kelvin | CounterACT |
| The carboxylesterase knockout mouse as a model to evaluate the efficacy of delayed medical countermeasures against soman exposure | Neurotoxic Agents | Geneva Foundation | Model Development | Lange, Lucille | CounterACT |
| Mitochondrial Targeted Biofuels as Countermeasures Against Chemical Threats | Metabolic/Cellular Poisons | Children's Hospital of Philadelphia | Drug (small molecule) | Kilbaugh, Todd | CounterACT |
| Computationally Designed Stable Artificial Phosphotriesterases for Detoxification of Organophosphorus Agents | Neurotoxic Agents | New York University | Protein Therapy | Montclare, Jin | CounterACT |
| Novel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus | Neurotoxic Agents | Virginia Commonwealth University | Drug (small molecule) | DeLorenzo, Robert | CounterACT |
| Identification of Novel Brain-penetrating Phenoxyalkyl Pyridinium Oxime Countermeasures | Neurotoxic Agents | Mississippi State University | Drug (small molecule) | Chambers, Janice | CounterACT |
| Cyanide/Azide Detoxification by New Cobalt Complexes and NO Donors | Metabolic/Cellular Poisons | University of Pittsburgh at Pittsburgh | Drug (small molecule) | Peterson, James | CounterACT |
| Rutgers University CounterACT Center of Excellence | Vesicating Agents | RBHS - Robert Wood Johnson Medical School | Drug (small molecule) | Laskin, Jeffrey D | CounterACT |
| Preclinical Development of Antisense Oligonucleotide Therapy for Spinocerebellar Ataxia Type 3 | Spinocerebellar Ataxia | UNIVERSITY OF MICHIGAN AT ANN ARBOR | Oligonucleotide Therapy | McLoughlin, Hayley Sarah | CREATE Bio |
| A Combined High-Throughput Single-Cell Transcriptomic and Secretomic Assay for Neurodegenerative Disease Biomarker Discovery | Frontotemporal dementia | ISOPLEXIS, INC. | Assay development | MCCONNELL, TIMOTHY S | Small Business |
| Synthetic hydrogels for biomanufacturing of iPSC-derived neural cells for precision medicine | Multiple Indications | STEM PHARM, INC. | Assay development | LEBAKKEN, CONNIE S | Small Business |
| Live Cell Assays to Identify and Interrogate Stressed Neurons in Models of Neurodegenerative Disease. | Multiple Indications | MONTANA MOLECULAR, LLC | Assay development | HARLEN, KEVIN MATTHEW | Small Business |
| Mimicking synuclein toxicity in plant cells to identify novel neuroprotective leadsv | Parkinson's Disease | NAPROGENIX, INC | Assay development | LITTLETON, JOHN M | Small Business |
| A user-friendly microfluidic chip for anti-epileptogenic drug screening | Epilepsy | XONA MICROFLUIDICS, LLC | Assay development | TAYLOR, ANNE MARION | Small Business |
| Targeted Degradation of CAG Repeat Expanded Huntingtin mRNA, Associated with Huntingtons Disease, Using Artificial Site-Specific RNA Endonucleases | Huntington's Disease | ENZERNA BIOSCIENCES, LLC | Oligonucleotide Therapy | SAZANI, PETER | Small Business |
| Development of Nasal IGF-1 as a Migraine Therapeutic | Migraine | SEURAT THERAPEUTICS, INC. | Protein Therapy | ZHANG, YUAN | Small Business |
| Intracerebroventricular Iduronidase Delivery to the Brain | Lysosomal storage disorder | TEGA THERAPEUTICS, INC. | Protein Therapy | BROWN, JILLIAN R | Small Business |
| Selective Inhibition of Platelet GPIb-alpha Binding to Leukocyte Mac-1 as a Therapeutic for Multiple Sclerosis | Multiple Sclerosis | SUJANA BIOTECH, LLC | Protein/Antibody Therapy | CHESS, DAVID | Small Business |
| Generation of Tissue Engineered Nerve Grafts from GalSafe Porcine Neurons | Spinal Cord Injury (SCI) | AXONOVA MEDICAL, LLC | Other | LEDEBUR, HARRY | Small Business |
| CN-105 Improves Functional Outcome After Intracranial Hemorrhage | Aneurysm | AEGISCN, LLC | Peptide Therapy | FREMEAU, ROBERT T | Small Business |
| Immunomodulatory Therapy for Neuropathic Pain | Pain | APT THERAPEUTICS, INC. | Protein Therapy | CHEN, RIDONG | Small Business |
| Enzyme Replacement Therapy For Infantile Onset Neuronal Ceroid Lipofuscinoses | Lysosomal storage disorder | COLLABORATIONS PHARMACEUTICALS, INC. | Protein Therapy | EKINS, SEAN | Small Business |
| Electrical impedance myography technology for quantitative, at-home muscle assessment in amyotrophic lateral sclerosis and other neuromuscular disorders. | Amyotrophic Lateral Sclerosis (ALS) | MYOLEX, INC. | Diagnostic Device | LUPTON, ELMER C | Small Business |
| Cerebral Palsy Risk Identification System | Cerebral Palsy | NEUROCOMP SYSTEMS, INC. | Diagnostic Device | O'HALLORAN, JAMES P | Small Business |
| Deep learning enhanced seizure monitoring from wearable sensors | Epilepsy | VIGILANT MEDICAL, INC. | Diagnostic Device | VENKATESHA, SANTOSH | Small Business |
| Prehospital and Emergency Room Stroke Diagnosis Using Quantitative Cerebral Hemodynamics | Stroke | NEURAL ANALYTICS, INC. | Diagnostic Device | THIBEAULT, COREY MICHAEL | Small Business |
| Lab-To-Marketplace: Commercialization of a stretchable microelectrode array | Other | BMSEED, LLC | Research tool | GRAUDEJUS, OLIVER | Small Business |
| Magnetic camera based on optical magnetometer for neuroscience research | Other | FIELDLINE, INC. | Research tool | ALEM, ORANG | Small Business |
| Neural Implant Insertion System using Ultrasonic Vibration to Reduce Tissue Dimpling and Improve Insertion Precision of Floating Arrays in the Neocortex | Other | ACTUATED MEDICAL, INC. | Research tool | MULVIHILL, MAUREEN L | Small Business |
| Wireless Implantable Neural Recording Device | Other | NEUROLUX, INC. | Research tool | GHAFFARI, ROOZBEH | Small Business |
| Introducing Neuroscience and Neurocomputation Concepts to High School Students using Brain-based Neurorobots | Other | BACKYARD BRAINS, INC. | Research tool | GAGE, GREGORY JOHN | Small Business |
| Sonomyographic Control of Fiber-Optically Sensorized Prosthetic Fingers for Graded Force Actuation | Nerve Injury | INTELLIGENT FIBER OPTIC SYSTEMS CORP | Therapeutic Device | BLACK, RICHARD J | Small Business |
| User-driven Retrospectively Supervised Classification Updating (RESCU) system for robust upper limb prosthesis control | Nerve Injury | INFINITE BIOMEDICAL TECHNOLOGIES, LLC | Therapeutic Device | KALIKI, RAHUL REDDY | Small Business |
| Device for Rapid, Complete & Durable Occlusion of Wide-Neck Cerebral Aneurysms | Aneurysm | METACTIVE MEDICAL, INC. | Therapeutic Device | FRANANO, F NICHOLAS | Small Business |
| Probe for Quantitative Fluorescence | Nervous System Tumor | INSIGHT SURGICAL TECHNOLOGIES, LLC | Therapeutic Device | ROBERTS, DAVID W | Small Business |
| Development of a novel Balloon Occlusion Sheath for Stroke (BOSS) | Stroke | MARBLEHEAD MEDICAL, LLC | Therapeutic Device | KALLMES, DAVID F | Small Business |
| Cuff Electrodes with Soft Wire Electrical Leads | Nerve Injury | TDA RESEARCH, INC. | Therapeutic Device | CLAPSADDLE, BRADY JOHN | Small Business |
| Soft-Focused HIFU Treatment of Common Peroneal Nerve Injury | Pain | ACOUSTIC MEDSYSTEMS, INC. | Therapeutic Device | BURDETTE, EVERETTE C | Small Business |
| CranialProgrammer: Image-Guided Directional Deep Brain Stimulation Programming Using Local-Field Potentials | Parkinson's Disease | NEXEON MEDSYSTEMS PUERTO RICO OPERATING COMPANY, INC | Therapeutic Device | DUKE, AUSTIN ROBERT | Small Business |
| Magnetically Enhanced Diffusion for Intra-Arterial Treatment of Acute Ischemic Stroke | Stroke | PULSE THERAPEUTICS, INC. | Therapeutic Device | TONES, MICHAEL ANTHONY | Small Business |
| Astroglial EAAT2 Changes in Live TBI Brain Determined by PET Imaging | Traumatic Brain Injury (TBI) | RIO PHARMACEUTICALS, INC. | Imaging | VANBROCKLIN, HENRY F | Small Business |
| Automated Assessment of Leptomeningeal Collaterals on CT Angiograms | Stroke | KITWARE, INC. | Imaging | LEE, YUEH Z | Small Business |
| Drug Eluting Embolization Coils for Improved Treatment of Intracranial Aneurysms | Aneurysm | ANCURE, LLC | Therapeutic Device | BETTINGER, CHRISTOPHER JOHN | Small Business |
| Zwitterionic oxime (RS194B) to reverse advanced symptoms and lethality of organophosphate pesticide exposure | Neurotoxin exposure | Neurotoxin exposure | Drug (small molecule) | ROSENBERG, YVONNE J | Small Business |
| Pivotal trial of vamorolone in Duchenne muscular dystrophy | Muscular Dystrophy | REVERAGEN BIOPHARMA, INC. | Drug (small molecule) | HOFFMAN, ERIC P | Small Business |
| Novel Therapy for Huntingtons Disease | Huntington's Disease | RESILIO THERAPEUTICS, LLC | Drug (small molecule) | VITEK, MICHAEL PETER | Small Business |
| Small Molecule Treatments to Enhance Neurological Recovery After Stroke | Stroke | STEMETIX, INC. | Drug (small molecule) | FINKLESTEIN, SETH | Small Business |
| Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein-protein interaction | Pain | ANAGIN | Drug (small molecule) | FLORIO, STEPHANIE KAY | Small Business |
| IND-enabling studies on novel Cav3 T-channel modulators for treatment of neuropathic pain | Pain | AFASCI, INC. | Drug (small molecule) | XIE, XINMIN SIMON | Small Business |
| Chemokine-receptor expression profiling in biological samples from human clinical trials | Pain | PLUMERIA THERAPEUTICS, INC. | Drug (small molecule) | RICHARDSON, THOMAS P | Small Business |
| NAAA Inhibition for Pain and Inflammation | Pain | NEOKERA, LLC | Drug (small molecule) | MONAGHAN, EDWARD PAUL | Small Business |
| Peripheral FAAH inhibitor, URB937, as an opioid-sparing analgesic for chronic pain. | Pain | ASPIREBIO CORPORATION | Drug (small molecule) | PIOMELLI, DANIELE | Small Business |
| Development of Novel Metformin Analog for Treatment of Parkinsons Disease | Parkinson's Disease | PK BIOSCIENCES CORPORATION | Drug (small molecule) | ANANTHARAM, VELLAREDDY | Small Business |
| Neo-Substrate Amplifiers of PINK1 for the Treatment of Parkinsons Disease | Parkinson's Disease | MITOKININ, INC. | Drug (small molecule) | WANG, CHENGZHONG | Small Business |
| An oral ROCK2-selective inhibitor for treatment of chronic spinal cord injury | Spinal Cord Injury (SCI) | BIOAXONE BIOSCIENCES, INC. | Drug (small molecule) | ROSEN, KENNETH M | Small Business |
| Cathepsin B inhibitor Drug Development for Traumatic Brain Injury | Traumatic Brain Injury (TBI) | AMERICAN LIFE SCIENCE PHARMACEUTICALS | Drug (small molecule) | HOOK, GREGORY R | Small Business |
| Preclinical development of AST-004 for astrocyte-mediated treatment of TBI. | Traumatic Brain Injury (TBI) | ASTROCTYE PHARMACEUTICALS, INC. | Drug (small molecule) | LISTON, THEODORE E | Small Business |
| Development of new anti-epilepsy treatments targeting cellular energetics through mitochondrial modulation with optimal pharmacokinetics and toxicity profiles | Epilepsy | NEUROENE THERAPEUTICS, LLC | Drug (small molecule) | CHAN, SHERINE S | Small Business |
| Kv7.2/7.3 Activators for the Treatment of Epilepsy Disorders | Epilepsy | KNOPP BIOSCIENCES, LLC | Drug (small molecule) | BOZIK, MICHAEL | Small Business |
| A Novel Treatment for Batten Disease | Lysosomal storage disorder | SENEB BIOSCIENCES, INC. | Diagnostic Device | DEFREES, SHAWN | Small Business |
| Non-Metal PN Scavenger/Decomposition Catalysts for Treatment of Migraine | Pain | CERSCI THERAPEUTICS, INC. | Drug (small molecule) | DUSSOR, GREGORY O | Small Business |
| In Silico Identification of Novel GHB Receptor Ligands for SSADH Deficiency, a Disorder of GABA Metabolism | Traumatic Brain Injury (TBI) | SPERAGEN, INC. | Drug (small molecule) | MCCONNELL, ALICE | Small Business |
| Farnesol as Novel Treatment in Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) | Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) | SPERAGEN, INC. | Drug (small molecule) | MCCONNELL, ALICE | Small Business |
| Inert Coating for Cerebral Shunts to Eliminate Clogging | Other | FREEFLOW MEDICAL DEVICES, LLC | Therapeutic Device | JONES, ANDREW K | Small Business |
| User-driven Retrospectively Supervised Classification Updating (RESCU) system for robust upper limb prosthesis control | Other | Infinite Biomedical Technologies, LLC | Other | KALIKI, RAHUL | NINDS Exploratory/Dev Projects |