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The Division of Translational Research funds programs to support new technology development and treatments for neurological disorders and prepares them for investor funding and corporate partnerships. We provide critical path funding and research resources for biotechnology companies and university researchers to advance early-stage neurological technologies, devices, and therapeutic programs to industry adoption (i.e., investor funding and corporate partnerships). In the last fiscal year, our division funded research projects covering a wide range of modalities (see chart).
Please find below a list of active projects that would welcome new partners.
Full List of Active Projects for Partnering
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| Title | Indication | Institution | Modality (Category) | PI | Program |
|---|---|---|---|---|---|
| Enzyme replacement therapy for GM1 gangliosidosis lysosomal rare disease | Genetic/Rare Disease | BIOSTRATEGIES, LC | Therapeutic - Biologic | RADIN, DAVID | Small Business |
| RNAi Therapy for Spinocerebellar Ataxia Type 1 | Genetic/rare disease | CHILDREN'S HOSP OF PHILADELPHIA | Therapeutic biologic | DAVIDSON, BEVERLY L | CREATE Bio |
| Peripheral nerve stimulation for amputee pain | Injury | SPR THERAPEUTICS, LLC | Therapeutic/prevention device | BOGGS, JOSEPH WILDER | Small Business |
| Human EGFRvIII-specific BiTE for the treatment of Glioblastoma | Brain tumor | DUKE UNIVERSITY | Therapeutic biologic | SAMPSON, JOHN H | CREATE Bio |
| Electrical impedance myography technology for quantitative, at-home muscle assessment in amyotrophic lateral sclerosis and other neuromuscular disorders. | Neurodegeneration | MYOLEX, INC. | Diagnostic device | LUPTON, ELMER C | Small Business |
| Stem Cells for Treating Acute Stroke | Stroke | SANERON CCEL THERAPEUTICS, INC. | Therapeutic biologic | KUZMIN-NICHOLS, NICOLE A | Small Business |
| Validation of a novel cortical biomarker signature for pain | Pain | UNIVERSITY OF MARYLAND BALTIMORE | Biomarker | DA SILVA, JOYCE TEIXEIRA | HEAL Biomarkers |
| Discovery of Biomarker Signatures Prognostic for Neuropathic Pain after Acute Spinal Cord Injury | Pain | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON | Biomarker | HERGENROEDER, GEORGENE W | HEAL Biomarkers |
| Discovery and Analytical Validation of Inflammatory Bio-Signatures of the Human Pain Experience | Pain | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON | Biomarker | PROSSIN, ALAN RODNEY | HEAL Biomarkers |
| Biomarker Signature to Predict the Persistence of Post-Traumatic Headache | Pain | MAYO CLINIC ARIZONA | Biomarker | CHONG, CATHERINE DANIELA | HEAL Biomarkers |
| Repression of Sodium Channels via a Gene Therapy for Treatment of Chronic Neuropathic Pain | Pain | NAVEGA THERAPEUTICS, INC. | Therapeutic biologic | MORENO, ANA MARIA | Small Business |
| Assessment of Peripherally Circulating Plasma Proteins and Clinical Risks to Differentiate Epileptic Seizure from Psychogenic Nonepileptic Seizure | Epilepsy | EVOGEN, INC. | Biomarker | GLEDHILL, JOHN | Small Business |
| Targeting lipid rafts for treatment of migraine | Pain | RAFT PHARMACEUTICALS, LLC | Therapeutic biologic | BACON, KEVIN | Small Business |
| Multielectrode Arrays for Neurotransmitter Detection with Fast Scan Cyclic Voltammetry | Neuroscience research tool | MICROPROBES FOR LIFE SCIENCE, INC. | Research tool | ZESTOS, ALEXANDROS GEORGE | Small Business |
| Pre-clinical evaluation of DT-001, a small molecule antagonist of MD2-TLR4 for utility in the treatment of pain. | Pain | DOULEUR THERAPEUTICS, INC. | Therapeutic small molecule | YAKSH, TONY L | Small Business |
| Optimization of non-addictive biologics to target sodium channels involved in pain signaling | Pain | UNIVERSITY OF CALIFORNIA AT DAVIS | Therapeutic biologic | YAROV-YAROVOY, VLADIMIR M | HEAL Biologics/ Small Molecules |
| The Inflammatory Index as a Biomarker for Pain in Patients with Sickle Cell Disease | Pain | MEDICAL COLLEGE OF WISCONSIN | Biomarker | BRANDOW, AMANDA M | HEAL Biomarkers |
| SPRINT: Signature for Pain Recovery IN Teens | Pain | STANFORD UNIVERSITY | Biomarker | SIMONS, LAURA E | HEAL Biomarkers |
| Implantable Peripheral Nerve Stimulator for Treatment of Phantom Limb Pain | Pain | RIPPLE, LLC | Therapeutic/prevention device | MCDONNALL, DANIEL | HEAL Devices |
| IND-enabling studies on novel Cav3 T-channel modulators for treatment of neuropathic pain | Pain | AFASCI, INC. | Therapeutic/prevention device | XIE, XINMIN SIMON | Small Business |
| Treatment of Lafora disease with an antibody-enzyme fusion | Epilepsy | UNIVERSITY OF KENTUCKY | Therapeutic - Biologic | GENTRY, MATTHEW S | IGNITE |
| IGNITE: Development of novel cyclophilin B/PIKfyve inhibitors for treatment of Malignant Peripheral Nerve Sheath Tumors | Genetic/rare disease | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE | Therapeutic - Small molecule | OLSON, STEVEN H | IGNITE |
| Advancing and calibrating anisotropic diffusion MR imaging brain connectome with Taxon brain network diffusion phantoms | Neuroscience Research Tool | PSYCHOLOGY SOFTWARE TOOLS, INC. | Research tool/assay/animal model | ZUCCOLOTTO, ANTHONY P | Small Business |
| High-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophy | Genetic/rare disease | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | Therapeutic - Small molecule | VOGT, ANDREAS | IGNITE |
| Soman-induced neuropathology in Gottingen minipig: large animal model assessment for MCM | Countermeasures | GENEVA FOUNDATION | Research tool/assay/animal model | LANGE, LUCILLE | CounterAct |
| A Double-Blind, Randomized, Controlled Trial of Epidural Conus Medullaris Stimulation to Alleviate Pain and Augment Rehabilitation in Patients with Subacute Thoracic Spinal Cord Injury (SCI) | Injury | DUKE UNIVERSITY | Therapeutic/prevention device | LAD, SHIVANAND P | HEAL Devices |
| Prehospital Diagnostic Biomarker for Large Vessel Occlusion | Stroke | NEURAL ANALYTICS, INC. | Biomarker | HAMILTON, ROBERT | Biomarkers |
| Optimizing oncolytic virus therapy for glioblastoma | Brain Tumor | UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON | Therapeutic - Biologic | KAUR, BALVEEN | IGNITE |
| The cyclic redox dye Azure B as a novel cyanide antidote: in vivo efficacy studies | Countermeasures | PENNSYLVANIA STATE UNIV HERSHEY MED CTR | Therapeutic - Small molecule | HAOUZI, PHILIPPE A | CounterAct |
| Calpastatin Peptide-based Calpain Inhibitor as a Traumatic Brain Injury Therapeutic | Injury | NEUROTHERANOSTICS, INC. | Therapeutic - Biologic | ANAGLI, JOHN Y | Small Business |
| An integrated electrical impedance myography platform for neuromuscular disease classification and diagnosis | Genetic/Rare Disease | MYOLEX, INC. | Diagnostic device/biomarker | LUPTON, ELMER C | Small Business |
| Targeted Therapy for Myasthenia Gravis | Genetic/Rare Disease | ARC BIOTECHNOLOGY, LLC | Therapeutic - Biologic | KAMINSKI, HENRY J | Small Business |
| Plasma MicroRNA Biomarkers to Guide Rehabilitation Therapy After Stroke | Stroke | GEORGETOWN UNIVERSITY | Biomarker | EDWARDSON, MATTHEW A | Biomarkers |
| Objective tests utilizing Vibrational Spectroscopy for Diagnosis and Severity of Fibromyalgia and Related Pain Syndromes | Pain | UNIVERSITY OF TEXAS AT AUSTIN | Biomarker | HACKSHAW, KEVIN VICTOR | Biomarkers |
| Therapeutics for Huntingtons Disease | Neurodegeneration | SYNTHETIC BIODESIGN, LLC | Multiple/other | RUFFNER, DUANE | Small Business |
| A rapid blood test to aid the triage of patients affected by head injuries. | Injury | ACCEL DIAGNOSTICS, LLC | Diagnostic device/biomarker | GANDINI, ALBERTO | Small Business |
| OPTIMIZATION AND ASSESSMENT OF A BIOLOGIC TO IMPROVE FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY | Injury | ALCAMENA STEM CELL THERAPEUTICS, LLC | Therapeutic - Biologic | PISARCHIK, ALEXANDER | Small Business |
| Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury | Stroke | MITOVATION, INC. | Therapeutic/prevention device | SANDERSON, THOMAS HUDSON | Small Business |
| Advanced therapeutic for Parkinsons Disease | Neurodegeneration | INHIBIKASE THERAPEUTICS | Therapeutic - Small molecule | WERNER, MILTON H | Small Business |
| Drug Eluting Embolization Coils for Improved Treatment of Intracranial Aneurysms | Stroke | ANCURE, LLC | Multiple/other | BETTINGER, CHRISTOPHER JOHN | Small Business |
| Rapid and Effective Localized Neurovascular Cooling Using the Khione Insulative Catheter | Stroke | FOCALCOOL, LLC | Therapeutic/prevention device | MERRILL, THOMAS L | Small Business |
| Human Neural Cell Exosomes as a Therapeutic Treatment for Stroke | Stroke | ARUNA BIOMEDICAL, INC. | Therapeutic - Biologic | BAKER, EMILY W | Small Business |
| User-driven Retrospectively Supervised Classification Updating (RESCU) system for robust upper limb prosthesis control | Injury | INFINITE BIOMEDICAL TECHNOLOGIES, LLC | Therapeutic/prevention device | KALIKI, RAHUL REDDY | Devices |
| Transcranial focused ultrasound for head and neck cancer pain. A pilot study | Multiple/other | UNIVERSITY OF VIRGINIA | Therapeutic/prevention device | ELIAS, WILLIAM JEFFREY | HEAL Devices |
| Novel monoclonal antibody for single dose treatment of acute CNS injury | Injury | ONCOSYNERGY, INC. | Therapeutic - Biologic | CARBONELL, ANNE-MARIE | Small Business |
| iPSC-derived neurovascular tissue model of cerebral amyloiad angiopathy | Neurodegeneration | VANDERBILT UNIVERSITY | Research tool/assay/animal model | LIPPMANN, ETHAN | IGNITE |
| Multi-Omic Biomarkers for Neuropathic Pain Secondary to Chemotherapy | Pain | CLEVELAND CLINIC LERNER COM-CWRU | Biomarker | ROTROFF, DANIEL | HEAL Biomarker |
| Ultra-low attachment coatings to maintain CSF shunt patency | Genetic/Rare Disease | INNOVATIVE SURFACE TECHNOLOGIES, INC. | Therapeutic/prevention device | TATON, KRISTIN S | Small Business |
| Antioxidant enzyme-loaded Pro-NP for treatment of TBI. | Injury | PROTRANSIT NANOTHERAPY, LLC | Therapeutic - Biologic | MADSEN, GARY LEONARD | Small Business |
| Advancing SRX246 to Commericialization | Neurodegeneration | AZEVAN PHARMACEUTICALS, INC. | Therapeutic/prevention device | BROWNSTEIN, MICHAEL J | Small Business |
| Rapid, Multiplexed, Idealized Antiepileptic Drug Monitoring | Epilepsy | ELECTRONIC BIOSCIENCES, INC. | Therapeutic/prevention device | SCHIBEL, ANNA | Small Business |
| Cryopreserved preparations of male and female brain cells to study gender-related issues | Multiple/Other | SPOT CELLS, LLC | Research tool/assay/animal model | KIEDROWSKI, LECH | Small Business |
| Eliminating the human factor from stereotaxic surgeries | Multiple/Other | POPNEURON LTD. | Research tool/assay/animal model | KLUG, ACHIM | Small Business |
| EpiZode: Noninvasive Seizure Screening in Preclinical Models of Epilepsy | Epilepsy | SIGNAL SOLUTIONS, LLC | Research tool/assay/animal model | SUNDERAM, SRIDHAR | Small Business |
| Refinement of a rapid saliva miRNA diagnostic test for concussion | Injury | QUADRANT BIOSCIENCES, INC. | Diagnostic device/biomarker | LEVITSKIY, DAVID | Small Business |
| Transposon Engineered B Cell Therapy for Hunter Syndrome | Genetic/Rare Disease | IMMUSOFT CORPORATION | Therapeutic - Biologic | HAMPE, CHRISTIANE S | Small Business |
| Developing Drug-like Small Molecules that Target Toxic Repeat RNAs to Alleviate Myotonic Dystrophy Type 1-derived Mis-Splicing | Genetic/Rare Disease | NYMIRUM, INC. | Therapeutic - Small molecule | KIMSEY, ISAAC J | Small Business |
| Selective actin remodeling of sensory neurons for acute pain management | Pain | NEUROCARRUS, INC. | Therapeutic - Small molecule | BLUM, PAUL | Small Business |
| Development of a topical fixed-dose combination drug for peripheral neuropathic pain. | Pain | WINSANTOR, INC. | Therapeutic - Small molecule | HANSEN, ANGELA | Small Business |
| Pharmacodynamics and in vivo efficacy of fumarate for mitochondrial disease in vivo | Neurodegeneration | UNIVERSITY OF CALIFORNIA AT DAVIS | Therapeutic - Small molecule | CORTOPASSI, GINO A | IGNITE |
| Prognostic biomarkers for high-impact chronic pain: Development and validation | Pain | STANFORD UNIVERSITY | Biomarker | MACKEY, SEAN C | HEAL Biomarker |
| Novel monoclonal antibody for single dose treatment of acute CNS injury | Injury | ONCOSYNERGY, INC. | Therapeutic - Biologic | CARBONELL, ANNE-MARIE | Small Business |
| Anticonvulsant screening using chronic epilepsy models | Epilepsy | MASSACHUSETTS GENERAL HOSPITAL | Therapeutic - Small molecule | STALEY, KEVIN J | IGNITE |
| Clinical Testing of an Intracortical Visual Prosthesis System | Multiple/other | ILLINOIS INSTITUTE OF TECHNOLOGY | Therapeutic/prevention device | TROYK, PHILIP R | Devices |
| The cyclic redox dye Azure B as a novel cyanide antidote: in vivo efficacy studies | Countermeasures | PENNSYLVANIA STATE UNIV HERSHEY MED CTR | Therapeutic - Small molecule | HAOUZI, PHILIPPE A | CounterAct |
| Early Feasibility Clinical Study of the VitalFlow Stimulator, an Emergency Treatment for Ischemic Stroke | Stroke | NERVIVE, INC. | Therapeutic/prevention device | SACRISTAN, EMILIO | Devices |
| Combined Cortical and Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder | Multiple/other | MASSACHUSETTS GENERAL HOSPITAL | Therapeutic/prevention device | DOUGHERTY, DARIN D | Devices |
| Clinical Translation of Targeted and Noninvasive Ultrasonic Propofol Uncaging | Epilepsy | STANFORD UNIVERSITY | Therapeutic/prevention device | AIRAN, RAAG D | Devices |
| Development of Therapeutic Antibody for Traumatic Brain Injury | Injury | BETH ISRAEL DEACONESS MEDICAL CENTER | Therapeutic - Biologic | ZEIDEL, MARK L | CREATE Bio |
| Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy | Epilepsy | MAYO CLINIC ROCHESTER | Therapeutic/prevention device | WORRELL, GREGORY A | Devices |
| Dual Lead Thalamic DBR-DBS Interface for Closed Loop Control of Severe Essential Tremor | Neurodegeneration | UNIVERSITY OF FLORIDA | Therapeutic/prevention device | OWEISS, KARIM G | Devices |
| Clinical Translation of Ultrasonic Ketamine Uncaging for Non-Opioid Therapy of Chronic Pain | Pain | STANFORD UNIVERSITY | Therapeutic/prevention device | AIRAN, RAAG D | HEAL Devices |
| Development of cellular HTS for 20S proteasome enhancers | Neurodegeneration | MICHIGAN STATE UNIVERSITY | Therapeutic - Small molecule | TEPE, JETZE J | IGNITE |
| Blood test to aid treatment decisions for perinatal asphyxiation | Injury | MESO SCALE DIAGNOSTICS, LLC | Biomarker | CAMPBELL, CHRISTOPHER T | Biomarkers |
| Slack Potassium Channel Inhibitors for the Treatment of Childhood Epilepsies | Epilepsy | VANDERBILT UNIVERSITY | Therapeutic - Small molecule | WEAVER, C DAVID | IGNITE |
| Pharmacokinetic assessment of peptide-based therapy HV-3 for the treatment of Huntingtons disease | Neurodegeneration | JANUSQ, LLC | Therapeutic - Biologic | SCHILB, ANDREW LORING | Small Business |
| Development of selective calpain-1 inhibitors for chronic pain | Pain | 1910 GENETICS INC. | Therapeutic - Biologic | NWANKWO, JENNIFER O | Small Business |
| Development of a novel analgesic for mixed inflammatory and neuropathic pain states | Pain | ANABIOS CORPORATION | Therapeutic - Small molecule | GHETTI, ANDREA | Small Business |
| Exploring Antisense Oligonucleotides as a potential therapy for Autosomal Dominant Leukodystrophy | Genetic/rare disease | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | Therapeutic - Biologic | PADIATH, QUASAR S | IGNITE |
| Humanization of a Notch 3 agonist antibody for pre-clinical development of a CADASIL treatment | Genetic/rare disease | SCHEPENS EYE RESEARCH INSTITUTE | Therapeutic - Biologic | ARBOLEDA-VELASQUEZ, JOSEPH | CREATE Bio |
| Extracellular RNA biomarkers of myotonic dystrophy type 1 | Genetic/rare disease | MASSACHUSETTS GENERAL HOSPITAL | Biomarker | WHEELER, THURMAN M | Biomarkers |
| Stimulation of novel spinal respiratory circuit to restore breathing in ventilator-dependent patients with SCI. | Injury | UNIVERSITY OF CALIFORNIA LOS ANGELES | Therapeutic/prevention device | LU, DANIEL | Devices |
| Clinical Validation of Serum Neurofilament Light as a Biomarker of Traumatic Axonal Injury | Injury | UNIVERSITY OF PENNSYLVANIA | Biomarker | DIAZ-ARRASTIA, RAMON | Biomarkers |
| Development of a Novel Chemokine Receptor Antagonist Peptide as a Non-Opioid Treatment for Relief of Chronic Pain | Pain | CREATIVE BIO-PEPTIDES, INC. | Therapeutic - Biologic | RUFF, MICHAEL R | Small Business |
| NINDS CREATE DISCOVERY: Development of dendrimer-N-acetylcysteine for the treatment of neonatal brain injury | Injury | JOHNS HOPKINS UNIVERSITY | Therapeutic - Biologic | RANGARAMANUJAM, KANNAN | CREATE Bio |
| Closed-Loop Micromagnetic Neuromodulation as a Non-Opioid Treatment for Neuropathic Pain. | Pain | QUANTUM NANOSTIM | Therapeutic/prevention device | REILLY, THOMAS | Small Business |
| Preclinical Development of VERSAMAB-101 for Spinal Cord Injury | Injury | VERSAPEUTICS INC | Therapeutic - Biologic | SUN, MIAO | Small Business |
| Development of gene therapy product for treating MPS IIIB | Genetic/Rare Disease | NEUROGT, INC. | Therapeutic - Biologic | FU, HAIYAN | Small Business |
| Explore Slow-Release Formulation of a Peptide Therapeutic for Migraine | Pain | ACHERX | Therapeutic - Biologic | SOARES, CHRISTOPHER JOSEPH | Small Business |
| Increasing NF1 Expression as a Treatment for NF1 Haploinsufficiency | Genetic/Rare Disease | INFIXION BIOSCIENCE, INC. | Therapeutic - Small molecule | SARNOFF, HERB | Small Business |
| High-throughput Screen for Discovery of Ciliary Neurotrophic Factor (CNTF) Receptor Agonists for the Treatment of Amyotrophic Lateral Sclerosis (ALS) | Neurodegeneration | MAYO CLINIC JACKSONVILLE | Therapeutic - Small molecule | ROSSOLL, WILFRIED | IGNITE |
| Novel Antidotes for H2S Poisoning | Countermeasures | MASSACHUSETTS GENERAL HOSPITAL | Therapeutic - Small molecule | ICHINOSE, FUMITO | CounterACT |
| Drug Discovery for Spinocerebellar Ataxia, using Novel Fluorescence Technology Targeting ?-III-Spectrin | Neurodegeneration | UNIVERSITY OF MINNESOTA | Therapeutic - Small molecule | HAYS, THOMAS S | IGNITE |
| Evaluating the Blood-Brain Barrier Bioavailability and in vivo Efficacy Potential of a Novel TAK1 Inhibitor Targeting Chronic Pain | Pain | EYDIS BIO, INC. | Therapeutic - Biologic | SCARNEO, SCOTT | Small Business |
| A Novel RNA Therapeutics Platform to Treat Facioscapulohumeral Muscular Dystrophy and other Neuromuscular Disorders | Genetic/Rare Disease | MIRECULE, INC. | Therapeutic - Biologic | SALEH, ANTHONY D | Small Business |
| Probe for Quantitative Fluorescence. Phase 2 | Brain Tumor | INSIGHT SURGICAL TECHNOLOGIES, LLC | Therapeutic/prevention device | ROBERTS, DAVID W | Small Business |
| Implantable Recording and Integrated Stimulation (IRIS) device for cortical experiments | Neuroscience Research Tool | RIPPLE, LLC | Research tool/assay/animal model | WILDER, ANDREW | Small Business |
| Central Vein Sign: A Diagnostic Biomarker in Multiple Sclerosis | Multiple Sclerosis | CLEVELAND CLINIC LERNER COM-CWRU | Biomarker | ONTANEDA, DANIEL | Biomarkers |
| Evaluation of Novel Dually Targeted Kinase Inhibitors for Therapy of Adult and Pediatric High-Grade Glioma | Brain Tumor | UNIVERSITY OF TX MD ANDERSON CAN CTR | Therapeutic - Small molecule | CHANDRA, JOYA | IGNITE |
| PIKFYVE antagonism as a therapy for C9ORF72-ALS/FTD | Neurodegeneration | ACURASTEM, INC. | Therapeutic - Small molecule | ALWORTH, SAMUEL V | Small Business |
| Deve inlopment of A High-Throughput Screen for Identification of Targeted Therapies in Brainstem Tumors with the H3K27M Mutation | Brain Tumor | MAYO CLINIC ROCHESTER | Therapeutic - Small molecule | DANIELS, DAVID | IGNITE |
| Preclinical Development of Antisense Oligonucleotide Therapy for Spinocerebellar Ataxia Type 3 | Neurodegeneration | UNIVERSITY OF MICHIGAN AT ANN ARBOR | Therapeutic - Biologic | MCLOUGHLIN, HAYLEY SARAH | CREATE Bio |
| Commercialization Readiness Pilot (CRP) to maximize vamorolone international labeling and sales | Genetic/Rare Disease | REVERAGEN BIOPHARMA, INC. | Therapeutic - Small molecule | HOFFMAN, ERIC P | Small Business |
| Epilepsy Seizure Detection with Innovative Tripolar EEG (tEEG) | Epilepsy | CREMEDICAL CORPORATION | Therapeutic/prevention device | BESIO, WALTER GRANT | Devices |
| Noninvasive, wireless thermal sensors for the quantitative monitoring of ventricular shunt function in patients with hydrocephalus | Genetic/rare disease | RHAEOS, INC. | Therapeutic/prevention device | SOMERA, ANNA LISA | Devices |
| Novel Anticonvulsant and Neuroprotective Therapies for TETS and OP Intoxication | Countermeasures | UNIVERSITY OF CALIFORNIA AT DAVIS | Therapeutic - Small molecule | LEIN, PAMELA J | CounterACT |
| Actigraphy Enhanced Clinical Chronic Lower Back Pain Management | Pain | ARBOR MEDICAL INNOVATIONS, LLC | Therapeutic/prevention device | KRUGER, GRANT H | Devices |
| Novel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus | Countermeasures | VIRGINIA COMMONWEALTH UNIVERSITY | Therapeutic - Small molecule | DELORENZO, ROBERT JOHN | CounterACT |
| Closed Loop Deep Brain Stimulation for Parkinsons Disease | Neurodegeneration | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | Therapeutic/prevention device | STARR, PHILIP ANDREW | Devices |
| Scalar Closed-Loop STN/GPi DBS Based on Evoked and Spontaneous Potentials | Neurodegeneration | DUKE UNIVERSITY | Therapeutic/prevention device | TURNER, DENNIS ALAN | Devices |
| Development of Novel Intra-aneurysmal Rapid Occlusion Device | Stroke | NEUROGAMI MEDICAL, INC. | Therapeutic/prevention device | HEBERT, STEPHEN J | Small Business |
| Plasma metabolite and proteome signatures for migraine classification | Pain | BRIGHAM AND WOMEN'S HOSPITAL | Biomarker | CHASMAN, DANIEL IAN | Biomarkers |
| Identification and verification of S-nitroysylated proteins in bodily fluids as biomarkers for Parkinsons disease and Lewy body dementia | Neurodegeneration | SCRIPPS RESEARCH INSTITUTE, THE | Biomarker | NAKAMURA, TOMOHIRO | Biomarkers |
| Catheter for Large Volume Intraparenchymal Brain Therapies | Multiple/Other | CREOSALUS, INC. | Therapeutic/prevention device | ABRAMOV, VASILIY | Small Business |
| Noninvasive Biomarkers to Advance Emerging DBS Electrode Technologies in Parkinsons Disease | Neurodegeneration | UNIVERSITY OF ALABAMA AT BIRMINGHAM | Therapeutic/prevention device | WALKER, HARRISON CARROLL | Devices |
| Advanced Development of Drugs to Mitigate Parathion Intoxication | Countermeasures | RBHS-SCHOOL OF PUBLIC HEALTH | Therapeutic - Small molecule | LASKIN, JEFFREY D | CounterACT |
| Analytical Validation of Tau and P-Tau as acute and subacute prognostic biomarkers for complicated mild TBI | Injury | UNIVERSITY OF FLORIDA | Biomarker | WANG, KEVIN KA WANG | Biomarkers |
| Deep cerebellar electrical stimulation for post-stroke motor recovery | Stroke | CLEVELAND CLINIC LERNER COM-CWRU | Therapeutic/prevention device | MACHADO, ANDRE GUELMAN | Devices |
| Educational Program on Translating Neural Medical Devices | Multiple/Other | UNIVERSITY OF MINNESOTA | Training | JOHNSON, MATTHEW DOUGLAS | Training |
| Development of IM Formulation of (2S,3S)-SPD for Nerve Agent Seizures | Countermeasures | UNIVERSITY OF CALIFORNIA AT DAVIS | Therapeutic - Small molecule | ROGAWSKI, MICHAEL A | CounterACT |
| Synthetic hydrogels for biomanufacturing of iPSC-derived neural cells for precision medicine | multiple/other | STEM PHARM, INC. | Research tool/assay/animal model | LEBAKKEN, CONNIE S | Small Business |
| Development of S-PCT3010 to treat Parkinsons Disease | Neurodegeneration | POLYCORE THERAPEUTICS, LLC | Therapeutic - Small molecule | BECK, KELLY A | Small Business |
| Improved Therapeutics for the Resurrection of the Aged Form of Acetylcholinesterase | Countermeasures | OHIO STATE UNIVERSITY | Therapeutic - Small molecule | HADAD, CHRISTOPHER M | CounterACT |
| Central thalamic stimulation for traumatic brain injury | Injury | WEILL MEDICAL COLL OF CORNELL UNIV | Therapeutic/prevention device | SCHIFF, NICHOLAS D | Devices |
| Novel pediatric anticonvulsants for nerve agents | Countermeasures | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR | Therapeutic - Small molecule | REDDY, DOODIPALA SAMBA | CounterACT |
| Network Pharmacology for Epilepsy Prevention | Epilepsy | PREVEP, INC. | Therapeutic - Small molecule | KLEIN, PAVEL | Small Business |
| High-Resolution, Spinal Cord Stimulation for Non-Opioid Treatment of Neuropathic Pain | Pain | MICRO-LEADS, INC. | Therapeutic/prevention device | MCLAUGHLIN, BRYAN L | HEAL Devices |
| tPA and NGF therapy for stroke | Stroke | HUMAN CELL CO | Therapeutic - Biologic | JEONG, SOON SEOG | Small Business |
| Automation of Extracorporeal Filtration of Subarachnoid Hemorrhage via Spinal Catheter | Stroke | MINNETRONIX, INC. | Therapeutic/prevention device | MCCABE, AARON RICHARD | Small Business |
| Kinase activation in multiple system atrophy | Neurodegeneration | INHIBIKASE THERAPEUTICS | Research tool/assay/animal model | WERNER, MILTON H | Small Business |
| Real-time three-dimensional spinal navigation system for bedside lumbar puncture placement | Multiple/other | RIVANNA MEDICAL, LLC | Diagnostic device | MAULDIN, FRANK WILLIAM | Small Business |
| Mitofusin agonists to prevent Charcot-Marie-Tooth disease 2A | Genetic/Rare Disease | MITOCHONDRIA IN MOTION, INC. | Therapeutic - Biologic | DORN, GERALD W | Small Business |
| Temporal Biomarker-Powered Immunotherapy Targeting GFAP for Traumatic Brain Injury | Injury | GRYPHON BIO, INC. | Therapeutic - Biologic | HASKINS, WILLIAM E | Small Business |
| HBI-002 to Treat Parkinsons Disease | Neurodegeneration | HILLHURST BIOPHARMACEUTICALS, INC. | Therapeutic - Small molecule | GOMPERTS, EDWARD | Small Business |
| Enabling rapid and effective stroke thrombectomy procedures from a Transradial approach: Combining introducer sheath, guide catheter, and distal access catheter into a single device. | Stroke | CONWAY MEDICAL LLC | Therapeutic/prevention device | KALLMES, DAVID F | Small Business |
| Neupron: A Neuroprotective Agent for Treating Acute Spinal Cord Injury | Injury | AXONEURAL THERAPEUTICS, INC. | Therapeutic - Small molecule | LABHASETWAR, VINOD D | Small Business |
| Plug-and-Play High-Order B0 Shimming for Reliable Temporal Lobe Epilepsy Magnetic Resonance Spectroscopic Imaging | Epilepsy | LUCIDITY MEDICAL, LLC | Diagnostic device | YANG, HSIN-JUNG | Small Business |
| Selection & Optimization of a Therapeutic Protein for Acute Ischemic Stroke Functional Recovery | Stroke | STREAM BIOMEDICAL, INC. | Therapeutic - Biologic | ADKISSON, HUSTON DAVIS | Small Business |
| Investigation of the Cortical Communication (CORTICOM) System | Injury | JOHNS HOPKINS UNIVERSITY | Therapeutic/prevention device | CRONE, NATHAN E | Devices |
| Preparing for IND-enabling safety studies for a potent and efficient neuroprotective drug. | Stroke | NEUREXIS THERAPEUTICS, INC. | Therapeutic - Biologic | GOFORTH, ROBYN | Small Business |
| AccuGyd: Accurate Guidance for MRI-Guided Minimally Invasive Neurosurgery | Multiple/other | IMGGYD LLC | Therapeutic/prevention device | OAKES, TERRENCE R | Small Business |
| Pre-clinical evaluation of a rationally designed nanotherapeutic for Huntingtons disease | Neurodegeneration | NEURANO BIOSCIENCE | Therapeutic - Small molecule | MOLOKANOVA, ELENA | Small Business |
| Circular mimics of Iron-response elements to inhibit ferroptosis | Neurodegeneration | CHIMERNA THERAPEUTICS INC. | Therapeutic - Biologic | PICKERING, BRIAN FREDERICK | Small Business |
| Development and clinical assessment of a robust, 3D printed titanium, myoelectric powered prosthetic digit system | Injury | POINT DESIGNS, LLC | Therapeutic/prevention device | SLIKER, LEVIN | Small Business |
| SensiTrak: Automated Assessment of Forelimb Sensation | Neuroscience Research Tool | VULINTUS, LLC | Research tool/assay/animal model | SLOAN, ANDREW MICHAEL | Small Business |
| Optimization of a Gene Therapy for Chronic Pain in Human DRGs | Pain | NAVEGA THERAPEUTICS, INC. | Therapeutic - Biologic | MORENO, ANA MARIA | Small Business |
| Selective Androgen Receptor Degraders (SARDs) as new therapeutics for spinal and bulbar muscular atrophy (SBMA) | Genetic/Rare Disease | ONCTERNAL THERAPEUTICS, INC. | Therapeutic - Biologic | KAUFMANN, GUNNAR JOERG FLORIS | Small Business |
| Clinical Evaluation of NoGo Trap Therapy in Chronic SCI | Injury | RENETX BIO, INC. | Therapeutic - Biologic | SMITH, ERIKA | Small Business |
| Novel Water-Soluble Adjunct Anticonvulsants for Nerve Agents | Countermeasures | TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR | Therapeutic - Small molecule | REDDY, DOODIPALA SAMBA | CounterACT |
| Development of a non-opioid chemogenetic therapy for chronic neuropathic pain | Pain | CODA BIOTHERAPEUTICS, INC. | Therapeutic - Small molecule | KERAVALA, ANNAHITA | Small Business |
| Mimicking synuclein toxicity in plant cells to identify novel neuroprotective leads | Neurodegeneration | NAPROGENIX, INC | Therapeutic - Small molecule | LITTLETON, JOHN M | Small Business |
| Algorithm for the Real-Time Detection of Absence Seizures from Oculometric Data | Epilepsy | EYSZ, INC. | Therapeutic/prevention device | KUPERMAN, RACHEL | Small Business |
| Circulating Organ-enriched microRNAs as biomarkers of Rett Syndrome | Genetic/Rare Disease | DIAMIR, LLC | Diagnostic device/biomarker | UMANSKY, SAMUIL R | Small Business |
| Pudendal neuromodulation for urinary and fecal incontinence and sphincter dyssynergia | Injury | DIGNIFY THERAPEUTICS, LLC | Therapeutic/prevention device | THOR, KARL B | Small Business |
| Generation of Tissue Engineered Nerve Grafts from GalSafe Porcine Neurons | Injury | AXONOVA MEDICAL, LLC | Therapeutic - Biologic | KATIYAR, KRITIKA | Small Business |
| A youth-specific helmet for preventing traumatic brain injury | Injury | SAVIOR BRAIN INC. | Therapeutic/prevention device | CAMARILLO, DAVID | Small Business |
| Analgesic Drug for Local Delivery by Fluoroscopy | Pain | INTERVENTIONAL ANALGESIX, INC. | Therapeutic - Small molecule | BEUTLER, ANDREAS S | Small Business |
| Development of Fluorescent Probes for Highlighting Nerves During Image Guided Surgeries | Multiple/other | ALUME BIOSCIENCES, INC. | Research tool/assay/animal model | WHITNEY, MICHAEL A | Small Business |
| Spinal Fiber Optic Monitoring | Injury | UT SOUTHWESTERN MEDICAL CENTER | Diagnostic device | FLOYD, THOMAS F | Devices |
| Microelectrode Array Insertion System using Ultrasonic Vibration to Improve Insertion Mechanics, Reduce Tissue Dimpling and Trauma, and Improve Placement Precision in the Neocortex | multiple/other | ACTUATED MEDICAL, INC. | Therapeutic/prevention device | MULVIHILL, MAUREEN L | Small Business |
| Omniphobic cerebral shunt to eliminate clogging and dysfunction | Genetic/Rare Disease | FREEFLOW MEDICAL DEVICES, LLC | Therapeutic/prevention device | BANDYOPADHYAY, SAIBAL | Small Business |
| Development of a novel therapeutic for treatment of white matter injury in premature infants | Injury | TELLUS THERAPEUTICS, INC. | Therapeutic - Biologic | KRALIC, JASON | Small Business |
| PHS 2019-02 Omnibus Solicitation of the NIH, CDC, and FDA for SmallBusiness Innovation Research Grant Applications (Parent Small Business [R43/R44] ClinicalTrial Not Allowed | Neurodegeneration | CUTANEOUS NEURODIAGNOSTICS, LLC | Diagnostic device/biomarker | LEVINE, TODD | Small Business |
| Defining Targets for Tic Detection and Suppression in Tourette Syndrome Deep Brain Stimulation | Genetic/rare disease | UNIVERSITY OF FLORIDA | Therapeutic/prevention device | OKUN, MICHAEL S | Devices |
| Acute Modulation of Stereotyped High Frequency Oscillations with a Closed-Loop Brain Interchange System in Drug Resistant Epilepsy | Epilepsy | UNIVERSITY OF HOUSTON | Therapeutic/prevention device | INCE, NURI FIRAT | Devices |
| Thin, High-Density, High-Performance, Depth and Surface Microelectrodes for Diagnosis and Treatment of Epilepsy | Epilepsy | UNIVERSITY OF CALIFORNIA, SAN DIEGO | Therapeutic/prevention device | DAYEH, SHADI | Devices |
| 20-HETE Formation Inhibitors in Cardiac Arrest | Stroke | UNIVERSITY OF PITTSBURGH AT PITTSBURGH | Therapeutic - Small molecule | HURYN, DONNA M | IGNITE |
| Development of a CCKBR-targeting scFv as Therapy for Chronic Pain Patients | Pain | UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR | Therapeutic - Biologic | WESTLUND-HIGH, KARIN N | HEAL Biologics/Small Molecules |
| Disease Modifying Analgesia with CA8 Gene Therapy | Pain | UNIVERSITY OF MIAMI SCHOOL OF MEDICINE | Therapeutic - Biologic | LEVITT, ROY C | HEAL Biologics/Small Molecules |
| Novel, non-opioid, non-addictive intrathecal therapy for the treatment of chronic pain | Pain | CENTREXION THERAPEUTICS CORPORATION | Therapeutic - Small molecule | CAMPBELL, JAMES N | HEAL Biologics/Small Molecules |
| Development of Nav1.7 Monoclonal Antibodies for Treating Pain | Pain | INTEGRAL MOLECULAR | Therapeutic - Biologic | RUCKER, JOSEPH BENJAMIN | Small Business |
| Targeting the neuropilin-1 receptor (NRP-1)/VEGF-A axis for neuropathic pain | Pain | REGULONIX, LLC | Therapeutic - Small molecule | KHANNA, RAJESH | Small Business |
| Brain-cell penetrating antibodies for treatment of progressive multiple sclerosis | Multiple Sclerosis | ABZYME THERAPEUTICS, LLC | Therapeutic - Biologic | TRAN, HIEP T | Small Business |
| Development of a stem cell platform for the treatment of neurodegenerativemicrogliopathies | Genetic/Rare Disease | NOVOGLIA, INC. | Therapeutic - Biologic | HASSELMANN, JONATHAN | Small Business |
| Differential diagnosis of Parkinsons and multiple system atrophy in non-human primate models using a novel a-synuclein retinal contrast agent and AI-assisted analytics | Neurodegeneration | AMYDIS DIAGNOSTICS, INC. | Biomarker | SARRAF, STELLA | Small Business |
| A device to prevent Sudden Unexpected Death in Epilepsy (SUDEP) | Epilepsy | SOTERYA, INC. | Therapeutic/prevention device | NGUYEN, JUSTIN KE | Small Business |
| NanO2 as a Cerebroprotectant in a tMCAO Stroke Model in Mice | Stroke | NUVOX PHARMA, LLC | Therapeutic - Small molecule | UNGER, EVAN CHARLES | Small Business |
| The first adaptable, 3D-formfitting microelectrode array for organoid-based models of neurological and neurodegenerative diseases | Neuroscience Research Tool | BMSEED, LLC | Research tool/assay/animal model | GRAUDEJUS, OLIVER | Small Business |
| Preclinical development of a novel therapeutic for Parkinsons disease | Neurodegeneration | SINOPIA BIOSCIENCES, INC. | Therapeutic - Small molecule | BORDBAR, AARASH | Small Business |
| Long acting and peripherally restricted kappa-opioid receptor agonists for acute migraine treatment | Pain | PEPTIDE LOGIC, LLC | Therapeutic - Biologic | RIVIERE, PIERRE | Small Business |
| Noninvasive challenge-free widely-accessible oxygen extraction fraction mapping | Multiple/Other | MEDIMAGEMETRIC, LLC | Diagnostic device | DORFMAN, GARY | Small Business |
| Towards a Virtual Biopsy: An improved multimodal imaging biomarker to guide treatment decisions in neuro-oncology by combining advanced tissue microstructure imaging with deep learning | Brain Tumor | CORTECHS LABS, INC. | Biomarker | WHITE, NATHAN SCOTT | Small Business |
| A Small Molecule Enzyme Replacement for the Treatment of CLN1 | Genetic/Rare Disease | PALM THERAPEUTICS, INC. | Therapeutic - Small molecule | RUDD, ANDREW | Small Business |
| Inhibition of NF1 Protein Degradation as a Treatment for NF1 Haploinsufficiency | Genetic/Rare Disease | INFIXION BIOSCIENCE, INC. | Therapeutic - Small molecule | MATTSON-HOSS, MICHELLE | Small Business |
| Development of a PIKFYVE antisense oligonucleotide treatment for FTD | Neurodegeneration | ACURASTEM, INC. | Therapeutic - Biologic | ALWORTH, SAMUEL V | Small Business |
| Development of KLS-13019 for Neuropathic Pain | Pain | KANNALIFE SCIENCES, INC. | Therapeutic - Small molecule | BRENNEMAN, DOUGLAS ERIC | Small Business |
| Chemokine-receptor profiling for painful diabetic neuropathy in biological samples from human clinical trials | Pain | PLUMERIA THERAPEUTICS, INC. | Biomarker | RICHARDSON, THOMAS P | Small Business |
| Immunomodulatory Therapy for Neuropathic Pain | Pain | APT THERAPEUTICS, INC. | Therapeutic - Biologic | CHEN, RIDONG | Small Business |
| Development of a Synthetic, Cell-Permeable Peptide for the Inhibition of CDK5-p25 Hyperactivity in Amyotrophic Lateral Sclerosis | Neurodegeneration | COGENTIS THERAPEUTICS, INC. | Therapeutic - Biologic | WERNER, JOHN KENT | Small Business |
| Sustained Delivery of Tizanidine for Maintenance Treatment of Moderate to Severe Spasticity | Multiple/other | DELPOR, INC. | Therapeutic/prevention device | MARTIN, FRANCIS JOSEPH | Small Business |
| Multi-path DCS as a novel non-invasive treatment for amyotrophic lateral sclerosis | Neurodegeneration | PATHMAKER NEUROSYSTEMS, INC. | Research tool/assay/animal model | AHMED, ZAGHLOUL | Small Business |
| Drug Free Nerve Block Device for the Relief of Pain and Symptoms in Migraines and other Headaches | Pain | THERMAQUIL, INC. | Therapeutic/prevention device | POPIELARSKI, STEPHEN | Small Business |
| Thalamic stimulation to prevent impaired consciousness in epilepsy | Epilepsy | YALE UNIVERSITY | Therapeutic/prevention device | BLUMENFELD, HAL | Devices |
| RNA Targeted Drug Discovery and Development for Parkinson Disease | Neurodegeneration | RBHS-ROBERT WOOD JOHNSON MEDICAL SCHOOL | Therapeutic - Small molecule | MOURADIAN, M MARAL | BPN |
| High-Resolution, Spinal Cord Stimulation for Non-Opioid Treatment of Neuropathic Pain | Pain | MICRO-LEADS, INC. | Therapeutic/prevention device | MCLAUGHLIN, BRYAN L | Devices |
| An Instrument to Assess the Functional Impact of Chronic Pain | Pain | BARRON ASSOCIATES, INC. | Diagnostic device | CLARK, BRIAN R | Small Business |
| Proteolipid protein suppression for Pelizaeus Merzbacher Disease | Genetic/rare disease | CASE WESTERN RESERVE UNIVERSITY | Therapeutic - Biologic | TESAR, PAUL JOSEPH | IGNITE |
| Development of MRGPRX1 positive allosteric modulators as non-addictive therapies for neuropathic pain | Pain | JOHNS HOPKINS UNIVERSITY | Therapeutic - Small molecule | TSUKAMOTO, TAKASHI | HEAL Biologics/Small Molecules |
| Novel mGlu5 negative allosteric modulators as first-in-class non-addictive analgesic therapeutics | Pain | VANDERBILT UNIVERSITY | Therapeutic - Small molecule | ROOK, JERRI MICHELLE | HEAL Biologics/Small Molecules |
| Development and Optimization of MNK Inhibitors for the Treatment of Neuropathic Pain | Pain | 4E THERAPEUTICS INC. | Therapeutic - Small molecule | SAHN, JAMES JEFFREY | HEAL Biologics/Small Molecules |
| Enhancing Physical Therapy with Brain Stimulation for Treating Postural Instability | Neurodegeneration | HIGHLAND INSTRUMENTS, INC. | Therapeutic/prevention device | WAGNER, TIMOTHY ANDREW | Small Business |
| Novel non-narcotic analgesic for acute and chronic pain | Pain | SOUTH RAMPART PHARMA, LLC | Therapeutic - Small molecule | BAZAN, NICOLAS G | Small Business |
| Internal and external validation of a porcine dystrophinopathy model | Genetic/rare disease | IOWA STATE UNIVERSITY | Research tool/assay/animal model | SELSBY, JOSHUA T | IGNITE |
| Magnetically Enhanced Diffusion for Intra-Arterial Treatment of Acute Ischemic Stroke | Stroke | PULSE THERAPEUTICS, INC. | Therapeutic/prevention device | ABENDSCHEIN, DANA R | Small Business |
| Modeling West Syndrome to Prevent Neurobehavioral Disabilities | Epilepsy | BAYLOR COLLEGE OF MEDICINE | Research tool/assay/animal model | SWANN, JOHN WILLIAM | IGNITE |