Active Projects for Partnering

29% funding to therapeutic/prevention devices, 28% to therapeutic small molecules, 16% to diagnostic devices and biomarkers, 14% to therapeutic biologics,  5% to research tools, 8% to other areas


The Division of Translational Research funds programs to support new technology development and treatments for neurological disorders and prepares them for investor funding and corporate partnerships. We provide critical path funding and research resources for biotechnology companies and university researchers to advance early-stage neurological technologies, devices, and therapeutic programs to industry adoption (i.e., investor funding and corporate partnerships). In the last fiscal year, our division funded research projects covering a wide range of modalities (see chart).

Please find below a list of active projects that would welcome new partners.

Full List of Active Projects for Partnering

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Download All OTR Active Projects (Excel)

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Title Indications Institution Modality Category PI Programs
Orexin Receptor Antagonists for Drug Addiction and Panic Disorder Addiction Eolas Therapeutics, Inc. Drug (small molecule) Kenny, Paul J. Blueprint
Small molecule drugs for treatment of dry age-related macular degeneration Macular Degeneration Columbia University Drug (small molecule) Petrukhin, Konstantin Blueprint
Neurophysiologically Based Brain State Tracking & Modulation in Focal Epilepsy Epilepsy Mayo Clinic Deep Brain Stimulation Worrell, Gregory A. BRAIN
High-Bandwidth Wireless Interfaces for Continuous Human Intracortical Recording Multiple Indications Massachusetts General Hospital; Brown University Microelectrode Development Hochberg, Leigh R.; Nurmikko, Arto BRAIN
Central thalamic stimulation for traumatic brain injury Traumatic Brain Injury (TBI) Cornell Deep Brain Stimulation Schiff, Nicholas; Butson, Christopher R.; Giancino, Joseph Thomas; Henderson, Jaimie M.; Machado, Andre Guelman BRAIN
Shape Memory Polymer Embolic Foams for Treating Cerebrovascular Aneurysms Aneurysm Texas Engineering Experiment Station Therapeutic Device Maitland, Duncan J. NINDS Cooperative Program
Human EGFRvIII-specific BiTE for the treatment of Glioblastoma Aneurysm Duke University Therapeutic Device Sampson, John NINDS Cooperative Program
Neural Stem Cell Mediated CE-CPT11 Therapy for Neuroblastoma Nervous System Tumor City of Hope/Beckman Research Institute Cell Therapy Aboody, Karen S. NINDS Cooperative Program
Development of a next-generation PSD95 Inhibitor for the treatment of acute ischemia Stroke University Health Network Peptide Therapy Tymianski, Michael NINDS Cooperative Program
Intralipid: A novel frontline countermeasure for brodifacoum poisoning Anticoagulants University of Illinois at Chicago Drug (small molecule) Feinstein, Douglas L CounterACT
Development of the Vitamin B12 Analog cobinamide as a Hydrogen Sulfide Antidote Metabolic/Cellular Poisons University of California San Diego Drug (small molecule) Boss, Gerry R CounterACT
Developing Drugs to Mitigate Parathion Intoxication Neurotoxic Agents RBHS - Robert Wood Johnson Medical School Drug (small molecule) Laskin, Jeffrey D CounterACT
Neuroprotective effects of AEOL 10150 against organophosphate toxicity Neurotoxic Agents University of Colorado Denver Drug (small molecule) Patel, Manisha N CounterACT
Accelerated AChE Reactivator Design by Mechanistic Neutron Scattering Studies Neurotoxic Agents University of California San Diego Drug (small molecule) Radic, Zoran CounterACT
Brain-penetrating acetylcholinesterase reactivators for several organophosphates Neurotoxic Agents Mississippi State University Drug (small molecule) Chambers, Janice Elaine CounterACT
Neurosteroid Treatment for OP Intoxication Neurotoxic Agents Texas A&M University Health Science Center Drug (small molecule) Reddy, Doodipala Samba CounterACT
Novel anticonvulsant and neuroprotective therapies for TETS and OP intoxication Neurotoxic Agents University of California Davis Drug (small molecule) Lein, Pamela J CounterACT
Targeting the Glutamatergic System to Counteract Soman Toxicity in Immature Rats Neurotoxic Agents Henry M. Jackson FDN for the ADV MIL/MED Drug (small molecule) Braga, Maria F CounterACT
Formulation and Encapsulation of Enzymic Countermeasures Against Organophosphorus Neurotoxic Agents Ohio State University Protein Therapy Magliery, Thomas J CounterACT
Amelioration of soman-induced neuropathology with NAAG-related compounds Neurotoxic Agents Henry M. Jackson FDN for the ADV MIL/MED Drug (small molecule) McCabe, Joseph T CounterACT
Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment Strategies Pulmonary Agents University of Alabama at Birmingham Drug (small molecule) Matalon, Sadis CounterACT
Nitrite dependent protection against Cl2 gas toxicity_role of chlorinated lipids Pulmonary Agents University of Alabama at Birmingham Diagnostic Device Patel, Rakesh Pravinchandra CounterACT
Thioredoxin mimicry: novel treatment of toxicant-mediated inhalational lung injury Pulmonary Agents Radikal Therapeutics, Inc. Drug (small molecule) Southan, Garry John CounterACT
Amelioration of Vesicant-Induced Skin Injury by High Dose 25-Hydroxyvitamin D Vesicating Agents Case Western Reserve University Drug (small molecule) Lu, Kurt CounterACT
Extracellular RNA as therapeutic target after toxic chemical inhalation Vesicating Agents University of Alabama at Birmingham Protein Therapy Ahmad, Aftab CounterACT
RNAI THERAPY FOR SPINOCEREBELLAR ATAXIA TYPE 1 Spinocerebellar Ataxia Children's Hosp of Philadelphia Oligonucleotide Therapy Davidson, Beverly L. CREATE Bio
Preclinical Testing of a Novel Flow Diverting Stent for Treating Intracranial Aneurysms Aneurysm Neurosigma, Inc. Therapeutic Device Kealey, Colin Small Business
Auto-Injectable Diazepam Formulation for Rapid Treatment of Uncontrolled Seizures Epilepsy Xeris Pharmaceuticals, Inc. Drug (small molecule) Kinzell, John Small Business
Enzyme Replacement Therapy for Sanfilippo A Lysosomal Rare Disease Lysosomal storage disorder Biostrategies, LLC Protein Therapy Radin, David Small Business
Highly efficient cerebral perfusion MRI Multiple Indications Advanced MRI Technology, LLC Imaging Device Feinberg, David Alan Small Business
High-Field MR Compatible Dense Array EEG using Polymer Thick Film Technology Multiple Indications Electrical Geodesics, Inc. Imaging Device Poulsen, Catherine Small Business
Microhook Nerve Tape: A Nerve Repair Coaptation Aid Nerve Injury Axion Biosystems, LLC. Intraoperative Device Clements, Isaac Small Business
Development of selective Cav3 channel blockers for treatment of neuropathic pain Pain AFASCI, Inc. Drug (small molecule) Xie, Xinmin Simon Small Business
DBS-Expert: Automated Deep Brain Stimulation Programming Using Functional Mapping Parkinson's Disease Great Lakes Neurotechnologies Research Devices/Software Heldman, Dustin A. Small Business
Rapid Magnetomotive Thrombolysis for Stroke Stroke Pulse Therapeutics, Inc. Drug Delivery Creighton, Francis Milton Small Business
Stroke Treatment by Chemically-induced Hypothermia Stroke JT Pharmaceuticals, Inc. Peptide Therapy Dix, Thomas Small Business
Targeted Transcranial Electrotherapy to Accelerate Stroke Rehabilitation-Exploratory Trial on Aphasia Stroke Soterix Medical, Inc. Therapeutic Device Datta, Abhishek Small Business
Multimodality Image-Based Assessment System for Traumatic Brain Injury Traumatic Brain Injury (TBI) Kitware, Inc Imaging Device Aylward, Stephen Small Business
Optimization of Compounds that Stabilize the SMN Protein for Treatment of SMA Spinal Muscular Atrophy (SMA) Indiana Univ-Purdue Univ At Indianapolis Drug (small molecule) Androphy, Elliot IGNITE
Neural Stem Cell Carriers for Glioblastoma Immunotherapy Other Northwestern University At Chicago Cell Therapy Balyasnikova, Irina IGNITE
Red blood cell microparticles (RMPs) to reduce bleeding following hemorrhagic stroke Stroke University Of Miami School Of Medicine Other Dave, Kunjan IGNITE
Inhibitors of TrkB Signaling Epilepsy Duke University Drug (small molecule) Mcnamara, James O. IGNITE
Developing Novel RNA-Based Therapeutics for Parkinson's Disease Parkinson's Disease Robert Wood Johnson Medical School Protein Therapy Mouradian, Maral IGNITE
New GAA expansion mouse for efficacy studies of treatments for Friedreich ataxia Spinocerebellar Ataxia University Of Alabama At Birmingham Model Development Napierala, Marek IGNITE
Anticonvulsant screening using chronic epilepsy models Epilepsy Massachusetts General Hospital Drug (small molecule) Staley, Kevin J. IGNITE
Development of Poly ICLC for neuroprotection against ischemic brain injury Stroke Oregon Health & Science University Oligonucleotide Therapy Stenzel-Poore, Mary P IGNITE
Complement inhibitors targeted to the ischemic brain for the treatment of stroke Stroke Medical University Of South Carolina Protein Therapy Tomlinson, Stephen IGNITE
Efficacies and Pharmacodynamic Assays for LRRK2 Small-Molecule Inhibitors Parkinson's Disease University Of Alabama At Birmingham Drug (small molecule) West, Andrew B IGNITE
Modified neural stem cells for glycosylation-independent treatment of MPS IIIB Lysosomal storage disorder Los Angeles Biomedical Research Institute/ Harbor UCLA Medical Center Cell Therapy Iacovino, Michelina IGNITE
Development of Therapeutic Antibody for Traumatic Brain Injury Traumatic Brain Injury (TBI) Beth Israel Deaconess Medical Center Protein Therapy Lu, Kun Ping CREATE Bio
In vivo efficacy studies to support the development of DUX4-targeted RNAi therapy for FSHD Muscular Dystrophy Research Institute Nationwide Children's Hospital Gene Therapy Harper, Scott Q. IGNITE
Development and validation of a genetically engineered model of neurofibromatosis type 2 to facilitate discovery of neurotherapeutics Neurofibromatosis SCRIPPS Florida Model Development Kissil, Joseph IGNITE
The Rat Pre-Formed Alpha-Synuclein Fibril Model of Parkinsons Disease Parkinson's Disease Michigan State University Model Development Sortwell, Caryl IGNITE
Discovery of Post-transcriptional utrophin upregulator small molecules for Duchenne Muscular Dystrophy therapeutics Muscular Dystrophy University of Pennsylvania Drug (small molecule) Khurana, Tejvir S. IGNITE
Innovation Grant to Nurture Initial Translational Efforts (IGNITE) to Neurotherapeutic Approaches in Minipig Models of PKU Disorders PKU Disorders University of Pittburgh at Pittsburgh Model Development Nicholls, Robert D. IGNITE
Allele-specific RNA-targeted lead compounds for Huntingtons disease Huntington's Disease Ribometrix, LLC Drug (small molecule) Warner, Katherine IGNITE
Discovery of non-addictive KOR antagonists for migraine prophylaxis Pain BlackThorn Therapeutics, Inc Drug (small molecule) Jones, Robert M. Blueprint
Discovery/Development of GABA-A α5 Positive Allosteric Modulators for Treatment of MCI due to AD Alzheimer's Disease AgeneBio, Inc. Drug (small molecule) Rozenzweig-Lipson, Sharon Blueprint
Development of an Oral Analgesic for Neuropathic Pain Pain Eicosis, LLC Drug (small molecule) Buckpitt, Alan R. Blueprint
Kv7.2/7.3 Activators for the Treatment of Epilepsy Disorders Epilepsy Knopp Biosciences, LLC Drug (small molecule) Bozik, Michael Blueprint
Developing nonmuscle II inhibitors for substance use relapse Addiction Scripps Florida Drug (small molecule) Miller, Courtney A. Blueprint
Disaggregation of Toxic Protein Oligomers in Brain with Electromagnetic Treatment Alzheimer's Disease NEUROEM THERAPEUTICS, INC. Therapeutic Device ARENDASH, GARY W Small Business
Development of an information-rich assay for C9ORF72 as a test for ALS and FTD Amyotrophic Lateral Sclerosis (ALS) Asuragen, Inc. Assay development Bram, Eran Small Business
Kinetic Phenotype Discovery Informatics for Neurological Diseases Amyotrophic Lateral Sclerosis (ALS) Drvision Technologies, LLC Research tool Lee, Shih-Jong J Small Business
Phase 1 Clinical Evaluation of NP10679, a GluN2B Selective, Context-Dependent NMDA Receptor Inhibitor for Subarachnoid Hemorrhage Aneurysm Neurop, Inc. Drug (small molecule) Zaczek, Robert Small Business
Development of BA-1049 for treatment of cerebral cavernous malformation Aneurysm Bioaxone Biosciences, INC. Drug (small molecule) Mckerracher, Lisa Joan Small Business
Recombinant Silk Elastin-like Protein Polymers for the Embolization of Cerebral Aneurysms Aneurysm Theratarget Protein Therapy Ghandehari, Hamid Small Business
Development of a Biochemical Diagnosis for Creutzfeldt-Jakob disease Creutzfeldt-Jakob disease AMPRION, INC. Biomarker Lebovitz, Russell M Small Business
High Performance Seizure Monitoring and Alert System Epilepsy Optima Neuroscience, INC. Diagnostic Device Shiau, Deng-Shan Small Business
EEG Patch Epilepsy Epitel, INC. Diagnostic Device Lehmkuhle, Mark J Small Business
Development of a large area high resolution micro ECoG electrode array Epilepsy Bmseed, LLC Research tool Graudejus, Oliver Small Business
Development and validation of therapy for mucopolysaccharidosis III Lysosomal storage disorder Phoenix Nest, INC. Gene Therapy Ekins, Sean Small Business
Pharmacological Chaperone Therapy for the GM2 Gangliosidoses Lysosomal storage disorder Orphi Therapeutics, INC. Drug (small molecule) Sjoberg, Eric Small Business
New Treatment of the Brain in Niemann Pick C Lysosomal storage disorder Lipogene Company, INC. Gene Therapy Pardridge, William M Small Business
Brain DNA Therapeutics with Trojan Horse Liposomes Lysosomal storage disorder Lipogene Company, INC. Gene Therapy Partridge, William Small Business
Enzyme replacement therapy for GM1 gangliosidosis lysosomal rare disease Lysosomal storage disorder Biostrategies, LC Protein Therapy Radin, David Small Business
Improving MPS I ERT Efficacy through Lectin-Mediated Delivery Lysosomal storage disorder Biostrategies, LC Protein Therapy Radin, David Small Business
High-quality compact portable low-field head MRI with ultra-fast gradients Multiple Indications Weinberg Medical Physics, LLC Imaging Weinberg, Irving Small Business
MRI brain morphometry for computer-aided detection of neurological disorders Multiple Indications Corticometrics, LLC Imaging SCHMANSKY, NICHOLAS JOHN Small Business
Modular antibody engineering to overcome the blood brain barrier Multiple Indications Abzyme Therapeutics, LLC Protein/Antibody Therapy Tran, Hiep T Small Business
Platform for practical delivery of oral autoantigens as co-therapies for neurological disease Myasthenia Gravis Soymeds, INC. Protein/Antibody Therapy Piller, Kenneth J Small Business
Development and Characterization of a Swine Model of Neurofibromatosis Type 2 Neurofibromatosis Recombinetics, INC. Model Development Watson, Adrienne Leigh Small Business
Development of NSI-189, a novel neurogenic molecule, to prevent and treat diabetic neuropathy Neuropathy Neuralstem, INC. Drug (small molecule) Johe, Karl K Small Business
Development of Pirenzepine for HIV-SN Neuropathy Winsantor, INC. Drug (small molecule) Mizisin, Andrew Small Business
Cyanalyzer A Medical Laboratory Device for the Rapid Diagnosis of Cyanide Exposure Metabolic/Cellular Poisons Seacoast Science, INC. Diagnostic Device Jackson, Randy Small Business
Cyanalyzer A Medical Laboratory Device for the Rapid Diagnosis of Cyanide Exposure Neurotoxin exposure SEACOAST SCIENCE, INC. Diagnostic Device Jackson, Randy Small Business
The Bilayer Nanopore Integrated Assay for Complete Toxin Characterization, Phase II Other ELECTRONIC BIOSCIENCES, INC. Assay development ERVIN, ERIC Small Business
NITRC Image Repository: A Commercial Solution to Advancing Data Sharing in Neuroscience Other TCG, INC. Imaging PREUSS, NINA Small Business
A novel 3D-ultrasound platform using traditional 2D probes Other URSUS MEDICAL, LLC Imaging HAYES, THOMAS Small Business
Software and hardware to study brain function during behavior using laser scanning microscopy. Other VIDRIO TECHNOLOGIES, LLC Imaging KIMMEL, BRUCE Small Business
Development of technologies to advance fast and accurate tools for measuring fluorescence in living cells, with emphasis on developing assays optimized for screening in neuronal cells and brain tissue Other MONTANA MOLECULAR, LLC Imaging QUINN, ANNE MARIE Small Business
High Speed Multiphoton Multifocal Whole Brain Imaging Other TISSUEVISION, INC. Other RAGAN, TIMOTHY M Small Business
NeuroPET HD: A low-cost, high performance neuro-PET imaging system Other PET/X, LLC Imaging HUNTER, WILLIAM COULIS JASON Small Business
Non-invasive integrated system for brain stimulation and magnetocorticography Other TRISTAN TECHNOLOGIES, INC. Imaging PAULSON, DOUGLAS N Small Business
A Microneedle Array System for Transcutaneous Nerve Mapping Other AXION BIOSYSTEMS, LLC Research tool ROSS, JAMES Small Business
Automated electrophysiological analysis of neural circuitry using a novel nano-electrode array for intracellular recording of membrane potential Other CYION TECHNOLOGIES, LLC Research tool JIANG, XIN Small Business
A microfluidic platform for modeling drug transport and cell trafficking across the blood-brain barrier Other NORTIS, INC. Research tool NEUMANN, THOMAS Small Business
An Implantable and High-Density, Multiplexed Micro-ECoG System Other MICRO-LEADS, INC. Research tool MCLAUGHLIN, BRYAN L Small Business
A Unified System for Wireless Optogenetics and Brain Microdialysis for Small Molecules: Prototype Development and Validation Other EICOM USA Research tool AZUMA, SHINJI Small Business
Prosthetic System for Large-Scale Recording and Manipulation of Neural Circuit Activity in Non-Human Primates Other GRAYMATTER RESEARCH Research tool GOODELL, ALBERT BALDWIN Small Business
Enterprise Neuroinformatics for Interoperable Data Management and Dissemination Other ADVANCED BIOMEDICAL INFORMATICS GROUP Research tool BOCKHOLT, HENRY JEREMY Small Business
Development of Selective Inhibitors of NaV1.7 as Therapeutics for Pain Pain SITEONE THERAPEUTICS, INC. Drug (small molecule) MULCAHY, JOHN VINCENT Small Business
Peripheral nerve stimulation for amputee pain Pain SPR THERAPEUTICS, LLC Therapeutic Device BOGGS, JOSEPH WILDER Small Business
Glycosaminoglycan-Interacting Small Molecule (GISMO) as Parkinsons Therapeutic Parkinson's Disease GISMO THERAPEUTICS, INC. Drug (small molecule) GREGOR, PAUL Small Business
Advanced therapeutic for Parkinsons Disease Parkinson's Disease INHIBIKASE THERAPEUTICS Drug (small molecule) WERNER, MILTON H Small Business
Improved Electrode Material for Deep Brain Stimulation and Neural Recording Parkinson's Disease PLATINUM GROUP COATINGS, LLC Therapeutic Device PETROSSIANS, ARTIN Small Business
Improved Electrode Material for High-Density Closed-Loop DBS. Parkinson's Disease PLATINUM GROUP COATINGS, LLC Therapeutic Device PETROSSIANS, ARTIN Small Business
Development of self-delivering RNAi targeted to PTEN for treatment of spinal cord injury Spinal Cord Injury (SCI) BIOAXONE BIOSCIENCES, INC. Drug (small molecule) MCKERRACHER, LISA JOAN Small Business
Discovering Novel Drug Targets for CNS Edema by In Vitro Genetics Stroke PREDICTIVE BIOLOGY Biomarker CHOI, TED Small Business
Human Neural Cell Exosomes as a therapeutic treatment for stroke Stroke ARUNA BIOMEDICAL, INC. Cell Therapy WEBB, ROBIN L Small Business
Epigenetic Markers and Sustained Cytoprotection for Stroke Treatment Stroke ZYMO RESEARCH CORPORATION Drug (small molecule) BOOHER, KEITH Small Business
Identifying activators of interferon regulatory factors for neuroprotection. Stroke NEURALEXO, LLC Drug (small molecule) STENZEL-POORE, MARY P Small Business
Human Apyrase Therapy for Acute Ischemic Stroke Stroke APT THERAPEUTICS, INC. Protein Therapy CHEN, RIDONG Small Business
Reducing Brain Injury After Focal Ischemia Using a Nitric Oxide-Neutral Oxygen Carrier Stroke OMNIOX, INC. Protein Therapy CARY, STEPHEN Small Business
Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury Stroke PROTHERA BIOLOGICS, LLC Protein Therapy LIM, YOW-PIN Small Business
DRα1-MOG: A Novel Immunomodulatory Therapeutic for Stroke Stroke VIROGENOMICS BIODEVELOPMENT, INC. Protein Therapy ALKAYED, NABIL J Small Business
A Combination Endovascular Device: Therapeutic Hypothermia with Stentriever Devices Stroke FOCALCOOL, LLC Therapeutic Device MERRILL, THOMAS L Small Business
Establishing the Functional Viability and Dose-Response of Duck, Duck Punch: A Stroke Rehabilitation Computer Game Stroke RECOVR, INC. Therapeutic Device HAYES, AUSTEN LUKE Small Business
Prediction Model for Incident Stroke for Early Screening of an Individual at Risk of Stroke Stroke IHEALTHSCREEN, INC. Biomarker BHUIYAN, ALAUDDIN Small Business
Early Feasibility Clinical Study of the VitalFlow Stimulator, an Emergency Treatment for Ischemic Stroke Stroke NERVIVE, INC. Therapeutic Device SACRISTAN, EMILIO Small Business
Bioimpedance-based Intracranial Mapping for Monitoring Evolving TBI Traumatic Brain Injury (TBI) RYTEK MEDICAL, INC. Diagnostic Device HALTER, RYAN JOSEPH Small Business
Advanced morphological analysis of cerebral blood flow for acute concussion diagnosis and return-to-play determination Traumatic Brain Injury (TBI) NEURAL ANALYTICS, INC. Diagnostic Device HAMILTON, ROBERT Small Business
Noninvasive scalp detection of cortical spreading depression for brain injury Traumatic Brain Injury (TBI) SCIENCEPLUSPLEASE, LLC Diagnostic Device JONES, STEPHEN CARTER Small Business
Novel Treatment for Traumatic Brain Injury Traumatic Brain Injury (TBI) EPIGEN BIOSCIENCES, INC. Drug (small molecule) UTESHEV-GAARD, VICTOR V Small Business
Advanced Bicycle Helmet Technology for Prevention of Traumatic Brain Injury Traumatic Brain Injury (TBI) APEX BIOMEDICAL COMPANY, LLC Prevention device BOTTLANG, MICHAEL Small Business
Internal and external validation of a porcine dystrophinopathy model Muscular Dystrophy Iowa State University Model Development Selsby, Joshua IGNITE
Use of CRISPR/Cas9 to treat Huntington disease Huntington's Disease Emory University Gene Therapy Li, Xiao-Jiang IGNITE
High-content screening for modulators of lamin B1 as a therapeutic target in autosomal dominant leukodystrophy Other University of Pittsburgh at Pittsburgh Protein Therapy Vogt, Andreas IGNITE
Long Acting Local Analgesics: HSV-CA8 Biotherapeutics Pain University Of Miami School Of Medicine Protein Therapy Levitt, Roy C. IGNITE
A software tool for objective identification of concussion-related vision disorders using a novel eye-tracking device Traumatic Brain Injury (TBI) Oculogica, INC. Diagnostic Device Master, Christina Small Business
Assessment of NOVO-118 as a regenerative therapeutic in acute spinal cord injury Spinal Cord Injury (SCI) Novoron Bioscience, INC. Protein Therapy Stiles, Travis Lee Small Business
Commercialization of a Rapid Blood Test for Traumatic Brain Injury Traumatic Brain Injury (TBI) Fawkes Biotechnology, LLC Diagnostic Device Lovell, Mark Anthony Small Business
Development of a syringe/sonication device employed to administer DDFPe in the prehospital setting Traumatic Brain Injury (TBI) Nuvox Pharma, LLC Therapeutic Device Unger, Evan Charles Small Business
Development of a unified information-rich test for CNBP and DMPK to improve assessment of Myotonic Dystrophy Type 1 and 2 Muscular Dystrophy Asuragen, INC. Diagnostic Device Hall, Bradley Small Business
Development of an Implantable Trigeminal Nerve Stimulation System for Drug Resist Epilepsy Neurosigma, INC. Therapeutic Device Cook, Ian Small Business
Form factor determination for the Talon microIPG system to treat Chronic Migraine Pain Neogenesis Technologies, LLC Therapeutic Device Dulak, Gary Small Business
Infant NeuroLUX: A Novel Non-invasive Therapeutic Device for Neonatal Hypoxic Brain Injury Stroke Mitovation, INC. Therapeutic Device Sanderson, Thomas Small Business
MRI-compatible and integrated devices for simultaneous neural recording, stimulation, imaging Other Mr-Link, LLC Research tool Liu, Zhongming Small Business
Nonsense Suppressing Drugs for Rett Syndrome Other Starwise Therapeutics, LLC Drug (small molecule) Kozikowski, Alan Small Business
Preclinical Testing of Splice Modulating Oligonucleotides Targeting SCN8A to Treat Dravet Syndrome Epilepsy Lifesplice Pharma, LLC Oligonucleotide Therapy Tallent, Melanie Small Business
Rapid Baseline Free Organophosphate Exposure Diagnostic Test Neurotoxin exposure Countervail Corporation Diagnostic Device Basinger, Bill Small Business
Retinal eye-tracking for the prognosis and monitoring of multiple sclerosis Multiple Sclerosis C.Light Technologies, INC. Diagnostic Device Sheehy, Christy Kathleen Small Business
Development of dendrimer-N-acetylcystein for the treatment of neonatal brain injury Cerebral Palsy Johns Hopkins University Other Rangaramanujam, Kannan CREATE Bio
Antisense Oligonucleotides for Treating Spinocerebellar Ataxia Type 2 Spinocerebellar Ataxia Pulst, Stefan M. Oligonucleotide Therapy Pulst, Stefan M. CREATE Bio
A Novel Myeloperoxidase Inhibitor for Treating Multiple Sclerosis Multiple Sclerosis RENEUROGEN, LLC Peptide Therapy Pritchard, Kirkwood Small Business
An all-optical electrophysiology platform for the discovery of pain therapeutics Pain Q-STATE BIOSCIENCES, INC. Drug (small molecule) McManus, Owen B Small Business
Micro-imaging catheters for high-resolution, image-guided, endovascular repair of brain aneurysms Stroke GENTUITY, LLC Intraoperative Device Ughi, Giovanni J Small Business
NeuroMAP System for Clinical Research Multiple Indications ALTEC, INC. Research tool De Luca, Gianluca Small Business
Optimization and Assessment of a Biologic to Improve Cognitive Function After Traumatic Brain Injury Traumatic Brain Injury (TBI) ALCAMENA STEM CELL THERAPEUTICS, LLC Peptide Therapy Verdecia, Mark A Small Business
Development of a novel bioabsorbable clip and applier for rapid closure of the dura mater in open and minimally invasive spine surgery Spinal Cord Injury (SCI) NEURAMEDICA, LLC Therapeutic Device Dreilinger, Rachel Small Business
Development of immunoassays for highly sensitive diagnostic monitoring of traumatic brain injury using novel astroglial injury-defined biomarkers Traumatic Brain Injury (TBI) IMMUNARRAY USA, INC. Assay development Vanmeter, Timothy E Small Business
MyoRegulator: A non-invasive neuromodulation device for treatment of spasticity in stroke patients Stroke PATHMAKER NEUROSYSTEMS, INC. Therapeutic Device Yaghoubi, Nader Small Business
Noninvasive Seizure Screening in Preclinical Models of Epilepsy Epilepsy SIGNAL SOLUTIONS, LLC Research Devices/Software Sunderam, Sridhar Small Business
Novel Highly Regenerative and Scalable Progenitor Cell Exosomes for Treating Stroke Stroke BIOTIME, INC. Other Larocca, Dana Small Business
PIKFYVE antagonism as a therapy for C9ORF72-ALS/FTD Multiple Indications ACURASTEM, INC. Assay development Alworth, Samuel V Small Business
TDP-43 aggregation inhibitors for the treatment of ALS Amyotrophic Lateral Sclerosis (ALS) AQUINNAH PHARMACEUTICALS, INC. Drug (small molecule) Larsen, Glenn Small Business
Tolerability of SRX246 in Huntingtons Disease Patients Huntington's Disease AZEVAN PHARMACEUTICALS, INC. Drug (small molecule) Brownstien, Michael Small Business
Topical selective T-type blockers for the treatment of neuropathic pain Pain DERMAXON, LLC Drug (small molecule) Astruc-Diaz, Fanny Small Business
Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntingtons Disease Huntington's Disease BIOSENSICS, LLC Monitoring Device Gwin, Joseph T Small Business
EP2 antagonists as novel anti-epileptogenic agents Epilepsy EMORY UNIVERSITY Gene Therapy GANESH, THOTA IGNITE
Development and validation of small molecules to treat neurofibromatosis associated schwannoma Neurofibromatosis SCRIPPS FLORIDA Drug (small molecule) KISSIL, JOSEPH IGNITE
Small molecule stabilizers of Hsp70 for treatment of spinal and bulbar muscular atrophy Spinal and Bulbar Muscular Atrophy UNIVERSITY OF MICHIGAN Drug (small molecule) LIEBERMAN, ANDREW P IGNITE
Development of SK channel modulators as therapeutic agents for ataxia Spinocerebellar Ataxia CHAPMAN UNIVERSITY Drug (small molecule) ZHANG, MIAO IGNITE
Development of Human 12/15-lioxygenase therapeutics for stroke Stroke Massachusetts General Hospital Drug (small molecule) van Leyen, Klaus Blueprint
Phosgene Oxime Cutaneous Toxicity and Mechanisms to Identify Therapeutic Targets Pulmonary Agents University of Colorado Denver Drug (small molecule) Tewari-Singh, Neera CounterACT
Functional Genomics of Chemical-Induced Acute Lung Injury Pulmonary Agents University of Pittsburgh at Pittsburgh Drug (small molecule) Leikauf, George CounterACT
Treatment of persistent chlorine-induced small airway disease Pulmonary Agents University of Louisville Drug (small molecule) Hoyle, Gary CounterACT
CIALIS® reverses halogen induced injury to pregnant animals and their offspring Pulmonary Agents University of Alabama at Birmingham Drug (small molecule) Matalon, Sadis CounterACT
Development of antidotes for toxic gases Pulmonary Agents University of Colorado Denver Drug (small molecule) White, Carl CounterACT
Targeting cardiopulmonary calpains to mitigate toxicity of halogen gases. Pulmonary Agents University of Alabama at Birmingham Drug (small molecule) Ahmad, Shama CounterACT
TIE2 Activation for the Treatment of Chemical-Induced Acute Lung Injury Pulmonary Agents Duke University Drug (small molecule) Kontos, Christopher CounterACT
Antidotes against Hydrochloric Acid-Induced Chronic Lung Injury Pulmonary Agents Old Dominion University Drug (small molecule) Catravas, John CounterACT
An Approach toward Antidotes for Phosphine Pulmonary Agents University of Pittsburgh at Pittsburgh Drug (small molecule) Pearce, Linda CounterACT
Methylene blue as an antidote against hydrogen sulfide intoxication Metabolic/Cellular Poisons Pennsylvania State Univ Hershey Med Ctr Drug (small molecule) Haouzi, Philippe CounterACT
New Chelating (decorporating) Agents for Azide Metabolic/Cellular Poisons University of Pittsburgh at Pittsburgh Drug (small molecule) Pearce, Linda CounterACT
Effects of acute administration of the Phenothiazinium Chromophore Methylene blue during life threatening cyanide intoxication Metabolic/Cellular Poisons Pennsylvania State Univ Hershey Med Ctr Drug (small molecule) Haouzi, Philippe CounterACT
Overlay independent X-ray data analysis for enhanced oxime OP-ChE reactivation Neurotoxic Agents University of California San Diego Research tool Radić, Zoran CounterACT
Toxin-specific and symptomatic drugs in combination with novel neuroprotectants effectively counteract DFP-induced long-term neurotoxicity Neurotoxic Agents Iowa State University Drug (small molecule) Thippeswamy, Thimmasettappa CounterACT
Epigenetic Attenuation of Long-Term Effects of Nerve Agents Neurotoxic Agents Texas A&M University Health Science Ctr Drug (small molecule) Reddy, Samba CounterACT
Anticholinergic and antiepileptic Therapies for Chlorine Toxicity Neurotoxic Agents University of Colorado Denver Drug (small molecule) Veress, Livia CounterACT
Neurosteroids as a standard medical countermeasure for OP poisoning Neurotoxic Agents University of California Irvine Drug (small molecule) Gee, Kelvin CounterACT
The carboxylesterase knockout mouse as a model to evaluate the efficacy of delayed medical countermeasures against soman exposure Neurotoxic Agents Geneva Foundation Model Development Lange, Lucille CounterACT
Mitochondrial Targeted Biofuels as Countermeasures Against Chemical Threats Metabolic/Cellular Poisons Children's Hospital of Philadelphia Drug (small molecule) Kilbaugh, Todd CounterACT
Computationally Designed Stable Artificial Phosphotriesterases for Detoxification of Organophosphorus Agents Neurotoxic Agents New York University Protein Therapy Montclare, Jin CounterACT
Novel Counteract Agents To Reduce Mortality And Morbidity Following Organophosphate Status Epilepticus Neurotoxic Agents Virginia Commonwealth University Drug (small molecule) DeLorenzo, Robert CounterACT
Identification of Novel Brain-penetrating Phenoxyalkyl Pyridinium Oxime Countermeasures Neurotoxic Agents Mississippi State University Drug (small molecule) Chambers, Janice CounterACT
Cyanide/Azide Detoxification by New Cobalt Complexes and NO Donors Metabolic/Cellular Poisons University of Pittsburgh at Pittsburgh Drug (small molecule) Peterson, James CounterACT
Rutgers University CounterACT Center of Excellence Vesicating Agents RBHS - Robert Wood Johnson Medical School Drug (small molecule) Laskin, Jeffrey D CounterACT
Preclinical Development of Antisense Oligonucleotide Therapy for Spinocerebellar Ataxia Type 3 Spinocerebellar Ataxia UNIVERSITY OF MICHIGAN AT ANN ARBOR Oligonucleotide Therapy McLoughlin, Hayley Sarah CREATE Bio
A Combined High-Throughput Single-Cell Transcriptomic and Secretomic Assay for Neurodegenerative Disease Biomarker Discovery Frontotemporal dementia ISOPLEXIS, INC. Assay development MCCONNELL, TIMOTHY S Small Business
Synthetic hydrogels for biomanufacturing of iPSC-derived neural cells for precision medicine Multiple Indications STEM PHARM, INC. Assay development LEBAKKEN, CONNIE S Small Business
Live Cell Assays to Identify and Interrogate Stressed Neurons in Models of Neurodegenerative Disease. Multiple Indications MONTANA MOLECULAR, LLC Assay development HARLEN, KEVIN MATTHEW Small Business
Mimicking synuclein toxicity in plant cells to identify novel neuroprotective leadsv Parkinson's Disease NAPROGENIX, INC Assay development LITTLETON, JOHN M Small Business
A user-friendly microfluidic chip for anti-epileptogenic drug screening Epilepsy XONA MICROFLUIDICS, LLC Assay development TAYLOR, ANNE MARION Small Business
Targeted Degradation of CAG Repeat Expanded Huntingtin mRNA, Associated with Huntingtons Disease, Using Artificial Site-Specific RNA Endonucleases Huntington's Disease ENZERNA BIOSCIENCES, LLC Oligonucleotide Therapy SAZANI, PETER Small Business
Development of Nasal IGF-1 as a Migraine Therapeutic Migraine SEURAT THERAPEUTICS, INC. Protein Therapy ZHANG, YUAN Small Business
Intracerebroventricular Iduronidase Delivery to the Brain Lysosomal storage disorder TEGA THERAPEUTICS, INC. Protein Therapy BROWN, JILLIAN R Small Business
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CN-105 Improves Functional Outcome After Intracranial Hemorrhage Aneurysm AEGISCN, LLC Peptide Therapy FREMEAU, ROBERT T Small Business
Immunomodulatory Therapy for Neuropathic Pain Pain APT THERAPEUTICS, INC. Protein Therapy CHEN, RIDONG Small Business
Enzyme Replacement Therapy For Infantile Onset Neuronal Ceroid Lipofuscinoses Lysosomal storage disorder COLLABORATIONS PHARMACEUTICALS, INC. Protein Therapy EKINS, SEAN Small Business
Electrical impedance myography technology for quantitative, at-home muscle assessment in amyotrophic lateral sclerosis and other neuromuscular disorders. Amyotrophic Lateral Sclerosis (ALS) MYOLEX, INC. Diagnostic Device LUPTON, ELMER C Small Business
Cerebral Palsy Risk Identification System Cerebral Palsy NEUROCOMP SYSTEMS, INC. Diagnostic Device O'HALLORAN, JAMES P Small Business
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Prehospital and Emergency Room Stroke Diagnosis Using Quantitative Cerebral Hemodynamics Stroke NEURAL ANALYTICS, INC. Diagnostic Device THIBEAULT, COREY MICHAEL Small Business
Lab-To-Marketplace: Commercialization of a stretchable microelectrode array Other BMSEED, LLC Research tool GRAUDEJUS, OLIVER Small Business
Magnetic camera based on optical magnetometer for neuroscience research Other FIELDLINE, INC. Research tool ALEM, ORANG Small Business
Neural Implant Insertion System using Ultrasonic Vibration to Reduce Tissue Dimpling and Improve Insertion Precision of Floating Arrays in the Neocortex Other ACTUATED MEDICAL, INC. Research tool MULVIHILL, MAUREEN L Small Business
Wireless Implantable Neural Recording Device Other NEUROLUX, INC. Research tool GHAFFARI, ROOZBEH Small Business
Introducing Neuroscience and Neurocomputation Concepts to High School Students using Brain-based Neurorobots Other BACKYARD BRAINS, INC. Research tool GAGE, GREGORY JOHN Small Business
Sonomyographic Control of Fiber-Optically Sensorized Prosthetic Fingers for Graded Force Actuation Nerve Injury INTELLIGENT FIBER OPTIC SYSTEMS CORP Therapeutic Device BLACK, RICHARD J Small Business
User-driven Retrospectively Supervised Classification Updating (RESCU) system for robust upper limb prosthesis control Nerve Injury INFINITE BIOMEDICAL TECHNOLOGIES, LLC Therapeutic Device KALIKI, RAHUL REDDY Small Business
Device for Rapid, Complete & Durable Occlusion of Wide-Neck Cerebral Aneurysms Aneurysm METACTIVE MEDICAL, INC. Therapeutic Device FRANANO, F NICHOLAS Small Business
Probe for Quantitative Fluorescence Nervous System Tumor INSIGHT SURGICAL TECHNOLOGIES, LLC Therapeutic Device ROBERTS, DAVID W Small Business
Development of a novel Balloon Occlusion Sheath for Stroke (BOSS) Stroke MARBLEHEAD MEDICAL, LLC Therapeutic Device KALLMES, DAVID F Small Business
Cuff Electrodes with Soft Wire Electrical Leads Nerve Injury TDA RESEARCH, INC. Therapeutic Device CLAPSADDLE, BRADY JOHN Small Business
Soft-Focused HIFU Treatment of Common Peroneal Nerve Injury Pain ACOUSTIC MEDSYSTEMS, INC. Therapeutic Device BURDETTE, EVERETTE C Small Business
CranialProgrammer: Image-Guided Directional Deep Brain Stimulation Programming Using Local-Field Potentials Parkinson's Disease NEXEON MEDSYSTEMS PUERTO RICO OPERATING COMPANY, INC Therapeutic Device DUKE, AUSTIN ROBERT Small Business
Magnetically Enhanced Diffusion for Intra-Arterial Treatment of Acute Ischemic Stroke Stroke PULSE THERAPEUTICS, INC. Therapeutic Device TONES, MICHAEL ANTHONY Small Business
Astroglial EAAT2 Changes in Live TBI Brain Determined by PET Imaging Traumatic Brain Injury (TBI) RIO PHARMACEUTICALS, INC. Imaging VANBROCKLIN, HENRY F Small Business
Automated Assessment of Leptomeningeal Collaterals on CT Angiograms Stroke KITWARE, INC. Imaging LEE, YUEH Z Small Business
Drug Eluting Embolization Coils for Improved Treatment of Intracranial Aneurysms Aneurysm ANCURE, LLC Therapeutic Device BETTINGER, CHRISTOPHER JOHN Small Business
Zwitterionic oxime (RS194B) to reverse advanced symptoms and lethality of organophosphate pesticide exposure Neurotoxin exposure Neurotoxin exposure Drug (small molecule) ROSENBERG, YVONNE J Small Business
Pivotal trial of vamorolone in Duchenne muscular dystrophy Muscular Dystrophy REVERAGEN BIOPHARMA, INC. Drug (small molecule) HOFFMAN, ERIC P Small Business
Novel Therapy for Huntingtons Disease Huntington's Disease RESILIO THERAPEUTICS, LLC Drug (small molecule) VITEK, MICHAEL PETER Small Business
Small Molecule Treatments to Enhance Neurological Recovery After Stroke Stroke STEMETIX, INC. Drug (small molecule) FINKLESTEIN, SETH Small Business
Development of novel small molecule analgesics modulating the nNOS-NOS1AP protein-protein interaction Pain ANAGIN Drug (small molecule) FLORIO, STEPHANIE KAY Small Business
IND-enabling studies on novel Cav3 T-channel modulators for treatment of neuropathic pain Pain AFASCI, INC. Drug (small molecule) XIE, XINMIN SIMON Small Business
Chemokine-receptor expression profiling in biological samples from human clinical trials Pain PLUMERIA THERAPEUTICS, INC. Drug (small molecule) RICHARDSON, THOMAS P Small Business
NAAA Inhibition for Pain and Inflammation Pain NEOKERA, LLC Drug (small molecule) MONAGHAN, EDWARD PAUL Small Business
Peripheral FAAH inhibitor, URB937, as an opioid-sparing analgesic for chronic pain. Pain ASPIREBIO CORPORATION Drug (small molecule) PIOMELLI, DANIELE Small Business
Development of Novel Metformin Analog for Treatment of Parkinsons Disease Parkinson's Disease PK BIOSCIENCES CORPORATION Drug (small molecule) ANANTHARAM, VELLAREDDY Small Business
Neo-Substrate Amplifiers of PINK1 for the Treatment of Parkinsons Disease Parkinson's Disease MITOKININ, INC. Drug (small molecule) WANG, CHENGZHONG Small Business
An oral ROCK2-selective inhibitor for treatment of chronic spinal cord injury Spinal Cord Injury (SCI) BIOAXONE BIOSCIENCES, INC. Drug (small molecule) ROSEN, KENNETH M Small Business
Cathepsin B inhibitor Drug Development for Traumatic Brain Injury Traumatic Brain Injury (TBI) AMERICAN LIFE SCIENCE PHARMACEUTICALS Drug (small molecule) HOOK, GREGORY R Small Business
Preclinical development of AST-004 for astrocyte-mediated treatment of TBI. Traumatic Brain Injury (TBI) ASTROCTYE PHARMACEUTICALS, INC. Drug (small molecule) LISTON, THEODORE E Small Business
Development of new anti-epilepsy treatments targeting cellular energetics through mitochondrial modulation with optimal pharmacokinetics and toxicity profiles Epilepsy NEUROENE THERAPEUTICS, LLC Drug (small molecule) CHAN, SHERINE S Small Business
Kv7.2/7.3 Activators for the Treatment of Epilepsy Disorders Epilepsy KNOPP BIOSCIENCES, LLC Drug (small molecule) BOZIK, MICHAEL Small Business
A Novel Treatment for Batten Disease Lysosomal storage disorder SENEB BIOSCIENCES, INC. Diagnostic Device DEFREES, SHAWN Small Business
Non-Metal PN Scavenger/Decomposition Catalysts for Treatment of Migraine Pain CERSCI THERAPEUTICS, INC. Drug (small molecule) DUSSOR, GREGORY O Small Business
In Silico Identification of Novel GHB Receptor Ligands for SSADH Deficiency, a Disorder of GABA Metabolism Traumatic Brain Injury (TBI) SPERAGEN, INC. Drug (small molecule) MCCONNELL, ALICE Small Business
Farnesol as Novel Treatment in Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD) SPERAGEN, INC. Drug (small molecule) MCCONNELL, ALICE Small Business
Inert Coating for Cerebral Shunts to Eliminate Clogging Other FREEFLOW MEDICAL DEVICES, LLC Therapeutic Device JONES, ANDREW K Small Business
User-driven Retrospectively Supervised Classification Updating (RESCU) system for robust upper limb prosthesis control Other Infinite Biomedical Technologies, LLC Other KALIKI, RAHUL NINDS Exploratory/Dev Projects


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Form Approved OMB# 0925-0648 Exp. Date 06/2024