Office of Neural Exposome and Toxicology Research

The National Institute of Neurological Disorders and Stroke (NINDS) supports basic, translational, and clinical research on the brain and nervous system and uses that knowledge to reduce the burden of neurological disease for all people. Within the Division of Translational Research (DTR) at NINDS, the Office of Neural Exposome and Toxicology (ONETOX) supports research and provides resources to advance knowledge of internal and external exposures that affect brain and nervous system health (Neural Exposome), leads research related to chemical threats, and provides resources that promote chemical safety.

ONETOX has three branches:

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Neural Exposome

The Neural Exposome, which includes environmental neurotoxicants, the gut-brain axis and microbiome, social behaviors, and other internal and external exposures that affect neurological disease and disorders

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Chemical Threats

Chemical Threats, which includes the NIH Countermeasures Against Chemical Threats (NIH CounterACT) program

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Chemical Safety

Chemical Safety, which provides resources to reduce safety liabilities related to neurotoxic drugs, biohazards, use of Select Agents, and Dual Use Research of Concern

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Dr. David Jett is the Director of the Office of Neural Exposome and Toxicology Research (ONETOX) at NINDS. He also serves as Program Director and Scientific Team Leader within the Division of Translational Research (DTR). Dr. Jett has been at NINDS since 2001 and has led several programs including the development and launching the NIH CounterACT program after 9/11. Prior to NINDS, he was faculty at Johns Hopkins University where his lab focused on the impact of chemical agents on nervous system function, including the molecular and cellular mechanisms of cognitive and neural development.