CounterACT Publications 2019



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Neurotoxic Agents

Bharate SB, Chao CK, Thompson CM. Comparison of the reactivation rates of acetylcholinesterase modified by structurally different organophosphates using novel pyridinium oximes. Environ Toxicol Pharmacol. 2019 Jul 5;71:103218. doi: 10.1016/j.etap.2019.103218. [Epub ahead of print] PubMed PMID: 31302432.

Bruun DA, Guignet M, Harvey DJ, Lein PJ. Pretreatment with pyridostigmine bromide has no effect on seizure behavior or 24 hour survival in the rat model of acute diisopropylfluorophosphate intoxication. Neurotoxicology. 2019 Jul;73:81-84. doi: 10.1016/j.neuro.2019.03.001. Epub 2019 Mar 7. PubMed PMID: 30853371; PubMed Central PMCID: PMC6634995.

Chuang SH, Reddy DS. Zinc reduces antiseizure activity of neurosteroids by selective blockade of extrasynaptic GABA-A receptor-mediated tonic inhibition in the hippocampus. Neuropharmacology. 2019 Apr;148:244-256. doi: 10.1016/j.neuropharm.2018.11.031. Epub 2018 Nov 22. PubMed PMID: 30471294; PubMed Central PMCID: PMC6424640.

Dail MB, Leach CA, Meek EC, Olivier AK, Pringle RB, Green CE, Chambers JE. Novel Brain-Penetrating Oxime Acetylcholinesterase Reactivators Attenuate Organophosphate-Induced Neuropathology in the Rat Hippocampus. Toxicol Sci. 2019 Jun 1;169(2):465-474. doi: 10.1093/toxsci/kfz060. PubMed PMID: 30835286; PubMed Central PMCID: PMC6542341.

Dail MB, Meek EC, Chambers HW, Chambers JE. In vitro P-glycoprotein activity does not completely explain in vivo efficacy of novel centrally effective oxime acetylcholinesterase reactivators. Drug Chem Toxicol. 2019 Jul;42(4):403-408. doi: 10.1080/01480545.2018.1461902. Epub 2018 May 3. PubMed PMID: 29722548; PubMed Central PMCID: PMC6215530.

Deshpande LS, DeLorenzo RJ. Novel therapeutics for treating organophosphate-induced status epilepticus co-morbidities, based on changes in calcium homeostasis. Neurobiol Dis. 2019 Mar 12;:104418. doi: 10.1016/j.nbd.2019.03.006. [Epub ahead of print] Review. PubMed PMID: 30872159.

Franjesevic AJ, Sillart SB, Beck JM, Vyas S, Callam CS, Hadad CM. Resurrection and Reactivation of Acetylcholinesterase and Butyrylcholinesterase. Chemistry. 2019 Apr 11;25(21):5337-5371. doi: 10.1002/chem.201805075. Epub 2019 Feb 13. Review. PubMed PMID: 30444932; PubMed Central PMCID: PMC6508893.

Gartung A, Yang J, Sukhatme VP, Bielenberg DR, Fernandes D, Chang J, Schmidt BA, Hwang SH, Zurakowski D, Huang S, Kieran MW, Hammock BD, Panigrahy D. Suppression of chemotherapy-induced cytokine/lipid mediator surge and ovarian cancer by a dual COX-2/sEH inhibitor. Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1698-1703. doi: 10.1073/pnas.1803999116. Epub 2019 Jan 15. PubMed PMID: 30647111; PubMed Central PMCID: PMC6358686.

Gerlits O, Ho KY, Cheng X, Blumenthal D, Taylor P, Kovalevsky A, Radić Z. A new crystal form of human acetylcholinesterase for exploratory room-temperature crystallography studies. Chem Biol Interact. 2019 Aug 25;309:108698. doi: 10.1016/j.cbi.2019.06.011. Epub 2019 Jun 7. PubMed PMID: 31176713; PubMed Central PMCID: PMC6679772.

Gerlits O, Kong X, Cheng X, Wymore T, Blumenthal DK, Taylor P, Radić Z, Kovalevsky A. Productive reorientation of a bound oxime reactivator revealed in room temperature X-ray structures of native and VX-inhibited human acetylcholinesterase. J Biol Chem. 2019 Jul 5;294(27):10607-10618. doi: 10.1074/jbc.RA119.008725. Epub 2019 May 28. PubMed PMID: 31138650; PubMed Central PMCID: PMC6615692.

Guignet M, Dhakal K, Flannery BM, Hobson BA, Zolkowska D, Dhir A, Bruun DA, Li S, Wahab A, Harvey DJ, Silverman JL, Rogawski MA, Lein PJ. Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication. Neurobiol Dis. 2019 Mar 21;:104431. doi: 10.1016/j.nbd.2019.03.019. [Epub ahead of print] Review. PubMed PMID: 30905768.

Hayes TR, Blecha JE, Thompson CM, Gerdes JM, VanBrocklin HF. Divergent synthesis of organophosphate [11C]VX- and [11C]Sarin-surrogates from a common set of starting materials. Appl Radiat Isot. 2019 Sep;151:182-186. doi: 10.1016/j.apradiso.2019.05.033. Epub 2019 May 24. PubMed PMID: 31202183; PubMed Central PMCID: PMC6688906.

Hiesinger K, Wagner KM, Hammock BD, Proschak E, Hwang SH. Development of multitarget agents possessing soluble epoxide hydrolase inhibitory activity. Prostaglandins Other Lipid Mediat. 2019 Feb;140:31-39. doi: 10.1016/j.prostaglandins.2018.12.003. Epub 2018 Dec 26. Review. PubMed PMID: 30593866; PubMed Central PMCID: PMC6345559.

Hossain MM, Sivaram G, Richardson JR. Regional Susceptibility to ER Stress and Protection by Salubrinal Following a Single Exposure to Deltamethrin. Toxicol Sci. 2019 Jan 1;167(1):249-257. doi: 10.1093/toxsci/kfy238. PubMed PMID: 30247739; PubMed Central PMCID: PMC6317433.

Lakkappa N, Krishnamurthy PT, M D P, Hammock BD, Hwang SH. Soluble epoxide hydrolase inhibitor, APAU, protects dopaminergic neurons against rotenone induced neurotoxicity: Implications for Parkinson's disease. Neurotoxicology. 2019 Jan;70:135-145. doi: 10.1016/j.neuro.2018.11.010. Epub 2018 Nov 22. PubMed PMID: 30472438.

Lautz AJ, Morgan RW, Karlsson M, Mavroudis CD, Ko TS, Licht DJ, Nadkarni VM, Berg RA, Sutton RM, Kilbaugh TJ. Hemodynamic-Directed Cardiopulmonary Resuscitation Improves Neurologic Outcomes and Mitochondrial Function in the Heart and Brain. Crit Care Med. 2019 Mar;47(3):e241-e249. doi: 10.1097/CCM.0000000000003620. PubMed PMID: 30779720; PubMed Central PMCID: PMC6561502.

Liang LP, Pearson-Smith JN, Huang J, Day BJ, Patel M. Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model. Redox Biol. 2019 Jan;20:275-284. doi: 10.1016/j.redox.2018.10.010. Epub 2018 Oct 16. PubMed PMID: 30384261; PubMed Central PMCID: PMC6215030.

Miller BA, Wang J, Song J, Zhang XQ, Hirschler-Laszkiewicz I, Shanmughapriya S, Tomar D, Rajan S, Feldman AM, Madesh M, Sheu SS, Cheung JY. Trpm2 enhances physiological bioenergetics and protects against pathological oxidative cardiac injury: Role of Pyk2 phosphorylation. J Cell Physiol. 2019 Jan 13;. doi: 10.1002/jcp.28146. [Epub ahead of print] PubMed PMID: 30637731; PubMed Central PMCID: PMC6626587.

Moeller B, Espelien B, Weber W, Kuehl P, Doyle-Eisele M, Garner CE, McDonald JD, Garcia E, Raulli R, Laney J. The pharmacokinetics of ketamine following intramuscular injection to F344 rats. Drug Test Anal. 2019 Jan;11(1):68-76. doi: 10.1002/dta.2468. Epub 2018 Aug 14. PubMed PMID: 30027605; PubMed Central PMCID: PMC6538562.

Pearson-Smith JN, Patel M. Antioxidant drug therapy as a neuroprotective countermeasure of nerve agent toxicity. Neurobiol Dis. 2019 Apr 25;:104457. doi: 10.1016/j.nbd.2019.04.013. [Epub ahead of print] Review. PubMed PMID: 31028872.

Reddy DS, Carver CM, Clossen B, Wu X. Extrasynaptic γ-aminobutyric acid type A receptor-mediated sex differences in the antiseizure activity of neurosteroids in status epilepticus and complex partial seizures. Epilepsia. 2019 Apr;60(4):730-743. doi: 10.1111/epi.14693. Epub 2019 Mar 20. PubMed PMID: 30895610; PubMed Central PMCID: PMC6447432.

Richardson JR, Fitsanakis V, Westerink RHS, Kanthasamy AG. Neurotoxicity of pesticides. Acta Neuropathol. 2019 Sep;138(3):343-362. doi: 10.1007/s00401-019-02033-9. Epub 2019 Jun 13. Review. PubMed PMID: 31197504.

Rojas A, Ganesh T, Wang W, Wang J, Dingledine R. A rat model of organophosphate-induced status epilepticus and the beneficial effects of EP2 receptor inhibition. Neurobiol Dis. 2019 Feb 25;:104399. doi: 10.1016/j.nbd.2019.02.010. [Epub ahead of print] Review. PubMed PMID: 30818067; PubMed Central PMCID: PMC6708729.

Thompson CM, Gerdes JM, VanBrocklin HF. Positron emission tomography studies of organophosphate chemical threats and oxime countermeasures. Neurobiol Dis. 2019 Apr 22;:104455. doi: 10.1016/j.nbd.2019.04.011. [Epub ahead of print] Review. PubMed PMID: 31022458.

Wulff H, Christophersen P, Colussi P, Chandy KG, Yarov-Yarovoy V. Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357. doi: 10.1038/s41573-019-0013-8. Review. PubMed PMID: 30728472; PubMed Central PMCID: PMC6499689.


Vesicating Agents

Das LM, Binko AM, Traylor ZP, Peng H, Lu KQ. Vitamin D improves sunburns by increasing autophagy in M2 macrophages. Autophagy. 2019 May;15(5):813-826. doi: 10.1080/15548627.2019.1569298. Epub 2019 Jan 24. PubMed PMID: 30661440; PubMed Central PMCID: PMC6526871.

Guillon C, Jan YH, Heck DE, Mariano TM, Rapp RD, Jetter M, Kardos K, Whittemore M, Akyea E, Jabin I, Laskin JD, Heindel ND. Phototoxicity of 7-oxycoumarins with keratinocytes in culture. Bioorg Chem. 2019 Aug;89:103014. doi: 10.1016/j.bioorg.2019.103014. Epub 2019 May 25. PubMed PMID: 31170642; PubMed Central PMCID: PMC6656587.

Guillon CD, Jan YH, Foster N, Ressner J, Heck DE, Laskin JD, Heindel ND. Synthetically modified methoxsalen for enhanced cytotoxicity in light and dark reactions. Bioorg Med Chem Lett. 2019 Feb 15;29(4):619-622. doi: 10.1016/j.bmcl.2018.12.048. Epub 2018 Dec 22. PubMed PMID: 30638875; PubMed Central PMCID: PMC6364570.

Jan YH, Heck DE, Laskin DL, Laskin JD. Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells. Chem Res Toxicol. 2019 Jun 17;32(6):1123-1133. doi: 10.1021/acs.chemrestox.8b00417. Epub 2019 Apr 22. PubMed PMID: 30964658; PubMed Central PMCID: PMC6626495.

Son Y, Mishin V, Laskin JD, Mainelis G, Wackowski OA, Delnevo C, Schwander S, Khlystov A, Samburova V, Meng Q. Hydroxyl Radicals in E-Cigarette Vapor and E-Vapor Oxidative Potentials under Different Vaping Patterns. Chem Res Toxicol. 2019 Jun 17;32(6):1087-1095. doi: 10.1021/acs.chemrestox.8b00400. Epub 2019 Apr 23. PubMed PMID: 30977360; PubMed Central PMCID: PMC6579624.

Szilagyi JT, Composto-Wahler GM, Joseph LB, Wang B, Rosen T, Laskin JD, Aleksunes LM. Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol Res. 2019 Mar;141:331-342. doi: 10.1016/j.phrs.2019.01.002. Epub 2019 Jan 2. PubMed PMID: 30610963; PubMed Central PMCID: PMC6391190.


Pulmonary Agents

Aggarwal S, Jilling T, Doran S, Ahmad I, Eagen JE, Gu S, Gillespie M, Albert CJ, Ford D, Oh JY, Patel RP, Matalon S. Phosgene inhalation causes hemolysis and acute lung injury. Toxicol Lett. 2019 Sep 15;312:204-213. doi: 10.1016/j.toxlet.2019.04.019. Epub 2019 Apr 30. PubMed PMID: 31047999; PubMed Central PMCID: PMC6653688.

Ahmad S, Masjoan Juncos JX, Ahmad A, Zaky A, Wei CC, Bradley WE, Zafar I, Powell P, Mariappan N, Vetal N, Louch WE, Ford DA, Doran SF, Matalon S, Dell'Italia LJ. Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats. Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H212-H223. doi: 10.1152/ajpheart.00652.2017. Epub 2018 Oct 31. PubMed PMID: 30379573; PubMed Central PMCID: PMC6383353.

Ahmad S, Zafar I, Mariappan N, Husain M, Wei CC, Vetal N, Eltoum IA, Ahmad A. Acute pulmonary effects of aerosolized nicotine. Am J Physiol Lung Cell Mol Physiol. 2019 Jan 1;316(1):L94-L104. doi: 10.1152/ajplung.00564.2017. Epub 2018 Oct 25. PubMed PMID: 30358437; PubMed Central PMCID: PMC6383503.

Barnes JW, Duncan D, Helton S, Hutcheson S, Kurundkar D, Logsdon NJ, Locy M, Garth J, Denson R, Farver C, Vo HT, King G, Kentrup D, Faul C, Kulkarni T, De Andrade JA, Yu Z, Matalon S, Thannickal VJ, Krick S. Role of fibroblast growth factor 23 and klotho cross talk in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2019 Jul 1;317(1):L141-L154. doi: 10.1152/ajplung.00246.2018. Epub 2019 May 1. PubMed PMID: 31042083; PubMed Central PMCID: PMC6689746.

Bachus H, Kaur K, Papillion AM, Marquez-Lago TT, Yu Z, Ballesteros-Tato A, Matalon S, León B. Impaired Tumor-Necrosis-Factor-α-driven Dendritic Cell Activation Limits Lipopolysaccharide-Induced Protection from Allergic Inflammation in Infants. Immunity. 2019 Jan 15;50(1):225-240.e4. doi: 10.1016/j.immuni.2018.11.012. Epub 2019 Jan 8. PubMed PMID: 30635238; PubMed Central PMCID: PMC6335154.

Musah S, Chen J, Schlueter C, Humphrey DM Jr, Stocke K, Hoyle MI, Hoyle GW. Inhibition of chlorine-induced airway fibrosis by budesonide. Toxicol Appl Pharmacol. 2019 Jan 15;363:11-21. doi: 10.1016/j.taap.2018.08.024. Epub 2018 Sep 3. PubMed PMID: 30189237; PubMed Central PMCID: PMC6342561.

Rancourt RC, Rioux JS, Veress LA, Garlick RB, Croutch CR, Peters E, Sosna W, White CW. Methyl isocyanate inhalation induces tissue factor-dependent activation of coagulation in rats. Drug Chem Toxicol. 2019 May;42(3):321-327. doi: 10.1080/01480545.2018.1517773. Epub 2018 Nov 14. PubMed PMID: 30426789; PubMed Central PMCID: PMC6405318.

Surolia R, Li FJ, Wang Z, Li H, Dsouza K, Thomas V, Mirov S, Pérez-Sala D, Athar M, Thannickal VJ, Antony VB. Vimentin intermediate filament assembly regulates fibroblast invasion in fibrogenic lung injury. JCI Insight. 2019 Apr 4;4(7). doi: 10.1172/jci.insight.123253. eCollection 2019 Apr 4. PubMed PMID: 30944258; PubMed Central PMCID: PMC6483650.

Tejero J, Shiva S, Gladwin MT. Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation. Physiol Rev. 2019 Jan 1;99(1):311-379. doi: 10.1152/physrev.00036.2017. Review. PubMed PMID: 30379623; PubMed Central PMCID: PMC6442925.


Metabolic/Cellular Poisons

Amdahl MB, Petersen EE, Bocian K, Kaliszuk SJ, DeMartino AW, Tiwari S, Sparacino-Watkins CE, Corti P, Rose JJ, Gladwin MT, Fago A, Tejero J. The Zebrafish Cytochrome b5/Cytochrome b5 Reductase/NADH System Efficiently Reduces Cytoglobins 1 and 2: Conserved Activity of Cytochrome b5/Cytochrome b5 Reductases during Vertebrate Evolution. Biochemistry. 2019 Jul 23;58(29):3212-3223. doi: 10.1021/acs.biochem.9b00406. Epub 2019 Jul 10. PubMed PMID: 31257865; PubMed Central PMCID: PMC6657698.

Cheung JY, Merali S, Wang J, Zhang XQ, Song J, Merali C, Tomar D, You H, Judenherc-Haouzi A, Haouzi P. The central role of protein kinase C epsilon in cyanide cardiotoxicity and its treatment. Toxicol Sci. 2019 Jun 7;. doi: 10.1093/toxsci/kfz137. [Epub ahead of print] PubMed PMID: 31173149.

Haouzi P, Sonobe T, Judenherc-Haouzi A. Hydrogen sulfide intoxication induced brain injury and methylene blue. Neurobiol Dis. 2019 May 16;:104474. doi: 10.1016/j.nbd.2019.05.013. [Epub ahead of print] Review. PubMed PMID: 31103557.

Haouzi P, McCann M, Tubbs N, Judenherc-Haouzi A, Cheung J, Bouillaud F. Antidotal Effects of the Phenothiazine Chromophore Methylene Blue Following Cyanide Intoxication. Toxicol Sci. 2019 Jul 1;170(1):82-94. doi: 10.1093/toxsci/kfz081. PubMed PMID: 30907955; PubMed Central PMCID: PMC6592189.

Haouzi P, Tubbs N, Cheung J, Judenherc-Haouzi A. Methylene Blue Administration During and After Life-Threatening Intoxication by Hydrogen Sulfide: Efficacy Studies in Adult Sheep and Mechanisms of Action. Toxicol Sci. 2019 Apr 1;168(2):443-459. doi: 10.1093/toxsci/kfy308. PubMed PMID: 30590764; PubMed Central PMCID: PMC6516679.

Morningstar J, Lee J, Hendry-Hofer T, Witeof A, Lyle LT, Knipp G, MacRae CA, Boss GR, Peterson RT, Davisson VJ, Gerszten RE, Bebarta VS, Mahon S, Brenner M, Nath AK. Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning. FASEB Bioadv. 2019 Feb;1(2):81-92. doi: 10.1096/fba.1024. Epub 2018 Oct 8. PubMed PMID: 31355359; PubMed Central PMCID: PMC6660183.

Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Haouzi P, Bebarta VS. Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development. J Med Toxicol. 2019 May 6;. doi: 10.1007/s13181-019-00710-5. [Epub ahead of print] Review. PubMed PMID: 31062177.

Ng PC, Hendry-Hofer TB, Garrett N, Brenner M, Mahon SB, Maddry JK, Haouzi P, Boss GR, Gibbons TF, Araña AA, Bebarta VS. Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine. Clin Toxicol (Phila). 2019 Mar;57(3):189-196. doi: 10.1080/15563650.2018.1504955. Epub 2018 Nov 15. PubMed PMID: 30430872; PubMed Central PMCID: PMC6540978.

Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB. Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B12 analog. Nat Commun. 2019 Aug 6;10(1):3533. doi: 10.1038/s41467-019-11389-1. PubMed PMID: 31387997; PubMed Central PMCID: PMC6684604.



Feinstein DL, Gierzal K, Iqbal A, Kalinin S, Ripper R, Lindeblad M, Zahkarov A, Lyubimov A, van Breemen R, Weinberg G, Rubinstein I. The relative toxicity of brodifacoum enantiomers. Toxicol Lett. 2019 May 15;306:61-65. doi: 10.1016/j.toxlet.2019.02.011. Epub 2019 Feb 16. PubMed PMID: 30779948; PubMed Central PMCID: PMC6408973.

Rubinstein I, van Breemen R, Nosal DG, Weinberg G, Hershow RC, Feinstein DL. Should Cytochrome P450 Inducers be Used to Accelerate Clearance of Brodifacoum from Poisoned Patients?. Drugs R D. 2019 Mar;19(1):67-71. doi: 10.1007/s40268-019-0261-4. PubMed PMID: 30689138; PubMed Central PMCID: PMC6380967.

Tole M, LaBedz S, Feinstein DL, Rubinstein I. Adherence to Long-Term Follow-Up of Patients with Life-Threatening, Inhaled Synthetic Cannabinoids-Associated Coagulopathy in Chicago. Lung. 2019 Jun;197(3):349-352. doi: 10.1007/s00408-019-00227-2. Epub 2019 Apr 19. PubMed PMID: 31004190; PubMed Central PMCID: PMC6522275.


Pharmaceutical-based Agents

Smith LC, Bremer PT, Hwang CS, Zhou B, Ellis B, Hixon MS, Janda KD. Monoclonal Antibodies for Combating Synthetic Opioid Intoxication. J Am Chem Soc. 2019 Jul 3;141(26):10489-10503. doi: 10.1021/jacs.9b04872. Epub 2019 Jun 25. PubMed PMID: 31187995; PubMed Central PMCID: PMC6662938.