ONETOX - Chemical Threats


Banner Logo for ONETOX Left side has head silhouette with symbols representing the three parts of ONETOX


The increased risk of a terrorist attack in the United States involving toxic chemicals has created new challenges for many programs across the federal government. Threat agents, including toxic industrial chemicals and pharmaceuticals as well as traditional chemical warfare agents, have become of more and more concern because of their recent use in terrorist incidents, warfare, and accidental and occupational poisonings. Although several medical countermeasures (MCMs) are already fielded for a few specific chemical threats, the U.S. government established the NIH Countermeasures Against Chemical Threats (CounterACT) Program to support research on improvement and optimization of the nation’s medical response capabilities

As part of the Chemical Countermeasures Research Program led by the National Institute of Allergy and Infectious Diseases (NIAID), the CounterACT Program is a trans-NIH effort developed and launched in 2006 by the NINDS. The NIH CounterACT Program supports a network of grants and cooperative agreements that conduct research on the discovery and early development of MCMs to reduce mortality and morbidity during and after exposure to chemical threat agents. In addition to NINDS, NIH CounterACT grants are managed by the National Eye Institute (NEI), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institute of Environmental Health Sciences (NIEHS), National Institute on Drug Abuse (NIDA), and with other subject matter experts across the NIH. The scope of research includes basic, translational, and pre-clinical research aimed at the discovery and/or identification of better MCMs against chemical threat agents and it supports their development in preparation for more advanced studies required for regulatory approval. Please see the NIH CounterACT website for more information on funding opportunities and research tools.

Resources and Tools


David A. Jett, Ph.D. | Director, ONETOX and NIH CounterACT Program

Shardell Spriggs, Ph.D. | Program Director

Neel Dhruv, Ph.D. | Health Program Specialist

Funding Opportunities

Chemical Threats Funding Opportunities

Chemical Threats Notices and Other Funding Announcements