It is widely acknowledged that most diseases and disorders cannot be attributed to genetic factors alone. Coined by Chris Paul Wild in 2005 (Wild, C.P. 2005 Cancer Epidemiol Biomarkers Prev. 14(8):1847-50), the term “exposome” describes the totality of internal and external exposures across the lifespan that affect human health. The “Neural Exposome” are those exposures that have an impact on neurological disease and disorders, and overall nervous system health. The exposures described in the exposome not only include environmental chemical and biological toxins, but also psychosocial factors and internal factors such as diet and the microbiome, and these exposures may occur anytime from in utero to late in life. A better understanding of how these exposomic factors interact with genes will lead to identifying more precise and effective intervention strategies, especially because many of the exposures are potentially modifiable.
The overall goal of ONETOX is to enhance basic, translational, and clinical NIH research on the effect of the neural exposome on nervous system diseases and disorders by fostering more collaborative research within the neuroscience research community. ONETOX provides information and tools to help break down barriers to research between different scientific disciplines which can be used to establish productive team science for targeted funding opportunities. Because of the large number and different kinds of exposures within the Neural Exposome that occur across the lifespan, ONETOX collaborates with many different Institutes and Centers across the NIH to obtain a full understanding of how these exposomic factors affect brain and nervous system health.
Neural Exposome Virtual Mini-Workshop:
February 29, 2024 | 1:00 pm EST
Research into the neural exposome space will often bridge multiple scientific disciplines, including neurobiology, environmental health science, social determinants of health and health inequities, epidemiology, geospatial modeling, and data science, among others. Several recent National Academy of Science, Engineering, and Medicine (NASEM) workshops (Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease, The Interplay between Environmental Exposures and Mental Health Outcomes, and Integrating the Science of Aging and Environmental Health Research), highlighted the importance of fostering interdisciplinary Team Research to harness the collective efforts of neuroscientists and the environmental health sciences community.
This mini-workshop explores best practices in building diverse teams to support multidisciplinary and multi-faceted research on the neural exposome.
OPEN Stage Webinar:
October 23, 2023 | 1:00 pm EDT
This webinar will describe a new area of research on the Neural Exposome at NINDS. The neural exposome refers to the non-heritable factors affecting the nervous system including environmental/chemical exposures, the microbiome, and socio-behavioral stress. We will spotlight Erica Glasper, PhD, an NINDS funded investigator, who will provide a summary of her exciting research.
Investigators looking to form collaborative interdisciplinary research projects, trainees and early career faculty are strongly encouraged to review the slides and webinar recording.
Resources and Tools
News & Events
Virtual Mini Workshop: Team Science to Advance Neural Exposome Research
February 29, 2024 | 1PM EST
OPEN Stage Webinar: The Neural Exposome - How NINDS is Supporting Exposomic Research
October 23, 2023 | 1PM EDT
Neuroscience 2022: The Neural Exposome and Why it's Important to You! | November 15, 2022; 6:30 pm PST
Comparative Toxicogenomic Database (CTD)
The Comparative Toxicogenomic Database (CTD) launched in 2004 is a well-known publicly available resource for curated data on the linkage between human exposures and how they influence genes, biology, and human health.
NeurotoxKB provides information on potential neurotoxicants that is compiled and manually curated along with supporting evidence from published scientific studies.
Environmental Neuroscience Reports:
The National Academies of Sciences Engineering Medicine Environmental Neuroscience: Advancing the Understanding of How Chemical Exposures Impact Brain Health and Disease: Proceedings of a Workshop