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Neurotoxic Agents
Ben-David M, Sussman JL, Maxwell CI, Szeler K, Kamerlin SC, Tawfik DS. (2015) Catalytic stimulation by restrained active-site floppiness - the case of high-density lipoprotein bound serum paraoxonase-1. J Mol Biol. 427(6 Pt B):1359-74. Abstract
Blair RE, Desphande LS, DeLorenzo RJ. (2015) Cannabinoids: Is there a potential treatment role in epilepsy? Expert Opin Pharmacother. 16(13): 1911-4. Abstract
Bruun DA, Cao Z, Inceoglu B, Vito ST, Austin AT, Hulsizer S, Hammock BD, Tancredi DJ, Rogawski MA, Pessah IN, Lein PJ. (2015) Combined treatment with diazepam and allopregnanolone reverses Tetramethylenedisulfotetramine (TETS)-induced calcium dysregulation in cultured neurons and protects TETS-intoxicated mice against lethal seizures. Neuropharmacology. 95:332-42. Abstract
Cao Z, Zou X, Cui Y, Hulsizer SC, Lein PJ, Wulff H, Pessah IN. (2015) Rapid Throughput Analysis Demonstrates that Chemicals with Distinct Seizurogenic Mechanisms Differentially Alter Ca2+ Dynamics in Networks Formed by Hippocampal Neurons in Culture. Mol Pharmacol. 87(4):595-605. Abstract
Chambers JE, Meek EC, Bennett JP, Bennett WS, Chambers HW, Leach CA, Pringle RB, Wills RW. (2015) Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates. Toxicology. 339: 51-57. Abstract
DeArmond PD, Brittain MK, Platoff GE Jr, Yeung DT. (2015) QuEChERS-based approach toward the analysis of two insecticides, methomyl and aldicarb, in blood and brain tissue. Anal Methods. 7(1):321-328. Abstract
Desai R, Savechenkov PY, Zolkowska D, Ge RL, Rogawski MA, Bruzik KS, Forman SA, Raines DE, Miller KW. (2015) Contrasting actions of a convulsant barbiturate and its anti-convulsant enantiomer on the α1β3γ2L GABAA receptor account for their in vivo effects. J Physiol. 593(22): 4943-61. Abstract
Ferchmin PA, Pérez D, Cuadrado BL, Carrasco M, Martins AH, Eterović VA. (2015) Neuroprotection against Diisopropylfluorophosphate in acute hippocampal slices. Neurochem Res. 40(10): 2143-51. Abstract
Fu Y, Yang MS, Jiang J, Ganesh T, Joe E, Dingledine R. (2015). EP2 receptor signaling regulates microglia death. Mol Pharmacol. 2015 Jul;88(1):161-70. Abstract
Golub VM, Brewer J, Wu X, Kuruba R, Short J, Manchi M, Swonke M, Younus I, Redd DS. (2015) Neurostereology protocol for unbiased quantification of neuronal injury and neurodegeneration. Front Aging Neurosci. 7:196. Abstract
Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD. (2015) Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication. Toxicol Appl Pharmacol. 288(1): 114-20. Abstract
Katz FS, Pecic S, Tran TH, Trakht I, Schneider L, Zhu Z, Ton-That L, Luzac M, Zlatanic V, Damera S, Macdonald J, Landry DW, Tong L, Stojanovic MN. (2015) Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates. Chembiochem. 16(15):2205-15. Abstract
Kovarik Z, Macek Hrvat N, Katalinic M, Sit RK, Paradyse A, Zunec S, Musilek K, Fokin VV, Taylor P, Radic Z. (2015) Catalytic soman scavenging by Y337A/F338A acetylcholinesterase mutant assisted with novel site-directed aldoximes. Chem Res Toxicol. 28(5):1036-44. Abstract
Li Y, Lein PJ, Ford GD, Liu C, Stovall KC, White TE, Bruun DA, Tewolde T, Gates AS, Distel TJ, Surles-Zeigler MC, Ford BD. (2015) Neuregulin-1 inhibits neuroinflammatory responses in a rat model of organophosphate-nerve agent-induced delayed neuronal injury. J Neuroinflammation. 2015 Apr 2;12(1):64. Abstract
Mangas I, Taylor P, Vilanova E, Estévez J, França TC, Komives E, Radić Z. (2015) Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches. Arch Toxicol. [Epub ahead of print] Abstract
Miller SL, Aroniadou-Anderjaska V, Figueiredo TH, Prager EM, Almeida-Suhett CP, Apland JP, Braga MF. (2015) A rat model of nerve agent exposure applicable to the pediatric population: The anticonvulsant efficacies of atropine and GluK1 antagonists. Toxicol Appl Pharmacol. 284(2):204-16. Abstract
Niquet J, Baldwin R, Gezalian M, Wasterlain CG. (2015) Deep hypothermia for the treatment of refractory status epilepticus. Epilepsy Behav. 49:313-7. Abstract
Niquet J, Gezalian M, Baldwin R, Wasterlain CG. (2015) Neuroprotective effects of deep hypothermia in refractory status epilepticus. Ann Clin Transl Neurol. 2(12): 1105-15. Abstract
Obiorah M, McCandlish E, Buckley B, DiCicco-Bloom E. (2015) Hippocampal developmental vulnerability to methylmercury extends into prepubescence. Front Neurosci. 9:150. Abstract
Prager EM, Bergstrom HC, Wynn GH, Braga MF. (2015) The basolateral amygdala γ-aminobutyric acidergic system in health and disease. J Neurosci Res. [Epub ahead of Print] Abstract
Reddy SD, Younus I, Clossen B, Reddy DS. (2015) Antiseizure Activity of Midazolam in Mice Lacking delta-Subunit Extrasynaptic GABA-A Receptors. J Pharmacol Exp Ther. 353(3):517-28. Abstract
Reddy SD, Reddy DS. (2015) Midazolam as an anticonvulsant antidote for organophosphate intoxication-A pharmacotherapeutic appraisal. Epilepsia. 56(6):813-21. Abstract
Rogawski MA, Tofighy A, White HS, Matagne A, Wolff C. (2015) Current understanding of the mechanism of action of the antiepileptic drug lacosamide. Epilepsy Res. 110:189-205. Abstract
Rojas A, Ganesh T, Lelutiu N, Gueorguieva P, Dingledine R. (2015) Inhibition of the prostaglandin EP2 receptor is neuroprotective and accelerates functional recovery in a rat model of organophosphorus induced status epilepticus. Neuropharmacology. 2015 Jun;93:15-27. Abstract
Rosenberg YJ, Adams RJ, Abanto SH, Jiang X, Sun W, Mao L, Lee KD. (2015) Pharmacokinetics and immunogenicity of a recombinant human butyrylcholinesterase bioscavenger in macaques following intravenous and pulmonary delivery. Chem Biol Interact. 242:219-226. Abstract
Rowley S, Liang LP, Fulton R, Shimizu T, Day B, Patel M. (2015) Mitochondrial Respiration Deficits Driven by Reactive Oxygen Species in Experimental Temporal Lobe Epilepsy. Neurobiol Dis. 75:151-8. Abstract
Ruiz CA, Rossi SG, Rotundo RL. (2015) Rescue and Stabilization of Acetylcholinesterase in Skeletal Muscle by N-Terminal Peptides Derived from the Non-Catalytic Subunits. J Biol Chem. 290(34):20774-81. Abstract
Schmidt HR, Radić Z, Taylor P, Fradinger EA. (2015) Quaternary and tertiary aldoxime antidotes for organophosphate exposure in a zebrafish model system. Toxicol Appl Pharmacol. 284(2):197-203. Abstract
Shakarjian MP, Ali MS, Velíšková J, Stanton PK, Heck DE, Velíšek L. (2015) Combined Diazepam and MK-801 Therapy Provides Synergistic Protection from Tetramethylenedisulfotetramine-induced Tonic-Clonic Seizures and Lethality in Mice. Neurotoxicology. 48:100-8. Abstract
Smith CD, Wright LK, Garcia GE, Lee RB, Lumley LA. (2015) Hormone-dependence of sarin lethality in rats: sex differences and stage of the estrous cycle. Toxicol Appl Pharmacol. 287(3):253-7. Abstract
Snider TH, Wilhelm CM, Babin MC, Platoff GE Jr, Yeung DT. (2015) Assessing the therapeutic efficacy of oxime therapies against percutaneous organophosphorus pesticide and nerve agent challenges in the Hartley guinea pig. J Toxicol Sci. 40(6):759-75. Abstract
Suchomelova L, Lopez-Meraz ML, Niquet J, Kubova H, Wasterlain CG. (2015) Hyperthermia aggravates status epilepticus-induced epileptogenesis and neuronal loss in immature rats. Neuroscience. 305:209-24. Abstract
Torolira D, Suchomelova L, Wasterlain CG, Niquet J. (2015) Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups. Epilepsy Res. 120: 47-54. Abstract
Varvel NH, Jiang J, Dingledine R. (2015) Candidate drug targets for prevention or modification of epilepsy. Annu Rev Pharmacol Toxicol. 2015;55:229-47. Abstract
Vélez-Carrasco W, Green CE, Catz P, Furimsky A, O'Loughlin K, Eterović VA, Ferchmin PA. (2015) Pharmacokinetics and Metabolism of 4R-Cembranoid. PLoS One. 2015 Mar 26;10(3) Abstract
Vezzani A, Dingledine R, Rossetti AO. (2015) Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application. Expert Rev Neurother. 15(9):1081-92. Abstract
Vesicating Agents
Au L, Meisch JP, Das LM, Binko AM, Boxer RS, Wen AM, Steinmetz NF, Lu KQ. (2015) Suppression of Hyperactive Immune Responses Protects against Nitrogen Mustard Injury. J Invest Dermatol. 135(12): 2971-81. Abstract
Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R. (2015) Nitrogen mustard-induced corneal injury involves DNA damage and pathways related to inflammation, epithelial-stromal separation, and neovascularization. Cornea. 35(2): 257-66. Abstract
Jain AK, Tewari-Singh N, Inturi S, Kumar D, Orlicky DJ, Agarwal C, White CW, Agarwal R. (2015) Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin. Toxicol Appl Pharmacol. 285(1):71-8. Abstract
Jan YH, Heck DE, Casillas RP, Laskin DL, Laskin JD. (2015) Thioredoxin cross-linking by nitrogen mustard in lung epithelial cells: formation of multimeric thioredoxin/thioredoxin reductase complexes and inhibition of disulfide reduction. Chem Res Toxicol. 28(11): 2091-103. Abstract
Kumar D, Tewari-Singh N, Agarwal C, Jain AK, Inturi S, Kant R, White CW, Agarwal R. (2015) Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators. Toxicol Lett. 235(3):161-71. Abstract
Malaviya R, Gow AJ, Francis M, Abramova EV, Laskin JD, Laskin DL. (2015) Radiation-induced lung injury and inflammation in mice: role of inducible nitric oxide synthase and surfactant protein D. Toxicol Sci. 144(1): 27-38. Abstract
Malaviya R, Sunil VR, Venosa A, Vayas KN, Heck DE, Laskin JD, Laskin DL. (2015) Inflammatory mechanisms of pulmonary injury induced by mustards. Toxicol Lett. [Epub ahead of Print] Abstract
Plahovinsak JL, Buccellato MA, Reid FM, Graham JS. (2015) Selection of non-steroidal anti-inflammatory drug and treatment regimen for sulfur mustard-induced cutaneous lesions. Cutan Ocul Toxicol. 11:1-10. Abstract
Saxena J, Meloni D, Huang MT, Heck DE, Laskin JD, Heindel ND, Young SC. (2015) Ethynylphenyl carbonates and carbamates as dual-action acetylcholinesterase inhibitors and anti-inflammatory agents. Bioorg Med Chem Lett. 25(23): 5609-12. Abstract
Son Y, Mishin V, Welsh W, Lu SE, Laskin JD, Kipen H, Meng Q. (2015) A Novel High-Throughput Approach to Measure Hydroxyl Radicals Induced by Airborne Particulate Matter. Int J Environ Res Public Health. 12(11):13678-95. Abstract
Spitler R, Ho H, Norpetlian F, Kong X, Jiang J, Yokomori K, Andersen B, Boss GR, Berns MW. (2015) Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing. J Biomed Opt. 20(5):051022. Abstract
Udasin RG, Wen X, Bircsak KM, Aleksunes LM, Shakarjian MP, Kong AT, Heck DE, Laskin DL, Laskin JD. (2015) Nrf2 regulates the sensitivity of mouse keratinocytes to nitrogen mustard via multidrug resistance-associated protein 1 (Mrp1). Toxicol Sci. 149(1): 202-12. Abstract
Venosa A, Malaviya R, Choi H, Gow AJ, Laskin JD, Laskin DL. (2015) Characterization of Distinct Macrophage Subpopulations During Nitrogen Mustard-Induced Injury and Fibrosis. Am J Respir Cell Mol Biol. [Epub ahead of print] Abstract
Pulmonary Agents
Aggarwal S, Lam A, Bolisetty S, Carlisle MA, Traylor A, Agarwal A, Matalon S. (2015) Heme attenuation ameliorates irritant gas inhalation induced acute lung injury. Antioxid Redox Signal. 24(2): 99-112. Abstract
Holmes WW, Keyser BM, Paradiso DC, Ray R, Andres DK, Benton BJ, Rothwell CC, Hoard-Fruchey HM, Dillman JF, Sciuto AM, Anderson DR. (2015) Conceptual approaches for treatment of phosgene inhalation-induced lung injury. Toxicol Lett. [Epub ahead of Print] Abstract
Jurkuvenaite A, Benavides GA, Komarova S, Doran SF, Johnson M, Aggarwal S, Zhang J, Darley-Usmar VM, Matalon S. (2015) Upregulation of autophagy Decreases chlorine gas induced Mitochondrial Injury and Lung Inflammation. Free Radic Biol Med. 85:83-94. Abstract
Lazrak A, Creighton JR, Yu Z, Komarova S, Doran SF, Aggarwal S, Emala CW Sr, Stober VP, Trempus CS, Garantziotis S, Matalon S. (2015) Hyaluronan mediates airway hyper-responsiveness in oxidative lung injury. Am J Physiol Lung Cell Mol Physiol. 308(9):L891-903. Abstract
Londino JD, Lazrak A, Noah JW, Aggarwal S, Bali V, Woodworth BA, Bebok Z, Matalon S. (2015) Influenza virus M2 targets cystic fibrosis transmembrane conductance regulator for lysosomal degradation during viral infection. FASEB J. 29(7):2712-25. Abstract
Matalon S, Bartoszewski R, Collawn JF. (2015) Role of Epithelial Sodium Channels (ENaC) In the Regulation of Lung Fluid Homeostasis. Am J Physiol Lung Cell Mol Physiol. 309(11):L1229-38. Abstract
McElroy C, Day BJ. (2015) Antioxidants as Potential Medical Countermeasures for Chemical Warfare Agents and Toxic Industrial Chemicals. Biochem Pharmacol. [Epub ahead of Print] Abstract
Plahovinsak JL, Perry MR, Knostman KA, Segal R, Babin MC. (2015) Characterization of a nose-only inhaled phosgene acute lung injury mouse model. Inhal Toxicol. 27(14): 832-840. Abstract
Song W, Yu Z, Doran SF, Ambalavanan N, Steele C, Garantziotis S, Matalon S. (2015) Respiratory Syncytial Virus Infection Increases Chlorine Induced Airway Hyper-responsiveness. Am J Physiol Lung Cell Mol Physiol. 309(3):L205-10. Abstract
Sunil VR, Francis M, Vayas KN, Cervelli JA, Choi H, Laskin JD, Laskin DL. (2015) Regulation of ozone-induced lung inflammation and injury by the β-galactoside-binding lectin galectin-3. Toxicol Appl Pharmacol. 284(2):236-45. Abstract
Surolia R, Karki S, Kim H, Yu Z, Kulkarni T, Mirov SB, Carter AB, Rowe SM, Matalon S, Thannickal VJ, Agarwal A, Antony VB. (2015) Heme oxygenase-1-mediated autophagy protects against pulmonary endothelial cell death and development of emphysema in cadmium-treated mice. Am J Physiol Lung Cell Mol Physiol. 309(3):L280-92. Abstract
Zaky A, Bradley WE, Lazrak A, Zafar I, Doran S, Ahmad A, White CW, Dell'Italia LJ, Matalon S, Ahmad S. (2015) Chlorine inhalation-induced myocardial depression and failure. Physiol Rep. [Epub ahead of print] Abstract
Venosa A, Malaviya R, Gow AJ, Hall L, Laskin JD, Laskin DL. (2015) Protective Role of Spleen-Derived Macrophages in Lung Inflammation, Injury and Fibrosis Induced by Nitrogen Mustard. Am J Physiol Lung Cell Mol Physiol. 309(12):L1487-98. Abstract
Zaky A, Ahmad A, Dell'Italia LJ, Jahromi L, Reisenberg LA, Matalon S, Ahmad S. (2015) Inhaled matters of the heart. Cardiovasc Regen Med. [Epub ahead of Print] Abstract
Metabolic/Cellular Poisons
Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu M, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR. (2015) Nitrocobinamide, a New Cyanide Antidote that can be Administered by Intramuscular Injection. J Med Chem. 58(4):1750-9. Abstract
Chenuel B, Sonobe T, Haouzi P. (2015) Effects of infusion of human methemoglobin solution following hydrogen sulfide poisoning. Clin Toxicol (Phila). 53(2):93-101 Abstract
Cronican AA, Frawley KL, Ahmed H, Pearce LL, Peterson J. (2015) Antagonism of Acute Sulfide Poisoning in Mice by Nitrite Anion without Methemoglobinemia. Chem Res Toxicol. 28(7):1398-408. Abstract
Haouzi P, Chenuel B, Sonobe T. (2015) High-dose hydroxocobalamin administered after H2S exposure counteracts sulfide-poisoning-induced cardiac depression in sheep. Clin Toxicol (Phila). 53(1):28-36. Abstract
Haouzi P, Sonobe T. (2015) Cardiogenic shock induced reduction in cellular O2 delivery as a hallmark of acute H2S intoxication. Clin Toxicol (Phila). 53(4):416-7. Abstract
McCracken BA, Brittain MK. (2015) High performance liquid chromatography tandem mass spectrometryassay for the determination of cobinamide in pig plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 1006: 104-11. Abstract
Sonobe T, Chenuel B, Cooper TK, Haouzi P. (2015) Immediate and Long-Term Outcome of Acute H2S Intoxication Induced Coma in Unanesthetized Rats: Effects of Methylene Blue.PLoS One. Abstract
Sonobe T, Haouzi P. (2015) H2S induced coma and cardiogenic shock in the rat: Effects of phenothiazinium chromophores. Clin Toxicol (Phila). 53(6):525-39. Abstract
Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA. (2015) Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 1008: 181-188. Abstract
Zhang D, Lee B, Nutter A, Song P, Dolatabadi N, Parker J, Sanz-Blasco S, Newmeyer T, Ambasudhan R, McKercher SR, Masliah E, Lipton SA. (2015) Protection from cyanide-induced brain injury by the Nrf2 transcriptional activator carnosic acid. J Neurochem. 133(6):898-908. Abstract
Anticoagulant
Fettiplace MR, Lis K, Ripper R, Kowal K, Pichurko A, Vitello D, Rubinstein I, Schwartz D, Akpa BS, Weinberg G (2105). Multi-modal contributions to detoxification of acute pharmacotoxicity by a triglyceride micro-emulsion. J Control Release. 198:62-70. Abstract
Ware KM, Feinstein DL, Rubinstein I, Weinberg G, Rovin BH, Hebert L, Muni N, Cianciolo RE, Satoskar AA, Nadasdy T, Brodsky SV. (2015) Brodifacoum Induces Early Hemoglobinuria and Late Hematuria in Rats: Novel Rapid Biomarkers of Poisoning. Am J Nephrol. 2015;41(4-5):392-9. Abstract
(76 Total 2015 Publications)