CounterACT Publications 2016

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Neurotoxic Agents

Aroniadou-Anderjaska V, Figueiredo TH, Apland JP, Prager EM, Pidoplichko VI, Miller SL, Braga MF. Long-term neuropathological and behavioral impairments after exposure to nerve agents. Ann N Y Acad Sci. 2016 Jun;1374(1):17-28. doi: 10.1111/nyas.13028. Epub 2016 Mar 22. Review. PubMed PMID: 27002925; PubMed Central PMCID: PMC4940270.

Bever CS, Dong JX, Vasylieva N, Barnych B, Cui Y, Xu ZL, Hammock BD, Gee SJ. VHH antibodies: emerging reagents for the analysis of environmental chemicals. Anal Bioanal Chem. 2016 Sep;408(22):5985-6002. doi: 10.1007/s00216-016-9585-x. Epub 2016 May 21. Review. PubMed PMID: 27209591; PubMed Central PMCID: PMC4983233.

Bird SB, Krajacic P, Sawamoto K, Bunya N, Loro E, Khurana TS. Pharmacotherapy to protect the neuromuscular junction after acute organophosphorus pesticide poisoning. Ann N Y Acad Sci. 2016 Jun;1374(1):86-93. doi: 10.1111/nyas.13111. Epub 2016 Jun 3. Review. PubMed PMID: 27258847.

Carver CM, Reddy DS. Neurosteroid Structure-Activity Relationships for Functional Activation of Extrasynaptic δGABA(A) Receptors. J Pharmacol Exp Ther. 2016 Apr;357(1):188-204. doi: 10.1124/jpet.115.229302. Epub 2016 Feb 8. PubMed PMID: 26857959; PubMed Central PMCID: PMC4809321.

Chambers JE, Meek EC, Chambers HW. Novel brain-penetrating oximes for reactivation of cholinesterase inhibited by sarin and VX surrogates. Ann N Y Acad Sci. 2016 Jun;1374(1):52-8. doi: 10.1111/nyas.13053. Epub 2016 May 6. PubMed PMID: 27153507; PubMed Central PMCID: PMC4940271.

Chambers JE, Meek EC, Bennett JP, Bennett WS, Chambers HW, Leach CA, Pringle RB, Wills RW. Novel substituted phenoxyalkyl pyridinium oximes enhance survival and attenuate seizure-like behavior of rats receiving lethal levels of nerve agent surrogates. Toxicology. 2016 Jan 2;339:51-57. doi: 10.1016/j.tox.2015.12.001. Epub 2015 Dec 17. PubMed PMID: 26705700; PubMed Central PMCID: PMC6699741.

Chao CK, Ahmed SK, Gerdes JM, Thompson CM. Novel Organophosphate Ligand O-(2-Fluoroethyl)-O-(p-Nitrophenyl)Methylphosphonate: Synthesis, Hydrolytic Stability and Analysis of the Inhibition and Reactivation of Cholinesterases. Chem Res Toxicol. 2016 Nov 21;29(11):1810-1817. doi: 10.1021/acs.chemrestox.6b00160. Epub 2016 Oct 17. PubMed PMID: 27551891; PubMed Central PMCID: PMC5575788.

Chapman CA, Chen H, Stamou M, Lein PJ, Seker E. Mechanisms of Reduced Astrocyte Surface Coverage in Cortical Neuron-Glia Co-cultures on Nanoporous Gold Surfaces. Cell Mol Bioeng. 2016 Sep;9(3):433-442. doi: 10.1007/s12195-016-0449-4. Epub 2016 May 31. PubMed PMID: 27795742; PubMed Central PMCID: PMC5079442.

Coban A, Carr RL, Chambers HW, Willeford KO, Chambers JE. Comparison of inhibition kinetics of several organophosphates, including some nerve agent surrogates, using human erythrocyte and rat and mouse brain acetylcholinesterase. Toxicol Lett. 2016 Apr 25;248:39-45. doi: 10.1016/j.toxlet.2016.03.002. Epub 2016 Mar 7. PubMed PMID: 26965078; PubMed Central PMCID: PMC4805473.

Deshpande LS, Blair RE, Phillips KF, DeLorenzo RJ. Role of the calcium plateau in neuronal injury and behavioral morbidities following organophosphate intoxication. Ann N Y Acad Sci. 2016 Jun;1374(1):176-83. doi: 10.1111/nyas.13122. Epub 2016 Jun 21. Review. PubMed PMID: 27327161; PubMed Central PMCID: PMC4940260.

Deshpande LS, Blair RE, Huang BA, Phillips KF, DeLorenzo RJ. Pharmacological blockade of the calcium plateau provides neuroprotection following organophosphate paraoxon induced status epilepticus in rats. Neurotoxicol Teratol. 2016 Jul-Aug;56:81-86. doi: 10.1016/ Epub 2016 May 17. PubMed PMID: 27224207; PubMed Central PMCID: PMC4935577.

Farrugia LA, Rhyee SH, Campleman SL, Ruha AM, Weigand T, Wax PM, Brent J. The Toxicology Investigators Consortium Case Registry-the 2015 Experience. J Med Toxicol. 2016 Sep;12(3):224-47. doi: 10.1007/s13181-016-0580-6. Epub 2016 Aug 12. Review. PubMed PMID: 27517280; PubMed Central PMCID: PMC4996797.

Flannery BM, Bruun DA, Rowland DJ, Banks CN, Austin AT, Kukis DL, Li Y, Ford BD, Tancredi DJ, Silverman JL, Cherry SR, Lein PJ. Persistent neuroinflammation and cognitive impairment in a rat model of acute diisopropylfluorophosphate intoxication. J Neuroinflammation. 2016 Oct 12;13(1):267. doi: 10.1186/s12974-016-0744-y. PubMed PMID: 27733171; PubMed Central PMCID: PMC5062885.

Galanopoulou AS, Wong M, Binder D, Hartman AL, Powell EM, Roopra A, Staba R, Vezzani A, Fureman B, Dingledine R. 2014 Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression. Epilepsy Curr. 2016 May-Jun;16(3):187-91. doi: 10.5698/1535-7511-16.3.187. PubMed PMID: 27330451; PubMed Central PMCID: PMC4913857.

Gao J, Naughton SX, Wulff H, Singh V, Beck WD, Magrane J, Thomas B, Kaidery NA, Hernandez CM, Terry AV Jr. Diisopropylfluorophosphate Impairs the Transport of Membrane-Bound Organelles in Rat Cortical Axons. J Pharmacol Exp Ther. 2016 Mar;356(3):645-55. doi: 10.1124/jpet.115.230839. Epub 2015 Dec 30. PubMed PMID: 26718240; PubMed Central PMCID: PMC4767389.

Heischmann S, Quinn K, Cruickshank-Quinn C, Liang LP, Reisdorph R, Reisdorph N, Patel M. Exploratory Metabolomics Profiling in the Kainic Acid Rat Model Reveals Depletion of 25-Hydroxyvitamin D3 during Epileptogenesis. Sci Rep. 2016 Aug 16;6:31424. doi: 10.1038/srep31424. PubMed PMID: 27526857; PubMed Central PMCID: PMC4985632.

Jan YH, Richardson JR, Baker AA, Mishin V, Heck DE, Laskin DL, Laskin JD. Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. Ann N Y Acad Sci. 2016 Aug;1378(1):80-86. doi: 10.1111/nyas.13156. Epub 2016 Jul 21. Review. PubMed PMID: 27441453; PubMed Central PMCID: PMC5220671.

Kovalevsky A, Blumenthal DK, Cheng X, Taylor P, Radić Z. Limitations in current acetylcholinesterase structure-based design of oxime antidotes for organophosphate poisoning. Ann N Y Acad Sci. 2016 Aug;1378(1):41-49. doi: 10.1111/nyas.13128. Epub 2016 Jul 2. Review. PubMed PMID: 27371941; PubMed Central PMCID: PMC5063671.

Liang LP, Patel M. Plasma cysteine/cystine redox couple disruption in animal models of temporal lobe epilepsy. Redox Biol. 2016 Oct;9:45-49. doi: 10.1016/j.redox.2016.05.004. Epub 2016 May 24. PubMed PMID: 27285054; PubMed Central PMCID: PMC4909713.

Long C, Fureman B, Dingledine R. 2014 Epilepsy Benchmarks: Progress and Opportunities. Epilepsy Curr. 2016 May-Jun;16(3):179-81. doi: 10.5698/1535-7511-16.3.179. PubMed PMID: 27330449; PubMed Central PMCID: PMC4913855.

Long Ii RP, Aroniadou-Anderjaska V, Prager EM, Pidoplichko VI, Figueiredo TH, Braga MF. Repeated Isoflurane Exposures Impair Long-Term Potentiation and Increase Basal GABAergic Activity in the Basolateral Amygdala. Neural Plast. 2016;2016:8524560. doi: 10.1155/2016/8524560. Epub 2016 May 23. PubMed PMID: 27313904; PubMed Central PMCID: PMC4893574.

Maček Hrvat N, Žunec S, Taylor P, Radić Z, Kovarik Z. HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants. Chem Biol Interact. 2016 Nov 25;259(Pt B):148-153. doi: 10.1016/j.cbi.2016.04.023. Epub 2016 Apr 12. PubMed PMID: 27083141; PubMed Central PMCID: PMC5061595.

Niquet J, Baldwin R, Norman K, Suchomelova L, Lumley L, Wasterlain CG. Midazolam-ketamine dual therapy stops cholinergic status epilepticus and reduces Morris water maze deficits. Epilepsia. 2016 Sep;57(9):1406-15. doi: 10.1111/epi.13480. Epub 2016 Aug 8. PubMed PMID: 27500978; PubMed Central PMCID: PMC5012923.

Niquet J, Baldwin R, Suchomelova L, Lumley L, Naylor D, Eavey R, Wasterlain CG. Benzodiazepine-refractory status epilepticus: pathophysiology and principles of treatment. Ann N Y Acad Sci. 2016 Aug;1378(1):166-173. doi: 10.1111/nyas.13147. Epub 2016 Jul 8. Review. PubMed PMID: 27392038; PubMed Central PMCID: PMC5063678.

Patel M. Targeting Oxidative Stress in Central Nervous System Disorders. Trends Pharmacol Sci. 2016 Sep;37(9):768-778. doi: 10.1016/ Epub 2016 Aug 1. Review. PubMed PMID: 27491897; PubMed Central PMCID: PMC5333771.

Pearson JN, Patel M. The role of oxidative stress in organophosphate and nerve agent toxicity. Ann N Y Acad Sci. 2016 Aug;1378(1):17-24. doi: 10.1111/nyas.13115. Epub 2016 Jul 2. Review. PubMed PMID: 27371936; PubMed Central PMCID: PMC5063722.

Pessah IN, Rogawski MA, Tancredi DJ, Wulff H, Zolkowska D, Bruun DA, Hammock BD, Lein PJ. Models to identify treatments for the acute and persistent effects of seizure-inducing chemical threat agents. Ann N Y Acad Sci. 2016 Aug;1378(1):124-136. doi: 10.1111/nyas.13137. Epub 2016 Jul 28. Review. PubMed PMID: 27467073; PubMed Central PMCID: PMC5063690.

Prager EM, Bergstrom HC, Wynn GH, Braga MF. The basolateral amygdala γ-aminobutyric acidergic system in health and disease. J Neurosci Res. 2016 Jun;94(6):548-67. doi: 10.1002/jnr.23690. Epub 2015 Nov 19. Review. PubMed PMID: 26586374; PubMed Central PMCID: PMC4837071.

Puttachary S, Sharma S, Verma S, Yang Y, Putra M, Thippeswamy A, Luo D, Thippeswamy T. 1400W, a highly selective inducible nitric oxide synthase inhibitor is a potential disease modifier in the rat kainate model of temporal lobe epilepsy. Neurobiol Dis. 2016 Sep;93:184-200. doi: 10.1016/j.nbd.2016.05.013. Epub 2016 May 18. PubMed PMID: 27208748.

Ramsden CE, Ringel A, Majchrzak-Hong SF, Yang J, Blanchard H, Zamora D, Loewke JD, Rapoport SI, Hibbeln JR, Davis JM, Hammock BD, Taha AY. Dietary linoleic acid-induced alterations in pro- and anti-nociceptive lipid autacoids: Implications for idiopathic pain syndromes?. Mol Pain. 2016;12. doi: 10.1177/1744806916636386. Print 2016. PubMed PMID: 27030719; PubMed Central PMCID: PMC4955998.

Reddy DS. Neurosteroids for the potential protection of humans against organophosphate toxicity. Ann N Y Acad Sci. 2016 Aug;1378(1):25-32. doi: 10.1111/nyas.13160. Epub 2016 Jul 23. Review. PubMed PMID: 27450921; PubMed Central PMCID: PMC5063687.

Reddy DS, Estes WA. Clinical Potential of Neurosteroids for CNS Disorders. Trends Pharmacol Sci. 2016 Jul;37(7):543-561. doi: 10.1016/ Epub 2016 May 5. Review. PubMed PMID: 27156439; PubMed Central PMCID: PMC5310676.

Rojas A, Ganesh T, Manji Z, O'neill T, Dingledine R. Inhibition of the prostaglandin E2 receptor EP2 prevents status epilepticus-induced deficits in the novel object recognition task in rats. Neuropharmacology. 2016 Nov;110(Pt A):419-430. doi: 10.1016/j.neuropharm.2016.07.028. Epub 2016 Jul 29. PubMed PMID: 27477533; PubMed Central PMCID: PMC5028311.

Shakarjian MP, Laukova M, Velíšková J, Stanton PK, Heck DE, Velíšek L. Tetramethylenedisulfotetramine: pest control gone awry. Ann N Y Acad Sci. 2016 Aug;1378(1):68-79. doi: 10.1111/nyas.13120. Epub 2016 Jul 6. Review. PubMed PMID: 27384716; PubMed Central PMCID: PMC5063667.

Sharma A, Hye Khan MA, Levick SP, Lee KS, Hammock BD, Imig JD. Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. Int J Mol Sci. 2016 May 18;17(5). doi: 10.3390/ijms17050751. PubMed PMID: 27213332; PubMed Central PMCID: PMC4881572.

Supp DM, Hahn JM, McFarland KL, Combs KA, Lee KS, Inceoglu B, Wan D, Boyce ST, Hammock BD. Soluble Epoxide Hydrolase Inhibition and Epoxyeicosatrienoic Acid Treatment Improve Vascularization of Engineered Skin Substitutes. Plast Reconstr Surg Glob Open. 2016 Dec;4(12):e1151. doi: 10.1097/GOX.0000000000001151. eCollection 2016 Dec. PubMed PMID: 28293507; PubMed Central PMCID: PMC5222652.

Tong X, Khandelwal AR, Wu X, Xu Z, Yu W, Chen C, Zhao W, Yang J, Qin Z, Weisbrod RM, Seta F, Ago T, Lee KS, Hammock BD, Sadoshima J, Cohen RA, Zeng C. Pro-atherogenic role of smooth muscle Nox4-based NADPH oxidase. J Mol Cell Cardiol. 2016 Mar;92:30-40. doi: 10.1016/j.yjmcc.2016.01.020. Epub 2016 Jan 23. PubMed PMID: 26812119; PubMed Central PMCID: PMC5008453.

Torolira D, Suchomelova L, Wasterlain CG, Niquet J. Widespread neuronal injury in a model of cholinergic status epilepticus in postnatal day 7 rat pups. Epilepsy Res. 2016 Feb;120:47-54. doi: 10.1016/j.eplepsyres.2015.11.005. Epub 2015 Nov 12. PubMed PMID: 26709882; PubMed Central PMCID: PMC4740206.

Ulu A, Inceoglu B, Yang J, Singh V, Vito S, Wulff H, Hammock BD. Inhibition of soluble epoxide hydrolase as a novel approach to high dose diazepam induced hypotension. J Clin Toxicol. 2016 Jun;6(3). doi: 10.4172/2161-0495.1000300. Epub 2016 May 30. PubMed PMID: 28255523; PubMed Central PMCID: PMC5328659.

Varvel NH, Neher JJ, Bosch A, Wang W, Ransohoff RM, Miller RJ, Dingledine R. Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5665-74. doi: 10.1073/pnas.1604263113. Epub 2016 Sep 6. PubMed PMID: 27601660; PubMed Central PMCID: PMC5035862.

Zhuang Q, Young A, Callam CS, McElroy CA, Ekici ÖD, Yoder RJ, Hadad CM. Efforts toward treatments against aging of organophosphorus-inhibited acetylcholinesterase. Ann N Y Acad Sci. 2016 Jun;1374(1):94-104. doi: 10.1111/nyas.13124. Epub 2016 Jun 21. Review. PubMed PMID: 27327269; PubMed Central PMCID: PMC4940266.

Vesicating Agents

Ahmad S, Ahmad A. Emerging targets for treating sulfur mustard-induced injuries. Ann N Y Acad Sci. 2016 Jun;1374(1):123-31. doi: 10.1111/nyas.13095. Epub 2016 Jun 10. Review. PubMed PMID: 27285828; PubMed Central PMCID: PMC5040592.

Businaro R, Corsi M, Di Raimo T, Marasco S, Laskin DL, Salvati B, Capoano R, Ricci S, Siciliano C, Frati G, De Falco E. Multidisciplinary approaches to stimulate wound healing. Ann N Y Acad Sci. 2016 Aug;1378(1):137-142. doi: 10.1111/nyas.13158. Epub 2016 Jul 19. Review. PubMed PMID: 27434638; PubMed Central PMCID: PMC5063689.

Campbell SC, Wisniewski PJ, Noji M, McGuinness LR, Häggblom MM, Lightfoot SA, Joseph LB, Kerkhof LJ. The Effect of Diet and Exercise on Intestinal Integrity and Microbial Diversity in Mice. PLoS One. 2016;11(3):e0150502. doi: 10.1371/journal.pone.0150502. eCollection 2016. PubMed PMID: 26954359; PubMed Central PMCID: PMC4783017.

Composto GM, Laskin JD, Laskin DL, Gerecke DR, Casillas RP, Heindel ND, Joseph LB, Heck DE. Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. Exp Mol Pathol. 2016 Jun;100(3):522-31. doi: 10.1016/j.yexmp.2016.05.008. Epub 2016 May 14. PubMed PMID: 27189522; PubMed Central PMCID: PMC4947376.

Das LM, Binko AM, Traylor ZP, Duesler LR, Dynda SM, Debanne S, Lu KQ. Early indicators of survival following exposure to mustard gas: Protective role of 25(OH)D. Toxicol Lett. 2016 Apr 25;248:9-15. doi: 10.1016/j.toxlet.2016.02.013. Epub 2016 Mar 2. PubMed PMID: 26940683; PubMed Central PMCID: PMC5588853.

DeSantis-Rodrigues A, Chang YC, Hahn RA, Po IP, Zhou P, Lacey CJ, Pillai A, C Young S, Flowers RA 2nd, Gallo MA, Laskin JD, Gerecke DR, Svoboda KK, Heindel ND, Gordon MK. ADAM17 Inhibitors Attenuate Corneal Epithelial Detachment Induced by Mustard Exposure. Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1687-98. doi: 10.1167/iovs.15-17269. PubMed PMID: 27058125; PubMed Central PMCID: PMC4829087.

Gao Y, Jin B, Shen W, Sinko PJ, Xie X, Zhang H, Jia L. China and the United States--Global partners, competitors and collaborators in nanotechnology development. Nanomedicine. 2016 Jan;12(1):13-9. doi: 10.1016/j.nano.2015.09.007. Epub 2015 Sep 30. PubMed PMID: 26427355.

Gordon MK, DeSantis-Rodrigues A, Hahn R, Zhou P, Chang Y, Svoboda KK, Gerecke DR. The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies. Ann N Y Acad Sci. 2016 Aug;1378(1):158-165. doi: 10.1111/nyas.13226. Review. PubMed PMID: 27737494; PubMed Central PMCID: PMC5221489.

Goswami DG, Tewari-Singh N, Agarwal R. Corneal toxicity induced by vesicating agents and effective treatment options. Ann N Y Acad Sci. 2016 Jun;1374(1):193-201. doi: 10.1111/nyas.13121. Epub 2016 Jun 21. Review. PubMed PMID: 27327041; PubMed Central PMCID: PMC4940229.

Goswami DG, Tewari-Singh N, Dhar D, Kumar D, Agarwal C, Ammar DA, Kant R, Enzenauer RW, Petrash JM, Agarwal R. Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea. 2016 Feb;35(2):257-66. doi: 10.1097/ICO.0000000000000685. PubMed PMID: 26555588; PubMed Central PMCID: PMC4706783.

Joseph LB, Composto GM, Heck DE. Tissue injury and repair following cutaneous exposure of mice to sulfur mustard. Ann N Y Acad Sci. 2016 Aug;1378(1):118-123. doi: 10.1111/nyas.13125. Epub 2016 Jul 2. Review. PubMed PMID: 27371823; PubMed Central PMCID: PMC5063676.

Lacey CJ, Wohlman I, Guillon C, Saxena J, Fianu-Velgus C, Aponte E, Young SC, Heck DE, Joseph LB, Laskin JD, Heindel ND. Multi-inhibitor prodrug constructs for simultaneous delivery of anti-inflammatory agents to mustard-induced skin injury. Ann N Y Acad Sci. 2016 Aug;1378(1):174-179. doi: 10.1111/nyas.13177. Epub 2016 Aug 9. Review. PubMed PMID: 27505078; PubMed Central PMCID: PMC5063683.

Lasfar A, de laTorre A, Abushahba W, Cohen-Solal KA, Castaneda I, Yuan Y, Reuhl K, Zloza A, Raveche E, Laskin DL, Kotenko SV. Concerted action of IFN-α and IFN-λ induces local NK cell immunity and halts cancer growth. Oncotarget. 2016 Aug 2;7(31):49259-49267. doi: 10.18632/oncotarget.10272. PubMed PMID: 27363032; PubMed Central PMCID: PMC5226505.

Li C, Srivastava RK, Weng Z, Croutch CR, Agarwal A, Elmets CA, Afaq F, Athar M. Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation: Chemical Chaperones as Potential Novel Antidotes. Am J Pathol. 2016 Oct;186(10):2637-49. doi: 10.1016/j.ajpath.2016.06.012. Epub 2016 Aug 12. PubMed PMID: 27528504; PubMed Central PMCID: PMC5222973.

Lioy PJ, Laskin JD, Georgopoulos PG. Preparedness and response to chemical and biological threats: the role of exposure science. Ann N Y Acad Sci. 2016 Aug;1378(1):108-117. doi: 10.1111/nyas.13173. Epub 2016 Aug 1. Review. PubMed PMID: 27479653; PubMed Central PMCID: PMC5239671.

Liu B, Tai Y, Achanta S, Kaelberer MM, Caceres AI, Shao X, Fang J, Jordt SE. IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):E7572-E7579. doi: 10.1073/pnas.1606608113. Epub 2016 Nov 7. PubMed PMID: 27821781; PubMed Central PMCID: PMC5127381.

Mandal M, Gardner CR, Sun R, Choi H, Lad S, Mishin V, Laskin JD, Laskin DL. The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury. Toxicol Appl Pharmacol. 2016 Aug 1;304:110-20. doi: 10.1016/j.taap.2016.04.019. Epub 2016 May 7. PubMed PMID: 27163765; PubMed Central PMCID: PMC5147741.

McElroy CS, Min E, Huang J, Loader JE, Hendry-Hofer TB, Garlick RB, Rioux JS, Veress LA, Smith R, Osborne C, Anderson DR, Holmes WW, Paradiso DC, White CW, Day BJ. From the Cover: Catalytic Antioxidant Rescue of Inhaled Sulfur Mustard Toxicity. Toxicol Sci. 2016 Dec;154(2):341-353. doi: 10.1093/toxsci/kfw170. Epub 2016 Sep 7. PubMed PMID: 27605419; PubMed Central PMCID: PMC5139068.

Srivastava RK, Li C, Weng Z, Agarwal A, Elmets CA, Afaq F, Athar M. Defining cutaneous molecular pathobiology of arsenicals using phenylarsine oxide as a prototype. Sci Rep. 2016 Oct 11;6:34865. doi: 10.1038/srep34865. PubMed PMID: 27725709; PubMed Central PMCID: PMC5057142.

Szilagyi JT, Mishin V, Heck DE, Jan YH, Aleksunes LM, Richardson JR, Heindel ND, Laskin DL, Laskin JD. Selective Targeting of Heme Protein in Cytochrome P450 and Nitric Oxide Synthase by Diphenyleneiodonium. Toxicol Sci. 2016 May;151(1):150-9. doi: 10.1093/toxsci/kfw031. Epub 2016 Feb 14. PubMed PMID: 26880746; PubMed Central PMCID: PMC4914801.

Tewari-Singh N, Agarwal R. Mustard vesicating agent-induced toxicity in the skin tissue and silibinin as a potential countermeasure. Ann N Y Acad Sci. 2016 Jun;1374(1):184-92. doi: 10.1111/nyas.13099. Epub 2016 Jun 21. Review. PubMed PMID: 27326543; PubMed Central PMCID: PMC4940265.

Tewari-Singh N, Croutch CR, Tuttle R, Goswami DG, Kant R, Peters E, Culley T, Ammar DA, Enzenauer RW, Petrash JM, Casillas RP, Agarwal R. Clinical progression of ocular injury following arsenical vesicant lewisite exposure. Cutan Ocul Toxicol. 2016 Dec;35(4):319-28. doi: 10.3109/15569527.2015.1127255. Epub 2016 Mar 22. PubMed PMID: 27002633; PubMed Central PMCID: PMC5082841.

Udasin RG, Wen X, Bircsak KM, Aleksunes LM, Shakarjian MP, Kong AN, Heck DE, Laskin DL, Laskin JD. Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1). Toxicol Sci. 2016 Jan;149(1):202-12. doi: 10.1093/toxsci/kfv226. Epub 2015 Oct 9. PubMed PMID: 26454883; PubMed Central PMCID: PMC4715259.

Venosa A, Malaviya R, Choi H, Gow AJ, Laskin JD, Laskin DL. Characterization of Distinct Macrophage Subpopulations during Nitrogen Mustard-Induced Lung Injury and Fibrosis. Am J Respir Cell Mol Biol. 2016 Mar;54(3):436-46. doi: 10.1165/rcmb.2015-0120OC. PubMed PMID: 26273949; PubMed Central PMCID: PMC4821033.

Weinberger B, Malaviya R, Sunil VR, Venosa A, Heck DE, Laskin JD, Laskin DL. Mustard vesicant-induced lung injury: Advances in therapy. Toxicol Appl Pharmacol. 2016 Aug 15;305:1-11. doi: 10.1016/j.taap.2016.05.014. Epub 2016 May 19. Review. PubMed PMID: 27212445; PubMed Central PMCID: PMC5119915.

White CW, Rancourt RC, Veress LA. Sulfur mustard inhalation: mechanisms of injury, alteration of coagulation, and fibrinolytic therapy. Ann N Y Acad Sci. 2016 Aug;1378(1):87-95. doi: 10.1111/nyas.13130. Epub 2016 Jul 6. Review. PubMed PMID: 27384912; PubMed Central PMCID: PMC5418856.

Wohlman IM, Composto GM, Heck DE, Heindel ND, Lacey CJ, Guillon CD, Casillas RP, Croutch CR, Gerecke DR, Laskin DL, Joseph LB, Laskin JD. Mustard vesicants alter expression of the endocannabinoid system in mouse skin. Toxicol Appl Pharmacol. 2016 Jul 15;303:30-44. doi: 10.1016/j.taap.2016.04.014. Epub 2016 Apr 26. PubMed PMID: 27125198; PubMed Central PMCID: PMC4947375.

Pulmonary Agents

Aggarwal S, Lam A, Bolisetty S, Carlisle MA, Traylor A, Agarwal A, Matalon S. Heme Attenuation Ameliorates Irritant Gas Inhalation-Induced Acute Lung Injury. Antioxid Redox Signal. 2016 Jan 10;24(2):99-112. doi: 10.1089/ars.2015.6347. Epub 2015 Dec 14. PubMed PMID: 26376667; PubMed Central PMCID: PMC4742996.

Azarov I, Wang L, Rose JJ, Xu Q, Huang XN, Belanger A, Wang Y, Guo L, Liu C, Ucer KB, McTiernan CF, O'Donnell CP, Shiva S, Tejero J, Kim-Shapiro DB, Gladwin MT. Five-coordinate H64Q neuroglobin as a ligand-trap antidote for carbon monoxide poisoning. Sci Transl Med. 2016 Dec 7;8(368):368ra173. doi: 10.1126/scitranslmed.aah6571. PubMed PMID: 27928027; PubMed Central PMCID: PMC5206801.

Bali V, Lazrak A, Guroji P, Matalon S, Bebok Z. Mechanistic Approaches to Improve Correction of the Most Common Disease-Causing Mutation in Cystic Fibrosis. PLoS One. 2016;11(5):e0155882. doi: 10.1371/journal.pone.0155882. eCollection 2016. PubMed PMID: 27214033; PubMed Central PMCID: PMC4877091.

Bali V, Lazrak A, Guroji P, Fu L, Matalon S, Bebok Z. A synonymous codon change alters the drug sensitivity of ΔF508 cystic fibrosis transmembrane conductance regulator. FASEB J. 2016 Jan;30(1):201-13. doi: 10.1096/fj.15-273714. Epub 2015 Sep 3. PubMed PMID: 26336913; PubMed Central PMCID: PMC4684529.

Carlisle M, Lam A, Svendsen ER, Aggarwal S, Matalon S. Chlorine-induced cardiopulmonary injury. Ann N Y Acad Sci. 2016 Jun;1374(1):159-67. doi: 10.1111/nyas.13091. Epub 2016 Jun 15. Review. PubMed PMID: 27303906; PubMed Central PMCID: PMC4940235.

Ford DA, Honavar J, Albert CJ, Duerr MA, Oh JY, Doran S, Matalon S, Patel RP. Formation of chlorinated lipids post-chlorine gas exposure. J Lipid Res. 2016 Aug;57(8):1529-40. doi: 10.1194/jlr.M069005. Epub 2016 Jun 20. PubMed PMID: 27324796; PubMed Central PMCID: PMC4959868. Hoyle GW, Svendsen ER. Persistent effects of chlorine inhalation on respiratory health. Ann N Y Acad Sci. 2016 Aug;1378(1):33-40. doi: 10.1111/nyas.13139. Epub 2016 Jul 6. Review. PubMed PMID: 27385061; PubMed Central PMCID: PMC5063681.

Hoyle GW, Chen J, Schlueter CF, Mo Y, Humphrey DM Jr, Rawson G, Niño JA, Carson KH. Development and assessment of countermeasure formulations for treatment of lung injury induced by chlorine inhalation. Toxicol Appl Pharmacol. 2016 May 1;298:9-18. doi: 10.1016/j.taap.2016.03.001. Epub 2016 Mar 4. PubMed PMID: 26952014; PubMed Central PMCID: PMC4821717.

Lam A, Vetal N, Matalon S, Aggarwal S. Role of heme in bromine-induced lung injury. Ann N Y Acad Sci. 2016 Jun;1374(1):105-10. doi: 10.1111/nyas.13086. Epub 2016 May 31. Review. PubMed PMID: 27244263; PubMed Central PMCID: PMC4940273.

Latoche JD, Ufelle AC, Fazzi F, Ganguly K, Leikauf GD, Fattman CL. Secreted Phosphoprotein 1 and Sex-Specific Differences in Silica-Induced Pulmonary Fibrosis in Mice. Environ Health Perspect. 2016 Aug;124(8):1199-207. doi: 10.1289/ehp.1510335. Epub 2016 Mar 8. PubMed PMID: 26955063; PubMed Central PMCID: PMC4977050.

Liu B, Tai Y, Caceres AI, Achanta S, Balakrishna S, Shao X, Fang J, Jordt SE. Oxidized Phospholipid OxPAPC Activates TRPA1 and Contributes to Chronic Inflammatory Pain in Mice. PLoS One. 2016;11(11):e0165200. doi: 10.1371/journal.pone.0165200. eCollection 2016. PubMed PMID: 27812120; PubMed Central PMCID: PMC5094666.

Malaviya R, Sunil VR, Venosa A, Vayas KN, Heck DE, Laskin JD, Laskin DL. Inflammatory mechanisms of pulmonary injury induced by mustards. Toxicol Lett. 2016 Feb 26;244:2-7. doi: 10.1016/j.toxlet.2015.10.011. Epub 2015 Oct 23. Review. PubMed PMID: 26478570; PubMed Central PMCID: PMC4753082.

McElroy CS, Day BJ. Antioxidants as potential medical countermeasures for chemical warfare agents and toxic industrial chemicals. Biochem Pharmacol. 2016 Jan 15;100:1-11. doi: 10.1016/j.bcp.2015.10.003. Epub 2015 Oct 22. Review. PubMed PMID: 26476351; PubMed Central PMCID: PMC4744107.

Rothenberg C, Achanta S, Svendsen ER, Jordt SE. Tear gas: an epidemiological and mechanistic reassessment. Ann N Y Acad Sci. 2016 Aug;1378(1):96-107. doi: 10.1111/nyas.13141. Epub 2016 Jul 8. Review. PubMed PMID: 27391380; PubMed Central PMCID: PMC5096012.

Tadokoro T, Gao X, Hong CC, Hotten D, Hogan BL. BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. Development. 2016 Mar 1;143(5):764-73. doi: 10.1242/dev.126656. Epub 2016 Jan 25. PubMed PMID: 26811382; PubMed Central PMCID: PMC4813333.

Metabolic/Cellular Poisons

Benz OS, Yuan Q, Cronican AA, Peterson J, Pearce LL. Effect of Ascorbate on the Cyanide-Scavenging Capability of Cobalt(III) meso-Tetra(4-N-methylpyridyl)porphine Pentaiodide: Deactivation by Reduction?. Chem Res Toxicol. 2016 Mar 21;29(3):270-8. doi: 10.1021/acs.chemrestox.5b00447. Epub 2016 Feb 10. PubMed PMID: 26692323; PubMed Central PMCID: PMC5555418.

Chang WC, Li J, Lee JL, Cronican AA, Guo Y. Mechanistic Investigation of a Non-Heme Iron Enzyme Catalyzed Epoxidation in (-)-4'-Methoxycyclopenin Biosynthesis. J Am Chem Soc. 2016 Aug 24;138(33):10390-3. doi: 10.1021/jacs.6b05400. Epub 2016 Aug 11. PubMed PMID: 27442345.

Greenawald LA, Boss GR, Reeder A, Bell S. Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide. Sens Actuators B Chem. 2016 Jul;230:658-666. doi: 10.1016/j.snb.2016.02.129. PubMed PMID: 27022206; PubMed Central PMCID: PMC4807636.

Haouzi P. Is exogenous hydrogen sulfide a relevant tool to address physiological questions on hydrogen sulfide?. Respir Physiol Neurobiol. 2016 Jul 15;229:5-10. doi: 10.1016/j.resp.2016.03.015. Epub 2016 Mar 30. Review. PubMed PMID: 27045466; PubMed Central PMCID: PMC4887406.

Haouzi P, Sonobe T, Judenherc-Haouzi A. Developing effective countermeasures against acute hydrogen sulfide intoxication: challenges and limitations. Ann N Y Acad Sci. 2016 Jun;1374(1):29-40. doi: 10.1111/nyas.13015. Epub 2016 Mar 4. Review. PubMed PMID: 26945701; PubMed Central PMCID: PMC4940262.

Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR. Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote. Sci Rep. 2016 Feb 15;6:20831. doi: 10.1038/srep20831. PubMed PMID: 26877209; PubMed Central PMCID: PMC4753484.

Judenherc-Haouzi A, Zhang XQ, Sonobe T, Song J, Rannals MD, Wang J, Tubbs N, Cheung JY, Haouzi P. Methylene blue counteracts H2S toxicity-induced cardiac depression by restoring L-type Ca channel activity. Am J Physiol Regul Integr Comp Physiol. 2016 Jun 1;310(11):R1030-44. doi: 10.1152/ajpregu.00527.2015. Epub 2016 Mar 9. PubMed PMID: 26962024; PubMed Central PMCID: PMC4935501.

Lee J, Mahon SB, Mukai D, Burney T, Katebian BS, Chan A, Bebarta VS, Yoon D, Boss GR, Brenner M. The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning. J Med Toxicol. 2016 Dec;12(4):370-379. doi: 10.1007/s13181-016-0566-4. Epub 2016 Sep 15. PubMed PMID: 27631586; PubMed Central PMCID: PMC5135677.

Li C, Srivastava RK, Athar M. Biological and environmental hazards associated with exposure to chemical warfare agents: arsenicals. Ann N Y Acad Sci. 2016 Aug;1378(1):143-157. doi: 10.1111/nyas.13214. Epub 2016 Sep 16. Review. PubMed PMID: 27636894; PubMed Central PMCID: PMC5063699.

Lopez-Manzano E, Cronican AA, Frawley KL, Peterson J, Pearce LL. Cyanide Scavenging by a Cobalt Schiff-Base Macrocycle: A Cost-Effective Alternative to Corrinoids. Chem Res Toxicol. 2016 Jun 20;29(6):1011-9. doi: 10.1021/acs.chemrestox.6b00070. Epub 2016 May 26. PubMed PMID: 27104767; PubMed Central PMCID: PMC5555407.

MacRae CA, Boss G, Brenner M, Gerszten RE, Mahon S, Peterson RT. A countermeasure development pipeline. Ann N Y Acad Sci. 2016 Aug;1378(1):58-67. doi: 10.1111/nyas.13224. Review. PubMed PMID: 27737495; PubMed Central PMCID: PMC6420827.

Rumbeiha W, Whitley E, Anantharam P, Kim DS, Kanthasamy A. Acute hydrogen sulfide-induced neuropathology and neurological sequelae: challenges for translational neuroprotective research. Ann N Y Acad Sci. 2016 Aug;1378(1):5-16. doi: 10.1111/nyas.13148. Epub 2016 Jul 21. Review. PubMed PMID: 27442775; PubMed Central PMCID: PMC5063677.

Sonobe T, Haouzi P. H2S concentrations in the heart after acute H2S administration: methodological and physiological considerations. Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1445-H1458. doi: 10.1152/ajpheart.00464.2016. Epub 2016 Sep 16. PubMed PMID: 27638880; PubMed Central PMCID: PMC5206345.

Sonobe T, Haouzi P. Sulfide Intoxication-Induced Circulatory Failure is Mediated by a Depression in Cardiac Contractility. Cardiovasc Toxicol. 2016 Jan;16(1):67-78. doi: 10.1007/s12012-015-9309-z. PubMed PMID: 25616319; PubMed Central PMCID: PMC4514577.

Srivastava RK, Li C, Ahmad A, Abrams O, Gorbatyuk MS, Harrod KS, Wek RC, Afaq F, Athar M. ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis. Arch Biochem Biophys. 2016 Nov 1;609:39-50. doi: 10.1016/ Epub 2016 Sep 13. PubMed PMID: 27638049; PubMed Central PMCID: PMC5077172.

Srivastava RK, Li C, Wang Y, Weng Z, Elmets CA, Harrod KS, Deshane JS, Athar M. Activating transcription factor 4 underlies the pathogenesis of arsenic trioxide-mediated impairment of macrophage innate immune functions. Toxicol Appl Pharmacol. 2016 Oct 1;308:46-58. doi: 10.1016/j.taap.2016.07.015. Epub 2016 Jul 25. PubMed PMID: 27461142; PubMed Central PMCID: PMC5978774.


Ayee MAA, Roth CW, Akpa BS. Structural perturbation of a dipalmitoylphosphatidylcholine (DPPC) bilayer by warfarin and its bolaamphiphilic analogue: A molecular dynamics study. J Colloid Interface Sci. 2016 Apr 15;468:227-237. doi: 10.1016/j.jcis.2016.01.056. Epub 2016 Jan 27. PubMed PMID: 26852346; PubMed Central PMCID: PMC4762473.

Feinstein DL, Akpa BS, Ayee MA, Boullerne AI, Braun D, Brodsky SV, Gidalevitz D, Hauck Z, Kalinin S, Kowal K, Kuzmenko I, Lis K, Marangoni N, Martynowycz MW, Rubinstein I, van Breemen R, Ware K, Weinberg G. The emerging threat of superwarfarins: history, detection, mechanisms, and countermeasures. Ann N Y Acad Sci. 2016 Jun;1374(1):111-22. doi: 10.1111/nyas.13085. Epub 2016 May 31. Review. PubMed PMID: 27244102; PubMed Central PMCID: PMC4940222.

Fettiplace MR, Kowal K, Ripper R, Young A, Lis K, Rubinstein I, Bonini M, Minshall R, Weinberg G. Insulin Signaling in Bupivacaine-induced Cardiac Toxicity: Sensitization during Recovery and Potentiation by Lipid Emulsion. Anesthesiology. 2016 Feb;124(2):428-42. doi: 10.1097/ALN.0000000000000974. PubMed PMID: 26646023; PubMed Central PMCID: PMC4718826.

Hauck ZZ, Feinstein DL, van Breemen RB. LC-MS-MS Analysis of Brodifacoum Isomers in Rat Tissue. J Anal Toxicol. 2016 May;40(4):304-9. doi: 10.1093/jat/bkw008. Epub 2016 Feb 23. PubMed PMID: 26912564; PubMed Central PMCID: PMC4834430.

Marangoni MN, Martynowycz MW, Kuzmenko I, Braun D, Polak PE, Weinberg G, Rubinstein I, Gidalevitz D, Feinstein DL. Membrane Cholesterol Modulates Superwarfarin Toxicity. Biophys J. 2016 Apr 26;110(8):1777-1788. doi: 10.1016/j.bpj.2016.03.004. PubMed PMID: 27119638; PubMed Central PMCID: PMC4850322.