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Notice Correct Application Review Date, the Phased Activity Description RFA-NS-16-013 Innovation Grants Nurture Initial Translational Efforts IGNITE): Development Validation Model Systems and/or Pharmacodynamic Markers Facilitate Discovery Neurotherapeutics R21/R33)" Notice Number: NOT-NS-16-001 Key Dates Release Date:   December 2, 2015 Related Announcements RFA-NS-16-013       Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to correct review date the activity description section NINDS RFA-NS-16-013 Innovation Grants Nurture Initial Translational Efforts IGNITE): Development Validation Model Systems and/or Pharmacodynamic Markers Facilitate Discovery Neurotherapeutics R21/R33)". Part 1. Overview Information Key Dates FOA currently reads: Scientific Merit Review June 2016; October 2106; February 2017; June 2017; October 2107; February 2018    FOA now changed read: Scientific Merit Review June 2016; October 2016; February 2017; June 2017; October 2017; February 2018    Part 2. Full Text Announcement Section I. Funding Opportunity Description FOA currently reads: Activities the R21 Phase Initial development the model, testing paradigm, ex vivo system PD measure Any optimization the above related feasibility, endpoint range sensitivity, potential scale for validation studies breeding, aging, etc.), specificity the model system/PD measure it relates the disease endpoint measures, identification confounding variables, etc. Activities the R33 Phase Complete internal validation endpoints used the model system PD measure Scale-up external validation studies external validation studies, including comparisons phenotype human disease, comparisons disease etiology preclinical species what known the human disease efficacy clinically tested therapeutic agents available) the new model system FOA now changed read:             Activities the R21 Phase: Initial development the model, testing paradigm, ex vivo system PD measure Any optimization the above related feasibility, endpoint range sensitivity, potential scale for validation studies breeding, aging, etc.), specificity the model system/PD measure it relates the disease endpoint measures, identification confounding variables, etc. Activities the R33 Phase: Complete internal validation endpoints used the model system PD measure Scale-up external validation studies external validation studies, including comparisons phenotype human disease, comparisons disease etiology preclinical species what known the human disease efficacy clinically tested therapeutic agents available) the new model system other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Mary Ann Pelleymounter, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: mary.pelleymounter@mail.nih.gov

Notice Correction Review Locus PAR-15-277 NINDS Exploratory Clinical Trials Small Business R44)" Notice Number: NOT-NS-15-050 Key Dates Release Date:   November 19, 2015 Related Announcements PAR-15-277 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to correct information regarding locus review applications submitted PAR-15-277 quot;NINDS Exploratory Clinical Trials Small Business R44)". Part 2. Section V. 2. Review Selection Process FOA currently reads: Applications be evaluated scientific technical merit an) appropriate Scientific Review Group(s) convened Center Scientific Review, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. FOA modified read: Applications be evaluated scientific technical merit an appropriate Scientific Review Group(s) convened NINDS, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. Part 2. Section VII. Agency Contacts FOA currently reads: Peer Review Contact(s) Joseph Rudolph, PhD Center Scientific Review CSR) Telephone: 301-408-9098 Email: josephru@mail.nih.gov . FOA modified read: Peer Review Contact(s) Chief, Scientific Review Branch National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9223 Email: nindsreview.nih.gov@mail.nih.gov other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov

Notice Correction Review Locus PAR-15-278 NINDS Exploratory Clinical Trials Small Business R42)" Notice Number: NOT-NS-15-049 Key Dates Release Date:   November 19, 2015 Related Announcements PAR-15-278     Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this notice to correct information regarding locus review applications submitted PAR-15-278 quot;NINDS Exploratory Clinical Trials Small Business R42)". Part 2. Section V. 2. Review Selection Process FOA currently reads: Applications be evaluated scientific technical merit an) appropriate Scientific Review Group(s) convened Center Scientific Review, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. FOA modified read: Applications be evaluated scientific technical merit an appropriate Scientific Review Group(s) convened NINDS, accordance NIH peer review policy procedures, using stated review criteria. Assignment a Scientific Review Group be shown the eRA Commons. Part 2. Section VII. Agency Contacts FOA currently reads: Peer Review Contact(s) Joseph Rudolph, PhD Center Scientific Review CSR) Telephone: 301-408-9098 Email: josephru@mail.nih.gov FOA modified read: Peer Review Contact(s) Chief, Scientific Review Branch National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9223 Email: nindsreview.nih.gov@mail.nih.gov other aspects the FOA remain unchanged Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov

Notice NINDS Encourages Clinicians Excellent Pre-residency Research Publication Records Apply Mentored Career Development K08/K23) Awards without Waiting Post-Residency Publications Notice Number: NOT-NS-15-048 Key Dates Release Date:   November 17, 2015 Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS)  Purpose Background. development outstanding clinician-scientists critical the mission NIH and, specifically related neurological disorders, NINDS. pathway this development for individuals 1) obtain both clinical research training an integrated MD/PhD program, 2) join residency program intensive clinical training, 3) obtain fellowship training, least part which directed re-engaging scientific research will position to obtain NIH career development K) award, then 4) obtain 5 year mentored K award will protect time research help launch independent research career. average, integrated MD/PhD program takes 8 years complete, residencies such neurology take 4 years complete, the standard NINDS mentored K award lasts 5 years. average time the end residency an NINDS K award a dual degree applicant 45 months. Thus, average training duration time the start medical school research independence) an individual an MD/PhD degree 21 years. NINDS made a high priority decrease time takes develop outstanding, independent, clinician-scientists.  help accomplish this, NINDS implementing programs reduce time residency K award. Change guidance NINDS K application reviewers. Prior residency, clinically-trained individuals, most PhD training also without, conducted or outstanding research projects published results highly regarded journals. Following residency, includes little time research, individuals must re-establish research programs, often a completely different research area. part the K application review process, reviewers have, the past, evaluated candidates part whether have published during after residency their proposed research topic an indicator they re-established research program). Consequently, time training a clinician-scientist extended  only the time takes obtain high quality preliminary data this new research project also delays associated completion the study publication the results a top journal. Effective immediately, NINDS provide guidance the NST-1 study section, reviews K08 K23 applications NINDS, is intended minimize impact delays associated final completion publication manuscripts related the proposed research project. premise this review guidance that publication important, high quality research prior residency be taken evidence the candidate's ability conduct, see completion, high quality research project. Consequently, NINDS suggest reviewers consider lack publication during and/or subsequent residency be limited concern under following set conditions, applicants are within approximately 18 months their residency training: 1. Applicants have, their prior record, demonstrated they conduct complete outstanding, significant, research project. record must include peer-reviewed research publications highly regarded journals, which applicants lead authors. 2. Applicants submitted well-organized, well-written application a significant topic i.e. science highly significant, application includes compelling, high quality preliminary data, approach excellent, etc.). 3. Applicants presented excellent career development plan. 4. Applicants outstanding mentors mentorship plans; strong mentorship becomes even important funding applicants earlier their research careers. 5. Applicants made convincing presentation the proposed project the potential provide significant information during K award period will form basis future, independently funded research. 6. Applicants provided reviewers confidence via aspects the application, than having residency post-residency publications, they be successful their K application research subsequent transition an independent research career. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: korns@ninds.nih.gov

Notice National Institute Neurological Disorders Stroke NINDS) Participation PAR-15-349 Health Disparities Alzheimer's Disease R01)" Notice Number: NOT-NS-15-047 Key Dates Release Date:   November 10, 2015 Related Announcements PAR-15-349  Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants the National Institute Neurological Disorders Stroke NINDS) participating, effective immediately, PAR-15-349 quot;Health Disparities Alzheimer's Disease R01)". following sections PAR-15-349 been updated reflect participation NINDS this Funding Opportunity Announcement FOA). Part 1. Overview Information Components Participating Organizations National Institute Aging NIA) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Catalog Federal Domestic Assistance CFDA) Numbers 93.866, 93.361, 93.853 Part 2. Full Text AnnouncementSection I. Funding Opportunity Description Objectives following text added the end this section. While applications submitted response this FOA address broader interests other institutes listed the FOA, NINDS interested the analyses pathways create sustain Alzheimer's Disease-Related Dementias ADRD) disparities well ADRD applications address health disparities recommendations the 2013 ADRD Conference.  recommendations be found the ADRD 2013 Report http://www.ninds.nih.gov/funding/areas/neurodegeneration/workshops/adrd… NINDS' interests under FOA limited applications where clear main focus on ADRDs: vascular dementia, vascular contributions cognitive impairment dementia, Fronto-Temporal Dementia FTD), Lewy Body Dementia LBD). NINDS not consider applications are primarily Alzheimer's disease, example. Health Disparities HD) defined Public Law 106-525 occurs there a significant disparity the overall rate disease incidence, prevalence, morbidity, mortality, survival rates the health disparities population compared the health status the general population. NIH determined the following populations constitute health disparity populations: a) racial/ethnic minority, 2) low socio-economic status, 3) rural populations. recommendations the ADRD 2013 Report are directly relevant this FOA, that of interest the NINDS terms applications response this FOA, include those address HD Recruitment well HD Treatment Prevention: Health Disparities Recruitment: Initiate leverage ongoing longitudinal community-based cohort studies incident dementia diverse populations incorporating imaging, fluid biomarkers, autopsy. mixed methodology studies improve assessment tools disparities populations. community outreach methods facilitate recruiting disparities populations FTD LBD clinical studies. Health Disparities Treatment Prevention: Enhance design all trials vascular health interventions improve application diverse populations. Assess life course risk factors cognitive decline ADRDs among disparities populations. Estimate disparities health burden ADRDs risk factors among disparities populations. Section VII. Agency Contacts Scientific/ Research Contact Salina P. Waddy, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: waddysp@mail.nih.gov Financial/Grants Management Contact Tijuanna DeCoster, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9231 Email: decostert@ninds.nih.gov other aspects this FOA remain same. Inquiries Please direct inquiries to: Salina P. Waddy, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: waddysp@mail.nih.gov

Notice Change the Application Due Date to Allow Foreign Components Applications RFA-NS-16-008 BRAIN Initiative: Research Opportunities Using Invasive Neural Recording Stimulating Technologies the Human Brain U01)" Notice Number: NOT-NS-15-044 Key Dates Release Date:   November 5, 2015 Related Announcements RFA-NS-16-008       Issued National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Mental Health NIMH) National Center Complementary Integrative Health NCCIH)  Purpose Notice to change application due date, to correct information eligible organizations RFA-NS-16-008 BRAIN Initiative:  Research Opportunities Using Invasive Neural Recording Stimulating Technologies the Human Brain U01).”  new due date be January 13, 2016.  Also changed Funding Opportunity Announcement FOA) allow applications include foreign components, such sub-contracts foreign organizations and/or activities performed foreign organizations.  Currently FOA reads: Key Dates Open Date Earliest Submission Date) November 15, 2015 Letter Intent Due Date(s) November 15, 2015 Application Due Date(s) December 15, 2015, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. late applications be accepted this Funding Opportunity Announcement. AIDS Application Due Date(s) Not  Applicable Scientific Merit Review February 2016 Advisory Council Review 2016 Earliest Start Date June 2016 Expiration Date December 16, 2015  Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) not eligible apply. Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement, not allowed. FOA now changed read: Key Dates Open Date Earliest Submission Date) December 13, 2015 Letter Intent Due Date(s) December 13, 2015 Application Due Date(s) January 13, 2016, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due this date. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. late applications be accepted this Funding Opportunity Announcement. AIDS Application Due Date(s) Not  Applicable Scientific Merit Review April 2016 Advisory Council Review August 2016 Earliest Start Date September 2016 Expiration Date January 14, 2016  Foreign Institutions Non-domestic non-U.S.) Entities Foreign Institutions) not eligible apply. Non-domestic non-U.S.) components U.S. Organizations not eligible apply. Foreign components, defined the NIH Grants Policy Statement,are allowed. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: James Gnadt, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9964 Email: BRAIN_ResOppHu@mail.nih.gov

Request Information RFI): Updating Alzheimer's Disease-Related Dementias Research Priorities Notice Number: NOT-NS-15-045 Key Dates Release Date: November 4, 2015 Response Date: December 18, 2015   Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) National Institute Aging NIA) Office Disease Prevention ODP)  Purpose National Alzheimer’s Project Act, became law January 2011, directed Health Human Services Secretary establish National Plan overcome Alzheimer’s disease related dementias.  First released 2012 updated annually, National Plan Address Alzheimer’s Disease includes goals the research, clinical care long-term services support are needed meet challenge addressing Alzheimer’s.  Goal 1 the National Plan to prevent effectively treat Alzheimer’s disease related dementias 2025. meet goal, NIH convened series summits develop research recommendations advancing research Alzheimer's disease related dementias.   Alzheimer’s Disease-Related Dementias: Research Challenges Opportunities ADRD 2013) Summit  held May 1-2, 2013 established prioritized recommendations research frontotemporal degeneration, health disparities, Lewy body dementia, multiple etiology dementias, vascular contributions dementia. ADRD 2013 research recommendations milestones included the National Plan were used develop ADRD research budget is included part the Alzheimer’s disease bypass budget proposal fiscal year 2017. March 29-30, 2016, National Institute Neurological Disorders Stroke NINDS), collaboration the National Institute Aging NIA) convene Alzheimer's Disease-Related Dementias Summit 2016 ADRD 2016) assess progress revise update recommendations ADRD 2013. updated recommendations be included part the National Plan used guide future bypass budget proposals NIH investments ADRD research. purpose this time-sensitive Request Information RFI) to seek input scientists, clinician, patients, advocates, the broader community the most important needs promising opportunities research ADRDs.  information be used committees scientists, clinicians, other members the public revise update ADRD 2013 research recommendations.  Revised recommendations presented the public further comment the ADRD 2016, will take place March 29-30, 2016 the Natcher Conference Center the main NIH campus Bethesda, MD. Register attend ADRD 2016 https://meetings.ninds.nih.gov/Home/Index/11958. Registration free open the public.) Recommendations developed through Summit guide research ADRDs over next 10 years we strive achieve goal preventing effectively treating Alzheimer’s disease related dementias 2025. Information Requested NINDS NIA invite scientists, clinicians, caregivers, advocates, patients, the general public provide comments suggestions regarding ADRD 2013 research recommendations ADRD 2013 research recommendations more information ADRD 2013 be found http://www.ninds.nih.gov/funding/areas/neurodegeneration/workshops/adrd… ). These comments include are limited priority level the recommendation relative other recommendations; suggestions revisions, updates clarifications ADRD 2013 recommendations; suggestions new recommendations were included ADRD 2013.  collected comments be reviewed considered during development draft recommendations will presented further comment ADRD 2016 March 29-30, 2016 the Natcher Conference Center the main NIH campus.  to Submit Response Responses this RFI must submitted electronically using web-based format at: http://www.ninds.nih.gov/funding/RFI_ADRD.htm. Responses be accepted until December 18, 2015.  Responses this RFI voluntary.  Submitted information not considered confidential.  request for information planning purposes only should be construed a solicitation as obligation the part the Federal Government. NIH does intend make any awards based responses this RFI to otherwise pay the preparation any information submitted for Government's of such information. NIH use information submitted response this RFI its discretion will provide comments any responder’s submission. However, responses the RFI be reflected future funding opportunity announcements. information provided be analyzed may appear reports. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted.  proprietary, classified, confidential, sensitive information should included your response. Government reserves right use any non-proprietary technical information any resultant solicitation(s). Inquiries Please direct inquiries to: Christine Torborg, Ph.D. Office Science Policy Planning National Institute Neurological Disorders Stroke NINDS) Email: torborgc@mail.nih.gov

Notice Announcing Creation a Dedicated NINDS Biomarkers Repository Biospecimen Banking NINDS Biomarkers Projects Notice Number: NOT-NS-15-046 Key Dates Release Date:   November 3, 2015 Related Announcements PAR-14-259 PAR-14-340 RFA-NS-15-010 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose National Institute Neurological Disorders Stroke NINDS) announcing creation a dedicated NINDS Biomarkers Repository, will housed curated Indiana University. NINDS releasing Notice order underscore 1) important dates activities those currently banking samples data biomarkers projects 2) inform future banking projects the need include budget their projects/applications order ensure ability bank the NINDS Repository. Biomarker collections already banked under NINDS Biomarkers Programs, including not limited the Parkinson's Disease Biomarkers Program PDBP), BioFIND, PREDICT-HD Huntington's Disease) Frontotemporal Lobar Degeneration due MAPT FTLD-MAPT) be transferred Indiana University their existing biobanks example, the case PDBP, Coriell Institute Medical Research). Background Identification validation biomarkers neurological disorders enable early diagnosis well provide information disease progression targets therapeutic development. Challenges biomarkers identification include lack standardization collection, storage, distribution protocols biospecimens, limited sample availability. overcome obstacles, National Institute Neurological Disorders Stroke NINDS) establishing dedicated Human Biomarkers Repository. date, NINDS several programs collect human biospecimens associated clinical data biomarkers research, including not limited Parkinson’s Disease PD), Huntington’s Disease HD), Traumatic Brain Injury, Fronto-temporal Lobar Degeneration FTLD); types activities likely expand include disorders. Considering significant potential biomarkers neurological disease, NINDS creating Biomarkers Repository provide dedicated infrastructure across NINDS portfolio towards advancement biomarker discovery validation. Description Timeline Requirements This Resource new biomarkers sample associated data collections be banked via grant Indiana University. Sample types include DNA, Plasma, Serum, Whole Blood, Cerebrospinal Fluid CSF), RNA. Collections limited DNA gene discovery, Immortalized Peripheral Stem Cells IPSC) Fibroblast lines be housed a separate, dedicated repository. Note in order accomplish transition this resource: future banking, funds planned grant application should allocated offset of cost biospecimen banking this resource. strategy this budget item should developed collaboration the Program Director/Principal Investigator the Biomarkers Repository your Program Official. you planning bank Biomarkers samples the future, please contact Program Official. Coriell no longer accepting requests current projects biomarkers collection kits of October 23, 2015) will stop accepting biospecimen submissions November 30, 2015. Indiana University begin accepting requests collection kits biomarkers projects November 2, 2015 will begin accepting biospecimen submissions December 1, 2015 specific instructions regarding particular existing banking project a planned project, please contact Program Official, the NINDS contact listed below. order manage resource a fiscally responsible manner, potential users this resource advised contact NINDS program staff advance submission a grant which resource be utilized banking samples. Inquiries Please direct inquiries to: Katrina Gwinn, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5745 Email: gwinnk@ninds.nih.gov

Request Information RFI): Inviting Comments Suggestions the Priorities specified the NIH-wide Rehabilitation Research Plan Notice Number: NOT-HD-15-032 Key Dates Release Date: November 3, 2015 Response Date:  December 11, 2015 Related Announcements NOT-HD-19-006 Issued National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Institute Aging NIA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS) Office Behavioral Social Sciences Research OBSSR) Office Disease Prevention ODP) Office Dietary Supplements ODS) Office Research Women’s Health ORWH) Purpose Notice a time-sensitive Request Information RFI) inviting comments suggestions the priorities specified the NIH-wide Rehabilitation Research Plan. NOTE: is important read entire RFI notice ensure adequate response prepared to a full understanding how response be utilized. Background response a legislative requirement Public Law), NIH developing 5-year NIH-wide Research Plan define priorities the area Rehabilitation Research is intended benefit individuals temporary chronic limitations physical, cognitive, sensory function require rehabilitation care. leadership staff the participating Institutes, Centers, Offices ICOs) contributing the proposed direction content the Research Plan, input the National Advisory Board Medical Rehabilitation Research. priorities included below identify crosscutting areas research exemplify breadth the ICO's priorities aims the area Rehabilitation Research help us achieve NIH mission seek fundamental knowledge the nature behavior living systems the application that knowledge enhance health, lengthen life, reduce illness disability. Rehabilitation Research Plan aimed improving health function individuals functional limitations and/or temporary chronic disability are result illness injury. purpose goal the Rehabilitation Research Plan not reference specific disease applications this work to highlight major trans-NIH themes. Research Plan intended be complete late August 2016. NIH-wide Rehabilitation Research Plan Priorities I. Rehabilitation across lifespan 1) Move toward more comprehensive understanding the effects disability functional limitations across lifespan. Determine through longitudinal population studies natural history conditions cause disability common secondary conditions develop over life course. Identify test strategies address care needs delivery the individual disability moves childhood adolescence, adolescence adulthood, adulthood late life. Determine factors affect rehabilitation service delivery an individual disability ages, including health disparities the effects multiple chronic health conditions. Advance understanding the role modifiable lifestyle health behaviors e.g., nutrition, physical activity, sleep) effectiveness rehabilitation interventions secondary prevention chronic health conditions individuals disability. Examine symptoms e.g., pain, cognitive impairment) sequelae e.g., depression) may associated a disability; evaluate interventions address symptoms sequelae. 2)  Encourage investigation rehabilitation interventions the pediatric population. Develop rehabilitation interventions take account developmental level maturation biological systems. Evaluate utility interventions developed adult populations, include family community involvement, improving rehabilitation outcomes infants, children, adolescents. Determine effect the transition adulthood health outcomes interventions individuals aging disability their family. Provide new directions flexible mobility systems, prosthetics, orthotics pediatric populations have grow their devices. Investigate impact health disparities the implementation effectiveness rehabilitation interventions. II. Family Community 1) Examine impact sociodemographic influences, including geography, socioeconomic status, education, culture, etc. rehabilitation success. 2) Develop self-management strategies can implemented community settings help individuals better understand manage disability achieve/maintain positive quality life independence. 3) Examine stressors challenges experienced caregivers individuals a disability, including impact these stressors challenges the health the caregiver the care recipient. Develop interventions address stress, burden, other adverse outcomes caregivers. III. Technology and development 1) Advance use telehealth rehabilitation assessment, delivery adherence monitoring. Examine novel telehealth platforms delivery remote locations clinics in-home protocols evaluate equivalence person-to-person treatments. Determine feasibility an in-home telehealth assessment treatment protocol. Explore use telehealth address disparities increase access either specialty general protocols rehabilitation specific populations. Encourage health services research test validate delivery methods, treatment approaches, quality life economic benefits telemedicine individuals disability. Develop tools new technology assist the care monitoring individuals disabilities. Support technology development incorporates telemetry remote access the acquisition, analysis monitoring data relevant rehabilitation. 2) Advance use assistive technologies AT), non-invasive sensors, mHealth approaches rehabilitation science. Identify methods incorporate needs requirements stakeholder groups end users technology design outcome evaluation. Better define metrics outcomes interest the of technologies rehabilitation medicine research. Enhance effective of or sensors monitoring adherence rehabilitation therapies. Integrate mHealth approaches self-management chronic conditions; determine best practices provision information providers alert systems. Support development noninvasive sensor technologies the detection, monitoring quantitation rehabilitation relevant data. Integrate developmental aging considerations device assistive technology development allow flexibility application. 3) Provide evidence base device fabrication implementation individuals disabilities Support development neuroprostheses neuroengineering systems, invasive non-invasive biologic control systems, robotics rehabilitation sensory motor), intelligent hardware software the control devices. Examine safety utility non-commercial e.g., non-profit, open source) motor sensory prosthetic design, especially the pediatric population, effectiveness these devices compared those in commercial settings. Identify solutions improved integration functionality neural prostheses biomaterials enhance rehabilitation. Improve control mechanisms end effectors attachments existing devices augment usage adherence. Encourage use computational models the design development new rehabilitation technologies including assistive technologies) for evaluating functional outcomes. IV. Research design methodology 1) Improve design methodology rehabilitation investigations especially the area clinical trials. Better define pathway clinical trials clinical trial designs may most appropriate rehabilitation medicine research propose initiatives focused these methodologies. Enhance development methodologies allow consideration individual treatment effects patient-oriented outcomes. Expand research toward understanding mechanisms action integration preclinical modeling research inform rehabilitation practice trial design. Explore use existing databases registries mechanisms discovery. Determine optimal practices clinical translation implementation enhance reach utilization evidence based approaches. 2) Develop precision medicine approaches relevant rehabilitation medicine Advance understanding omic genomic, epigenomic, proteomic, metabolomic, etc.) underpinnings plasticity response rehabilitation interventions. Characterize biomarkers improve prescription interventions. Encourage better understanding environmental barriers biological comorbidities might impede rehabilitation adherence efficacy a rehabilitation intervention. Examine psychosocial influences associated rehabilitation interventions e.g., social withdrawal, lack social support, difficulty adjusting disability). 3) Standardization approaches data elements interest Provide evidence base specific interventions treatment approaches an emphasis validated protocols associated improved outcomes particular conditions cut across populations individuals disability e.g., spasticity, bowel bladder control, gait disturbance). Continue develop, validate, encourage use common data elements metrics sponsored projects expand available knowledge base provide aggregation data secondary analyses. Harmonize terminology standards rehabilitation research ensure comparability findings across studies. Support development dissemination shared standards consensus recommendations measurable outcome assessment tools. Information Requested RFI seeks input stakeholders throughout scientific research community the general public regarding above proposed priorities the NIH-wide Rehabilitation Research Plan. NIH seeks comments any all of, not limited to, following topics: * Potential benefits, challenges, areas consideration the proposed priority areas. * Compatibility the proposed priorities the NIH mission * Compatibility the framework the NIH Rehabilitation Research Plan available models rehabilitation research * Comprehensive trans-NIH research themes rehabilitation have been captured the Priority Areas      * Future opportunities emerging research needs to Submit Response comments must submitted electronically Rehabilitation1@mail.nih.gov. Responses longer 300 words MS or pdf format) must received 11:59:59 ET) December 11, 2015. will an electronic confirmation acknowledging receipt your response. Responses this RFI voluntary. not include any proprietary, classified, confidential, trade secret, sensitive information your response. responses be reviewed NIH staff, individual feedback not provided any responder. Government use information submitted response this RFI its discretion. Government reserves right use any submitted information public NIH websites, reports, summaries the state the science, any possible resultant solicitation(s), grant(s), cooperative agreement(s), in development future funding opportunity announcements. RFI for information planning purposes only shall be construed a solicitation, grant, cooperative agreement, as obligation the part the Federal Government, NIH, individual NIH Institutes Centers provide support any ideas identified response it. Government not pay the preparation any information submitted for Government's of such information. basis claims against U.S. Government shall arise a result a response this request information from Government's of such information. look forward your input hope you share RFI document your colleagues. Inquiries Please direct inquiries to: National Center Medical Rehabilitation Research NCMRR) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Email: Rehabilitation1@mail.nih.gov

Notice Informational Webinar PAR-15-345 BRAIN Initiative: Pre-Applications Industry Partnerships Provide Early Access Devices Stimulation Recording the Human Central Nervous System X02)" Notice Number: NOT-NS-15-043 Key Dates Release Date:   October 15, 2015   Related Announcements PAR-15-345 RFA-NS-16-009 RFA-NS-16-010     Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative Funding Opportunity Announcement Next-Generation Invasive Devices Recording Modulation the Human Central Nervous System RFA-NS-16-009 RFA-NS-16-010) a webinar provide technical assistance the optional pre-application, PAR-NS-15-345 BRAIN Initiative:  Pre-Applications Industry Partnerships Provide Early Access Devices Stimulation Recording the Human Central Nervous System X02). webinar optional not required submission PAR-NS-15-345, RFA-NS-16-009, RFA-NS-16-010. Webinar Information Date: Friday, October 30, 2015 Time: 3:30 PM EDT Duration: 1 hour register the webinar, to submit questions, please email BRAIN-FOAs@nih.gov Wednesday, October 28, 2015. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: BRAIN-FOAs@nih.gov