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Notice Intent Publish Funding Opportunity a Clinical Trials Network Emergency Care Research: Data Coordinating Center U24) Notice Number: NOT-NS-15-023 Key Dates Release Date:   May 5, 2015 Estimated Publication Date Announcement: November 2015  First Estimated Application Due Date: March 2016  Earliest Estimated Award Date: December 2016  Earliest Estimated Start Date: December 2016   Related Announcements NOT-NS-15-022 NOT-NS-15-021     Issued National Institute Neurological Disorders Stroke NINDS) National Heart, Lung, Blood Institute NHLBI) National Center Advancing Translational Sciences NCATS) Purpose National Institute Neurologic Disorders Stroke NINDS), National Heart, Lung Blood Institute NHLBI), National Center Advancing Translational Science NCATS), the Defense Medical Research Development Program Combat Casualty Care DMRDP), expert consultation the Office Emergency Care Research OECR), intend publish Funding Opportunity Announcement FOA) solicit applications an emergency care clinical trials network entitled Strategies Innovate EmeRgENcy Care Clinical Trials SIREN).  network be composed a Clinical Coordinating Center CCC), Data Coordinating Center DCC), multiple Regional Clinical Centers their linked clinical sites. network be charged executing trials high impact the treatment patients traumatic, neurologic, cardiac, pulmonary, hematologic traumatic medical surgical emergencies.  Proposals SIREN trials be solicited the national scientific community. Investigator-initiated clinical trials are considered highly meritorious peer-review be funded separately execution the network, some cases coordinated additional trial-specific sites.   Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  will three FOAs the emergency care network, for CCC, for DCC one the Regional Clinical Centers.   FOA the DCC expected be published November, 2015 an expected application due date March, 2016. FOA utilize U24 activity code. Research Initiative Details Notice encourages investigators expertise emergency care research, particularly neurologic, heart, lung, blood trauma related indications, begin consider applying this new FOA. SIREN network be responsible simultaneously executing least 4 large, randomized, clinical trials focus improving care patients emergency conditions relevant the mission NINDS, NHLBI the DMRDP presenting the pre-hospital emergency department setting.  DCC be responsible all components data management, data quality data analysis, including provision data Data Safety Management Boards.  SIREN DCC work closely collaboratively the SIREN Clinical Coordinating Center.  CCC DCC be located different institutions.  APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Robin Conwit, MD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-3299 Email: conwitr@ninds.nih.gov Monica Shah, MD, FACC National Heart, Lung, Blood Institute NHLBI) Telephone: 301-435-0504 Email: shahmr@nhlbi.nih.gov

Notice Intent Publish Funding Opportunity a Clinical Trials Network Emergency Care Research: Regional Clinical Centers U24) Notice Number: NOT-NS-15-021 Key Dates Release Date: 5, 2015 Estimated Publication Date Announcement: November 2015  First Estimated Application Due Date: March 2016  Earliest Estimated Award Date: December 2016  Earliest Estimated Start Date: December 2016   Related Announcements NOT-NS-15-022 NOT-NS-15-023  Issued National Institute Neurological Disorders Stroke NINDS) National Heart, Lung, Blood Institute NHLBI) National Center Advancing Translational Sciences NCATS) Purpose National Institute Neurologic Disorders Stroke NINDS), National Heart, Lung Blood Institute NHLBI), National Center Advancing Translational Science NCATS), Office Emergency Care Research OECR) the National Institute General Medical Sciences NIGMS), the Defense Medical Research Development Program Combat Casualty Care DMRDP) intend publish Funding Opportunity Announcement FOA) solicit applications an emergency care clinical trials network entitled Strategies Innovate EmeRgENcy Care Clinical Trials SIREN).  network be composed a Clinical Coordinating Center CCC), Data Coordinating Center DCC), multiple Regional Clinical Centers their linked clinical sites. network be charged executing trials high impact the treatment patients neurological, cardiac, pulmonary, hematologic traumatic medical surgical emergencies.  Applications SIREN trials be solicited the national scientific community. Investigator-initiated clinical trials are considered highly meritorious peer-review be funded separately execution the network, some cases coordinated additional trial-specific sites.   Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published November, 2015 an expected application due date March, 2016. FOA utilize U24 activity code. Research Initiative Details Notice encourages investigators expertise emergency care research, particularly neurologic, heart, lung, blood trauma related indications, begin consider applying this new FOA. SIREN network be responsible simultaneously executing least 4 large, randomized, clinical trials focus improving care patients emergency conditions relevant the mission NINDS, NHLBI the Defense Medical Research Development Program Combat Casualty Care DMRDP) presenting the pre-hospital emergency department setting.  Regional Clinical Centers work collaboratively the SIREN Clinical Data Coordinating Centers, including of central IRB master trial agreements formed the Clinical Coordinating Center coordination the new Trial Innovation Centers being set by National Center Advancing Translational Science.  Regional Coordinating Centers expected establish work subsidiary clinical sites, identity number which vary protocol protocol. SIREN Regional Clinical Centers be responsible patient recruitment treatment SIREN studies APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Robin Conwit, MD National Institute Neurologic Disorders Stroke NINDS) Telephone: 301-496-3299 Email: conwitr@ninds.nih.gov Monica Shah, MD, FACC National Heart, Lung, Blood Institute NHLBI) Telephone: 301-435-0504 Email: shahmr@nhlbi.nih.gov Jeremy Brown, MD National Institute General Medical Sciences NIGMS) Telephone: 301-594-4481 Email: jeremy.brown@nih.gov

Notice Intent Publish Funding Opportunity a Clinical Trials Network Emergency Care Research: Clinical Coordinating Center U24) Notice Number: NOT-NS-15-022 Key Dates Release Date:   May 5, 2015 Estimated Publication Date Announcement: November 2015  First Estimated Application Due Date: March 2016  Earliest Estimated Award Date: December 2016  Earliest Estimated Start Date: December 2016   Related Announcements NOT-NS-15-021 NOT-NS-15-023   Issued National Institute Neurological Disorders Stroke NINDS) National Heart, Lung, Blood Institute NHLBI) National Center Advancing Translational Sciences NCATS) Purpose National Institute Neurologic Disorders Stroke NINDS), National Heart, Lung Blood Institute NHLBI), National Center Advancing Translational Science NCATS) the Defense Medical Research Development Program Combat Casualty Care DMRDP), expert consultation the Office Emergency Care Research OECR), intend publish Funding Opportunity Announcement FOA) solicit applications an emergency care clinical trials network entitled Strategies Innovate EmeRgENcy Care Clinical Trials SIREN).  network be composed a Clinical Coordinating Center CCC), Data Coordinating Center DCC), multiple Regional Clinical Centers their linked clinical sites. network be charged executing trials high impact the treatment patients neurologic, cardiac, pulmonary, hematologic traumatic medical surgical emergencies.  Proposals SIREN trials be solicited the national scientific community. Investigator-initiated clinical trials are considered highly meritorious peer-review be funded separately execution the network, some cases coordinated additional trial-specific sites.   Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published November, 2015 an expected application due date March, 2016. FOA utilize U24 activity code. Research Initiative Details Notice encourages investigators expertise emergency care research, particularly neurological, heart, lung, blood trauma related indications, begin consider applying this new FOA. SIREN network be responsible simultaneously executing least 4 large, randomized, clinical trials focus improving care patients emergency conditions relevant the mission NINDS, NHLBI the Defense Medical Research Development Program Combat Casualty Care DMRDP) presenting the pre-hospital emergency department setting.  SIREN Clinical Coordinating Center, coordination the new Trial Innovation Centers being set by National Center Advancing Translational Science, form manage central IRB master contract process SIREN studies APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Robin Conwit, MD National Institute Neurologic Disorders Stroke NINDS) Telephone: 301-496-3299 Email: conwitr@ninds.nih.gov Monica Shah, MD, FACC National Heart, Lung, Blood Institute NHLBI) Telephone: 301-435-0504 Email: shahmr@nhlbi.nih.gov

Notice Intent Publish Funding Opportunity Announcement NLM Administrative Supplements Informationist Services NIH-funded Research Projects Admin Supp) Notice Number: NOT-LM-15-006 Key Dates Release Date:   April 28, 2015 Estimated Publication Date Announcement: 29, 2015  First Estimated Application Due Date: July 30, 2015  Earliest Estimated Award Date: September 15, 2015   Earliest Estimated Start Date: September 30, 2015  Related Announcements PA-13-276  Issued National Library Medicine NLM) National Cancer Institute NCI) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) Purpose NLM other participating NIH Institutes Centers intend promote ongoing initiative publishing Funding Opportunity Announcement FOA) solicit applications administrative supplements eligible NIH awardees active R01 grants and, depending each participating Institute Center's preferences, active P01, P20, P30, P50, R21, R34, U01, U19, U24, UM1 U54 grants. administrative supplements informationist services provide funds awarded research center grants order enhance storage, organization, management use electronic research data through involvement informationists, also known in-context information specialists. purposes this administrative supplement program 1) enhance collaborative, multi-disciplinary basic clinical research integrating information specialist the research team order improve capture, storage, organization, management, integration, presentation dissemination biomedical research data; 2) assess document value impact the informationist’s participation. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA expected be published May 2015 an expected application due date July 2015. FOA provide support through Administrative Supplements active awards the participating Institutes Centers. Research Initiative Details Notice encourages eligible NIH awardees described above, are interested integrating informationist their research teams the above-stated purposes begin consider applying this new FOA. Interested eligible awardees encouraged begin seeking collaborative arrangements informationists their institutions another institution appropriate. Informationists information specialists, usually health sciences librarians, have graduate training practical experience provides with disciplinary background biomedical, behavioral biological sciences in library information sciences/informatics. cross training provides informationists a unique perspective the acquisition, synthesis, management use information research. Informationists work team members research scientists health professionals, are sometimes called in-context lsquo;embedded’ information specialists that reason. Details the goals, application instructions, budget the forthcoming FOA expected be similar the previous issuance, PA-13-276. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Alan VanBiervliet, Ph.D. National Library Medicine NLM) Telephone: 301-594-1297 Email: alan.vanbiervliet@nih.gov

Notice a Change the Response Method NOT-NS-15-020 quot;Request Information RFI) the Proposed Funding Priorities Neuroscience Research, Input High Impact Cross-Cutting Opportunities NIH Neuroscience Blueprint)" Notice Number: NOT-NS-15-027 Key Dates Release Date:   April 13, 2015 Related Announcements NOT-NS-15-020     Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) Office Behavioral Social Sciences Research OBSSR)  Purpose purpose this notice to inform potential respondents the NIH Blueprint funding priorities RFI an additional preferred method responses.  NIH Blueprint like respondents use website NIH-Blueprint-Responses.  other aspects this RFI remain unchanged, are follows: National Institutes Health Blueprint Neuroscience Research Blueprint) collaboration among 15 participating NIH Institutes, Centers Offices support research the nervous system. Blueprint’s goal to accelerate discovery neuroscience research, this Request Information RFI) seeks input the scientific community how Blueprint might best so the future. Responses this RFI should suggest future Blueprint investments have broad impact neuroscience serve interests more one the Blueprint Institutes listed above. Blueprint invites input stakeholders including not limited researchers academia industry, healthcare professionals, patient advocates advocacy organizations, scientific professional organizations, Federal agencies other interested members the public. Organizations encouraged submit single response reflects views the organization a whole. Background Neuroscience research a unifying theme across NIH Institutes Centers. Sixteen participating Institutes Centers launched Blueprint 2004 provide framework coordinating research, developing tools resources broadly advance neuroscience research http://neuroscienceblueprint.nih.gov/). pooling resources expertise, NIH Blueprint taking advantage economies scale confronting challenges too large any single NIH Institute Center. Previous NIH Blueprint Resources, Tools, Training, Grand Challenges Blueprint supported development new research resources, tools, training. examples include Neuroscience Information Framework NIF), Neuroimaging Informatics Tools Resources Clearinghouse NITRC), NIH Toolbox, the NIH Blueprint Enhancing Neuroscience Diversity through Undergraduate Research Experiences ENDURE). 2009, Blueprint launched Grand Challenges catalyze research the potential transform our basic understanding the brain our approaches treating brain disorders. Grand Challenges included Human Connectome Project map connections the healthy brain, Grand Challenge Chronic Neuropathic Pain understand changes the nervous system cause acute, temporary pain become chronic, the Blueprint Neurotherapeutics Network help investigators develop new drugs nervous system disorders. NIH Blueprint one the inaugural sponsors the Brain Research through Advancing Innovative NeurotechnologiesSM BRAIN) Initiative, has focused large portion its funding efforts 2014 2015 the initial high priority research areas established the NIH Advisory Committee the Director BRAIN Working Group. following website provides overview previous current NIH Blueprint activities: http://www.neuroscienceblueprint.nih.gov/ Information Requested Blueprint considering best invest funds future fiscal years. Please note while NIH BRAIN Initiative concerned the development application innovative technologies interrogating circuit activity the nervous system, NIH Blueprint focuses broadly all aspects research the nervous system have potential transform our basic understanding the brain our approaches treating brain disorders. Keeping mind the Blueprint interested ideas are broadly relevant across multiple diseases disorders across missions the 15 participating NIH Institutes Centers, responses this RFI take following areas consideration. Comments include are limited the following areas: major impediments advancing neuroscience research are addressed current research programs. major opportunities advancing neuroscience research are well served current research programs. Research opportunities where Blueprint investment have highest impact neuroscience. comments include these opportunities lead a quantum leap basic, translational, and/or clinical neuroscience. Identify ideas research programs would address opportunities impediments. Programs should cross-cutting benefit broad neuroscience community, address multiple diseases disorders the nervous system, including disorders hearing, vision, aging, neurology, mental health, drug alcohol abuse, well brain development degeneration gender differences. might relate to: Specific high impact scientific questions could best answered a Blueprint Grand Challenge; Research resources would of high value a broad neuroscience community; Programs address cross-cutting issues such as: - training next generation neuroscientists, - computational neuroscience research, - increasing diversity the neuroscience workforce, - dissemination neuroscience tools improve health outcomes, - behavioral approaches symptom self-management neuro/mental/substance abuse disorders, - biomarkers a) correlate the symptoms, b) mirror biologic processes underlying neuro/mental/substance abuse disorders, - neuroethics research, - neuroscience policy research. Development neurotechnologies advance broad spectrum neuroscience. to Submit Response comments must submitted electronically to: NIH-Blueprint-Responses. Responses this RFI be accepted through 25, 2015. will receive electronic confirmation acknowledging receipt your response, will receive individualized feedback any suggestions. RFI for information planning purposes only should be construed a solicitation as obligation the part the Federal Government, National Institutes Health NIH), individual NIH Institutes Centers. NIH does intend make any awards based responses this RFI pay the preparation any information submitted for Government's of such information. basis claims against U.S. Government shall arise a result a response this request information from Government’s of such information. NIH use information submitted response this RFI its discretion will provide comments any responder’s submission. However, responses the RFI be reflected future planning activities funding opportunity announcements. information provided be analyzed may appear reports. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted. proprietary, classified, confidential, sensitive information should included your response. Government reserves right use any non-proprietary technical information any resultant solicitation(s). Inquiries Please direct inquiries to: Meghan Mott, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-596-4470 Email: nihblueprint@nih.gov

Request Information RFI) the Proposed Funding Priorities Neuroscience Research, Input High Impact Cross-Cutting Opportunities NIH Neuroscience Blueprint) Notice Number: NOT-NS-15-020 Key Dates Release Date: April 1, 2015 Response Date: 25, 2015 Related Announcements April 13, 2015 - Notice a Change the Response Method NOT-NS-15-020. Notice NOT-NS-15-027. Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Institute Neurological Disorders Stroke NINDS) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Center Complementary Integrative Health NCCIH) Office Behavioral Social Sciences Research OBSSR) Purpose National Institutes Health Blueprint Neuroscience Research Blueprint) a collaboration among 15 participating NIH Institutes, Centers Offices support research the nervous system.  Blueprint’s goal to accelerate discovery neuroscience research, this Request Information RFI) seeks input the scientific community how Blueprint might best so the future. Responses this RFI should suggest future Blueprint investments have broad impact neuroscience serve interests more one the Blueprint Institutes listed above. Blueprint invites input stakeholders including not limited researchers academia industry, healthcare professionals, patient advocates advocacy organizations, scientific professional organizations, Federal agencies other interested members the public. Organizations encouraged submit single response reflects views the organization a whole. NIH Blueprint like respondents use website NIH-Blueprint-Responses. Background Neuroscience research a unifying theme across NIH Institutes Centers. Sixteen participating Institutes Centers launched Blueprint 2004 provide framework coordinating research, developing tools resources broadly advance neuroscience research http://neuroscienceblueprint.nih.gov/). pooling resources expertise, NIH Blueprint taking advantage economies scale confronting challenges too large any single NIH Institute Center. Previous NIH Blueprint Resources, Tools, Training, Grand Challenges Blueprint supported development new research resources, tools, training. examples include Neuroscience Information Framework NIF), Neuroimaging Informatics Tools Resources Clearinghouse NITRC), NIH Toolbox, the NIH Blueprint Enhancing Neuroscience Diversity through Undergraduate Research Experiences ENDURE). 2009, Blueprint launched Grand Challenges catalyze research the potential transform our basic understanding the brain our approaches treating brain disorders. Grand Challenges included Human Connectome Project map connections the healthy brain, Grand Challenge Chronic Neuropathic Pain understand changes the nervous system cause acute, temporary pain become chronic, the Blueprint Neurotherapeutics Network help investigators develop new drugs nervous system disorders. NIH Blueprint one the inaugural sponsors the Brain Research through Advancing Innovative NeurotechnologiesSM BRAIN) Initiative, has focused large portion its funding efforts 2014 2015 the initial high priority research areas established the NIH Advisory Committee the Director BRAIN Working Group. following website provides overview previous current NIH Blueprint activities: http://www.neuroscienceblueprint.nih.gov/ Information Requested Blueprint considering best invest funds future fiscal years. Please note while NIH BRAIN Initiative concerned the development application innovative technologies interrogating circuit activity the nervous system, NIH Blueprint focuses broadly all aspects research the nervous system have potential transform our basic understanding the brain our approaches treating brain disorders. Keeping mind the Blueprint interested ideas are broadly relevant across multiple diseases disorders across missions the 15 participating NIH Institutes Centers, responses this RFI take following areas consideration. Comments include are limited the following areas: major impediments advancing neuroscience research are addressed current research programs.   major opportunities advancing neuroscience research are well served current research programs. Research opportunities where  Blueprint investment have highest impact neuroscience. comments include these opportunities lead a quantum leap basic, translational, and/or clinical neuroscience. Identify ideas research programs would address opportunities impediments. Programs should cross-cutting benefit broad neuroscience community, address multiple diseases disorders the nervous system, including disorders hearing, vision, aging, neurology, mental health, drug alcohol abuse, well brain development degeneration gender differences. might relate to: Specific high impact scientific questions could best answered a Blueprint Grand Challenge; Research resources would of high value a broad neuroscience community; Programs address cross-cutting issues such as: training next generation neuroscientists, computational neuroscience research, increasing diversity the neuroscience workforce, dissemination neuroscience tools improve health outcomes,   behavioral approaches symptom self-management neuro/mental/substance abuse disorders, biomarkers that  a) correlate the symptoms, b) mirror biologic processes underlying neuro/mental/substance abuse disorders, neuroethics research, neuroscience policy research. Development neurotechnologies advance broad spectrum neuroscience. to Submit Response comments must submitted electronically to: NIH-Blueprint-Responses. Responses this RFI be accepted through 25, 2015. will receive electronic confirmation acknowledging receipt your response, will receive individualized feedback any suggestions. RFI for information planning purposes only should be construed a solicitation as obligation the part the Federal Government, National Institutes Health NIH), individual NIH Institutes Centers. NIH does intend make any awards based responses this RFI pay the preparation any information submitted for Government's of such information. basis claims against U.S. Government shall arise a result a response this request information from Government’s of such information. NIH use information submitted response this RFI its discretion will provide comments any responder’s submission. However, responses the RFI be reflected future planning activities funding opportunity announcements. information provided be analyzed may appear reports. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted. proprietary, classified, confidential, sensitive information should included your response. Government reserves right use any non-proprietary technical information any resultant solicitation(s). Inquiries Please direct inquiries to: Meghan Mott, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-596-4470 Email: nihblueprint@nih.gov

Notice Correction the First Advisory Council Review Date the Earliest Start Date PAR-15-121 BRAIN Initiative: Optimization Novel Tools Technologies Neuroscience Research R44)" Notice Number: NOT-NS-15-017 Key Dates Release Date:   March 26, 2015 Related Announcements PAR-15-121 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose purpose this Notice to correct First Advisory Council Review Date the Earliest Start Date PAR-15-121 quot;BRAIN Initiative: Optimization Novel Tools Technologies Neuroscience Research R44)". corrections as follows: Part 1. Key Dates Currently reads: Advisory Council Review August, 2015 the first receipt date, then standard dates apply nbsp; Earliest Start Date September, 2015 the first receipt date, standard dates apply nbsp; nbsp; Modified read: Advisory Council Review October 2015 the first due date, then standard dates apply nbsp; Earliest Start Date November 2015 the first due date, standard dates apply nbsp; nbsp; other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Stephanie Fertig, MBA National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: fertigs@ninds.nih.gov

Notice Correction the Budget Instructions PAR-15-070 Innovation Grants Nurture Initial Translational Efforts IGNITE): Assay Development Therapeutic Agent Identification Characterization Support Therapeutic Discovery R21/R33)" Notice Number: NOT-NS-15-018 Key Dates Release Date:   March 24, 2015 Related Announcements PAR-15-070 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to correct budget instructions PAR-15-070 quot;Innovation Grants Nurture Initial Translational Efforts IGNITE): Assay Development Therapeutic Agent Identification Characterization Support Therapeutic Discovery R21/R33)". Part 2. Section IV. Application Submission Information instructions currently read: Modular R&R Budget instructions the SF424 R&R) Application Guide must followed. instructions modified read: R&R Budget instructions the SF424 R&R) Application Guide must followed. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Amir Tamiz, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: amir.tamiz@mail.nih.gov

Notice Correction the Budget Instructions PAR-15-071 " Innovation Grants Nurture Initial Translational Efforts IGNITE): Pharmacodynamics In vivo Efficacy Studies Small Molecules Biologics/Biotechnology Products R21/R33)" Notice Number: NOT-NS-15-019 Key Dates Release Date:   March 24, 2015 Related Announcements PAR-15-071 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to correct budget instructions PAR-15-071 quot; Innovation Grants Nurture Initial Translational Efforts IGNITE): Pharmacodynamics In vivo Efficacy Studies Small Molecules Biologics/Biotechnology Products R21/R33) quot;. Part 2. Section IV. Application Submission Information instructions currently read: Modular R&R Budget instructions the SF424 R&R) Application Guide must followed. instructions modified read: R&R Budget instructions the SF424 R&R) Application Guide must followed. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Amir Tamiz, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: amir.tamiz@mail.nih.gov

Request Information RFI) the Draft 2015 Action Plan the Muscular Dystrophies Notice Number: NOT-NS-15-014 Key Dates Release Date: February 13, 2015 Related Announcements None Issued National Institute Neurological Disorders Stroke NINDS) National Heart, Lung, Blood Institute NHLBI) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) Purpose NIH, together the Muscular Dystrophy Coordinating Committee MDCC), leading effort update Action Plan the Muscular Dystrophies, was first released 2005.  have significant advances muscular dystrophy research an update the plan intended reflect progress new challenges opportunities. help inform planning process, NIH the MDCC welcome comments the public regarding draft the 2015 plan. Background NIH’s mission to seek fundamental knowledge the nature behavior living systems the application that knowledge enhance health, lengthen life, reduce illness disability. National Institute Neurological Disorders Stroke NINDS), National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), the National Heart, Lung, Blood Institute NHLBI) fund majority muscular dystrophy-related research NIH work together coordinate muscular dystrophy research activities across NIH.  muscular dystrophies a group hereditary, progressive degenerative disorders causing weakness the skeletal voluntary muscles.  are different forms muscular dystrophy, differ their age onset, severity, pattern muscles other body systems affected.  Among provisions, Muscular Dystrophy Community Assistance, Research, Education Amendments 2001 MD-CARE Act, Public Law 107-84) established MDCC prompted series activities leading the development the Action Plan the Muscular Dystrophies.  Action Plan, developed input an MDCC Scientific Working Group, includes research objectives five areas: Mechanisms Muscular Dystrophy, Diagnosis Screening Muscular Dystrophy, Therapy Muscular Dystrophy, Living Muscular Dystrophy, Research Infrastructure Needs Muscular Dystrophy.  Through individual collaborative activities researchers, clinicians, stakeholders in  muscular dystrophy community, driven, part, the Action Plan, have significant advances understanding disease mechanisms, development new diagnostic tools reduce diagnostic odyssey affected individuals their families, evolution drug discovery development partnerships have advanced candidate therapeutics, improvements the care quality life affected individuals.  While type muscular dystrophy distinctive, has required disease-appropriate activities, has benefited a shared focus the muscular dystrophy community.  this time, are new challenges gaps require revision the original Action Plan the Muscular Dystrophies. Information Requested NIH the MDCC invite muscular dystrophy research, advocacy, family communities provide comments suggestions regarding content organization the draft version the 2015 Action Plan.  collected comments be reviewed considered the MDCC finalizes revised 2015 Action Plan.  to Submit Response Responses this RFI must submitted electronically using web-based format at: http://mdcc.nih.gov/. Responses be accepted until March 10, 2015.  Responses this RFI voluntary.  Submitted information not considered confidential.  Any personal identifiers be removed responses compiled. request for information planning purposes only should be construed a solicitation as obligation the part the Federal Government. NIH does intend make any awards based responses this RFI to otherwise pay the preparation any information submitted for Government's of such information. NIH use information submitted response this RFI its discretion will provide comments any responder’s submission. However, responses the RFI be reflected future funding opportunity announcements. information provided be analyzed may appear reports. Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted.  proprietary, classified, confidential, sensitive information should included your response. Government reserves right use any non-proprietary technical information any resultant solicitation(s). Inquiries Please direct inquiries to: Glen H. Nuckolls, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5745 Email: glen.nuckolls@nih.gov