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National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite exploratory and innovative researchapplications focused on theneurological and neuropsychiatric manifestationsof COVID-19 (neuro-COVID) andPost-Acute Sequelae of SARS-CoV-2 Infection (neuro-PASC) and on the effect of COVID-19 on pre-infection neurologic conditions. Applications investigating the pathophysiology and mechanisms of neuro-COVID and neuro-PASC and neurologically-focused human subjects research, as well as those proposing studies of scientifically compelling pathways to prevent the development of neuro-PASC or to accelerate the development of effective treatments forPASC-related neurological complications are of particular interest for this FOA. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in the first quarter of 2023 with an expected application due date in late Spring 2023. This FOA will utilize the R01 activity code. Details of the planned FOA are provided below.

National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Mental Health (NIMH) and the National Institute on Aging (NIA) intend to promote a new initiative by publishing a Funding Opportunity Announcement (FOA) to invite exploratory and innovative researchapplications focused on theneurological and neuropsychiatric manifestationsof COVID-19 (neuro-COVID) andPost-Acute Sequelae of SARS-CoV-2 Infection (neuro-PASC) and on the effect of COVID-19 on pre-infection neurologic conditions. Applications investigating the pathophysiology and mechanisms of neuro-COVID and neuro-PASC and neurologically-focused human subjects research, as well as those proposing studies of scientifically compelling pathways to prevent the development of neuro-PASC or to accelerate the development of effective treatments forPASC-related neurological complications are of particular interest for this FOA. This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The FOA is expected to be published in the first quarter of 2023 with an expected application due date in late Spring 2023. This FOA will utilize the R21 activity code. Details of the planned FOA are provided below.

Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approaches to address major challenges associated with recording and modulating CNS activity, at or near cellular resolution, at multiple spatial and/or temporal scales, in any region and throughout the entire depth of the brain. It is expected that the proposed research may be high-risk, but if successful, could profoundly change the course of neuroscience research. Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, magnetic, acoustic and/or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). These technologies and approaches should have previously demonstrated their transformative potential through initial proof-of-concept testing and are now ready for accelerated refinement. In conjunction, the manufacturing techniques should be scalable towards sustainable, broad dissemination and user-friendly incorporation into regular neuroscience research.Proposed technologies should be compatible with experiments in behaving animals, validated under in vivo experimental conditions, and capable of reducing major barriers to conducting neurobiological experiments and making new discoveries about the CNS. Technologies may engage diverse types of signaling beyond neuronal electrical activity such as optical, electrical, magnetic, acoustic or genetic recording/manipulation. Applications that seek to integrate multiple approaches are encouraged. If suitable, applications are expected to integrate appropriate domains of expertise, including biological, chemical and physical sciences, engineering, computational modeling and statistical analysis.

The purpose of this notice is to inform applicants of the early expiration of RFA-NS-21-026 "BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)" and RFA-NS-21-027 "BRAIN Initiative: Optimization of Transformative Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)". The remaining receipts date of May 1, 2023 and October 27, 2023 have been cancelled.

NINDS ALS NOSI

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This Notice of Special Interest (NOSI) highlights interest in receiving grant applications focused on mechanistic, genetic, and other studies to evaluate causes and consequences of and risk factors for sudden death in the young. Studies are required to use phenotypic data and/or DNA samples and/or associated sequence data from the NIH/CDC Sudden Death in the Young (SDY) Case Registry as foundations for their research. Studies may use SDY Case Registry phenotypic data and/or samples and/or sequence data alone or in combination with other cohorts. Results of such studies are required to adhere to the NIH Data Sharing Policy https://sharing.nih.gov/data-management-and-sharing-policy so that the data is disseminated widely and provides an evidence base to advance discussions about screening and prevention of SDY.

The purpose of this notice is to inform applicants of a correction to the Eligibility Information for RFA-NS-23-003 "HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional)". For this Funding Opportunity Announcement (FOA), "Section III. Eligibility Information" and "Section IV. Application and Submission Information, 7. Other Submission Requirements and Information" have been corrected to allow intramural participation.

The Federal Interagency Traumatic Brain Injury Research (FITBIR) Informatics System is supported by a collaboration between the National Institutes of Health (NIH) and the Department of Defense (DoD) with the expressed mission to accelerate the pace of discovery and advance research through data sharing, increase investigator collaboration, and comply with Federal policies relating to data sharing of publicly-funded research. The FITBIR Informatics System provides the traumatic brain injury (TBI) research community with a common platform for exchanging data, protocols, and research-related information. There are no changes to the expectations and data sharing requirements for studies subject to the policy outlined in NOT-NS-17-029. Rather, the policy outlined below is designed to optimize use of the current FITBIR resources, maximize data sharing access, and centralize federally supported TBI-related research data. The policy modification outlined here applies to NINDS-funded TBI research data involving human subjects research that is not covered by the FITBIR data sharing requirements outlined in NOT-NS-17-029. This policy modification also aligns with and satisfies the requirements defined in the NIH Data Management and Sharing Policy, and will provide a consistent and sustainable data repository for all NIH-funded TBI-related human subjects research. Consistent with the overall NIH Data Management and Sharing Policy, this TBI-specific data sharing policy modification will be effective as of January 25, 2023. NINDS-funded TBI research data involving human subjects research that is not covered by the NOT-NS-17-029 will now be required to house data in the Meta Studies Module within FITBIR. Exceptions to this requirement are outlined in Research Covered Under the Data Management & Sharing Policy.