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Purpose. This FOA issued by the Basic Behavioral and Social Sciences Research Opportunity Network (OppNet), National Institutes of Health, solicits Research Project Grant (R01) applications from institutions/organizations that propose to investigate the reciprocal interactions of the processes of sleep and circadian regulation and function with behavioral and social environment processes. Sleep is a complex biological phenomenon that is essential to normal behavioral and social functioning, as well as optimal health. In spite of its vital nature, the mechanisms by which social environment factors affect sleep behavior patterns have not been studied systematically, especially within the contexts of individual vulnerabilities and resilience. There is a need for greater understanding of the dynamic relationships between behavioral and social environment factors on the one hand and the basic mechanisms of sleep-wake and circadian regulation and function on the other. This FOA is not intended to support research on or development of treatments or interventions for disorders of sleep or circadian rhythms. Mechanism of Support. This FOA will utilize the R01 award mechanism and runs in parallel with a FOA of identical scientific scope, RFA-HD-11-102, that encourages applications under the R21 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit up to $2 million in FY 2011 to fund 5-6 applications submitted in response to this FOA, pending the number and quality of applications and availability of funds.

Purpose. This FOA issued by the Basic Behavioral and Social Sciences Research Opportunity Network (OppNet), National Institutes of Health, solicits Research Project Grant (R21) applications from institutions/organizations that propose to investigate the reciprocal interactions of the processes of sleep and circadian regulation and function with behavioral and social environment processes. Sleep is a complex biological phenomenon that is essential to normal behavioral and social functioning, as well as optimal health. In spite of its vital nature, the mechanisms by which social environment factors affect sleep behavior patterns have not been studied systematically, especially within the context of individual vulnerabilities and resilience. There is a need for greater understanding of the dynamic relationships between behavioral and social environment factors on the one hand and the basic mechanisms of sleep-wake and circadian regulation and function on the other. This FOA is not intended to support research on or development of treatments or interventions for disorders of sleep or circadian rhythms. Mechanism of Support. This FOA will utilize the R21 award mechanism and runs in parallel with a FOA of identical scientific scope, RFA-HD-11-101, that encourages applications under the R01 award mechanism. Funds Available and Anticipated Number of Awards. OppNet intends to commit up to $1 million in FY 2011 to fund 5-6 applications submitted in response to this FOA, pending the number and quality of applications and availability of funds.

Purpose. This FOA, issued as part of the NIH Basic Behavioral and Social Science Opportunity Network (OppNet), solicits Research Project Grant (R01) applications from institutions/organizations that propose to investigate structural, behavioral, sociocultural, environmental, cognitive, emotional, and/or biological mechanisms through which the social environment affects health outcomes. To address this objective, applicants should propose research studies that will: (1) deepen our understanding of which aspects of social environments affect health outcomes for women and men at different stages of the lifecourse and in different social, economic, geographic, racial and ethnic sub-populations; (2) lead to a clearer understanding of mechanisms through which social environments have such effects; or (3) improve measurement methods and/or contribute to advances in analytic methods used in the study of social environments and health. Mechanism of Support. This FOA will utilize the R01 award mechanism. Funds Available and Anticipated Number of Awards. The NIH will commit approximately $5 million to this funding initiative in 2011, allowing the support of 8-9 new R01 applications, for a total of approximately $24 million over the next 5 years.

Purpose. The National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to support studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). Recent clinical studies indicate that over 50% of HIV-infected patients manifest HAND despite receiving HAART. The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the virus, the host, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND. The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, and systems biology) to identify and validate (including in vitro models, animal models, and human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged. Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental Grant (R21) award mechanism and runs in parallel with an FOA of identical scientific scope, MH-11-020, which encourages applications under the Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. The NIMH and NINDS intend to commit approximately $2.0 million and $1.0 million respectively in FY 2011 to fund awards in response to the FOA and the companion announcement.

Purpose. The National Institute of Mental Health (NIMH) and The National Institute of Neurological Disorders and Stroke (NINDS) solicit research grant applications to support studies focused on viral and host genetic factors involved in HIV-1 Associated Neurocognitive Disorders (HAND) in the setting of highly active anti-retroviral therapy (HAART). Recent clinical studies indicate that over 50% of HIV-infected patients manifest HAND despite receiving HAART. The focus of this initiative is to encourage studies to discover novel genetic paradigms that may account for the interactions between the virus, the host, and the therapeutic drugs in the central nervous system (CNS) that result in the pathogenesis, progression, and clinical manifestations of HAND. The use of state-of-the-art genetic approaches (including transcriptomics, phenomics, epigenomics, whole genome association studies, next generation sequencing, exome sequencing, and systems biology) to identify and validate (including in vitro models, animal models, and human samples) viral and host genetic factors which influence the pathophysiology of HAND are encouraged. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope, MH-11-021, which encourages applications under the Exploratory/Developmental Grant (R21) award mechanism. Funds Available and Anticipated Number of Awards. NIMH has set aside a total of $2.0 million in FY 2011 and NINDS a total of $1.0 million for this FOA and the companion announcement. It is anticipated that 5-7 R01 awards will be funded.

Purpose. Participating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic, applied, and translational multi-disciplinary research that addresses important biological, clinical or biomedical research problems. In the context of this program, a partnership is a multi-disciplinary research team, that applies an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. The partnership must operate according to a clear leadership plan and include appropriate bioengineering or allied quantitative sciences in combination with biomedical and/or clinical components. BRPs may propose, within a 12-page research strategy section, design-directed, developmental, discovery-driven, or hypothesis-driven research at universities, national laboratories, medical schools, large or small businesses, or other public and private entities or combinations of these entities, and will be evaluated against expanded review criteria. It is expected that a BRP will have a well-defined goal or deliverable that will be achieved in a 5-10 year timeframe based on objective milestones specified in the initial application. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. Budget and Project Period. Because the

Purpose. This Funding Opportunity Announcement (FOA) issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Disease (NIDDK), the National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute on Deafness and Other Communication Disorders (NIDCD) encourages Research Project Grant (R01) applications from institutions/ organizations that propose research relevant to the basic understanding and development of therapeutic interventions for currently screened conditions and high priority genetic conditions for which screening could be possible in the near future. In this FOA, a high priority condition is one for which the development of an efficacious therapy would make the condition amenable to newborn screening. Mechanism of Support. This FOA will utilize the R01 funding mechanism and runs in parallel with two FOAs of identical scientific scope, PAR-10-231 and PAR-10-232 that encourage applications under the R03 and R21 mechanisms (FOA numbers/URLs). Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration, and costs of the applications received.

Purpose: The purpose of the Neurological Academic Development Award (K12) is to facilitate and support the career development of pediatric neurologists who have made a commitment to independent research careers. Under this award, newly trained pediatric neurologists are to be selected and appointed to this program by the grantee institution. It is expected that individuals appointed to the NSADA program will subsequently apply for their own Mentored Clinical Scientist Development Award (K08), the Mentored Patient-Oriented Career Development Award (K23), an NINDS Research Scientist Development Award (K02) or a Research Project Grant (R01), Mechanism of Support: This FOA will use the NIH Institutional Research Career Development K12 grant mechanism. K12 programs may not be transferred from one institution to another. (See section VI.2.) This Funding Opportunity Announcement (FOA) will utilize the Mentored Clinical Scientist Development Institutional Program Award (K12) mechanism. The NINDS K12 program provides support for up to three years of supervised study and research for clinically trained professionals who have the potential to develop into productive, clinical investigators. Funds Available and Anticipated Number of Awards: Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

Purpose. This funding opportunity announcement (FOA) invites applications proposing highly innovative research that will investigate the epigenetic basis of human diseases. These studies will discover and define epigenetic marks or features and their possible interactions in cells and tissues that are representative of various human disease states, conditions or processes. Studies may also investigate the mechanism by which epigenetic changes occur in diseased or otherwise compromised states, and how these changes result in phenotypic differences. Mechanism of Support. This FOA will utilize the R01 award mechanism. Funds Available and Anticipated Number of Awards. The participating agencies intend to commit a total of $6.7 million. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. The anticipated number of awards is 10-15.

Purpose. The purpose of this Funding Opportunity Announcement (FOA), issued by the Office of Research on Womens Health (ORWH) and co-sponsoring NIH institutes and centers (ICs), is to promote innovative, interdisciplinary research that will advance new concepts in womens health research and the study of sex/gender differences. Recent research reports have established the importance of studying issues specific to women, including the scientific and clinical importance of analyzing data separately for females and males. ORWH is particularly interested in encouraging extramural investigators to undertake new interdisciplinary research to advance studies on how sex and gender factors affect women's health; however, applications in all areas of womens health and/or sex/gender research are invited. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) award mechanism. Funds Available and Anticipated Number of Awards. It is anticipated that $4 million will be available for FY 2011. The total amount awarded and the number of awards will depend upon the number, quality, and costs of the applications received. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.