The purpose of this initiative is to stimulate research to increase
understanding of the role of fusin co-factors in HIV infection of the CNS and
to identify and develop analogs and related compounds of these co-factors as
potential therapeutic agents.
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COVID-19 Funding Notices | Approved Initiative Concepts | Research Opportunity Announcements
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Expiration Date: Tuesday, January 29, 2002 NOFO Number: PA-99-056 Release Date: Friday, January 29, 1999 Notice Type: PA
Expiration Date: Tuesday, January 29, 2002 NOFO Number: PAS-99-054 Release Date: Friday, January 29, 1999 Notice Type: PAS
The objective of this Program Announcement (PA) is to stimulate research on
the relative roles of environmental, endogenous neurochemical and genetic
factors in the cause of neurodegenerative diseases. The results of these
investigations should help clarify the part xenobiotics play in the etiology
of these diseases.
Expiration Date: Friday, May 14, 1999 NOFO Number: RFA-MH-99-009 Release Date: Friday, January 29, 1999 Notice Type: RFA
This request for applications (RFA) will solicit research grants directed
toward expanding the use of SIV-infected non-human primates to address the
effects of this virus on the CNS to increase understanding of the resulting
pathology and identify therapeutic targets for prevention and/or treatment of
the functional and neurological consequences.
Expiration Date: Thursday, April 29, 1999 NOFO Number: RFA-MH-99-006 Release Date: Friday, January 22, 1999 Notice Type: RFA
The purpose of this Request for Applications (RFA) is to solicit applications for
research projects to develop objective and standardized criteria and new, cost-
effective, high-throughput phenotyping tools and methods to assess specific
components of nervous system function and complex behaviors in the laboratory
mouse. Projects supported under this RFA will develop and apply high-throughput
phenotyping protocols to evaluate standard inbred strains of mice, and deposit
the data so generated into databases of quantitative behavioral, physiological,
pharmacological, and neuroanatomical profiles across different strains. These
diverse phenotyping tools and assays will provide invaluable endpoints for the
comprehensive characterization of nervous system function and complex behaviors
in mouse mutants, and will facilitate the genetic analysis of these complex
traits. Protocols, assays, assessment criteria, data on reference strains, and
other material and information generated in projects funded under this RFA will
be made widely available to the scientific community. This RFA is part of a
broader NIH initiative to support large-scale functional genetic studies and
characterize the murine nervous system and behavior. Techniques and data
generated under this RFA will be available to support this broader initiative.
Expiration Date: Saturday, April 24, 1999 NOFO Number: RFA-OD-99-005 Release Date: Friday, January 22, 1999 Notice Type: RFA
The Office of Behavioral and Social Sciences Research (OBSSR), National Cancer
Institute (NCI), National Heart, Lung, and Blood Institute (NHLBI), National
Institute on Aging (NIA), National Institute on Alcohol Abuse and Alcoholism
(NIAAA), National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS), National Institute of Child Health and Human Development (NICHD),
National Institute on Drug Abuse (NIDA), National Institute of Dental and
Craniofacial Research (NIDCR), National Institute of General Medical Sciences
(NIGMS), National Institute of Mental Health (NIMH), National Institute of
Neurological Disorders and Stroke (NINDS), and the National Institute of Nursing
Research (NINR) invite applications for Specialized Center Grants (P50) grants
in order to encourage behavioral, psychological, social, and biomedical research
on the interrelationships among cognition, emotion, biological processes, and
physical health. The NIH sponsoring organizations are issuing this Request for
Applications (RFA) to foster interdisciplinary research on the interactions among
the mind and body in health and disease. Applications in response to this RFA
are encouraged to propose research topics ranging from basic research to those
involving clinical applications.
Expiration Date: Saturday, May 22, 1999 NOFO Number: RFA-NR-99-004 Release Date: Wednesday, January 20, 1999 Notice Type: RFA
The National Institute of Nursing Research (NINR), the Agency for Health Care
Policy and Research (AHCPR), the National Cancer Institute (NCI), the National
Center for Complementary and Alternative Medicine (NCCAM) the National Institute
of Allergy and Infectious Diseases (NIAID), the National Institute of Dental and
Craniofacial Research (NIDCR), the National Institute of Mental Health (NIMH),
and the National Institute on Aging (NIA) seek research grant applications that
will generate scientific knowledge to lead to improved care for those at the end
of life. Research applications may include basic, clinical or health care
studies focused on the clinical management of physical and psychological
symptoms, patient-provider and patient-family communication, ethics and clinical
decision-making, caregiver support, or the context of care delivery for those
facing life-limiting illnesses. The purpose of this initiative is to generate
research that will improve the quality of dying for Americans and decrease the
distress for their caregivers.
Expiration Date: Monday, January 14, 2002 NOFO Number: PA-99-038 Release Date: Thursday, January 14, 1999 Notice Type: PA
The National Institute on Aging (NIA), the National Institute of Mental Health
(NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS)
invite qualified investigators to submit research grant applications for pilot
clinical drug trials directed toward the treatment of the cognitive and
behavioral symptoms of Alzheimer"s Disease (AD). Data from pilot clinical
studies are often required before proceeding to a full-scale clinical trial. The
NIA, the NIMH, and the NINDS are interested in supporting exploratory studies
required to obtain the necessary information to establish the basis for
proceeding to a full-scale trial. The purpose of the Alzheimer"s Disease Pilot
Clinical Trials initiative is to obtain preliminary data and conduct studies to
support the rationale for a subsequent full-scale clinical drug trial of an
intervention to slow, halt, or reverse the progressive decline in cognitive
function and/or to modify the cognitive and behavioral symptoms in Alzheimer"s
disease victims as well as to delay the onset of or prevent Alzheimer"s disease.
Note: There is a companion Program Announcement available, the "Alzheimer"s
Disease Clinical Trial Planning Grant" (PA-99-039).
Expiration Date: Monday, January 14, 2002 NOFO Number: PA-99-039 Release Date: Thursday, January 14, 1999 Notice Type: PA
The National Institute on Aging (NIA), the National Institute of Mental Health
(NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS)
invite qualified investigators to submit research grant applications for clinical
trial planning grants directed toward the drug treatment of the cognitive and
behavioral symptoms of Alzheimer"s Disease (AD). The purpose of the Alzheimer"s
Disease Clinical Trial Planning Grant is to allow for early peer review of the
rationale and design for Alzheimer"s disease clinical drug trials and to provide
support for the development of a detailed clinical trial research plan, including
a manual of operations and procedures.
Note: There is a companion Program Announcement available for "Alzheimer"s
Disease Pilot Clinical Trials" (PA-99-038).
Expiration Date: Saturday, January 12, 2002 NOFO Number: PAS-99-037 Release Date: Tuesday, January 12, 1999 Notice Type: PAS
The Mental Retardation and Developmental Disabilities (MRDD) Branch, Center for
Research for Mothers and Children (CRMC), of the National Institute of Child
Health and Human Development (NICHD) and the Division of Fundamental Neuroscience
and Developmental Disorders (DFNDD) of the National Institute of Neurological
Disorders and Stroke (NINDS) invite research grant applications that address the
genetics, pathophysiological mechanisms, and the development of biomarkers for
Rett Syndrome. Areas of interest include developmental neurobiology,
pathophysiology, genetics, epidemiology, structure-function correlations, and
clinical studies that have a direct link to Rett Syndrome. Specific funds will
be set aside to support investigator-initiated applications responsive to this
grant solicitation.
Expiration Date: Wednesday, April 28, 1999 NOFO Number: RFA-NS-99-005 Release Date: Tuesday, December 22, 1998 Notice Type: RFA
The National Institute of Neurological Disorders and Stroke (NINDS) and the
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) invite
investigator-initiated research grant applications to study the mechanisms by
which diabetes results in painful and disabling neuropathies and other
neurological complications and to apply this information to the development of
interventions to prevent, limit, or reverse these complications. The etiology
of diabetic neuropathy is complex, involving metabolic and vascular effects.
Recent evidence suggests that deficiencies in neurotrophic factors may also play
a role. Diabetic autonomic neuropathy is a particularly understudied area. The
intent of this RFA is to intensify investigator-initiated research, to attract
new investigators to the field and to enhance interdisciplinary approaches to
research in these areas.