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Discontinuation PAR-13-127 NINDS Ruth L. Kirschstein National Research Service Awards Individual Predoctoral Fellows MD-PhD Programs F31)" Notice Number: NOT-NS-14-018 Key Dates Release Date: March 14, 2014 Related Announcements PAR-13-127 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants NINDS discontinue PAR-13-127 NINDS Ruth L. Kirschstein National Research Service Awards Individual Predoctoral Fellows MD-PhD Programs F31)".   New applications be accepted NINDS this Funding Opportunity Announcement FOA) through April 8, 2014, due date 7, 2014, AIDS AIDS-related applications).  order accommodate applicants need revise resubmit fellowship applications, NINDS accept resubmission applications A1) through December 8, 2014, due date January 7, 2015, AIDS AIDS-related applications). Starting the April 8, 2014, fellowship application due date, applicants submit F30 applications NINDS support dual-degree training using Ruth L. Kirschstein National Research Service Award NRSA) Individual Predoctoral MD/PhD Other Dual-Doctoral Degree Fellowship Parent F30). Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-4188 Email: Korns@ninds.nih.gov  

Notice Clarify Intellectual Property Requirements PAR-11-344 NeuroNEXT Infrastructure Resource Access X01)" Notice Number: NOT-NS-14-019 Key Dates Release Date: March 13, 2014 Related Announcements PAR-11-344 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice modifies language NINDS PAR-11-344 quot;NeuroNEXT Infrastructure Resource Access X01)" regarding intellectual property requirements. Part 2. Section I. Funding Opportunity Description Purpose Currently reads: Applicants should note the following: 1) applicant must hold intellectual property rights IP) the investigational agent/device proposed study. Modified read: Applicants should note the following: 1) applicants industry must hold intellectual property IP) rights the investigational agent/device proposed study. However, applicants non-profits not need hold IP rights the investigational agent/device under study. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Amanda Sibley, DPhil, MPH National Institute Neurological Disorders Stroke NINDS) Telephone: 301-451-1449 Email: amanda.sibley@nih.gov nbsp;

Notice the Extension the Expiration Date PAR-11-344 NeuroNEXT Infrastructure Resource Access X01)" Notice Number: NOT-NS-14-011 Key Dates Release Date: March 12, 2014 Related Announcements PAR-11-344 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose Notice extends expiration date PAR-11-344 quot;NeuroNEXT Infrastructure Resource Access X01)" one receipt cycle. Current Expiration Date: October 22, 2014 New Expiration Date: December 31, 2014 Inquiries Please direct inquiries to: Amanda Sibley, DPhil, MPH National Institute Neurological Disorders Stroke NINDS) Phone: 301-451-1449 Email: amanda.sibley@nih.gov nbsp;

Notice Extension the Expiration Date PA-11-345 NeuroNEXT Small Business Innovation Clinical Trials U44)" Notice Number: NOT-NS-14-012 Key Dates Release Date: March 12, 2014 Related Announcements PAR-11-345 Issued National Institute Neurological Disorders Stroke NINDS)  Purpose Notice extends expiration date PAR-11-345, quot;NeuroNEXT Small Business Innovation Clinical Trials U44)" one receipt date. Due the extension, following application due date be added, December 2, 2014. Current Expiration Date: August 2, 2014. New Expiration Date: December 3, 2014. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Amanda Sibley, DPhil, MPH National Institute Neurological Disorders Stroke NINDS) Phone: 301-451-1449 Email: amanda.sibley@nih.gov nbsp;

Notice the Transition New Application Forms NeuroNEXT Infrastructure Resource Access X01)” Notice Number: NOT-NS-14-015 Key Dates Release Date: March 7, 2014 Related Announcements PAR-11-344 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform applicants new application forms now available Funding Opportunity Announcement FOA) PAR-11-344 ldquo;NeuroNEXT Infrastructure Resource Access X01)”. new application forms be identified the Grants.gov Download Application Package screen the Competition ID lsquo;FORMS-C’. older application forms a Competition ID lsquo;ADOBE-FORMS-B1’. Although FORMS-C application forms available immediate use, National Institute Neurological Disorders Stroke NINDS) allow transition period through March 28, 2014 during time applications using ADOBE-FORMS-B1 forms still accepted. application submissions PAR-11-344 on after March 29, 2014 must FORMS-C application forms NOT-OD-13-074). other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: D. Elizabeth McNeil, MD MSc National Institute Neurological Disorders amp; Stroke NINDS) Telephone: 301-496-9135 Email: mcneilde@ninds.nih.gov nbsp;

Notice Extend Due Date Expiration Date RFA-MH-14-217 BRAIN Initiative: Planning Next Generation Human Brain Imaging R24)" Notice Number: NOT-MH-14-010 Key Dates Release Date: March 5, 2014 Related Announcements RFA-MH-14-217 Issued NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Center Complementary Alternative Medicine NCCAM) National Center Advancing Translational Sciences NCATS) Office Behavioral Social Sciences Research OBSSR) Purpose purpose this Notice to inform interested applicants the Application Due Date RFA-MH-14-217 quot;BRAIN Initiative:  Planning Next Generation Human Brain Imaging R24)" being extended March 13, 2014, March 27, 2014. Accordingly, expiration date RFA-MH-14-217 now March 28, 2014. other aspects the FOA remain unchanged. Inquiries Please direct inquiries to: Greg Farber, Ph.D. National Institute Mental Health NIMH) Telephone: 301-435-0778 Email: faberg@mail.nih.gov nbsp;

Notice Correct NINDS CFDA Number Associated PAR-13-278 NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)" Notice Number: NOT-NS-14-017 Key Dates Release Date: March 4, 2014 Related Announcements PAR-13-278 NOT-NS-14-008 Issued National Institute Neurological Disorders Stroke NINDS) Purpose January 16, 2014 National Institute Neurological Disorders Stroke NINDS) issued Notice NOT-NS-14-008) informing applicants the CFDA number for  PAR-13-278 quot;NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)" should 93.853. Unfortunately, application packages available Grants.gov still reflected old CFDA number. Although is standard practice NIH staff verify correct CFDA numbers after submission, applicants raised concerns regarding display the incorrect CFDA their applications. address concerns, have posted new application package Grants.gov identified a Competition ID lsquo;FORMS-C-REVISED’ a Competition Title lsquo;Includes CFDA correction – must used due dates or after 8, 2014'. you already started prepare application the March 5, 2014 due date renewal, resubmission revision applications the 7, 2014 due date AIDS AIDS-Related applications, you two options: 1. Submit using old application package. Although application image eRA Commons show old CFDA, NIH staff adjust CFDA number our system process application correctly. 2. Revisit PAR-13-278, download new application package, transfer application data submission. After May 7, 2014 AIDS due date, old application package be closed application submissions using old package no longer accepted. Inquiries Please direct inquiries to: Wendy Galpern, MD, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-9135 Email: Phase3Trial@ninds.nih.gov

Notice NINDS Participation PAR-14-092 Bioengineering Research Partnerships BRP) R01)" Notice Number: NOT-NS-14-014 Key Dates Release Date: March 3, 2014 Related Announcements PAR-14-092 Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform applicants the National Institute Neurological Disorders Stroke NINDS) joined funding opportunity announcement PAR-14-092, entitled ldquo;Bioengineering Research Partnerships BRP) R01)”, effective immediately. following sections PAR-14-092 been updated reflect participation NINDS this FOA. Part 1. Overview Information Components Participating Organizations National Institute Biomedical Imaging Bioengineering NIBIB) National Cancer Institute NCI) National Eye Institute NEI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Neurological Disorders Stroke NINDS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.286, 93.172, 93.865, 93.399, 93.396, 93.395, 93.394, 93.393, 93.273, 93.867, 93.279, 93.113, 93.866, 93.853 Part 2. Section I. Funding Opportunity Description  Scope the Program applications relevant the mission the National Institute Neurological Disorders Stroke NINDS): NINDS not support first human demonstrations, early Feasibility studies definitive clinical trials therapeutics through BRP mechanism Phase I, Phase II, Phase III, Feasibility/Pivotal trials), does support efforts through mechanisms http://www.ninds.nih.gov/research/clinical_research/ details).  Pre-clinical efforts leading directly an FDA submission obtain Investigational Device Exemption IDE) also supported through mechanisms http://www.ninds.nih.gov/funding/funding_announcements/Funding-Bins-Tra… details).  Investigators should contact NINDS Program Staff identify appropriate mechanism such clinical efforts. other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Kip Ludwig, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1447 Email: Kip.Ludwig@nih.gov

Notice Correct NINDS CFDA number associated PAR-13-281 NINDS Exploratory Clinical Trials R01)" Notice Number: NOT-NS-14-016 Key Dates Release Date: March 3, 2014 Related Announcements PAR-13-281 NOT-NS-14-007 Issued National Institute Neurological Disorders Stroke NINDS) Purpose January 16, 2014 National Institute Neurological Disorders Stroke NINDS) issued Notice NOT-NS-14-007) informing applicants the CFDA number PAR-13-281 quot;NINDS Exploratory Clinical Trials R01)" should 93.853. Unfortunately, application packages available Grants.gov still reflected old CFDA number. Although is standard practice NIH staff verify correct CFDA numbers after submission, applicants raised concerns regarding display the incorrect CFDA their applications. address concerns, have posted new application package Grants.gov identified a Competition ID lsquo;FORMS-C-REVISED’ a Competition Title lsquo;Includes CFDA correction – must used due dates or after 8, 2014'. you already started prepare application the March 5, 2014 due date renewal, resubmission revision applications the 7, 2014 due date AIDs AIDS-Related applications, you two options: 1. Submit using old application package. Although application image eRA Commons show old CFDA, NIH staff adjust CFDA number our system process application correctly. 2. Revisit PAR-13-281, download new application package, transfer application data submission. After May 7, 2014 AIDS due date, old application package be closed application submissions using old package no longer accepted. Inquiries Please direct inquiries to: Peter R. Gilbert, Sc.M. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-0870 Email: ExploratoryTrial@ninds.nih.gov

Discontinuation PAR-13-022 NINDS Cooperative Program Translational Research U01)" Notice Number: NOT-NS-14-013 Key Dates Release Date: February 13, 2014 Related Announcements PAR-13-022 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform potential applicants NINDS discontinue PAR-13-022 quot;NINDS Cooperative Program Translational Research U01)." Applications not accepted NINDS this Funding Opportunity Announcement after February 7, 2014 application due date.  Notices announcing related new programs be forthcoming. Inquiries Please direct inquiries to: Linda McGavern, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1779 Email: CREATEinquiries@mail.nih.gov nbsp;