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This Request for Applications (RFA) solicits research grant applications to examine the feasibility of using Xenopus tropicalis for standard genetic manipulations. The research proposed should optimize the conditions required to perform efficient, large-scale mutagenesis, and should use the optimized parameters to perform small-scale mutagenesis, phenotyping, and gene cloning, identification, and characterization. Mutant animals, protocols, and data produced by these projects should be made available to the scientific community. We anticipate that the mutants, data and procedures developed by the projects funded under this RFA will enable Xenopus tropicalis to play a significant role in identifying and characterizing genes that regulate cellular and developmental processes.

This RFA solicits proposals for development of tools and techniques for the establishment of random and targeted sequence-tagged insertion libraries of embryonic stem (ES) cells that can be used to generate mutant mice in which the expression of the tagged gene could be controlled temporally and spatially. The development of such a resource for wide distribution to the scientific community would make it possible to scan the sequence database for any gene of interest and order the corresponding targeted ES cell line. Ideally, the insertional mutagenesis system developed would permit a wide range of genetic analyses and manipulations, including enhancer-trapping, conditional knockouts, conditional expression or overexpression, etc. It also would permit the larger community of investigators to utilize genomic resources efficiently.

This Request for Applications (RFA) solicits proposals for development of tools and techniques for the establishment of random and targeted sequence- tagged insertion libraries of embryonic stem (ES) cells that can be used to generate mutant mice in which the expression of the tagged gene could be controlled temporally and spatially. The development of such a resource for wide distribution to the scientific community would make it possible to scan the sequence database for any gene of interest and order the corresponding targeted ES cell line. Ideally, the insertional mutagenesis system developed would permit a wide range of genetic analyses and manipulations, including enhancer-trapping, conditional knockouts, conditional expression or overexpression, etc. It also would permit the larger community of investigators to utilize genomic resources efficiently.

The overall goal of this initiative is to invite qualified researchers to submit new research grant applications to conduct mechanistic studies using patients, patient materials or information from multi-site pediatric drug trials sponsored by the National Institute of Child Health and Human Development (NICHD), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Mental Health (NIMH), and the National Institute of Neurological Disorders and Stroke (NINDS).

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the National Institute of Neurological Disorders and Stroke (NINDS) encourage investigator-initiated research grant applications of therapeutic and pathogenic approaches for the muscular dystrophies. Responses to this program announcement may include studies in appropriate animal models or preclinical or clinical studies in patients with Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), facioscapulohumeral dystrophy (FSHD), limb-girdle muscular dystrophy (LGMD), myotonic dystrophy (DM), congenital muscular dystrophy (CMD), Emery-Dreifuss muscular dystrophy (EMD), or other forms of muscular dystrophy.

In July of 2000 it was announced that the NIH would set aside $50 million over five years to support research on new ways to treat Alzheimer's disease, an ongoing commitment, by targeting the production of disease-associated processes, such as formation of amyloid plaques and neurofibrillary tangles with a special emphasis on the development of a vaccine to prevent the disease. This RFA is intended to assist in the development of immunological preventive and treatment strategies for Alzheimer’s disease. As part of the overall initiative, several related program announcements, with set-asides, are also being developed.

The National Gene Vector Laboratories (NGVL) were established in 1995 to produce clinical grade vectors for human gene transfer protocols. The purpose of this Request for Applications (RFA) is to continue the support of the NGVL to produce and distribute such vectors and to perform related toxicology studies for Phase I and II human clinical gene transfer protocols.

Participating Institutes and Centers (ICs) of the National Institutes of Health (NIH) invite applications for R01 awards to support Bioengineering Research Partnerships (BRPs) for basic multidisciplinary research addressing important biological or medical research problems. A BRP is a multidisciplinary research team applying an integrative, systems approach to develop knowledge and/or methods to prevent, detect, diagnose, or treat disease or to understand health and behavior. The partnership must include appropriate bioengineering expertise in combination with basic and/or clinical investigators. A BRP may propose discovery-driven, developmental, non-hypothesis-driven, design-directed, or hypothesis-driven research at universities, national laboratories, medical schools, large or small businesses, or other public and private entities.

This Request for Applications (RFA) solicits applications to study the development or refinement of behavioral, pharmacological or other innovative treatment interventions for individuals with autism or other autism-spectrum disorders.

The National Institute of Neurological Disorders and Stroke (NINDS) and the Office of AIDS Research (OAR) invite applications for Specialized Neuroscience Research Programs (SNRP) on Health Disparity: HIV and the Nervous System. The purpose of this Request for Applications (RFA) is to augment and strengthen the research capabilities of faculty, students, and fellows at minority institutions by supporting the development of new, and/or the enhancement of ongoing basic and clinical neuro-AIDS related research projects and programs. These awards will be made to support individuals at minority institutions who collaborate with one or more established NIH supported investigators at research intensive organizations. Applications submitted in response to this RFA should be focused on research related to the neurological complications of HIV infection.