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This Request for Applications (RFA) has been developed to encourage research on the standards and methods for identifying and characterizing optimal human fetal tissue for use in transplantation therapy. Joint funding by the National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute of Neurological Disorders and Stroke (NINDS) reflects the extent of interest in evaluating human fetal tissues and their biological potentials. Attention should be given to proper collection, processing, culturing and preserving these tissues to ensure highest quality control. This research should consider addressing methods for acquisition, handling, and processing, establishing morphologic status, determining developmental age and viability, assessing sterility and genetic normality, preserving by cryopreservation, storing and establishing cell lines. President Clinton's directive of January 22 ended the moratorium on Federal funding for use of fetal tissue from induced abortions in human transplantation research. Therefore, human fetal tissues studied under this solicitation may be derived from spontaneous abortion, ectopic pregnancy, or induced abortion.

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Child Health and Human Development (NICHD), invite research grant applications for support of research on the restitution of ambulation following disability from neurological disorders or injury.

The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), the National Institute of Child Health and Human Development (NICHD), and the National Center for Nursing Research (NCNR) invite applications that take advantage of new opportunities for research into understanding phenomena in the central nervous system (CNS) essential for cognitive and behavioral activity. What CNS changes occur during different types of learning situations are substantial issues in the neurobiology of cognition and behavior. Integrative biological research is needed, not only for the development of sounder theory in the treatment and rehabilitation of brain dysfunctions, but also to advance an understanding of the fundamental neurobiological basis of perception, cognition, and behavior throughout the lifespan.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) encourages the submission of research grant applications related to genetics of the epilepsies. The NINDS solicits submission of research project grants to stimulate research in both basic and clinical aspects of genetics of the epilepsies. The scope of this program encompasses both animal and human studies which would utilize a variety of experimental approaches and methods.

The purpose of this announcement is to facilitate a research area that defines a comparative framework for understanding the neural substrates of behavior, its principles, organization, and disorders. Applicants are encouraged to consider the advantages of using animal species representing different evolutionary levels including species that expand the kinds of animals conventionally used in brain and behavior research, as well as those that may require further development as experimental models.

The National Institute of Neurological Disorders and Stroke (NINDS) invites research grant applications seeking support of a wide spectrum of research directed at generating improved knowledge concerning amyotrophic lateral sclerosis (ALS).

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Allergy and Infectious Diseases (NIAID) invite research grant applications seeking support of a wide spectrum of research directed at generating improved knowledge concerning Lyme disease of the nervous system.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) is revising and reissuing an existing NINDS program announcement published January 8, 1988 to notify the scientific community of continuing NINDS interest in research addressing the surgical management of epilepsies.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) are revising and reissuing a NINDS program announcement on narcolepsy published in the NIH Guide to Grants and Contracts, Vol. 19, No. 15, April 13, 1990, to notify the scientific community of continuing NINDS/NIMH interest in the submission of research project grant applications related to narcolepsy.

The National Institute of Neurological Disorders and Stroke (NINDS), a component of the National Institutes of Health, invites research grant applications seeking support of a wide spectrum of research on multiple sclerosis.