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Notice Termination PAR-11-037, quot;Limited Competition: Fogarty International Research Collaboration - Basic Biomedical FIRCA-BB) Research Award R03)" Notice Number: NOT-TW-12-004 Key Dates Release Date: December 9, 2011 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform prospective applicants the Fogarty International Center FIC) terminate Funding Opportunity Announcement FOA) PAR-11-037 effective January 11, 2012. Therefore, NIH not accept applications submitted after January 10, 2012 response the Limited Competition: Fogarty International Research Collaboration - Basic Biomedical FIRCA-BB) Research Award R03) originally the final submission date January 10, 2013. Please note this NOTICE only pertains the Basic Biomedical program not the FIRCA Behavioral Social Sciences program. Inquiries Please direct inquiries to: Xingzhu Liu, M.D., Ph.D. FIRCA-BSS Program Officer Division International Training Research Fogarty International Center FIC) National Institutes Health Building 31, Room B2C39 31 Center Drive, MSC 2220 Bethesda, MD 20892-2220 Telephone: 301-496-1653 Fax: 301-402-0779 Email:   Xingzhu.Liu@nih.gov

Notice Termination PAR-10-278, Limited Competition the Global Research Initiative Program, Basic/Biomedical Sciences R01)" Notice Number: NOT-TW-12-003 Key Dates Release Date: December 8, 2011 Issued Fogarty International Center FIC) National Cancer Institute NCI) National Eye Institute NEI) National Institute Aging NIA) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) Office Dietary Supplements ODS) Purpose purpose this Notice to inform prospective applicants the Fogarty International Center FIC) terminate Funding Opportunity Announcement FOA) PAR-10-278 effective March 9, 2012, both AIDS non-AIDS applications. Therefore, NIH not accept applications submitted after March 9, 2012 response the Limited Competition: Global Research Initiative Program, Basic/Biomedical Sciences R01) originally the final submission date March 8, 2013. Please note this NOTICE only pertains the Basic Biomedical program not the GRIP Behavioral Social Sciences program. Inquiries Please direct inquiries to: Xingzhu Liu, M.D., Ph.D. FIRCA-BSS Program Officer Division International Training Research Fogarty International Center FIC) National Institutes Health Building 31, Room B2C39 31 Center Drive, MSC 2220 Bethesda, MD 20892-2220 Telephone: 301-496-1653 Fax: 301-402-0779 Email:   Xingzhu.Liu@nih.gov

Notice Intent Publish Funding Opportunity Announcement the National NeuroAIDS Tissue Consortium NNTC) U01) Notice Number: NOT-MH-12-010 Key Dates Release Date: December 7, 2011 Issued National Institute Mental Health,(NIMH) National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) intend issue Funding Opportunity Announcement FOA) support applications the National NeuroAIDS Tissue Consortium NNTC) U01). NNTC currently consists four clinical sites, California NeuroAIDS Tissue Network CNTN), Manhattan HIV Brain Bank MHBB), National Neurological AIDS Bank NNAB), the Texas NeuroAIDS Research Center TNRC), a Statistics Data Coordinating Center housed Indiana University.  goals the planned FOA to continue having NNTC serve a resource clinical specimens datasets NeuroAIDS investigators.  Applicants encouraged recruit end-stage HIV-infected subjects based current scientific priorities within NeuroAIDS field. Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA, will the NIH Cooperative Agreement U01) award mechanism, expected be published Spring 2012 an expected receipt date Fall 2012.  Details the planned FOA provided below.  Research Initiative Details planned FOA intended encourage applications design scientific agenda the NNTC ensure subject recruitment acquisition specimen database resources are relevant NeuroAIDS investigators.  scientific agenda is focused end-stage HIV-associated central peripheral nervous system diseases encouraged may include, yet not limited to, following topics:  a) define pathogenic mechanisms involved HIV Associated Neurocognitive Disorders HAND) the setting long-term Highly Active Anti-Retroviral Therapy HAART); b) study interactions chronic HIV-1 infection, living HAART long term, aging associated neurodegenerative processes, the impact cardiovascular disease HAND; c) discovery research identify parameters contribute HAND end-stage, chronic HIV-1 infection. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Interested parties contact: Dianne Rausch, Ph.D. Acting Director, Division AIDS Research National Institute Mental Health 6001 Executive Boulevard, Room 6218, MSC 9616 Rockville, MD 20852-9616 Telephone:  301) 443-7281 Email: drausch@mail.nih.gov

Meeting Introduce Network Excellence Neuroscience Clinical Trials NeuroNEXT) Notice Number: NOT-NS-12-005 Key Dates Release Date: December 6, 2011 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Network Excellence Neuroscience Clinical Trials NeuroNEXT) designed increase efficiency clinical trials, facilitate patient recruitment retention, increase quality neuroscience clinical trials, to enable public-private partnerships. network includes multiple Clinical Sites, Clinical Coordinating Center CCC), one Data Coordinating Center DCC); listing the sites be found the NeuroNEXT website www.ninds.nih.gov/NeuroNEXT). clinical research network provide robust, standardized, accessible infrastructure facilitate rapid development implementation protocols neurological disorders affecting adult and/or pediatric populations. webinar intended give overview the application process NeuroNEXT presentations the NeuroNEXT CCC/DCC NINDS. Time be allotted questions answers. January 6, 2012 3:30 PM - 4:30 PM EST) Teleconference number 1-877-568-4108 Access Code: 415-771-923 Audio PIN: Shown after joining Webinar Weblink:  Reserve Webinar seat at: https://www1.gotomeeting.com/register/770404089 Title: Network Excellence Neuroscience Clinical Trials NeuroNEXT) Date: Friday, January 6, 2012 Time: 3:30 PM - 4:30 PM EST After registering will receive confirmation email containing information joining Webinar. Inquiries Please direct inquiries to: D. Elizabeth McNeil, MD MSc NINDS Telephone: 301-496-9135 mcneilde@ninds.nih.gov www.ninds.nih.gov/NeuroNEXT

Frequently Asked Questions RFA-MH-12-130 - OppNet's Basic Research Decision Making: Cognitive, Affective, Developmental Perspectives R01) Notice Number: NOT-OD-12-019 Key Dates Release Date: December 1, 2011 Issued NIH Basic Behavioral Social Science Opportunity Network OppNet http://oppnet.nih.gov/) its member institutes, centers offices: National Cancer Institute NCI) National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) National Library Medicine NLM) Fogarty International Center FIC) National Center Complementary Alternative Medicine NCCAM) National Center Research Resources NCRR) Office Behavioral Social Sciences Research OBSSR) Office Dietary Supplements ODS) Office Rare Diseases ORD) Office Research Women’s Health ORWH) Purpose OppNet, NIH's Basic Behavioral Social Science Opportunity Network, issued RFA-MH-12-130 - Basic Research Decision Making: Cognitive, Affective, Developmental Perspectives R01) - September 2, 2011.  Previously, OppNet released frequently asked questions FAQs) basic behavioral social science research b-BSSR).  Similarly, OppNet released FAQs answers this OppNet FOA released through member NIMH.  Interested parties find document available the OppNet website: http://oppnet.nih.gov/pdf/FAQsRFA-MH-12-130.pdf.  Potential applicants direct questions the OppNet-affiliated program, grants management, review staff listed the FOA's Section VII. Inquiries Please direct inquiries to: Janine M. Simmons, MD, Ph.D. OppNet RFA Leader Chief, Affect, Social Behavior Social Cognition Program National Institute Mental Health 6001 Executive Boulevard, Room 7179, MSC9637 Bethesda, MD  20892-9637 301-443-1576 janine.simmons@nih.gov William N. Elwood OppNet Facilitator Office Behavioral Social Sciences Research National Institutes Health 31 Center Drive, Suite B1C19, MSC2027 Bethesda, MD  20892-2027 301-402-0116 William.elwood@nih.gov http://oppnet.nih.gov

Notice Total Costs allowed RFA-RM-11-008—H3Africa Collaborative Centers U54) Notice Number: NOT-RM-12-006 Key Dates Release Date:   November 16, 2011 Issued National Institutes Health NIH) National Human Genome Research Institute NHGRI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) Office AIDS Research OAR) nbsp; Fogarty International Center FIC) Office Strategic Coordination Common Fund) nbsp;  Purpose purpose this Notice to clarify budget requests applications RFA-RM-11-008 should exceed 1 million total costs the collaborative center research, including foreign components, each the five years requested plus 250,000 equipment the first year. Current Language:  Award Budget Applications limited 920,000 direct costs include salaries, supplies, training, equipment, travel, other allowed expenses research grants.  order address H3Africa's goals build infrastructure applicant request to additional 250,000 equipment.  request equipment must very well justified.  subsequent years research plan budget not exceed 920,000 direct costs.  35,000 direct costs/year must also set aside participation the International Extramural Administrative Research Development Program component above) under Implementation H3Africa Objectives section. New Language: Award Budget Applications limited 1 million total costs include salaries, supplies, training, equipment, travel, other allowed expenses research grants.  order address H3Africa's goals build infrastructure applicant request to additional 250,000 equipment the first year.  request equipment must very well justified.  subsequent years research plan budget not exceed 1 million total costs.  all years, 35,000 direct costs/year must set aside participation the International Extramural Administrative Research Development Program component above) under Implementation H3Africa Objectives section. Inquiries Please direct inquiries to: Jane L. Peterson, Ph.D. National Human Genome Research Institute National Institutes Health 5635 Fishers Lane, Suite 4076, MSC 9305 Bethesda, MD 20892-9305 Phone: 301 496 7531 Fax: 301 480 2770 Email: Jane_Peterson@nih.gov H3Africa website: http://H3Africa.org

NINDS Human Genetics Resource Center/NINDS Repository Goals, Access, Use Notice Number: NOT-NS-12-003 Update: following update relating this announcement been issued: 13, 2014 - Notice NOT-NS-14-032. NINDS Requirements Induced Pluripotent Stem Cell Development Resource Sharing. 8, 2014 - Notice NOT-NS-14-027. Notice Intent Publish Funding Opportunity Announcement Biomarker Discovery through Use Data Resources Developed the NINDS Parkinson's Disease Biomarker Program PDBP) U01). Key Dates Release Date: November 15, 2011   Issued National Institute Neurological Disorders Stroke NINDS) Purpose NINDS committed reducing burden neurological disorders human lives. mission the NINDS Human Genetics Resource Center, also known the NINDS Repository, to accelerate discovery causes risk factors neurological disorders through broad sharing de-identified human samples clinical data across research community. purpose this notice to explain scope the Repository to provide guidelines submitting withdrawing samples data. NINDS Repository currently funded through contract the Coriell Institute Medical Research includes samples clinical data more 35,000 subjects, more 22,000 these samples available researchers academia industry. listing available samples information how obtain can found http://ccr.coriell.org/Sections/Collections/NINDS/?SsId=10. present collection includes genomic DNA lymphoblastoid cell lines associated de-identified clinical data individuals dystonia, epilepsy, motor neuron disease including ALS), Parkinson’s disease, stroke, Tourette syndrome, neurologically normal controls. addition supporting genetic discovery, NINDS Repository broadened scope recently launching resources sharing fibroblasts induced pluripotent stem cells iPSC) individuals Parkinson’s disease, ALS, Huntington’s disease, a resource support biomarker discovery. core standardized de-identified HIPAA-compliant clinical data elements CDEs) available each sample. Repository CDEs, found http://ccr.coriell.org/Sections/Collections/NINDS/ClinicalDataForms.asp…, broad enough discovery research, compact enough be streamlined, are harmonized the NINDS Common Data Elements: http://www.commondataelements.ninds.nih.gov/. Repository also makes available number data dictionaries. Repository CDEs developed committee, including NINDS, Repository staff, experts the field. NINDS Repository CDEs modified phenotypic characterizations genetic knowledge evolve over time. Given practical limits the number samples can stored distributed, opportunity submit samples generally limited NINDS-funded investigators. Decisions which samples be accepted be by representatives the NINDS including Program Director most relevant the proposed submitter’s grant application NINDS Offices Programs http://www.ninds.nih.gov/research/index.htm), Repository Contract Officer, the Repository Contract Officer's Technical Representative COTR). resource also available submissions, a case-by-case basis, other investigators samples collections may of value the wider research community. all instances, investigators are interested submitting samples should contact Repository COTR early possible the purpose planning, including budget considerations. Because the limits mentioned above, access submitting samples cannot assumed, may be granted, investigators should prepared make alternative plans. Requests add new disease collections and/or different sample types be considered an internal NINDS committee. samples accepted the NINDS Repository must collected under IRB-approved consent allows broad sharing de-identified samples clinical data use investigators academia industry discovery research relevant any medical disorder. Repository provides example consent criteria is available preview consents before are submitted IRBs; http://ccr.coriell.org/Sections/Support/NINDS/Submissions.aspx. Samples received the NINDS Repository become property the NINDS, be shared the research community. Withdrawal samples the NINDS Repository available, a cost-offsetting fee, industry, not-for-profit organizations, to academic institutions. Withdrawers submit statement research intent via Repository. statement, may publicly posted, be reviewed NINDS staff.  Prior distribution, appropriate signing official the requesting institution must sign Material Transfer Agreement MTA) assuring appropriate use: http://ccr.coriell.org/Sections/Support/NINDS/assurance.aspx?PgId=307. MTAs not acceptable unless specifically indicated the Contract Officer COTR. Requests items are non-renewable therefore risk being depleted such genomic DNA whole blood, fibroblasts, samples biomarker discovery) reviewed the Repository NINDS staff a case-by-case basis. Acknowledgement the NINDS Repository required publications use samples clinical data the Repository. Model language acknowledging Repository provided the NINDS Repository website http://ccr.coriell.org/Sections/Collections/NINDS/ackGuidelines.aspx?Pg…). Inquiries Please direct inquiries to: Roderick A. Corriveau, Ph.D. Program Director, Neurodegeneration & COTR, NINDS Repository NIH/NINDS 6001 Executive Blvd., Room 2153 Bethesda, MD  20892-9531 FedEx/courier use:  Rockville, MD  20852) Phone:  301-496-5680 roderick.corriveau@nih.gov

Extension Expiration Date PAR-09-065, NINDS Career Development Award Promote Diversity Neuroscience Research K01) Notice Number: NOT-NS-12-001 Key Dates Release Date: November 3, 2011 Related Notices PAR-09-065 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice extends expiration date Funding Opportunity Announcement FOA) PAR-09-065, NINDS Career Development Award Promote Diversity Neuroscience Research K01). new expiration date PAR-09-065 May 8, 2012. other aspects these FOAs remain same.  Please review incorporate updates relating this announcement; updates located Part Overview Information. Inquiries Please direct inquiries to: Michelle D. Jones-London, Ph.D. Office Training, Career Development Workforce Diversity National Institute Neurological Disorders Stroke NSC 2181 6001 Executive Blvd. Bethesda, MD 20892 Rockville, MD 20852 express/courier service) Telephone: 301) 451-7966 Email: jonesmiche@ninds.nih.gov

Notice Revision RFA-RM-11-008, Human Heredity Health Africa H3Africa): Collaborative Centers U54) Notice Number: NOT-RM-12-002 Key Dates Release Date: October 14, 2011 Issued National Institutes Health NIH) National Human Genome Research Institute NHGRI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) Office AIDs Research OAR) nbsp; Fogarty International Center FIC) Office Strategic Coordination Common Fund)       Purpose purpose this Notice to revise wording three passages RFA-RM-11-008: READS: Section IV, 2. Page Limitations quot;The Research Strategy section each component the scientific the collaborative center limited 12 pages length.  there an administrative core, is limited 6 pages length."   SHOULD READ: quot;The Research Strategy section each component the scientific plan the collaborative center limited 12 pages length.  Administration Management Component, also limited 12 pages length. IEARD request also limited 12 pages." READS: Section IV, 2. Administration Management:  quot;If desired, activities be included a separate Administrative Core."  SHOULD READ: quot;These activities be included a separate Administration Management Component.  Additionally IEARD request limited 12 pages length." READS: Section IV, 2. Under Collaborations. quot;If appropriate, of collaborating components be management core." SHOULD READ: Section IV, 2. Under Collaborations. appropriate, of collaborating components be Administration Management Component.” READS: Section I, Part 2, B under Implementation the Objectives H3Africa, Interactions other programs.  quot;The H3Africa requires collaborative centers form partnerships Africa institutions have ongoing studies offer infrastructure the research focus area are currently conducting genomics environmental research." SHOULD READ: quot;The H3Africa requires collaborative centers form partnerships Africa institutions have ongoing studies offer infrastructure the research focus area." Inquiries Please direct inquiries to: Jane L. Peterson, Ph.D. National Human Genome Research Institute National Institutes Health 5635 Fishers Lane, Suite 4076, MSC 9305 Bethesda, MD 20892-9305 Phone: 301 496 7531 Fax: 301 480 2770 Email: Jane_Peterson@nih.gov H3Africa website: http://H3Africa.org

Notice Revision RFA-RM-11-009, Human Health Heredity Africa H3Africa): Research Projects U01) Notice Number: NOT-RM-12-003 Key Dates Release Date: October 14, 2011 Issued National Institutes Health NIH) National Human Genome Research Institute NHGRI) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) Office AIDs Research OAR)  Fogarty International Center FIC) Office Strategic Coordination Common Fund) Purpose purpose this Notice to revise wording two passages RFA-RM-11-009: READS: Part 2, Section I, Purpose.  quot;The current FOA a call applications new established genomicists propose establish collaboration between independently funded H3Africa genomics/genetics project an ongoing, funded project does currently a genomics focus.” SHOULD READ: quot;The current FOA a call applications new established genomicists propose establish genomics/genetics research project collaborate an ongoing, funded project either does currently a genomics focus where augmentation expansion a current genomics/genetics component enable funded work accomplish larger, complete genomics study would otherwise possible.” READS: Part 2, Section I, Research Objectives. quot; objective this FOA to solicit applications establish independent H3Africa Research Projects will collaborate ongoing grants, cooperative agreements, contracts, awards the U.S. government USG) e.g. CDC, DOD, HRSA, NIH, USAID, others) non-USG funders e.g., Wellcome Trust, Doris Duke Charitable Foundation, Bill amp; Melinda Gates Foundation, others) add genomics-based approach the study a chronic infectious disease an on-going funded study does currently a genetics component."  SHOULD READ: quot; objective this FOA to solicit applications establish independent H3Africa Research Projects will collaborate ongoing grants, cooperative agreements, contracts, awards the U.S. government USG) e.g. CDC, DOD, HRSA, NIH, USAID, others) non-USG funders e.g., Wellcome Trust, Doris Duke Charitable Foundation, Bill amp; Melinda Gates Foundation, others) add genomics-based approach the study a chronic infectious disease an on-going funded study does currently a genetics component to augment expand current genomics/genetics component enable funded work accomplish larger, complete genomics study would otherwise possible." READS: quot;The Office Strategic Coordination OSC), NHGRI, NIDA, NINDS, NICHD, OAR reserve right withhold funding curtail study an individual award) the event a) substantive changes the agreed-upon work scope which OSC, NHGRI, NIDA, NINDS, NICHD, OAR cannot concur, b) human subject ethical issues may dictate premature termination." SHOULD READ:  "The Office Strategic Coordination OSC), NHGRI, NIDA, NINDS, NICHD, OAR reserve right withhold funding curtail study an individual award) the event a) substantive changes the agreed-upon work scope which OSC, NHGRI, NIDA, NINDS, NICHD, OAR cannot concur, b) human subject ethical issues may dictate premature termination.  term the H3Africa Research Grant award be five years, unless funded grant which is collaborating terminated prior the end the H3Africa Research Grant's funding period.  that case, Office Strategic Coordination OSC), NHGRI, NIDA, NINDS, NICHD, OAR reserve right consider current status the H3Africa Research grant, progress other factors may relevant order make decision to whether not H3Africa Research Grant be terminated prior its full term." Inquiries Please direct inquiries to: Jane L. Peterson, Ph.D. National Human Genome Research Institute National Institutes Health 5635 Fishers Lane, Suite 4076, MSC 9305 Bethesda, MD 20892-9305 Phone: 301 496 7531 Fax: 301 480 2770 Email: Jane_Peterson@nih.gov H3Africa website: http://H3Africa.org