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Notice NINDS' Participation PA-16-183 Limited Competition: Rare Diseases Clinical Research Network RDCRN) Project Supplements Clinical Trials Repurpose Drugs Collaboration E-Rare Awardees Admin Supp)" Notice Number: NOT-NS-16-030 Key Dates Release Date: June 1, 2016 Related Announcements PA-16-183     Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to inform potential applicants the National Institute Neurological Disorders Stroke NINDS) participate, effective immediately, PAR-16-183, ldquo;Limited Competition: Rare Diseases Clinical Research Network RDCRN) Project Supplements Clinical Trials Repurpose Drugs Collaboration E-RARE Awardees Admin Supp)".  following sections been updated reflect participation NINDS this PAR: nbsp; Part 1. Overview Information Components Participating Organizations National Heart, Lung, Blood Institute NHLBI) National Center Advancing Translational Sciences NCATS) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Allergy Infectious Diseases NIAID)  National Institute Neurological Disorders Stroke NINDS) Catalog Federal Domestic Assistance CFDA) Number(s) 93.350, 93.855, 93.856, 93.847, 93.846, 93.837, 93.838, 93.839, 93.233, 93.840, 93.853 other aspects this FOA remain unchanged. Inquiries Please direct inquiries to: Jill Morris Program Director, NINDS Telephone: 301-496-5745 Email: jill.morris@nih.gov  

Notice Clarification Research Areas Included PAR-16-106 Rapid Assessment Zika Virus ZIKV) Complications R21)” Notice Number: NOT-NS-16-027 Key Dates Release Date: 27, 2016 Related Announcements PAR-16-106  Issued National Institute Neurological Disorders Stroke NINDS) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Allergy Infectious Diseases NIAID) National Institute Dental Craniofacial Research NIDCR) National Eye Institute NEI) National Institute Biomedical Imaging NIBIB) National Heart, Lung, Blood Institute NHLBI) Division Program Coordination, Planning Strategic Initiatives, Office Research Infrastructure Programs ORIP) Purpose purpose this Notice to clarify areas high priority research are included the focus the funding opportunity announcement PAR-16-106, quot;Rapid Assessment Zika Virus ZIKV) Complications R21)".  the time publication this funding opportunity announcement, data not yet available the association ZIKV Guillain-Barré Syndrome GBS) other neurological complications adults.  that such data emerging, Notice intended amend list possible areas high priority include: Studies Guillain-Barré Syndrome GBS), encephalitis encephalomyelitis associated ZIKV infection determine disease course outcomes, causality, disease mechanisms, effectiveness current treatments to develop novel treatments. Notice also intended encourage immunologists apply expertise understanding treating immune mechanisms ZIKV-associated GBS other neurological complications. other aspects the FOA remain same. Inquiries Please direct inquiries to: Wong, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-1431 Email:  wongm@ninds.nih.gov

Request Information RFI): Guidance Opportunities Neuroethics NIH BRAIN Initiative) Notice Number: NOT-MH-16-014 Key Dates Release Date: 27, 2016 Response Date: July 29, 2016 Related Announcements None     Issued NIH BRAIN Initiative braininitiative.nih.gov) National Institute Mental Health NIMH) National Eye Institute NEI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Drug Abuse NIDA) National Institute Neurological Disorders Stroke NINDS) National Center Complementary Integrative Health NCCIH) Purpose is Request Information RFI) soliciting input identify set core ethical issues associated research involving human brain resulting advancements neurotechnology research development. Background BRAIN Initiative: Brain Research through Advancing Innovative Neurotechnologies BRAIN) Initiative® aimed revolutionizing our understanding the human brain. accelerating development application innovative technologies, researchers be able produce new dynamic picture the brain that, the first time, show individual cells complex neural circuits interact both time space. work well underway http://www.braininitiative.nih.gov) the application the innovative tools technologies ultimately lead new ways treat prevent brain disorders. NIH one several federal agencies involved the BRAIN Initiative. Planning the NIH component the BRAIN initiative guided the long-term scientific plan, ldquo;BRAIN 2025: Scientific Vision,” details seven high-priority research areas calls a sustained federal commitment 4.5 billion over 12 years. address current challenges lay more stable foundation future generations researchers, NIH seeking input the community opportunities areas/topics where ethical issues related neuroscience research might considered. overall aim to integrate ethical insight progress under BRAIN Initiative, proactively consider ethical implications the research. Information Requested NIH strives maximize impact the taxpayers’ investments biomedical research. Specific this RFI, input researchers, academic institutions, professional societies other stakeholders solicited potential topics explore where BRAIN Initiative might invest resources the area neuroethics, particularly pertaining emerging neurotechnologies. While welcome input the community any areas germane neuroethics, are particularly interested feedback the following topics: Areas policy guidance might useful Principal Investigators Institutional Review Boards regarding emerging neuroethics issues associated neurotechnology research development. welcome responses point specific strengths weaknesses current policies suggestions how can expand and/or improve policies. evolving breadth neural data associated issues such as: should own data research participant, investigator, institution, public)? Storage data the cloud, via federated databases?) security concerns should access these data whom, quickly, how long, types data)? Privacy concerns protection discrimination those whose neural data shared Unintended uses data Special considerations associated novel neuromodulation neuroimaging technologies: Activation monitoring devices does it, is done) Responsibility the long-term maintenance such devices Security regarding telemetry data remote storage devices Potential culpability concerns regarding predictions neural data Informed consent issues, specifically pertaining studies using novel neurotechnologies Establishing greater uniformity the informed consent process participant perspective the consent process consent permits/hinders is possible technological advances Issues special populations such pregnant women, children, those physical and/or intellectual disabilities cognitive impairment to best integrate neuroethics, appropriate, workshops training opportunities when communicating neuroscience research findings to: Press Lay public Political leaders Scientific Community Translation new tools technologies neuroscience research contexts beyond clinic/bench: Ethics commercialization, public-private partnerships, wider application imaging technologies commercial purposes, conflicts interest use ex vivo human brain tissue; including ownership privacy issues Specific neuroethics questions could addressed using focused research approach Any issues respondents feel relevant to Submit Response Responses must submitted electronically through BRAIN-info-nimh@mail.nih.gov July 29, 2016. RFI for planning purposes only should be construed a solicitation applications an obligation the part the government. The government not pay the preparation any information submitted for government’s of information. NIH use information submitted response this RFI its discretion will provide comments any responder's submission. Responses the RFI be reflected future funding opportunity announcements. information provided be analyzed, appear reports, may shared publicly an NIH website. Respondents advised the government under obligation acknowledge receipt the information provide feedback respondents respect any information submitted. proprietary, classified, confidential, sensitive information should included your response. government reserves right use any non-proprietary technical information any resultant solicitation(s), policies procedures. Inquiries Please direct inquiries to: Email: BRAIN-info-nimh@mail.nih.gov  

Notice the Extension the Expiration Date PAR-13-281 NINDS Exploratory Clinical Trials R01)" Notice Number: NOT-NS-16-029 Key Dates Release Date: 25, 2016 Related Announcements PAR-13-281  Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice inform interested applicants the expiration date PAR-13-281 NINDS Exploratory Clinical Trials R01)" be extended one funding cycle. Key Dates table updated accordingly: Part 2. Key Dates Posted Date July 22, 2013 Open Date Earliest Submission Date) September 5, 2013 Letter Intent Due Date(s) Applicable Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2017 Due Dates E.O. 12372 Applicable Inquiries Please direct inquiries to: Peter Gilbert National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-0870 Email: gilbertp@ninds.nih.gov  

Request Information: Soliciting Input New Research Strategies Myalgic Encephalomyelitis/Chronic Fatigue Syndrome ME/CFS) Notice Number: NOT-NS-16-024 Key Dates Release Date: 24, 2016 Response Date: June 24, 2016   Related Announcements None     Issued National Institute Neurological Disorders Stroke NINDS) National Heart, Lung, Blood Institute NHLBI) National Institute Aging NIA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute Mental Health NIMH) National Institute Nursing Research NINR) National Library Medicine NLM) National Center Complementary Integrative Health NCCIH) National Center Advancing Translational Sciences NCATS)  Purpose Trans-National Institutes Health NIH) ME/CFS Working Group developing new strategies guide NIH's research efforts priority setting research ME/CFS.  Seeking input the planning process through Request Information RFI) critical identification consideration research areas topics be included future efforts.  members the Trans-NIH ME/CFS Working Group review consider comments received under RFI regard current future needs direction ME/CFS research research training. Information Requested Through RFI, Trans-NIH ME/CFS Working Group invites input researchers, health care providers, patient advocates health advocacy organizations, scientific professional organizations, Federal agencies, other interested parties.  Organizations strongly encouraged submit single response reflects views their organization membership a whole. Please provide perspective the following issues they relate the Working Group's planning efforts: Emerging needs opportunities should considered new ME/CFS research strategies developed. Challenges barriers progress research ME/CFS. Gaps opportunities across research continuum basic through clinical studies. commenting a research need scientific opportunity, Working Group suggests your comments contain following our full consideration: Description the need opportunity Scientific rationale potential public health impact Anticipated challenges will need be addressed Appropriate benchmarks evaluating progress. this RFI, NIBIB interested the ideas the development new imaging bioengineering technologies could the potential a significant impact ME/CFS research. Trans-NIH ME/CFS Working Group also welcomes general comments. Responses Responses this RFI must submitted via email MECFSRFI@mail.nih.gov  Responses be accepted through June 24, 2016. Responses voluntary may submitted anonymously.  Respondents advised the Government under obligation acknowledge receipt the information received provide feedback respondents respect any information submitted.  Please not include any personally identifiable other information you not wish make public.  proprietary, classified, confidential, sensitive information should included your response. request for information planning purposes only should be construed a solicitation as obligation the part the United States Government.  Trans-NIH ME/CFS Working Group not any awards based responses this RFI pay the preparation any information submitted for Government's of such information. Inquiries Please direct inquiries to: Vicky Whittemore, PhD National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-1917 Email: vicky.whittemore@nih.gov

Notice the Extension the Expiration Date PAR-13-278 NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)" Notice Number: NOT-NS-16-028 Key Dates Release Date: 24, 2016 Related Announcements PAR-13-278     Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice inform interested applicants the expiration date PAR-13-278 quot;NINDS Phase III Investigator-Initiated Efficacy Clinical Trials U01)" be extended one funding cycle. Key Dates table updated accordingly: Part 1. Key Dates Posted Date July 22, 2013 Open Date Earliest Submission Date) September 5, 2013 Letter Intent Due Date(s) Applicable Application Due Date(s) Standard dates apply, 5:00 PM local time applicant organization. types non-AIDS applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. AIDS Application Due Date(s) Standard AIDS dates apply, 5:00 PM local time applicant organization. types AIDS AIDS-related applications allowed this funding opportunity announcement due these dates. Applicants encouraged apply early allow adequate time make any corrections errors found the application during submission process the due date. Scientific Merit Review Standard dates apply Advisory Council Review Standard dates apply Earliest Start Date Standard dates apply Expiration Date January 8, 2017 Due Dates E.O. 12372 Applicable nbsp; Inquiries Please direct inquiries to: Peter Gilbert National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-0870 Email: gilbertp@ninds.nih.gov  

Notice Travel Support PDs/PIs NINDS-Funded Institutional Training T32) Programs Attend NINDS T32 Regional Meetings Notice Number: NOT-NS-16-025 Key Dates Release Date:   May 10, 2016 Related Announcements NOT-NS-14-026 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice supersedes NOT-14-NS-026, establishes maximum travel support NINDS award T32 PDs/PIs cover costs associated attending T32 Regional Meetings. NINDS supports institutional training programs T32s) both predoctoral postdoctoral fellows are intended develop strong next generation neuroscientists engaged research NINDS-mission relevant research-associated occupations. programs expected facilitate development a highly qualified, diverse workforce. purpose this Notice to inform awardees NINDS T32 training programs it continue holding periodic meetings among PDs/PIs, to offset costs associated attendance these meetings, NINDS provide to 700 direct cost directly the T32 grants grant PDs/PIs their designees attend meetings.  meetings scheduled, Director, NINDS Office Training, Career Development Workforce Diversity notify PDs/PIs additional information, including instructions requesting funds. Inquiries Please direct inquiries to: Letitia Weigand, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:  301-496-4188 Email: letitia.weigand@nih.gov

Notice Clarify PAR-15-146 Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)" Notice Number: NOT-NS-16-026 Key Dates Release Date: 5, 2016 Related Announcements PAR-15-146    Issued National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to amend Award Information section, the Application Submission section PAR-15-146 quot;Countermeasures Against Chemical Threats CounterACT) Research Centers Excellence U54)". Part 2. Section II. Award Information Award Budget FOA currently reads: Application budgets not limited need reflect actual needs the proposed project. most studies within scope this FOA, anticipated direct cost individual awards 2-3 million per year a total 10-15 million over maximum five-year project period. is modified read: Application budgets not exceed 2.5 million direct costs per year over. applications not need request maximum budget the size duration the awards vary depending upon nature scope research programs. Section IV. Application Submission Information 6. Submission Requirements Information FOA currently reads: Requests 500,000 more direct costs any year Applicants requesting 500,000 more direct costs any year excluding consortium F&A) must contact NIH program staff least 6 weeks before submitting application follow Policy the Acceptance Review Unsolicited Applications Request 500,000 More Direct Costs described the SF424 R&R) Application Guide. is modified read: Applicable nbsp; other aspects this FOA remain same. Inquiries Please direct inquiries to: David A. Jett, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-6035 Email: jettd@ninds.nih.gov

Notice Extend PA-13-216 Research Autism Spectrum Disorders R01)" Notice Number: NOT-MH-16-009 Key Dates Release Date:   May 2, 2016 Related Announcements PA-13-216     Issued National Institute Mental Health NIMH) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Environmental Health Sciences NIEHS) National Institute Neurological Disorders Stroke NINDS) Purpose purpose this Notice to extend PA-13-216 “Research Autism Spectrum Disorders R01)" invites applications support research designed elucidate etiology, epidemiology, diagnosis, treatment, optimal means service delivery relation autism spectrum disorders ASD).  current expiration date May 8, 2016. new expiration date September 8, 2016. other aspects this FOA remain same. Inquiries Please direct inquiries to: Lisa Gilotty, Ph.D. National Institute Mental Health NIMH) Telephone: 301-443-3825 Email: gilottyl@mail.nih.gov

Notice Intent Publish Funding Opportunity Announcement NINDS Postdoctoral Training F32) Includes Specific Eligibility Requirements Notice Number: NOT-NS-16-012 Key Dates Release Date:   May 2, 2016 Estimated Publication Date Announcement: August 2016  First Estimated Application Due Date: December 2016 Earliest Estimated Award Date: 2017  Earliest Estimated Start Date: June 2017 Related Announcements NOT-NS-16-013 NOT-NS-17-002 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institutes Neurological Disorders Stroke NINDS) intends restructure support postdoctoral researchers publishing Funding Opportunity Announcements FOAs) solicit applications support postdoctoral research training career development. FOA described this Notice utilize F32 activity code another FOA utilize K01 activity code NOT-NS-16-013) NINDS F32 FOA intended facilitate early planning creative, innovative projects well-designed training experiences conceived discussions between excellent candidates outstanding mentors. aid the early planning support highly significant, creative innovative projects, preliminary data be expected the application. Starting the first application due date this FOA estimated be December, 2016), NINDS only accept F32 applications candidates who, the due date, within year prior joining postdoctoral laboratory are within first year their research experience the laboratory which training proposed. F32 only support postdoctoral fellows while are within first 3 years research training any specific laboratory research environment candidates apply an F32 a second postdoctoral laboratory experience, must apply prior to, within first year of, joining second postdoctoral laboratory). Simultaneously the first due date this FOA, NINDS cease accepting F32 applications response the omnibus NIH F32 FOA. NINDS also intends issue FOA solicit K01 applications candidates a Ph.D. equivalent research doctoral degree NOT-NS-16-013 details). Candidates be eligible apply this K01 anytime within second through fourth year cumulative postdoctoral research experience, may supported the NINDS K01 within first 6 years cumulative postdoctoral research experience. Notice being provided allow potentially eligible applicants sufficient time develop plans their upcoming postdoctoral training. Similarly, Notice informs postdoctoral fellows will been their current postdoctoral laboratory more a year December, 2016 their final opportunity apply support an NINDS F32 that laboratory, response PA-14-149 its reissue , expected be August, 2016 receipt date. new NINDS F32 FOA expected be published the fall 2016, an expected initial application due date December, 2016. Research Initiative Details Notice encourages graduate students postdoctoral fellows have identified postdoctoral research mentor who within time window spans year before one year after entering postdoctoral laboratory the December 2016 application due date begin consider applying this new FOA. research areas within NINDS mission, all types research fundamental basic research, disease-related basic research, clinical research translational research), encouraged. key aspect the F32 FOA the expectation NO preliminary data be required. NINDS seek applications propose highly significant highly innovative projects excellent candidates working outstanding mentors. Consequently, applications should contain carefully planned, well-integrated research training plans, devised prepared close collaboration between applicant mentor(s). Applications should contain clearly described plans accomplish highly significant research critical training goals. unique aspect this FOA the goal supporting innovative, creative perhaps bold research ideas without delay associated the need the applicant collect high quality data prior obtaining support. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Stephen Korn, Ph.D. National Institute Neurological Disorders Stroke NINDS) Telephone:301-496-4188 Email: korns@ninds.nih.gov