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Change Procedure Requests NINDS Administrative Research Supplements Promote Diversity Re-entry Health-Related Research PA-08-190 PA-08-191) Notice Number: NOT-NS-11-010 Key Dates Release Date: February 9, 2011 Issued National Institute Neurological Disorders Stroke NINDS) Purpose Notice to inform scientific community the NINDS amending procedures Program Announcements PA-08-190 Research Supplements Promote Diversity Health-Related Research” PA-08-191 Supplements Promote Re-entry Biomedical Behavioral Research Careers” follows: NINDS strongly encourages electronic submission the completed request, including appropriate signatures supporting documents, a single PDF document. subject line the email should contain only phrase, NINDS DIVERSITY SUPPLEMENT APPLICATION PDF”, all caps. Complete applications should submitted the email address below: NINDSDiversityTraining@ninds.nih.gov information also provided the Table IC contacts information associated each supplement FOA: PA-08-190 Table, PA-08-191 Table. other aspects PA-08-190 PA-08-191 remain unchanged. Paper submissions continue be mailed the following address: Melissa R. Copeland Grants Management Specialist, Division Extramural Research National Institute Neurological Disorders Stroke NINDS) 6001 Executive Blvd. NSC/Rm. 3260 Bethesda, MD 20892-9537 Rockville, MD 20852 Express Mail) Inquiries Inquiries concerning NINDS Supplement Program should directed to: Michelle D. Jones-London, Ph.D. Program Director National Institute Neurological Disorders Stroke, NIH Office Minority Health Research 6001 Executive Blvd, NSC, Suite 2149 Bethesda, MD 20892-9535 Rockville, MD 20852 Express/Courier Service) Telephone: 301) 451-7966 FAX: 301) 594-5929 Email: jonesmiche@ninds.nih.gov 

Applications the Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program the Neurosciences T32) Not Accepted 2011 Notice Number: NOT-NS-11-009 Key Dates Release Date: January 21, 2011 Issued National Institute Neurological Disorders Stroke NINDS) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) Purpose Funding Opportunity Announcement FOA) the Jointly Sponsored Ruth L. Kirschstein National Research Service Award Institutional Predoctoral Training Program Neurosciences JSPTPN; PAR-10-116) expired. purpose this Notice to inform extramural community a new FOA this program not reissued submission applications the 25, 2011 receipt date. NIH institutes above committed the continuation a broad-based, early stage predoctoral training program neurosciences, plan issue new FOA this program time receipt applications May 2012. Inquiries Direct questions this Notice to: Stephen J. Korn, Ph.D. Chair, JSPTPN Steering Committee Director Training Career Development NIH/NINDS e-mail: korns@ninds.nih.gov

NHLBI Announces Participation PA-10-056, Mentored Research Scientist Development Award Parent K01)” Notice Number: NOT-HL-11-114 Key Dates Release Date: January 14, 2011 Issued National Human Genome Research Institute NHGRI), http://www.nhgri.nih.gov/) National Heart, Lung, Blood Institute NHLBI), http://www.nhlbi.nih.gov) National Institute Aging NIA), http://www.nia.nih.gov/) National Institute Alcohol Abuse Alcoholism NIAAA), http://www.niaaa.nih.gov/) National Institute Allergy Infectious Diseases NIAID), http://www.niaid.nih.gov/) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS), http://www.niams.nih.gov/) National Institute Biomedical Imaging Bioengineering NIBIB), http://www.nibib.nih.gov/) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD), http://www.nichd.nih.gov/) National Institute Deafness Other Communication Disorders NIDCD), http://www.nidcd.nih.gov) National Institute Diabetes Digestive Kidney Diseases NIDDK), http://www.niddk.nih.gov/) National Institute Drug Abuse NIDA), http://www.nida.nih.gov/) National Institute Environmental Health Sciences NIEHS), http://www.niehs.nih.gov) National Institute Mental Health NIMH), http://www.nimh.nih.gov/) National Institute Neurological Disorders Stroke NINDS), http://www.ninds.nih.gov/) National Institute Nursing Research NINR), http://ninr.nih.gov/) National Center Complementary Alternative Medicine NCCAM), http://www.nccam.nih.gov/) National Center Research Resources NCRR), http://www.ncrr.nih.gov/) Purpose Notice to inform potential applicants the NHLBI announces participation, effective February 12, 2011, PA-10-056, Mentored Research Scientist Development Award Parent K01).” NHLBI seeks career training applications the following focused research areas: Highly innovative epidemiological research elucidates mechanisms, etiology, pathogenesis, prevention, diagnosis treatment heart, lung, blood diseases sleep disorders. Biostatistics research leading the development new methods designing analyzing clinical studies, including clinical trials, epidemiologic genetics studies heart, lung, blood diseases sleep disorders. Comparative effectiveness research involves comparison screening, diagnostic, preventive treatment strategies heart, lung, blood diseases sleep disorders using appropriate methods randomized controlled trials the analysis electronic medical records. research project proposed must relevant the mission the NHLBI must focused one more the target areas listed above. Training should ensure candidates develop relevant research skills, gain knowledge state-of-the art concepts, advanced methods experimental approaches will allow to become independent investigators play leading roles these areas. Professionals quantitative e.g., mathematics, statistics, economics, computer science, imaging science, informatics, physics, chemistry) engineering backgrounds wish gain fundamental knowledge develop research skills biomedicine, bioengineering, bioimaging, behavioral research should apply the Mentored Quantitative Research Career Development Award K25). The NHLBI also participates the K08 K23 programs focus research training clinical scientists clinically trained professionals wish conduct basic patient-oriented research respectively. NHLBI does support projects primarily focused malignancy-related research. Studies address mechanistic correlation between cancer i.e., lung cancer) primary pulmonary diseases be considered within mission the NHLBI. Applications vaccine development be considered outside NHLBI’s focused intent this Funding Opportunity Announcement FOA). Applications respiratory pathogens be considered within NHLBI’s intent this FOA studies focus the host immune response. potential overlapping areas interest shared the NHLBI other Institutes/Centers the NIH include myeloproliferative myelodysplastic disorders, hematological malignancies resulting disruptions hematopoiesis, the of hematopoietic stem cell transplantation other cellular therapies. Therefore, applicants strongly encouraged contact NHLBI before submitting application determine NHLBI programmatic appropriateness this FOA. other aspects the FOA remain unchanged. Inquiries Lorraine M. Silsbee, M.H.S. Division Cardiovascular Sciences National Heart, Lung, Blood Institute 6701 Rockledge Drive, MSC 7936 Bethesda, MD 20892-7936 Express mail zip: 20817) Telephone: 301) 435-0709 FAX: 301) 480-1455 Email: silsbeeL@nhlbi.nih.gov Jane D. Scott, ScD, MSN, FAHA Director, Office Research Training Career Development, Division Cardiovascular Sciences DCVS - responding all NHLBI programmatic Divisions) National Heart, Lung, Blood Institute NHLBI), NIH Rockledge II, 8138, 6701 Rockledge Drive Bethesda, Maryland 20892-7940 Telephone: 301) 435-0535 Email: scottj2@nhlbi.nih.gov

Notice Correction the Non-AIDS Related Application Due Dates PAR-11-031, Brain Disorders the Developing World: Research Across Lifespan R21) Notice Number:  NOT-TW-11-007 Key Dates Release Date:   December 22, 2010 Issued Fogarty International Center FIC) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Institute Minority Health Health Disparities NIMHD) Office Dietary Supplements ODS) Autism Speaks www.autismspeaks.org) Purpose purpose this Notice to inform scientific community the Non-AIDS Related Application Due Dates PAR-11-031, Brain Disorders the Developing World: Research Across Lifespan R21), published November 12, 2010, incorrectly listed January 10, 2010, January 10, 2011, January 10, 2012 5:00 PM local time applicant organization.  correct Non-AIDS Related Application Due Dates January 10, 2011, January 10, 2012, January 13, 2013 5:00 PM local time applicant organization. other aspects the funding opportunity announcement remain same. Inquiries Please direct inquiries to: Kathleen Michels, Ph.D. Program Director Division International Training Research Fogarty International Center 31 Center Drive, MSC-2220 Building 31, Room B2-C39 Bethesda, MD 20892-2220 Telephone:  301-496-1653 Fax:  301-402-0779 Email:  brainfic@nih.gov

Collaborative Research Computational Neuroscience CRCNS) Innovative Approaches Science Engineering Research Brain Function R01] Notice Number:  NOT-NS-11-006 Key Dates Release Date: December 20, 2010 Receipt Dates: February 16, 2011, November 2, 2011 November 2, 2012   Related Notices NSF 11-505 http://www.nsf.gov/pubs/2011/nsf11505/nsf11505.htm) Issued National Science Foundation NSF) National Institute Neurological Disorders Stroke NINDS) National Institute Mental Health NIMH) National Institute Drug Abuse NIDA) National Institute Deafness Other Communication Disorders NIDCD) National Eye Institute NEI) National Institute Biomedical Imaging Bioengineering NIBIB) National Institute Alcohol Abuse Alcoholism NIAAA) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Center Complementary Alternative Medicine NCCAM) Federal Ministry Education Research Bundesministerium für Bildung und Forschung, BMBF), Germany http://www.bmbf.de/) Purpose Notice announces re-issue a joint initiative, Collaborative Research Computational Neuroscience CRCNS), among seven National Science Foundation NSF) Directorates Offices DOs), nine participating National Institutes Health NIH) Institutes Centers ICs). CRCNS announcement released under NSF 11-505 http://www.nsf.gov/pubs/2011/nsf11505/nsf11505.htm).  announcement supersedes NSF 08-514 NSF 09-60: Collaborative Research Computational Neuroscience CRCNS) – Innovative Approaches Science Engineering Research Brain Function.  German Federal Ministry Education Research Bundesministerium für Bildung und Forschung, BMBF http://www.bmbf.de/) now formal partner this program, along the NSF the NIH.  NIH, CRCNS now affiliated the NIH Blueprint Neuroscience Research http://neuroscienceblueprint.nih.gov). Computational neuroscience provides theoretical foundation a rich set technical approaches understanding complex neurobiological systems, building the theory, methods, findings computer science, neuroscience, numerous disciplines.  Through CRCNS program, participating NSF DOs, NIH ICs BMBF support innovative interdisciplinary collaborative research make significant advances the understanding structures functions the nervous system, mechanisms underlying nervous system disorders, computational strategies used the nervous system. participating agencies recognize need research focuses integrating computational models methods neuroscience.  solicitation designed encourage new collaborations this interface.  Appropriate scientific areas investigations those are currently supported NSF NIH, related the missions the agencies.  participating this broadly based program cooperation between agencies, NIH focus creating new research teams biomedical quantitative scientists explore questions directly relevant the missions participating NIH ICs. Three classes proposals be considered response this solicitation: Research proposals - describing new collaborative research projects US-German Research Proposals - describing international collaborative research projects be funded parallel US German agencies Data Sharing Proposals - enable sharing data other resources Appropriate scientific areas investigations those related the mission participating funding agencies. Questions concerning particular project’s focus, direction relevance a participating funding agency should addressed the appropriate person the list agency contacts the NSF Program Solicitation NSF 11-505, http://www.nsf.gov/pubs/2011/nsf11505/nsf11505.htm). computational research supported under program must impact on, relate biological processes, optimally generate hypotheses are testable biological studies.  is expected that: 1) applications include collaborations among computational and/or modeling experts, theorists, experimental neuroscientists; 2) collaborations involve dynamic and, possibly, protracted period model theory development refinement, intense interaction among scientists engineers different disciplines; 3) development testing new models theories provide framework the design experiments the generation new hypotheses can help reveal mechanisms underlying normal disease states the nervous system, 4) development distribution professional quality software tools e.g., modeling algorithms analytic tools). Award Information Award sizes research projects expected range approximately 100,000 250,000 per year direct costs, durations three five years.  awards be the smaller end this range; award exceed 250,000 per year direct costs.  Applicants strongly discouraged requesting greater budgets are necessary the activities being proposed. is estimated data sharing projects range approximately 25,000 100,000 cumulative award size a one- three-year project. Estimated program budget, number awards average award size duration subject the availability funds. Upon conclusion the review process, meritorious applications be recommended funding either participating NSF DOs NIH ICs, the option the agencies, the applicant.  Data sharing proposals be funded only NSF. Subsequent grant administration procedures be accordance the individual policies the awarding agency. Proposal Preparation Submission Instructions Applications submitted response this program announcement/solicitation should prepared submitted accordance the general guidelines contained the NSF Grant Proposal Guide GPG).  Applications must submitted the NSF, to NIH.  complete text the GPG available electronically the NSF Web Site at: http://www.nsf.gov/publications/pub_summ.jsp?ods_key=gpg. Applicants reminded identify program announcement number 11-505) the program announcement block the NSF Cover Sheet Proposal the National Science Foundation.  Compliance this announcement critical determining relevant proposal processing guidelines.  Failure submit information delay processing. Budgetary Information Cost sharing not required NSF proposals submitted under Program Solicitation. Budgets should include travel funds the PI team members attend annual CRCNS Principal Investigators' meeting. NIH Process those proposals are selected potential funding participating NIH ICs, PI be required resubmit proposal an NIH-approved format directly the Center Scientific Review http://www.csr.nih.gov/) the NIH.  PIs invited resubmit NIH receive further information resubmission procedures the NIH. applicant not allowed increase proposed budget change scientific content the application the resubmission the NIH. applications where principal investigators at different institutions, applicants be expected utilize Multiple Principal Investigator option the NIH http://grants.nih.gov/grants/multi_PI/) appropriate.  NIH applications be entered the NIH IMPAC II system. results the review be presented the involved IC's National Advisory Councils the second level review. Subsequent the Council reviews, NIH ICs make funding determinations selected awards be made.  Subsequent grant administration procedures NIH awardees, including those related New Early Stage Investigators http://grants.nih.gov/grants/new_investigators/) be accordance the policies NIH. Applications selected NIH funding use NIH R01 funding mechanism. Please note applications submitted the NSF February 16, 2011, selected potential funding the participating NIH ICs, have extremely short conversion time.  applicants be notified the end March, 2011, the resubmission be due the NIH April 6, 2011.  Applicants wish give Grants Office advance notice this timetable. Inquiries Written telephone inquiries encouraged.  Please the NSF program announcement names contact information each the participating NSF DOs and/or NIH ICs http://www.nsf.gov/crcns. .

Pre-application Meeting the Network Excellence Neuroscience Clinical Trials NEXT) Notice Number: NOT-NS-11-005 Key Dates Release Date: December 7, 2010 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) hold pre-application meeting regarding Request Applications RFA) Clinical Research Sites the Network Excellence Neuroscience Clinical Trials RFA-NS-11-008), the Clinical Coordinating Center RFA-NS-11-009), for Data Coordinating Center RFA-NS-11-010). meeting intended be informative all prospective applicants consider responding these Funding Opportunity Announcements FOAs). NINDS Program Review Staff provide overview the network initiative will explain specific aspects the FOAs a brief presentation followed a question answer session. Participation the meeting, although encouraged, optional not required application submission.   Questions prior and during meeting be submitted e-mail NEXT@ninds.nih.gov. Research Initiative Details Title: Pre-application Meeting the NINDS NEXT Initiative Location: 6001 Executive Boulevard, Rockville, MD, Conference Room 2172 Date: Friday, December 17, 2010 Time: 12:00 PM - 1:00 PM GMT - 05:00) ET U.S. Canada). Teleconference: 1-800-988-9536 (U.S. only) Participant Code:     54989 Webinar: https://webmeeting.nih.gov/r59127599/ Access: Anyone has URL the meeting enter room Prospective applicants interested attending meeting person asked provide advance contact below) names, contact information, institutional affiliation. informal registration optional is primarily planning purposes. Please advised the NINDS not cover expenses attend meeting. Inquiries Please direct inquiries to: Crina Frincu, PhD National Institute Neurological Disorders Stroke 6001 Executive Boulevard, Room 2192 Rockville, MD 20852 Telephone: 301-496-5446 Email: NEXT@ninds.nih.gov

Pre-application Meeting RFA-NS-11-005 - Clinical Data Coordinating Center(s) Parkinson's Disease Biomarkers Identification Network PD-BIN) U01) Notice Number:  NOT-NS-11-003 Key Dates Release Date:   November 24, 2010 Pre-Application Meeting Date: December 17, 2010 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke NINDS) hold pre-application meeting regarding RFA-NS-11-005 http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-11-005.html), Clinical Data Coordinating Center(s) Parkinson’s Disease Biomarkers Identification Network PD-BIN) U01), which prospective applicants invited. is intended explain goals objectives this initiative answer questions prospective applicants. Participation this meeting neither required nor necessary a successful application. Details Meeting: Title: Pre-application Meeting RFA-NS-11-005 When: Friday, December 17th, 2010; 3:00pm-4:00pm Time Zone: GMT - 05:00) Eastern Time US Canada) Website: https://webmeeting.nih.gov/pdbinccc-dccrfa/ Telephone information audio): Conference number US Participants): 1-866-692-4538 Participant Code: 2145501 Non-US participants, please email contact listed below call-in information your specific location be provided. Please email questions advance, wished, the below contact. While effort be to include questions, is possible not will addressed during meeting due time constraints. Inquiries questions further information, contact: Katrina Gwinn MD National Institute Neurological Disorders Stroke 6001 Executive Blvd Room 2143 Bethesda MD 20892 Telephone: 301-496-5745 Fax: 301-502-1501 Email: gwinnk@ninds.nih.gov

Notice Intent Publish Limited Competition Program Announcement Applications Rare Diseases Clinical Research Consortia RDCRC) the Rare Diseases Clinical Research Network U54) Notice Number:  NOT-NS-11-004 Key Dates Release Date:   November 24, 2010 Issued National Institute Neurological Disorders Stroke NINDS) Office Rare Diseases Research ORD) Purpose National Institute Neurological Disorders Stroke NINDS), the NIH Office Rare Diseases Research ORDR), intend publish Funding Opportunity Announcement FOA) solicit applications research rare diseases via Rare Diseases Clinical Research Network.  FOA be limited competition available only the current American Recovery Reinvestment Act ARRA)-supported Rare Disease Clinical Research Consortia awardees.  Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.  FOA expected be published the winter 2011 a receipt date the spring 2011. FOA utilize U54 activity code. Details the planned FOA provided below. Research Initiative Details Notice encourages investigators expertise insights the area rare neurological disorders begin consider applying this limited competition FOA.  objective to facilitate clinical research rare diseases through support for: 1) collaborative clinical research rare diseases, including longitudinal studies individuals rare diseases, clinical studies and/or phase I, II II/III trials; 2) training clinical investigators rare diseases research; 3) pilot demonstration projects; 4) access information related rare diseases basic clinical researchers, academic practicing physicians, patients, the lay public.  total project period an application submitted response this FOA not exceed 3 years. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Randall R. Stewart, PhD Program Director National Institute Neurological Disorders Stroke 6001 Executive Blvd., Room 2135 Bethesda, MD 20892 Telephone: 301-496-1917 Fax:  301-402-1501 stewartr@ninds.nih.gov

Correction RFA-CA-10-017, quot;Scientific Meetings Creating Interdisciplinary Research Teams Basic Behavioral Social Science Research R13)," Order Simplify Submission Requirements Notice Number:  NOT-CA-11-001 Key Dates Release Date: November 18, 2010 Related Notices None Issued NIH Basic Behavioral Social Science Opportunity Network OppNet; http://oppnet.nih.gov/) and, member institutes, centers, offices) National Cancer Institute NCI) National Center Minority Health Health Disparities NCMHD) nbsp; National Eye Institute NEI) National Heart, Lung, Blood Institute NHLBI) National Human Genome Research Institute NHGRI) National Institute Aging NIA) National Institute Alcohol Abuse Alcoholism NIAAA) National Institute Allergy Infectious Diseases NIAID) National Institute Arthritis Musculoskeletal Skin Diseases NIAMS) National Institute Biomedical Imaging Bioengineering NIBIB) Eunice Kennedy Shriver National Institute Child Health Human Development NICHD) National Institute Deafness Other Communication Disorders NIDCD) National Institute Dental Craniofacial Research NIDCR) National Institute Diabetes Digestive Kidney Diseases NIDDK) National Institute Drug Abuse NIDA) National Institute Environmental Health Sciences NIEHS) National Institute General Medical Sciences NIGMS) National Institute Mental Health NIMH) National Institute Neurological Disorders Stroke NINDS) National Institute Nursing Research NINR) National Library Medicine NLM) Fogarty International Center FIC) National Center Complementary Alternative Medicine NCCAM) National Center Research Resources NCRR) Office AIDS Research OAR) Office Behavioral Social Sciences Research OBSSR) Office Dietary Supplements ODS) Office Disease Prevention ODP)  Office Research Women’s Health ORWH) Purpose purpose this Notice to correct RFA-CA-10-017, quot;Scientific Meetings Creating Interdisciplinary Research Teams Basic Behavioral Social Science Research R13)," eliminating requirement a quot;Permission-to-Submit Letter" the appropriate NIH Institute Center IC) Conference Grant Contact. such quot;Permission-to-Submit Letter" required order submit application.  Thus, Section IV.2 Content Form Application Submission RFA-CA-10-017, last item the block subtitled quot;Required Components" changed from: quot;PHS398 Cover Letter File, including Permission-to-Submit Letter appropriate IC Conference Grant Contact" quot;PHS398 Cover Letter File." other aspects RFA-CA-10-017 remain unchanged. Inquiries Please direct inquiries to: Kara L. Hall, Ph.D. Behavioral Research Program Division Cancer Control Population Sciences National Cancer Institute NCI) 6130 Executive Boulevard, EPN Room 4078, MSC 7326 Bethesda, MD 20892-7326 U.S. Postal Service express regular mail) Rockville, MD 20852 non-USPS delivery) Telephone: 301-594-9056 Fax: 301-480-2087 Email: hallka@mail.nih.gov Lis Nielsen, Ph.D. Division Behavioral Social Research National Institute Aging NIA) 7201 Wisconsin Avenue, 533 Bethesda, MD 20892-9205 Telephone: 301-402-4156 Fax: 301-402-0051 Email: nielsenli@nia.nih.gov Mariela C. Shirley, Ph.D. Division Epidemiology Prevention Research DEPR) National Institute Alcohol Abuse Alcoholism NIAAA) 5635 Fishers Lane, Room 2086, MSC 9304 Bethesda, MD 20892-9304 U.S. Postal Service express regular mail) Rockville, MD 20852-1705 non-USPS delivery) Telephone:  301-443-9787 Fax: 301-443-8614 Email:  shirleym@mail.nih.gov

Notice Intent Publish Request Applications Core Cohort Discovery Validation Studies the Parkinson's Disease Biomarkers Identification Network PD-BIN) U01) Notice Number:  NOT-NS-11-001 Key Dates Release Date:   November 10, 2010 Issued National Institute Neurological Disorders Stroke NINDS) Purpose National Institute Neurological Disorders Stroke intends promote new initiative publishing Funding Opportunity Announcement FOA) solicit applications hypothesis-driven clinical research studies will accelerate augment discovery biomarkers a component the NINDS Parkinson's Disease Biomarkers Identification Network PD-BIN). Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects.   FOA expected be published late spring, 2011 an expected receipt date fall, 2011. FOA utilize U01 activity code. Details the FOA provided below. Research Initiative Details Notice encourages investigators expertise insights the area clinical Parkinson's disease research biomarker discovery begin consider applying this new Funding Opportunity Announcement FOA).  May 2010, Workshop convened the National Institute Neurological Disorders Stroke NINDS) http://www.ninds.nih.gov/research/parkinsonsweb/PD_meeting_schedule.htm) discuss current state biomarker development PD how discovery, standardization validation biomarkers most effectively facilitate therapy development PD.  Given insights recommendations provided the workshop, Parkinson's Disease Biomarkers Identification Network PD-BIN) being developed part the NINDS response the critical need biomarker development PD. September 2010, RFA NS-11-005; http://grants.nih.gov/grants/guide/rfa-files/RFA-NS-11-005.html) released linked U01s a Clinical Coordinating Center CCC) Data Coordinating Center DCC) the initial step the Parkinson's Disease Biomarker Identification Network PD-BIN). CCC under intended award include sites will recruit characterize core cohort de novo subjects Parkinson's disease control subjects be evaluated a longitudinal manner.  FOA not allow hypothesis driven research. purpose this Notice to inform potential applicants the intention develop initiative will enable hypothesis-driven studies validate promising biomarkers require active participation the core cohort may include clinical imaging studies).  timing this intended FOA be such measures be integrated the longitudinal planning efforts the CCC DCC.  projects under PD-BIN program expected fully cooperate and utilize core resources the PD-BIN CCC-DCC biorepository order allow full sharing future cross sectional well longitudinal studies members the Network. FOA not include cohort studies, animal studies, assay design, other laboratory based studies, are expected be solicited via different mechanisms the future. APPLICATIONS NOT BEING SOLICITED THIS TIME. Inquiries Please direct inquiries to: Katrina Gwinn, M.D. National Institute Neurological Disorders Stroke NINDS) Telephone: 301-496-5745 Email: gwinnk@ninds.nih.gov