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The purpose of this funding opportunity announcement (FOA) is to invite applications to participate as the National Data Management Center (NDMC) for the NIH Stroke Trials Network. Established by NINDS in 2013, the goal of the NIH StrokeNet is to harness the leadership and experience of the stroke research field to maximize efficiencies for developing, promoting and conducting high-quality, multi-site clinical trials focused on promising interventions for stroke prevention, treatment, and recovery with the objective of having a balanced portfolio between all three approaches. Multi-site exploratory and confirmatory Phase 3 clinical trials as well as biomarker-validation studies that are immediately preparatory to trials and ancillary studies designed to add scientific aims to active studies will be coordinated through a National Coordinating (NCC) and National Data Management Centers (NDMC) and multiple regional coordinating stroke centers (RCC's) with strong collaborative relationships between vascular neurology, emergency medicine, interventional neuroradiology, neurosurgery, neurointensive care, neuroimaging, stroke rehabilitation, and pediatric neurology. The network will provide a robust, standardized, and accessible infrastructure to provide the development and implementation of protocols in stroke prevention, treatment, and recovery. The NDMC will be responsible for centralizing, harmonizing and coordinating all aspects of data collection for studies conducted in the network. Projects will be developed both from investigators both within the network as well as from investigators or industry partners outside of the network; therefore the data center for the stroke network must be able to efficiently collaborate with all parties. This FOA solicits applications for the National Data Management Center for the Stroke Trials Network. Separate FOAs solicit applications for the Regional Coordinating Stroke Centers and the National Coordinating Center.

This Notice of Special Interest is to advise the research community of NINDS interest in clinical trials to study epidural stimulation in spinal cord injury that meet the requirements of PAR-21-237 NINDS Efficacy Clinical Trials (UG3/UH3 Clinical Trial Required) Funding Opportunity Announcement.

The National Institutes of Health (NIH) participating Institutes and Centers (ICs), in collaboration with the Global Alliance for Chronic Diseases (GACD), invite applications for implementation research focused on addressing risk factors for common noncommunicable diseases (NCDs) in World Bank-defined low- and middle-income countries (LMICs) and American Indian/Alaska Native (AI/AN) Tribal Nation populations in the United States. This Funding Opportunity Announcement (FOA) supports innovative approaches to identifying, understanding, developing, and implementingstrategies for overcoming barriers to the adoption, adaptation, integration, scale-up, and sustainability of evidence-based interventions, tools, policies, and guidelines. In addition, studies to advance dissemination and implementation research methods and measures into application are encouraged. Specifically, this FOA invites applications that propose implementation research targeted to reducing the risks of NCDs in the context of cities in LMICs and/or among AI/AN Tribal Nation populations in cities in the United States, with the potential to equip policymakers and practitioners with evidence-based strategies for prevention and/or management of NCDs among disadvantaged populations globally. In the context of this FOA, "cities" include urban centers, informal settlements and slums, and periurban areas.

The purpose of this notice is to inform interested applicants of a change to the Key Dates for PAR-20-049 "NINDS Postdoctoral Mentored Career Development Award (K01 - No Independent Clinical Trial Allowed)". This Funding Opportunity Announcement (FOA) has been extended by one additional council round.

The purpose of this notice is to inform interested applicants of a change to the Key Dates for PAR-20-050 "NINDS Postdoctoral Mentored Career Development Award (K01 - Clinical Trial Required)". This Funding Opportunity Announcement (FOA) has been extended by one additional council round.

The NIH Office of Science Policy (OSP) within the Office of the Director (OD) announces the availability of administrative supplements to support 1) research on bioethical issues to develop or support the development of an evidence base that may inform future policy directions, and/or 2) certain efforts to develop or augment bioethics research capacity. Applicants may propose to supplement parent awards focused on bioethics or to address a component related to bioethics in a biomedical research study. Note that applications must be within the general scope of the parent award.

The purpose of this notice is to inform applicants of a change to the Key dates and review locus for RFA-NS-19-043 "BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Not Allowed)". This Funding Opportunity Announcement (FOA) has been extended by one additional council round.

The purpose of this notice is to inform applicants of a change to the Key dates and review locus for RFA-NS-19-044 "BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity (K99/R00 Independent Clinical Trial Required)". This Funding Opportunity Announcement (FOA) has been extended by one additional council round.

This funding opportunity announcement (FOA) is designed to support integrated efforts of three or more (up to six) PDs/PIs to pursue bold, impactful, and challenging research in basic and clinical pain domains to understand the biology of specific human pain conditions as well as pain associated with diverse diseases/disorders, including mechanistic underpinning of heterogeneity and stratification of patients with specific pain conditions and co-morbidities. The research approach should be interdisciplinary in nature, and the research teams are expected to establish a common goal that requires collaboration, synergy, and managed team interactions. Proposed research should not represent a collection of individual efforts or parallel projects. Proposed research should support a cohesive, single, well-integrated research plan with a singular focus, one set of aims, and a budget without subprojects. Teams must leverage appropriate multi-disciplinary expertise to develop new principles and methods for experimentation, analysis, and interpretation. Teams are encouraged to consider transformative objectives with defined 5-year outcomes that will produce major advances in the understanding of human pain conditions and are likely to improve strategies for effective managementof human pain.

This R34 Funding Opportunity Announcement (FOA) seeks applications with limited scope proposing a set of planning activities that will lay the groundwork for a scientific project aimed at integrating complementary theories and methods to 1) develop, validate and apply cutting-edge tools and methods for minimally invasive, multi-dimensional, high-resolution measurement of behavior at the level of the organism, with synchronous capture of changes in the organisms social or physical environment; and/or 2) develop computational methods that allow for integration of multidimensional behavioral and environmental datarepresenting multiple timescales into a conceptual and/or computational model of behavior as a complex dynamic system, designed with the capacity to integrate synchronously recorded neural data and/or inform existing models of neurobehavioral function, such as those developed with the support of the NIH BRAIN Initiative. The purpose of this R34 funding opportunity is to support planning and development of the research framework, design, and approach, including activities that will establish feasibility, validity, and/or other technically qualifying results that, if successful, would support a competitive application for a U01, R01 or equivalent NIH research award.