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The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Allergy and Infectious Diseases (NIAID) invite research grant applications seeking support of a wide spectrum of research directed at generating improved knowledge concerning Lyme disease of the nervous system.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) is revising and reissuing an existing NINDS program announcement published January 8, 1988 to notify the scientific community of continuing NINDS interest in research addressing the surgical management of epilepsies.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH) are revising and reissuing a NINDS program announcement on narcolepsy published in the NIH Guide to Grants and Contracts, Vol. 19, No. 15, April 13, 1990, to notify the scientific community of continuing NINDS/NIMH interest in the submission of research project grant applications related to narcolepsy.

The National Institute of Neurological Disorders and Stroke (NINDS), a component of the National Institutes of Health, invites research grant applications seeking support of a wide spectrum of research on multiple sclerosis.

The olfactory nerve provides a direct anatomic conduit between the external chemical environment and the brain. This location puts the olfactory system at risk for damage from environmental toxicants and pathogens. These toxic agents comprise the major health hazard to human olfaction. However, the direct and indirect effects of these agents on the peripheral and central olfactory system are poorly understood. The purpose of this Program Announcement (PA) is to foster investigator-initiated research fundamental to understanding the impact of environmental toxicants and pathogens on the olfactory system. A broad range of studies extending from the molecular to the behavioral areas of basic and clinical research is applicable to this PA. The scope of these areas encompasses the transport of toxic substances into the brain through the olfactory nerve, olfactory mucosal defense mechanisms, neurogenesis, the relation of neurodegenerative diseases, such as Alzheimer"s disease, to olfactory abnormalities induced by toxic agents, and the vulnerability of an aged olfactory system to toxic agents.

The Division of Stroke and Trauma (DST), National Institute of Neurological Disorders and Stroke (NINDS), invites applications for support of research that will increase our knowledge of the mechanisms underlying the neuronal regeneration and plasticity that can follow spinal cord injury.

The Division of Stroke and Trauma (DST), National Institute of Neurological Disorders and Stroke (NINDS), invites applications for support of research that will increase our understanding of the causes of, and add to our ability to treat and prevent, recurrent headache, especially migraine.

The National Institute of Mental Health (NIMH) and the National Institute of Neurological Disorders and Stroke (NINDS) invite research grant applications for studies of neuro-endocrine-immune interactions, neuroimmunomodulation, psychoneuroimmunology, and the effects of viral and other infectious challenges on such interactions. Applications are also invited for studies of the health and treatment implications of such interactions. The goal of this program announcement is to promote research which will advance understanding of how the brain influences, and is influenced by, the various systems that maintain homeostasis and defend/repair the body"s tissues. This research will increase knowledge of the interrelationships between psychological states and physical health. Research is encouraged to improve behavioral and medical outcomes by the application of knowledge about neuro-endocrine-immune interactions.

The National Institute of Neurological Disorders and Stroke (NINDS) encourages the submission of research grant applications to pursue a promising new approach to cognitive neuroscience that will identify relations between cognitive function and neurostructure through the study of specific, atypical patterns of cognitive deficit associated with neurodevelopmental syndromes of known or suspected biological origin. Examples of three clinical entities that can be studied from this perspective are Williams syndrome, Turner syndrome and autism. An FY 91 NINDS workshop was devoted to the discussion and confirmation of the usefulness of in depth, systematic investigation of patterns or profiles of selective cognitive impairment in these unusual conditions.

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Mental Health (NIMH), components of the National Institutes of Health (NIH), invite research grant applications through this Program Announcement (PA) for support of research on neurological aspects of human immunodeficiency virus (HIV) infection (neuro-AIDS) in adults and children. It is well recognized that HIV-I infection, directly and/or indirectly, causes central and peripheral nervous system abnormalities that later may be compounded by opportunistic infections and malignancies. Applications are solicited covering a broad range of activities in the neurological sciences from basic research to diagnosis and management of neurological complications including therapeutic investigations of HIV-related neurological disease in adults and children. Research applications supporting the establishment or enlargement of collaborative and consultative neurologic units coordinated with AIDS Clinical Treatment Units (ACTUs) of the AIDS Clinical Treatment Group (ACTG), Women and Infants Transmission Study (WITS), and Multicenter AIDS Cohort Study (MACS) supported by the National Institute of Allergy and Infectious Diseases (NIAID) are especially solicited but are not required.