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The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) encourage the submission of research grant applications to investigate the potential for gene therapy in Duchenne muscular dystrophy. Responses to this program announcement may include studies in appropriate animal models of gene replacement using viral vectors, myoblast transfer, or other means of dystrophin enhancement.

The objective of the RFA is to stimulate research on the development of effective technologies to assess the integrity and function of the developing brain in the human fetus and newborns. The long-term goal of this research is the identification of newborns with brain dysfunction due to early, repetitive or chronic intrauterine central nervous system (CNS) influences/insults, which may result in Sudden Infant Death Syndrome (SIDS) and developmental disabilities including cerebral palsy. Postnatally acquired and acute perinatal deficits are not within the scope of this RFA. The National Institute of Child Health and Human Development (NICHD) and the National Institute of Neurological Disorders and Stroke (NINDS) invite applications for studies in animals and/or humans that (1) elucidate the physiological parameters that would serve as reliable markers of central nervous system integrity/pathology; and (2) explore the development of technologies/clinical tools that might identify infants who have, or are at risk for, abnormal neurologic development or sudden death from prenatal insults.

The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Institute of Neurological Diseases and Stroke, (NINDS) invite investigators to submit innovative research applications for the development or improvement of techniques focused on achieving successful human gene therapy for the treatment of metabolic diseases. The ultimate goal of this program is to extend the repertoire of diseases that can be successfully treated by gene therapy. The diseases of interest include disorders of cellular transport, disorders of lysosome metabolism, peroxisome metabolism, amino acid and organic acid metabolism, carbohydrate metabolism, purine and pyrimidine metabolism, metal metabolism, lipid metabolism, and mucopolysaccharide metabolism. Many of these diseases require the ability to deliver DNA to diverse tissue types. This program will support regular research grants as well as limited feasibility studies for new, highly innovative aspects of gene therapy.

The National Cancer Institute (NCI) through the Diagnostic Imaging Research Branch (DIRB) of the Radiation Research Program, the National Library of Medicine (NLM), and the Division of Stroke and Trauma, National Institute of Neurological Disorders and Stroke (NINDS) are seeking grant applications that will address new medical imaging database designs that focus on non-textual paradigms. The goal of medical imaging databases is to provide a means for organizing a large mass of heterogeneous, changing, pictorial, and symbolic data into a structured environment that can be synthesized, classified, and presented in an organized efficient manner to facilitate optimal decision making in a health care environment. A properly organized imaging database can compensate for human memory limitations and provide an environment for improved patient care, research, and education. Development of an effective and useful medical imaging database must take place in an interdisciplinary environment, using the medical knowledge from radiologists, radiation and medical oncologists, neurologists and other specialties in collaboration with the database research community and the imaging expertise of the computer and Picture Archiving and Communications System (PACS) sciences.

This Request for Applications (RFA) has been developed to encourage research on the standards and methods for identifying and characterizing optimal human fetal tissue for use in transplantation therapy. Joint funding by the National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute of Neurological Disorders and Stroke (NINDS) reflects the extent of interest in evaluating human fetal tissues and their biological potentials. Attention should be given to proper collection, processing, culturing and preserving these tissues to ensure highest quality control. This research should consider addressing methods for acquisition, handling, and processing, establishing morphologic status, determining developmental age and viability, assessing sterility and genetic normality, preserving by cryopreservation, storing and establishing cell lines. President Clinton's directive of January 22 ended the moratorium on Federal funding for use of fetal tissue from induced abortions in human transplantation research. Therefore, human fetal tissues studied under this solicitation may be derived from spontaneous abortion, ectopic pregnancy, or induced abortion.

The National Institute of Neurological Disorders and Stroke (NINDS) and the National Institute of Child Health and Human Development (NICHD), invite research grant applications for support of research on the restitution of ambulation following disability from neurological disorders or injury.

The National Institute of Neurological Disorders and Stroke (NINDS), the National Institute on Aging (NIA), the National Institute of Child Health and Human Development (NICHD), and the National Center for Nursing Research (NCNR) invite applications that take advantage of new opportunities for research into understanding phenomena in the central nervous system (CNS) essential for cognitive and behavioral activity. What CNS changes occur during different types of learning situations are substantial issues in the neurobiology of cognition and behavior. Integrative biological research is needed, not only for the development of sounder theory in the treatment and rehabilitation of brain dysfunctions, but also to advance an understanding of the fundamental neurobiological basis of perception, cognition, and behavior throughout the lifespan.

The Division of Convulsive, Developmental, and Neuromuscular Disorders, National Institute of Neurological Disorders and Stroke (NINDS) encourages the submission of research grant applications related to genetics of the epilepsies. The NINDS solicits submission of research project grants to stimulate research in both basic and clinical aspects of genetics of the epilepsies. The scope of this program encompasses both animal and human studies which would utilize a variety of experimental approaches and methods.

The purpose of this announcement is to facilitate a research area that defines a comparative framework for understanding the neural substrates of behavior, its principles, organization, and disorders. Applicants are encouraged to consider the advantages of using animal species representing different evolutionary levels including species that expand the kinds of animals conventionally used in brain and behavior research, as well as those that may require further development as experimental models.

The National Institute of Neurological Disorders and Stroke (NINDS) invites research grant applications seeking support of a wide spectrum of research directed at generating improved knowledge concerning amyotrophic lateral sclerosis (ALS).