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BRAIN Initiative: Targeted BRAIN Circuits Planning Projects TargetedBCPP (R34 Clinical Trials Not Allowed)

RFA
Monday, April 5, 2021
Thursday, November 11, 2021
R34
RFA-NS-21-014

Funding Opportunity Purpose

(Reissue of RFA-NS-18-014) This R34 FOA solicits applications that offer a limited scope of aims and an approach that will establish feasibility, validity, or other technically qualifying results that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent Targeted Brain Circuits Projects - TargetedBCP R01, as described in the companion FOA (RFA-NS-18-009). Applications should be exploratory research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior.

BRAIN Initiative: Targeted BRAIN Circuits Projects- TargetedBCP (R01 Clinical Trial Not Allowed)

RFA
Monday, April 5, 2021
Thursday, November 11, 2021
R01
RFA-NS-21-013

Funding Opportunity Purpose

(Reissue of RFA-NS-18-030) This FOA solicits applications for research projects that use innovative, methodologically-integrated approaches to understand how circuit activity gives rise to mental experience and behavior. The goal is to support projects that can realize a meaningful outcome within 5 years. Applications should address circuit function in the context of specific neural systems such as sensation, perception, attention, reasoning, intention, decision-making, emotion, navigation, communication or homeostasis. Projects should link theory and data analysis to experimental design and should produce predictive models as deliverables. Projects should aim to improve the understanding of circuits of the central nervous system by systematically controlling stimuli and/or behavior while actively recording and/or manipulating dynamic patterns of neural activity. Projects can use non-human and human species, and applications should explain how the selected species offers ideal conditions for revealing general principles about the circuit basis of a specific behavior.

NINDS Program Project Grant (P01 Clinical Trial Optional)

PAR
Monday, April 5, 2021
Wednesday, May 8, 2024
P01
PAR-21-181

Funding Opportunity Purpose

This funding opportunity announcement (FOA) is issued by the National Institute of Neurological Disorders and Stroke to enable submission of program project grant applications that propose to conduct innovative, interactive research to answer significant scientific questions that are important for the mission of NINDS, via a synergistic collaboration between outstanding scientists who might not otherwise collaborate. The program project grant is designed to support research in which the funding of several interdependent highly meritorious projects as a group offers significant scientific advantages over support of these same projects as individual research grants.

Notice of Special Interest (NOSI): Administrative Supplements to Support Enhancement of Software Tools for Open Science

Notice of Special Interest
Monday, April 5, 2021
Sunday, May 16, 2021
333
NOT-OD-21-091

Funding Opportunity Purpose

This Notice announces the reissue of administrative supplements to active awards that focus on biomedical software development or have a significant software development component. The goal of these supplements is to invest in research software tools with recognized value in a scientific community to enhance their impact by leveraging best practices in software development and advances in cloud computing. This initiative is part of a plan for implementing the NIH Strategic Plan for Data Science which describes actions aimed at modernizing the biomedical research data ecosystem and making data findable, accessible, interoperable, and reusable (FAIR) with high impact for open science. The supplements are intended to support collaborations between biomedical scientists and software engineers to enhance the design, implementation, and cloud-readiness of research software. Through these awards, the NIH Office of Data Science Strategy (ODSS) intends to help researchers who have developed scientifically valuable software to make tools sustainable, contribute to open science, and take advantage of new data science and computing paradigms.

Notice of Special Interest: Support for existing data repositories to align with FAIR and TRUST principles and evaluate usage, utility, and impact

Notice of Special Interest
Monday, April 5, 2021
Friday, May 21, 2021
333
NOT-OD-21-089

Funding Opportunity Purpose

The goal of this Notice of Special Interest (NOSI) is to strengthen NIH-funded biomedical data repositories to better enable data discoverability, interoperability, and reuse by aligning with the FAIR and TRUST principles and using metrics to measure their effectiveness. This NOSI provides an opportunity for existing repositories to increase FAIR-ness and TRUST-worthiness to improve their usage, utility, and impact throughout the data resource lifecycle.

Research on Autism Spectrum Disorders (R01 Clinical Trial Optional)

PA
Wednesday, March 31, 2021
Wednesday, March 6, 2024
R01
PA-21-201

Funding Opportunity Purpose

Reissue of the PA-18-401. The purpose of this Funding Opportunity Announcement (FOA) is to encourage research grant applications to support research designed to elucidate the etiology, epidemiology, diagnosis, and optimal means of service delivery in relation to Autism Spectrum Disorders (ASD).

Research on Autism Spectrum Disorders (R21 Clinical Trial Optional)

PA
Wednesday, March 31, 2021
Sunday, March 17, 2024
R21
PA-21-200

Funding Opportunity Purpose

Reissue of the PA-18-400. The purpose of this Funding Opportunity Announcement (FOA) is to encourage research grant applications to support research designed to elucidate the etiology, epidemiology, diagnosis, and optimal means of service delivery in relation to Autism Spectrum Disorders (ASD).

Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

PAR
Monday, March 29, 2021
Saturday, April 6, 2024
U44
PAR-21-162
Ann-Marie Broome

Funding Opportunity Purpose

The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program.

Notice of Special Interest (NOSI): Stimulate Research on the Diagnosis, Treatment, and Mechanistic Understanding of Postural Orthostatic Tachycardia Syndrome (POTS)

Notice of Special Interest
Friday, March 26, 2021
Wednesday, May 8, 2024
R01
NOT-HL-21-008

Funding Opportunity Purpose

Individuals with Postural Orthostatic Tachycardia Syndrome (POTS) suffer from an excessive increase in heart rate (tachycardia) and other symptoms that worsen upon standing or sitting up, such as light-headedness, shortness of breath, chest pain, and palpitations. It is likely that POTS has multiple underlying mechanisms resulting in subtypes of POTS that need to be identified and characterized. There is evidence that POTS can arise from abnormalities in autonomic nervous system function, immune system function including autoimmunity, regulation of blood volume and blood flow, or a combination of these factors. Genetic factors probably also affect susceptibility to POTS. Many people with POTS report a preceding medical or life-changing event such as viral infection, concussion, surgery, pregnancy, or puberty. Due to the highly variable symptoms and signs of POTS across different people, it is likely that POTS is best defined as a syndrome with several subtypes that have distinct underlying causes.

Neural Mechanisms of Force-Based Manipulations: High Priority Research Networks (U24 Clinical Trial Optional)

RFA
Tuesday, March 23, 2021
Thursday, July 15, 2021
U24
RFA-AT-21-006

Funding Opportunity Purpose

This proposed initiative aims to solicit applications that focus on developing resources by refining and testing key concepts that will advance and further support the study of the neurocircuitry of force-based manipulations. This grant funding initiative will support research networks through meetings, conferences, small-scale pilot research, multidisciplinary cross training (such as intensive workshops, summer institutes, or visiting scholar programs), and information dissemination to foster the growth and development of research in the specified priority areas listed below.

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